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PE20120024A1 - DERIVADOS DE LA PIRIDINA SUSTITUIDO CON ANILLO HETEROCICLICO Y GRUPO y- GLUTAMINICO, Y AGENTES ANTIFUNGALES QUE LOS CONTIENEN - Google Patents

DERIVADOS DE LA PIRIDINA SUSTITUIDO CON ANILLO HETEROCICLICO Y GRUPO y- GLUTAMINICO, Y AGENTES ANTIFUNGALES QUE LOS CONTIENEN

Info

Publication number
PE20120024A1
PE20120024A1 PE2011000914A PE2011000914A PE20120024A1 PE 20120024 A1 PE20120024 A1 PE 20120024A1 PE 2011000914 A PE2011000914 A PE 2011000914A PE 2011000914 A PE2011000914 A PE 2011000914A PE 20120024 A1 PE20120024 A1 PE 20120024A1
Authority
PE
Peru
Prior art keywords
pyridin
glutaminic
group
heterocyclic ring
antifungal agents
Prior art date
Application number
PE2011000914A
Other languages
English (en)
Inventor
Keigo Tanaka
Original Assignee
Eisai Randd Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Randd Man Co Ltd filed Critical Eisai Randd Man Co Ltd
Publication of PE20120024A1 publication Critical patent/PE20120024A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, HALOGENO, AMINO, -(ALQUILO C1-C6)-NH, ENTRE OTROS; R2 ES -NH-CO-CH2-CH2-C(NH2)-CO-OR, DONDE R ES H, ALQUILO C1-C6 SUSTITUIDO O NO CON DIMETILAMINO; UNO DE X E Y ES N Y EL OTRO ES N, O; EL ANILLO A ES DE PREFERENCIA BENCENO; Z ES ENLACE SENCILLO, METILENO, ETILENO, O, S, ENTRE OTROS; R3 ES H, HALOGENO, ALQUILO C1-C6, ENTRE OTROS; R4 ES H, HALOGENO. SON COMPUESTOS PREFERIDOS: ACIDO (S)-2-AMINO-4-(3-(3-(4-(PIRIDIN-2-ILOXIMETIL)-BENCIL)-ISOXAZOL-5-IL)-PIRIDIN-2-ILCARBAMOIL)-BUTIRICO; ESTER METILICO DE ACIDO (S)-2-TER-BUTOXICARBONILAMINO-4-(3-{3-[4-(PIRIDIN-2-ILOXIMETIL)-BENCIL]-ISOXAZOL-5-IL}-PIRIDIN-2-PIRIDIN-2-ILCARBAMOIL)-BUTIRICO. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE INFECCIONES PRODUCIDAS POR HONGOS
PE2011000914A 2008-10-24 2009-10-22 DERIVADOS DE LA PIRIDINA SUSTITUIDO CON ANILLO HETEROCICLICO Y GRUPO y- GLUTAMINICO, Y AGENTES ANTIFUNGALES QUE LOS CONTIENEN PE20120024A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10820108P 2008-10-24 2008-10-24
JP2008274060 2008-10-24

Publications (1)

Publication Number Publication Date
PE20120024A1 true PE20120024A1 (es) 2012-02-22

Family

ID=42118103

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000914A PE20120024A1 (es) 2008-10-24 2009-10-22 DERIVADOS DE LA PIRIDINA SUSTITUIDO CON ANILLO HETEROCICLICO Y GRUPO y- GLUTAMINICO, Y AGENTES ANTIFUNGALES QUE LOS CONTIENEN

Country Status (16)

Country Link
US (2) US8188119B2 (es)
EP (1) EP2351752A4 (es)
JP (1) JPWO2010047120A1 (es)
KR (1) KR20110069823A (es)
CN (1) CN102186846A (es)
AU (1) AU2009307574A1 (es)
BR (1) BRPI0920614A2 (es)
CA (1) CA2740982A1 (es)
IL (1) IL211980A0 (es)
MX (1) MX2011003389A (es)
NZ (1) NZ592416A (es)
PE (1) PE20120024A1 (es)
RU (1) RU2011116160A (es)
TW (1) TW201018676A (es)
WO (1) WO2010047120A1 (es)
ZA (1) ZA201102840B (es)

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WO2015027067A2 (en) * 2013-08-23 2015-02-26 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
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JP2012176900A (ja) 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd （（ホスホノオキシ）メチル）ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤

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