[go: up one dir, main page]

PE20080734A1 - Inhibidores no nucleosidicos de la transcriptasa inversa - Google Patents

Inhibidores no nucleosidicos de la transcriptasa inversa

Info

Publication number
PE20080734A1
PE20080734A1 PE2007001087A PE2007001087A PE20080734A1 PE 20080734 A1 PE20080734 A1 PE 20080734A1 PE 2007001087 A PE2007001087 A PE 2007001087A PE 2007001087 A PE2007001087 A PE 2007001087A PE 20080734 A1 PE20080734 A1 PE 20080734A1
Authority
PE
Peru
Prior art keywords
chloro
phenoxy
reverse transcriptase
pirazole
benzyl
Prior art date
Application number
PE2007001087A
Other languages
English (en)
Inventor
Zachary Kevin Sweeney
Wylie Solang Palmer
Joshua Kennedy-Smith
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20080734A1 publication Critical patent/PE20080734A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN DERIVADO DE PIRAZOL DE FORMULA (I), DONDE A ES A1, A2, A3 O A4; X1, X2 Y X3 SON CR3, N, N ?O, ENTRE OTROS; UNO DE X4 Y X5 ES NR5 Y EL OTRO ES C(=0); R1 ES H O F; R2 ES H, HALOGENO, ALQUILO C1-C6, ENTRE OTROS; Ar ES FENILO SUSTITUIDO CON H, HALOGENO, CIANO, ENTRE OTROS; R3 ES H, HIDROXI, ALCOXI C1-C6, ENTRE OTROS; R6 ES H O ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS: 5-(4-METIL-3-FENOXI-BENCIL)-2H-PIRAZOL-3-OL, 3-[4-CLORO-3-(3-CLORO-FENOXI)-BENCIL]-1H-PIRAZOL, 3-CLORO-5-[6-CLORO-2-FLUORO-3-(1H-INDAZOL-3-ILMETIL)-FENOXI]-BENZONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TRANSCRIPTASA INVERSA DEL VIRUS DE INMUNODEFICIENCIA HUMANA (VIH) Y SON UTILES EN EL TRATAMIENTO DE INFECCION CAUSADAS POR ESTE VIRUS
PE2007001087A 2006-08-16 2007-08-14 Inhibidores no nucleosidicos de la transcriptasa inversa PE20080734A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83827206P 2006-08-16 2006-08-16

Publications (1)

Publication Number Publication Date
PE20080734A1 true PE20080734A1 (es) 2008-06-14

Family

ID=38663155

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001087A PE20080734A1 (es) 2006-08-16 2007-08-14 Inhibidores no nucleosidicos de la transcriptasa inversa

Country Status (23)

Country Link
US (2) US7713974B2 (es)
EP (1) EP2057125B1 (es)
JP (1) JP5216768B2 (es)
KR (1) KR101401811B1 (es)
CN (1) CN101501002B (es)
AR (1) AR062366A1 (es)
AT (1) ATE503744T1 (es)
AU (1) AU2007286345B2 (es)
BR (1) BRPI0715193A2 (es)
CA (1) CA2658984C (es)
CL (1) CL2007002346A1 (es)
DE (1) DE602007013573D1 (es)
DK (1) DK2057125T3 (es)
ES (1) ES2360893T3 (es)
IL (1) IL196655A (es)
MX (1) MX2009001198A (es)
NO (1) NO20090405L (es)
PE (1) PE20080734A1 (es)
PL (1) PL2057125T3 (es)
PT (1) PT2057125E (es)
RU (1) RU2451676C2 (es)
TW (1) TWI417293B (es)
WO (1) WO2008019968A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
TW200831085A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
KR20100015435A (ko) * 2007-04-09 2010-02-12 에프. 호프만-라 로슈 아게 비뉴클레오시드 역전사효소 저해제
US8877816B2 (en) * 2007-11-21 2014-11-04 Decode Genetics Ehf 4-(or 5-) substituted catechol derivatives
RU2495878C2 (ru) 2007-12-21 2013-10-20 Ф.Хоффманн-Ля Рош Аг Гетероциклические антивирусные соединения
JP2012509342A (ja) 2008-11-20 2012-04-19 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド 置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン
JP2013526570A (ja) * 2010-05-14 2013-06-24 オーエスアイ・ファーマシューティカルズ，エルエルシー 縮合二環式キナーゼ阻害剤
AR081039A1 (es) 2010-05-14 2012-05-30 Osi Pharmaceuticals Llc Inhibidores biciclicos fusionados de quinasa
US20120142627A1 (en) * 2010-12-06 2012-06-07 Emory University Monophosphate prodrugs of dapd and analogs thereof
EP2697203B1 (en) * 2011-04-13 2017-05-24 Merck Sharp & Dohme Corporation Mineralocorticoid receptor antagonists
JP5841239B2 (ja) 2011-04-26 2016-01-13 ザ プロクター アンド ギャンブルカンパニー 嵩増加された吸収性部材
WO2013163388A1 (en) 2012-04-25 2013-10-31 The Procter & Gamble Company Corrugated and apertured web
CA2871673C (en) 2012-04-25 2018-04-17 The Procter & Gamble Company Apparatus and process for aperturing and stretching a web
WO2014091265A1 (en) 2012-12-11 2014-06-19 Aurigene Discovery Technologies Limited Pyrimidine-2,4-diamine derivatives as kinase inhibitors
JP6321965B2 (ja) 2014-01-09 2018-05-09 富士フイルム株式会社 有機薄膜トランジスタ、有機半導体薄膜および有機半導体材料
CN106614663A (zh) * 2016-12-29 2017-05-10 新沂市中诺新材料科技有限公司 一种新型纳米级吲唑类农药合成方法
CN113511960A (zh) * 2021-08-20 2021-10-19 郑州华赞医药科技有限公司 一种1-氯-3-甲氧基-5-甲基苯的合成方法

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB427857A (en) 1934-08-02 1935-05-01 Newsum Sons & Company Ltd H A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames
US4949314A (en) 1966-08-16 1990-08-14 The United States Of America As Represented By The Secretary Of The Navy Method and means for increasing echo-ranging-search rate
US3682932A (en) 1970-11-23 1972-08-08 Hoffmann La Roche 2-chloro-6-hydroxynicotinic acid
US4211771A (en) 1971-06-01 1980-07-08 Robins Ronald K Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
US4189718A (en) * 1978-03-02 1980-02-19 Carson Manufacturing Company, Inc. Electronic siren
US4518584A (en) 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
GB8327880D0 (en) 1983-10-18 1983-11-16 Ajinomoto Kk Saccharomyces cerevisiae
US4604377A (en) 1984-03-28 1986-08-05 Cetus Corporation Pharmaceutical compositions of microbially produced interleukin-2
US4530787A (en) 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
US4569790A (en) 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
US4752585A (en) 1985-12-17 1988-06-21 Cetus Corporation Oxidation-resistant muteins
US4748234A (en) 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
AU622926B2 (en) 1988-09-09 1992-04-30 Nippon Kayaku Kabushiki Kaisha Pyrimidine or purine cyclobutane derivatives
US5925643A (en) 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US5464933A (en) 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US5489697A (en) 1994-08-03 1996-02-06 Medichem Research, Inc. Method for the preparation of (+)-calanolide A and intermediates thereof
DK0786455T3 (da) 1994-09-26 2004-03-29 Shionogi & Co Imidazolderivater
AU4788396A (en) 1995-02-16 1996-09-04 Children's Medical Center Corporation Inhibition of angiogenesis using interleukin-12
IL117574A0 (en) 1995-04-03 1996-07-23 Bristol Myers Squibb Co Processes for the preparation of cyclobutanone derivatives
WO2000016625A1 (en) 1998-09-23 2000-03-30 University Of Kentucky Research Foundation Antiviral drug compositions containing lithium inorganic salts
FR2783826B1 (fr) 1998-09-29 2002-07-19 Rhodia Chimie Sa Procede de preparation de 4-hydroxyquinoleines et/ou formes tautomeres
US7217714B1 (en) 1998-12-23 2007-05-15 Agouron Pharmaceuticals, Inc. CCR5 modulators
IL145741A0 (en) 1999-05-04 2002-07-25 Schering Corp Piperazine derivatives useful as ccrs antagonists
KR100439357B1 (ko) 1999-05-04 2004-07-07 쉐링 코포레이션 Ｃｃｒ５ 길항제로서 유용한 피페리딘 유도체
ES2215129T3 (es) 2000-05-26 2004-10-01 Pfizer Inc. Derivados de triazolil tropano como modulares de ccr5.
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
GB0024795D0 (en) * 2000-10-10 2000-11-22 Hoffmann La Roche Pyrazole derivatives for the treatment of viral diseases
US6620586B2 (en) 2001-02-20 2003-09-16 Applied Gene Technologies, Inc. Methods and compositions for analyzing nucleic acids
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
GB0108046D0 (en) 2001-03-30 2001-05-23 Astrazeneca Ab Chemical compounds
AU2002242926B2 (en) 2001-04-10 2007-10-11 Pfizer Inc. Pyrazole derivatives for treating HIV
GB0113524D0 (en) 2001-06-04 2001-07-25 Hoffmann La Roche Pyrazole derivatives
GB0127547D0 (en) 2001-11-16 2002-01-09 Astrazeneca Ab Chemical compounds
SE0200919D0 (sv) 2002-03-25 2002-03-25 Astrazeneca Ab Chemical compounds
SE0202483D0 (sv) 2002-08-21 2002-08-21 Astrazeneca Ab Chemical compounds
DE60319254T2 (de) 2002-09-26 2009-02-12 Pfizer Inc. Pyrazolamide zur behandlung von hiv-infektionen
EP1546132A1 (en) 2002-09-26 2005-06-29 Pfizer Limited Pyrazole derivatives as reverse transcriptase inhibitors
GB0223234D0 (en) 2002-10-07 2002-11-13 Pfizer Ltd Chemical compounds
GB0223232D0 (en) 2002-10-07 2002-11-13 Pfizer Ltd Chemical compounds
AR042628A1 (es) 2002-12-20 2005-06-29 Astrazeneca Ab Derivados de piperidina como moduladores del receptor ccr5
TW200423930A (en) 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
TW200505441A (en) * 2003-03-24 2005-02-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitorsⅠ
CA2518823A1 (en) 2003-03-24 2004-10-07 F.Hoffmann-La Roche Ag Benzyl-pyridazinons as reverse transcriptase inhibitors
US7220772B2 (en) * 2003-09-05 2007-05-22 Pfizer, Inc. Pyrazole derivatives
AU2005211499A1 (en) 2004-02-10 2005-08-18 F. Hoffmann-La Roche Ag Chemokine CCR5 receptor modulators
CA2559552A1 (en) * 2004-03-23 2005-09-29 F. Hoffmann-La Roche Ag Benzyl-pyridazinone derivatives as non-nucleoside reverse transcriptase inhibitors
US7625949B2 (en) * 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
US7166738B2 (en) * 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
ES2297727T3 (es) 2004-06-09 2008-05-01 F. Hoffmann-La Roche Ag Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos.
CN1993332B (zh) * 2004-07-27 2011-04-06 弗·哈夫曼-拉罗切有限公司 作为非核苷逆转录酶抑制剂的苄基三唑酮化合物
EP1797062B8 (en) * 2004-09-30 2011-05-25 Boehringer Ingelheim International GmbH Alkynyl based dervatives of benzophenone as non-nucleoside reverse transcriptase inhibitors
JP2008525419A (ja) 2004-12-22 2008-07-17 ファイザー・リミテッド Ｈｉｖ−１逆転写酵素の非ヌクレオシド阻害剤
JP2008534456A (ja) * 2005-03-24 2008-08-28 エフ．ホフマン−ラ ロシュ アーゲー ヘテロ環式逆転写酵素インヒビターとしての１，２，４−トリアゾール−５−オン化合物
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
EP1937651B1 (en) * 2005-09-30 2008-12-24 F.Hoffmann-La Roche Ag Nnrt inhibitors
EP1940782B1 (en) * 2005-10-19 2009-03-11 F.Hoffmann-La Roche Ag N-phenyl phenylacetamide non-nucleoside reverse transcriptase inhibitors
JP2009515826A (ja) * 2005-10-19 2009-04-16 エフ．ホフマン−ラ ロシュ アーゲー フェニル−アセトアミドｎｎｒｔ阻害剤
RU2008139599A (ru) * 2006-03-07 2010-04-20 Эррэй Биофарма Инк. (Us) Гетеробициклические производные пиразола и способы их применения
EP2124944B1 (en) * 2007-03-14 2012-02-15 Ranbaxy Laboratories Limited Pyrazolo[3,4-b]pyridine derivatives as phosphodiesterase inhibitors
US20100317646A1 (en) * 2009-03-19 2010-12-16 Medical Research Council Technology Compounds

Also Published As

Publication number Publication date
WO2008019968A1 (en) 2008-02-21
IL196655A0 (en) 2009-11-18
US20080045511A1 (en) 2008-02-21
JP2010500392A (ja) 2010-01-07
CN101501002A (zh) 2009-08-05
KR20090040438A (ko) 2009-04-24
TW200817397A (en) 2008-04-16
TWI417293B (zh) 2013-12-01
ATE503744T1 (de) 2011-04-15
US8063064B2 (en) 2011-11-22
ES2360893T3 (es) 2011-06-10
CA2658984C (en) 2014-12-02
CA2658984A1 (en) 2008-02-21
DK2057125T3 (da) 2011-05-16
CL2007002346A1 (es) 2008-03-14
NO20090405L (no) 2009-01-30
US7713974B2 (en) 2010-05-11
CN101501002B (zh) 2012-06-27
MX2009001198A (es) 2009-02-11
BRPI0715193A2 (pt) 2013-10-01
PT2057125E (pt) 2011-05-31
AR062366A1 (es) 2008-11-05
KR101401811B1 (ko) 2014-05-29
AU2007286345A1 (en) 2008-02-21
RU2009109354A (ru) 2010-09-27
DE602007013573D1 (de) 2011-05-12
AU2007286345B2 (en) 2012-03-08
US20110059975A1 (en) 2011-03-10
IL196655A (en) 2012-09-24
JP5216768B2 (ja) 2013-06-19
EP2057125A1 (en) 2009-05-13
EP2057125B1 (en) 2011-03-30
PL2057125T3 (pl) 2011-09-30
RU2451676C2 (ru) 2012-05-27

Similar Documents

Publication Publication Date Title
PE20080734A1 (es) Inhibidores no nucleosidicos de la transcriptasa inversa
PE20091000A1 (es) Inhibidores de la replicacion del virus de la inmunodeficiencia humana
PE20120690A1 (es) Derivados de 5-fluoropirimidinona
PE20120024A1 (es) DERIVADOS DE LA PIRIDINA SUSTITUIDO CON ANILLO HETEROCICLICO Y GRUPO y- GLUTAMINICO, Y AGENTES ANTIFUNGALES QUE LOS CONTIENEN
CR20220371A (es) Agonistas heterocíclicos de glp-1
PE20070585A1 (es) Derivados de sulfonamida como activadores de glucoquinasa
PE20081532A1 (es) Compuestos novedosos
PE20061357A1 (es) COMPUESTOS DERIVADOS DE AMINOSULFONILO COMO INHIBIDORES DE LA 11-ß-HSD-1
PE20090601A1 (es) Derivados de piridin-il-oxi-piridinas como inhibidores de alk5
PE20091841A1 (es) Inhibidores del virus de hepatitis c
NO20044534L (no) Substituerte fenylacetamider og deres anvendelse som glukokinaseaktivatorer
PE20090813A1 (es) Inhibidores de la 11b-hidroxiesteroide-deshidrogenasa
PE20080075A1 (es) Compuestos fenil amido heterociclicos condensados
PE20120659A1 (es) Inhibidores de la replicacion del virus de la inmunodeficiencia humana
PE20090982A1 (es) Derivados de piperidina como inhibidores de la proteina de transferencia de colesteril-ester (cetp)
PE20071031A1 (es) Derivados de tiadiazolidinona como inhibidores de ptpasas
CY1110753T1 (el) Αναστολεις της 11-βητα-υδροξυστεροειδους αφυδρογονασης i
PE20200342A1 (es) Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue
PE20130158A1 (es) Inhibidores no nucleosidicos de la transcriptasa inversa
PE20130157A1 (es) Inhibidores de la polimerasa virica
PE20140703A1 (es) Derivados de heteroarilo como moduladores de nachr alfa 7
PE20081375A1 (es) Derivados octahidro-pirrolo[3,4-c]pirrol como antagonistas del receptor ccr5
PE20080136A1 (es) Arilsulfonamidas sustituidas como agentes antivirales
PE20080211A1 (es) Compuestos derivados de 6-(bencilo sustituido con heterociclilo)-4-oxoquinolina como inhibidores de integrasa del vih
AR055563A1 (es) Compuestos de piridil acido acetico, agente farmaceutico y utilizacion del compuesto para preparar dicho agente

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed