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PE20081467A1 - Compuestos de benzoil amino heterociclico como mediadores de glucoquinasas (glk) - Google Patents

Compuestos de benzoil amino heterociclico como mediadores de glucoquinasas (glk)

Info

Publication number
PE20081467A1
PE20081467A1 PE2007001425A PE2007001425A PE20081467A1 PE 20081467 A1 PE20081467 A1 PE 20081467A1 PE 2007001425 A PE2007001425 A PE 2007001425A PE 2007001425 A PE2007001425 A PE 2007001425A PE 20081467 A1 PE20081467 A1 PE 20081467A1
Authority
PE
Peru
Prior art keywords
oxi
glucokinases
mediators
het
heterocyclic compounds
Prior art date
Application number
PE2007001425A
Other languages
English (en)
Inventor
Leonie Campbell
Kurt Gordon Pike
Abid Suleman
Michael James Waring
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20081467A1 publication Critical patent/PE20081467A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Catching Or Destruction (AREA)

Abstract

SE REFIERE A COMPUESTOS DE BENZOIL AMINO HETEROCICLICO DE FORMULA (I), EN DONDE R1 ES ALQUILO(C1-C4), CICLOALQUILO(C3-C6); HET-1 ES UN HETEROARILO DE 5 A 6 MIEMBROS CON UN N EN LA POSICION 2 EN RELACION CON EL N DE LA AMIDA AL CUAL ESTA UNIDO EL ANILLO Y OPCIONALMENTE 1 O 2 HETEROATOMOS ADICIONALES DE O, N Y S; DONDE OPCIONALEMNTE ESTA SUSTITUIDO EN CUAKQUIR N POR R7, ENTRE OTROS; EL ANILLO A ES FENILO SUSTITUIDO CON R2, HET-2 Y HET-3. SON SELECCIONADOS: 3-[6-(AZETIDIN-1-CARBONIL)PIRIDIN-3-IL]OXI-5-[(3S)-1-METIL-2-OXO-PIRROLIDIN-3-IL] OXI-N-(5-METILPIPERAZIN-2-IL)BENZAMINA, 3-[5-(AZETIDIN-1-CARBONIL)PIRAZIN-2-IL]OXI-5-[(3R)-1-METIL-2-OXO-PIRROLIDIN-3-IL]OXI-N-(4-METIL-1,3-TIAZOL-2-IL)BENZAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON MEDIADORES DE GLUCOQUINASAS, SIENDO UTILES EN EL TRATAMIENTO DE DIABETES DE TIPO 2 Y OBESIDAD
PE2007001425A 2006-10-23 2007-10-22 Compuestos de benzoil amino heterociclico como mediadores de glucoquinasas (glk) PE20081467A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86249306P 2006-10-23 2006-10-23
US89199307P 2007-02-28 2007-02-28

Publications (1)

Publication Number Publication Date
PE20081467A1 true PE20081467A1 (es) 2008-12-07

Family

ID=39324963

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001425A PE20081467A1 (es) 2006-10-23 2007-10-22 Compuestos de benzoil amino heterociclico como mediadores de glucoquinasas (glk)

Country Status (18)

Country Link
US (1) US7902200B2 (es)
EP (1) EP2086964A2 (es)
JP (1) JP2010507640A (es)
KR (1) KR20090068289A (es)
AR (1) AR063499A1 (es)
AU (1) AU2007310608A1 (es)
BR (1) BRPI0718504A2 (es)
CA (1) CA2667435A1 (es)
CL (1) CL2007003033A1 (es)
CO (1) CO6160318A2 (es)
IL (1) IL198142A0 (es)
MX (1) MX2009004362A (es)
NO (1) NO20091599L (es)
PE (1) PE20081467A1 (es)
RU (1) RU2009114982A (es)
TW (1) TW200825063A (es)
UY (1) UY30660A1 (es)
WO (1) WO2008050101A2 (es)

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TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
NZ575512A (en) 2005-07-09 2009-11-27 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
TW200825060A (en) * 2006-10-26 2008-06-16 Astrazeneca Ab Chemical compounds
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GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
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AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
WO2010150280A1 (en) * 2009-06-22 2010-12-29 Cadila Healthcare Limited Disubstituted benzamide derivatives as glucokinase (gk) activators
CN102482267B (zh) * 2009-07-31 2014-12-03 卡迪拉保健有限公司 作为葡萄糖激酶(gk)活化剂的取代苯甲酰胺衍生物
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US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
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CL2007003033A1 (es) 2008-05-16
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RU2009114982A (ru) 2010-11-27
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US7902200B2 (en) 2011-03-08
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