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CO2022004698A2 - Aminas de heteroaril-bifenilo para el tratamiento de enfermedades pd-l1 - Google Patents

Aminas de heteroaril-bifenilo para el tratamiento de enfermedades pd-l1

Info

Publication number
CO2022004698A2
CO2022004698A2 CONC2022/0004698A CO2022004698A CO2022004698A2 CO 2022004698 A2 CO2022004698 A2 CO 2022004698A2 CO 2022004698 A CO2022004698 A CO 2022004698A CO 2022004698 A2 CO2022004698 A2 CO 2022004698A2
Authority
CO
Colombia
Prior art keywords
heteroaryl
diseases
treatment
compounds
biphenyl amines
Prior art date
Application number
CONC2022/0004698A
Other languages
English (en)
Inventor
Pingchen Fan
Christopher W Lange
Rebecca M Lui
Darren J Mcmurtrie
Ryan J Scamp
Ju Yang
Yibin Zeng
Penglie Zhang
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of CO2022004698A2 publication Critical patent/CO2022004698A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporcionan compuestos que son útiles como inmunomoduladores. Los compuestos tienen la Fórmula (I) (I) incluidos estereoisómeros y sales farmacéuticamente aceptables de estos, donde R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 y n son como se definen en el presente documento. Además se describen métodos relacionados con la preparación y el uso de dichos compuestos, así como las composiciones farmacéuticas que comprenden dichos compuestos. 103856239v.1
CONC2022/0004698A 2019-10-16 2022-04-13 Aminas de heteroaril-bifenilo para el tratamiento de enfermedades pd-l1 CO2022004698A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962915771P 2019-10-16 2019-10-16
PCT/US2020/055669 WO2021076688A1 (en) 2019-10-16 2020-10-15 Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases

Publications (1)

Publication Number Publication Date
CO2022004698A2 true CO2022004698A2 (es) 2022-04-29

Family

ID=75538872

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0004698A CO2022004698A2 (es) 2019-10-16 2022-04-13 Aminas de heteroaril-bifenilo para el tratamiento de enfermedades pd-l1

Country Status (19)

Country Link
US (3) US11866429B2 (es)
EP (1) EP4045037A4 (es)
JP (1) JP7686634B2 (es)
KR (1) KR20220083775A (es)
CN (1) CN114555080B (es)
AR (1) AR120246A1 (es)
AU (1) AU2020368392A1 (es)
BR (1) BR112022006279A2 (es)
CA (1) CA3152714A1 (es)
CL (2) CL2022000955A1 (es)
CO (1) CO2022004698A2 (es)
CR (1) CR20220216A (es)
EC (1) ECSP22038509A (es)
IL (1) IL291735A (es)
MX (1) MX2022004450A (es)
PE (1) PE20221764A1 (es)
PH (1) PH12022550877A1 (es)
TW (1) TWI873207B (es)
WO (1) WO2021076688A1 (es)

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