PE20080211A1 - Compuestos derivados de 6-(bencilo sustituido con heterociclilo)-4-oxoquinolina como inhibidores de integrasa del vih - Google Patents
Compuestos derivados de 6-(bencilo sustituido con heterociclilo)-4-oxoquinolina como inhibidores de integrasa del vihInfo
- Publication number
- PE20080211A1 PE20080211A1 PE2007000805A PE2007000805A PE20080211A1 PE 20080211 A1 PE20080211 A1 PE 20080211A1 PE 2007000805 A PE2007000805 A PE 2007000805A PE 2007000805 A PE2007000805 A PE 2007000805A PE 20080211 A1 PE20080211 A1 PE 20080211A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- benzyl
- halogen
- oxoquinoline
- dihydroquinolin
- Prior art date
Links
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical group [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 229940099797 HIV integrase inhibitor Drugs 0.000 title 1
- 239000003084 hiv integrase inhibitor Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE 6-(BENCILO SUSTITUIDO CON HETEROCICLILO)-4-OXOQUINOLINA DE FORMULA (I) DONDE EL ANILLO A ES UN HETEROCICLICO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO(C1-C4), ENTRE OTROS; R1 ES H, ALQUILO(C1-C6), UN ANILLO DE CARBONO(C3-C10), ENTRE OTROS; R2 ES H, ALQUILO(C1-C4) U OR11, DONDE R11 ES H O ALQUILO(C1-C4); R3 Y R4 SON CADA UNO H, HALOGENO, ALQUILO(C1-C4) U OR12, DONDE R12 ES H O ALQUILO(C1-C4); R5 ES HALOGENO, ALQUILO(C1-C4) U OR13, DONDE R13 ES H O ALQUILO(C1-C4); m ES DE 0 A 2; R6 ES H O R1 Y R6 JUNTO CON LOS ATOMOS DE C A LOS QUE SE UNEN FORMAN UN CICLOALQUILO(C3-C10) OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO(C1-C4), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO 6-[3-CLORO-2-FLUORO-5-(MORFOLIN-4-IL)BENCIL]-1-((R)-1-ETOXIMETIL-2-HIDROXIETIL)-7-ETIL-4-OXO-1,4-DIHIDROQUINOLIN-3-CARBOXILICO, ACIDO 6-[3-CLORO-2-FLUORO-5-(2-OXOPIRROLIDIN-1-IL)BENCIL]-1-((S)-1-HIDROXIMETIL-2-METILPROPIL)-7-METOXI-4-OXO-1,4-DIHIDROQUINOLIN-3-CARBOXILICO, ACIDO 6-[3-CLORO-2-FLUORO-5-(PIRROLIDIN-1-IL)BENCIL]-1-((S)-1-HIDROXIMETIL-2-METILPROPIL)-7-METOXI-4-OXO-1,4-DIHIDROQUINOLIN-3-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE INTEGRASA DEL VIRUS DE INMUNODEFICIENCIA HUMANA (VIH) SIENDO UTILES EN EL TRATAMIENTO DE SIDA
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006174331 | 2006-06-23 | ||
| JP2006220082 | 2006-08-11 | ||
| JP2006274143 | 2006-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080211A1 true PE20080211A1 (es) | 2008-04-23 |
Family
ID=38833517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000805A PE20080211A1 (es) | 2006-06-23 | 2007-06-22 | Compuestos derivados de 6-(bencilo sustituido con heterociclilo)-4-oxoquinolina como inhibidores de integrasa del vih |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7872004B2 (es) |
| EP (2) | EP2368880A1 (es) |
| JP (1) | JP4038231B1 (es) |
| KR (1) | KR101053811B1 (es) |
| AR (1) | AR061583A1 (es) |
| AU (1) | AU2007262010B2 (es) |
| BR (1) | BRPI0713336A2 (es) |
| CA (1) | CA2653830C (es) |
| CL (1) | CL2007001838A1 (es) |
| CO (1) | CO6150181A2 (es) |
| IL (1) | IL195862A0 (es) |
| MX (1) | MX2009000159A (es) |
| MY (1) | MY144773A (es) |
| NO (1) | NO20090322L (es) |
| NZ (1) | NZ573709A (es) |
| PE (1) | PE20080211A1 (es) |
| SA (1) | SA07280343B1 (es) |
| TW (1) | TW200811153A (es) |
| WO (1) | WO2007148780A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20040840A1 (es) * | 2002-11-20 | 2004-12-30 | Japan Tobacco Inc | Derivados de 4-oxoquinolina como inhibidores de la integrasa del vih |
| CA2661943C (en) * | 2006-09-12 | 2015-11-03 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
| AR068403A1 (es) | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
| ES2446720T3 (es) | 2009-10-13 | 2014-03-10 | Elanco Animal Health Ireland Limited | Inhibidores de la integrasa macrocíclica |
| US8716293B2 (en) | 2010-04-02 | 2014-05-06 | Janssen R&D Ireland | Macrocyclic integrase inhibitors |
| EP2785184B1 (en) | 2011-11-30 | 2020-06-10 | Emory University | Compositions comprising jak inhibitors and haart drugs for use in the prevention or treatment of hiv |
| PT2880017T (pt) | 2012-08-03 | 2016-12-14 | Gilead Sciences Inc | Processo e intermediários para preparar inibidores da integrase |
| HUE059677T2 (hu) | 2019-03-22 | 2022-12-28 | Gilead Sciences Inc | Áthidalt triciklusos karbamoilpiridon-vegyületek és ezek gyógyszerészeti alkalmazása |
| EP4110783A1 (en) | 2020-02-24 | 2023-01-04 | Gilead Sciences, Inc. | Tetracyclic compounds for treating hiv infection |
| CA3192145A1 (en) | 2020-09-30 | 2022-04-07 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| PE20231297A1 (es) | 2021-01-19 | 2023-08-22 | Gilead Sciences Inc | Compuestos de piridotriazina sustituidos y usos de estos |
| TW202446773A (zh) | 2022-04-06 | 2024-12-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| CN115448866B (zh) * | 2022-10-13 | 2023-11-21 | 中北大学 | 一种1-甲基-2,3,4,5-四硝基吡咯的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ503740A (en) | 1997-09-15 | 2002-09-27 | Procter & Gamble | Antimicrobial quinolones, their compositions and uses |
| WO2004004611A1 (en) | 2002-07-08 | 2004-01-15 | Coloplast A/S | Conduit device |
| PE20040840A1 (es) | 2002-11-20 | 2004-12-30 | Japan Tobacco Inc | Derivados de 4-oxoquinolina como inhibidores de la integrasa del vih |
| EP1730135B1 (en) | 2004-03-10 | 2010-09-22 | The United States of America, represented by the Secretary, Department of Health and Human Services | Qiunolin-4-ones as inhibitors of retroviral integrase for the treatment of hiv, aids and aids related complex (arc) |
| WO2005113509A1 (en) | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| US7745459B2 (en) | 2004-09-21 | 2010-06-29 | Japan Tobacco Inc. | Quinolizinone compound and use thereof as HIV integrase inhibitor |
| WO2006033422A1 (ja) | 2004-09-21 | 2006-03-30 | Japan Tobacco Inc. | キノリジノン化合物、およびそのｈｉｖインテグラーゼ阻害剤としての利用 |
| JP2006174331A (ja) | 2004-12-20 | 2006-06-29 | Fuji Xerox Co Ltd | 画像圧縮装置、画像圧縮方法及びそのプログラム |
| JP2006220082A (ja) | 2005-02-10 | 2006-08-24 | Denso Corp | 燃料噴射装置 |
| JP4572720B2 (ja) | 2005-03-30 | 2010-11-04 | Ｄｉｃ株式会社 | 水分散型アクリル系樹脂の製造方法、並びにそれにより製造される水分散型アクリル粘着剤組成物及び粘着シート |
| DE102006005861A1 (de) | 2006-02-09 | 2007-08-23 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone III |
-
2007
- 2007-06-21 TW TW096122234A patent/TW200811153A/zh unknown
- 2007-06-22 EP EP11168760A patent/EP2368880A1/en not_active Withdrawn
- 2007-06-22 CL CL200701838A patent/CL2007001838A1/es unknown
- 2007-06-22 US US11/767,021 patent/US7872004B2/en not_active Expired - Fee Related
- 2007-06-22 EP EP07845259A patent/EP2033954A4/en not_active Withdrawn
- 2007-06-22 KR KR1020097001497A patent/KR101053811B1/ko not_active Expired - Fee Related
- 2007-06-22 NZ NZ573709A patent/NZ573709A/en not_active IP Right Cessation
- 2007-06-22 PE PE2007000805A patent/PE20080211A1/es not_active Application Discontinuation
- 2007-06-22 MX MX2009000159A patent/MX2009000159A/es active IP Right Grant
- 2007-06-22 AU AU2007262010A patent/AU2007262010B2/en not_active Ceased
- 2007-06-22 WO PCT/JP2007/062579 patent/WO2007148780A1/ja not_active Ceased
- 2007-06-22 AR ARP070102755A patent/AR061583A1/es not_active Application Discontinuation
- 2007-06-22 BR BRPI0713336-7A patent/BRPI0713336A2/pt not_active IP Right Cessation
- 2007-06-22 CA CA2653830A patent/CA2653830C/en not_active Expired - Fee Related
- 2007-06-22 JP JP2007164676A patent/JP4038231B1/ja not_active Expired - Fee Related
- 2007-06-23 SA SA7280343A patent/SA07280343B1/ar unknown
-
2008
- 2008-12-10 MY MYPI20085006A patent/MY144773A/en unknown
- 2008-12-11 IL IL195862A patent/IL195862A0/en unknown
-
2009
- 2009-01-16 CO CO09003378A patent/CO6150181A2/es unknown
- 2009-01-21 NO NO20090322A patent/NO20090322L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009000159A (es) | 2009-01-23 |
| US20080207618A1 (en) | 2008-08-28 |
| CL2007001838A1 (es) | 2008-02-08 |
| SA07280343B1 (ar) | 2011-01-15 |
| KR101053811B1 (ko) | 2011-08-03 |
| JP4038231B1 (ja) | 2008-01-23 |
| EP2033954A4 (en) | 2009-08-12 |
| CO6150181A2 (es) | 2010-04-20 |
| JP2008110960A (ja) | 2008-05-15 |
| US7872004B2 (en) | 2011-01-18 |
| CA2653830C (en) | 2011-11-22 |
| AR061583A1 (es) | 2008-09-03 |
| AU2007262010A1 (en) | 2007-12-27 |
| EP2368880A1 (en) | 2011-09-28 |
| KR20090023731A (ko) | 2009-03-05 |
| WO2007148780A1 (ja) | 2007-12-27 |
| IL195862A0 (en) | 2009-09-01 |
| MY144773A (en) | 2011-10-31 |
| CA2653830A1 (en) | 2007-12-27 |
| NO20090322L (no) | 2009-03-20 |
| NZ573709A (en) | 2011-04-29 |
| AU2007262010B2 (en) | 2011-05-12 |
| EP2033954A1 (en) | 2009-03-11 |
| BRPI0713336A2 (pt) | 2012-11-06 |
| TW200811153A (en) | 2008-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |