PE20091057A1 - Antagonistas del receptor mineralcorticoide y metodos de uso - Google Patents
Antagonistas del receptor mineralcorticoide y metodos de usoInfo
- Publication number
- PE20091057A1 PE20091057A1 PE2008002008A PE2008002008A PE20091057A1 PE 20091057 A1 PE20091057 A1 PE 20091057A1 PE 2008002008 A PE2008002008 A PE 2008002008A PE 2008002008 A PE2008002008 A PE 2008002008A PE 20091057 A1 PE20091057 A1 PE 20091057A1
- Authority
- PE
- Peru
- Prior art keywords
- oxepin
- iliden
- dibenzo
- methyl
- mineralcorticoid receptor
- Prior art date
Links
- 239000002395 mineralocorticoid Substances 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010020571 Hyperaldosteronism Diseases 0.000 abstract 1
- -1 IMIDAZOL-2 (3H) -YLIDENE Chemical class 0.000 abstract 1
- XZMCDFZZKTWFGF-NJFSPNSNSA-N aminoformonitrile Chemical compound N#[14C]N XZMCDFZZKTWFGF-NJFSPNSNSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- UZVGSSNIUNSOFA-UHFFFAOYSA-N dibenzofuran-1-carboxylic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C(=O)O UZVGSSNIUNSOFA-UHFFFAOYSA-N 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- ATYBXHSAIOKLMG-UHFFFAOYSA-N oxepin Chemical compound O1C=CC=CC=C1 ATYBXHSAIOKLMG-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE DIBENZO[b,e]OXEPIN DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H O F; L ES -(CH2)2-, -CH(CH3)-CH2- O UN ENLACE DIRECTO; R3 ES UN COMPUESTO DE FORMULA (i), (ii), (iii), ENTRE OTROS; R4 ES CN O -C(O)NH2. SON COMPUESTOS PREFERIDOS: (E)-N-(5-((E)-3-FLUORO-6H-DIBENZO[b,e]OXEPIN-11-ILIDENMETIL)-1-(1-METIL-AZETIDIN-3-IL)-1,3-DIHIDRO-BENZOIMIDAZOL-2-ILIDEN)-CIANAMIDA, (E)-N-(5-((E)-(3-FLUORODIBENZO[b,e]OXEPIN-11(6H)-ILIDEN)METIL)-1-((3S,4S)-4-HIDROXI-1-METILPIRROLIDIN-3-IL)-1H-BENZO[d]IMIDAZOL-2(3H)-ILIDEN)CIANAMIDA, (E)-N-[5-((E)-3-FLUORO-6H-DIBENZO[b,e]OXEPIN-11-ILIDENMETIL)-1-((3S,4S)-4-HIDROXI-1-METIL-PIRROLIDIN-3-IL)-1,3-DIHIDRO-BENZOIMIDAZOL-2-ILIDEN]-UREA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR MINERALCORTICOIDE SIENDO UTILES EN EL TRATAMIENTO DE NEFROPATIA DIABETICA, ENFERMEDAD RENAL CRONICA, ARRITMIA MIOCARDIAL, HIPERALDOSTERONISMO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1477607P | 2007-12-19 | 2007-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091057A1 true PE20091057A1 (es) | 2009-07-20 |
Family
ID=40430143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008002008A PE20091057A1 (es) | 2007-12-19 | 2008-12-02 | Antagonistas del receptor mineralcorticoide y metodos de uso |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US7994164B2 (es) |
| EP (2) | EP2537845B1 (es) |
| JP (1) | JP5562866B2 (es) |
| KR (1) | KR101254382B1 (es) |
| CN (1) | CN101903377B (es) |
| AR (1) | AR069554A1 (es) |
| AU (1) | AU2008343524B2 (es) |
| BR (1) | BRPI0820805A2 (es) |
| CA (1) | CA2710409C (es) |
| CL (1) | CL2008003600A1 (es) |
| CO (1) | CO6300953A2 (es) |
| DK (1) | DK2235007T3 (es) |
| DO (1) | DOP2010000185A (es) |
| EA (1) | EA017668B1 (es) |
| EC (2) | ECSP10010266A (es) |
| ES (2) | ES2396605T3 (es) |
| GT (1) | GT201000179A (es) |
| HR (1) | HRP20120916T1 (es) |
| IL (1) | IL206353A (es) |
| MA (1) | MA31910B1 (es) |
| MX (1) | MX2010006911A (es) |
| MY (1) | MY150474A (es) |
| NZ (1) | NZ586300A (es) |
| PE (1) | PE20091057A1 (es) |
| PL (1) | PL2235007T3 (es) |
| PT (1) | PT2235007E (es) |
| RS (1) | RS52594B (es) |
| SI (1) | SI2235007T1 (es) |
| TN (1) | TN2010000292A1 (es) |
| TW (1) | TWI431010B (es) |
| UA (1) | UA100131C2 (es) |
| WO (1) | WO2009085584A1 (es) |
| ZA (1) | ZA201004257B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009018657A1 (en) | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| NZ585370A (en) | 2007-12-19 | 2012-09-28 | Boehringer Ingelheim Int | Viral polymerase inhibitors |
| CA2751901C (en) | 2009-03-12 | 2013-08-06 | Eli Lilly And Company | Mineralocorticoid receptor antagonist and methods of use |
| CA2796307A1 (en) | 2010-05-10 | 2011-11-17 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
| EP2582365B1 (en) | 2010-06-16 | 2019-03-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions for stimulating reepithelialisation during wound healing |
| CN102060670A (zh) * | 2011-01-04 | 2011-05-18 | 常州大学 | 一种2-溴-6-氟苯甲醇的制备方法 |
| GEP201706675B (en) | 2013-05-02 | 2017-05-25 | Pfizer | Imidazo-triazine derivatives as pde10 inhibitors |
| AR099416A1 (es) | 2014-02-28 | 2016-07-20 | Lilly Co Eli | Terapia combinada para la hipertensión resistente |
| PL3160948T3 (pl) | 2014-06-30 | 2019-04-30 | Astrazeneca Ab | Amidy benzoksazynonu jako modulatory receptorów mineralokortykoidowych |
| US20170246166A1 (en) * | 2014-11-21 | 2017-08-31 | Eli Lilly And Company | 1,2-benzothiazole compounds for the treatment of kidney disorders |
| WO2017064121A1 (en) | 2015-10-13 | 2017-04-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation |
| US20190262363A1 (en) | 2016-07-26 | 2019-08-29 | INSERM (Institut National de la Santé et de la Recherche Médicale | Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis |
| CN109069502B (zh) * | 2016-09-24 | 2021-08-06 | 山东亨利医药科技有限责任公司 | 含盐皮质激素受体拮抗剂的药物组合物及其用途 |
| US20230151425A1 (en) | 2020-03-11 | 2023-05-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of determining whether a subject has or is at risk of having a central serous chorioretinopathy |
| EP4395785A1 (en) | 2021-08-31 | 2024-07-10 | Inserm (Institut National de la Santé et de la Recherche Scientifique) | Methods for the treatment of ocular rosacea |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4072756A (en) * | 1973-05-17 | 1978-02-07 | Sandoz Ltd. | Tricyclo piperidino ketones and soporific compositions thereof |
| SE426341C (sv) * | 1980-02-14 | 1985-09-23 | Fagersta Ab | Sett att forhindra korrosion i en forbrenningsanleggnings kylare och skorsten vid kylning av rokgaser |
| FR2603713B1 (fr) * | 1986-09-10 | 1992-07-24 | Canon Kk | Derive nouveau de 5h-dibenzo(a,d)cycloheptane-(ene)ylidene, son procede de production et support electrophotographique photosensible le contenant |
| CA1338625C (en) * | 1988-06-09 | 1996-10-01 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
| GB8914061D0 (en) * | 1989-06-19 | 1989-08-09 | Wellcome Found | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
| US5378701A (en) * | 1991-12-27 | 1995-01-03 | Kyowa Hakko Kogyo | Tricyclic compounds |
| AR014195A1 (es) | 1997-12-29 | 2001-02-07 | Ortho Mcneil Pharm Inc | Compuestos de trifenilpropanamida utiles para el tratamiento de procesos inflamatorios, composiciones anti-inflamatorias que los comprenden, ymetodos para prepararlos |
| JP2002541144A (ja) | 1999-01-26 | 2002-12-03 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | 医薬的に活性のある化合物及びその使用方法 |
| NZ596484A (en) * | 2001-11-21 | 2013-05-31 | Millennium Pharm Inc | Chemokine receptor antagonists and methods of use thereof |
| TW200400816A (en) * | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
| WO2005066153A1 (en) | 2003-12-19 | 2005-07-21 | Eli Lilly And Company | Tricyclic steroid hormone nuclear receptor modulators |
| DK1697350T3 (da) | 2003-12-19 | 2008-10-13 | Lilly Co Eli | Tricykliske modulatorer af cellekernereceptor for steroidhormon |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| EP1778242A4 (en) | 2004-07-28 | 2010-10-20 | Irm Llc | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROIDHORMONE NUCLEAR RECEPTORS |
| MX2007005527A (es) | 2004-11-10 | 2007-07-09 | Incyte Corp | Compuestos de lactama y sus usos como farmaceuticos. |
| RS20090208A (sr) | 2006-10-31 | 2010-06-30 | Pfizer Products Inc. | Pirazolin jedinjenja kao antagonisti mineralokortikoid receptora |
| US20100120736A1 (en) | 2007-03-29 | 2010-05-13 | N.V. Organon | Mineralocorticoid Receptor Antagonists |
| GB0725102D0 (en) | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Compounds |
| PE20091339A1 (es) | 2007-12-21 | 2009-09-26 | Glaxo Group Ltd | Derivados de oxadiazol con actividad sobre receptores s1p1 |
| WO2009094157A1 (en) | 2008-01-25 | 2009-07-30 | Arena Pharmaceuticals, Inc. | Dihydro- 1h- pyrrolo [1,2-a] indol-1-yl carboxylic derivatives which act as s1p1 agonists |
| CA2751901C (en) | 2009-03-12 | 2013-08-06 | Eli Lilly And Company | Mineralocorticoid receptor antagonist and methods of use |
-
2008
- 2008-12-02 PE PE2008002008A patent/PE20091057A1/es not_active Application Discontinuation
- 2008-12-02 TW TW097146779A patent/TWI431010B/zh not_active IP Right Cessation
- 2008-12-03 AR ARP080105263A patent/AR069554A1/es unknown
- 2008-12-03 CL CL2008003600A patent/CL2008003600A1/es unknown
- 2008-12-09 EP EP12185389.9A patent/EP2537845B1/en active Active
- 2008-12-09 ES ES08866835T patent/ES2396605T3/es active Active
- 2008-12-09 AU AU2008343524A patent/AU2008343524B2/en not_active Ceased
- 2008-12-09 RS RS20120541A patent/RS52594B/sr unknown
- 2008-12-09 PL PL08866835T patent/PL2235007T3/pl unknown
- 2008-12-09 ES ES12185389.9T patent/ES2459318T3/es active Active
- 2008-12-09 BR BRPI0820805-0A patent/BRPI0820805A2/pt not_active IP Right Cessation
- 2008-12-09 EP EP08866835A patent/EP2235007B1/en active Active
- 2008-12-09 NZ NZ586300A patent/NZ586300A/en not_active IP Right Cessation
- 2008-12-09 WO PCT/US2008/085997 patent/WO2009085584A1/en not_active Ceased
- 2008-12-09 CN CN200880121527.2A patent/CN101903377B/zh not_active Expired - Fee Related
- 2008-12-09 CA CA2710409A patent/CA2710409C/en not_active Expired - Fee Related
- 2008-12-09 DK DK08866835.5T patent/DK2235007T3/da active
- 2008-12-09 US US12/330,539 patent/US7994164B2/en not_active Expired - Fee Related
- 2008-12-09 KR KR1020107013601A patent/KR101254382B1/ko not_active Expired - Fee Related
- 2008-12-09 HR HRP20120916AT patent/HRP20120916T1/hr unknown
- 2008-12-09 EA EA201070762A patent/EA017668B1/ru not_active IP Right Cessation
- 2008-12-09 MY MYPI20102867 patent/MY150474A/en unknown
- 2008-12-09 PT PT88668355T patent/PT2235007E/pt unknown
- 2008-12-09 MX MX2010006911A patent/MX2010006911A/es active IP Right Grant
- 2008-12-09 UA UAA201007627A patent/UA100131C2/uk unknown
- 2008-12-09 JP JP2010539618A patent/JP5562866B2/ja not_active Expired - Fee Related
- 2008-12-09 SI SI200830852T patent/SI2235007T1/sl unknown
-
2010
- 2010-06-14 IL IL206353A patent/IL206353A/en not_active IP Right Cessation
- 2010-06-14 MA MA32909A patent/MA31910B1/fr unknown
- 2010-06-15 ZA ZA2010/04257A patent/ZA201004257B/en unknown
- 2010-06-16 CO CO10072532A patent/CO6300953A2/es not_active Application Discontinuation
- 2010-06-17 GT GT201000179A patent/GT201000179A/es unknown
- 2010-06-17 EC EC2010010266A patent/ECSP10010266A/es unknown
- 2010-06-17 DO DO2010000185A patent/DOP2010000185A/es unknown
- 2010-06-18 TN TN2010000292A patent/TN2010000292A1/fr unknown
-
2012
- 2012-07-17 EC ECSP12012048 patent/ECSP12012048A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |