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PE20091413A1 - (DIHIDRO)PIRROLO[2,1-a] ISOQUINOLINAS - Google Patents

(DIHIDRO)PIRROLO[2,1-a] ISOQUINOLINAS

Info

Publication number
PE20091413A1
PE20091413A1 PE2009000177A PE2009000177A PE20091413A1 PE 20091413 A1 PE20091413 A1 PE 20091413A1 PE 2009000177 A PE2009000177 A PE 2009000177A PE 2009000177 A PE2009000177 A PE 2009000177A PE 20091413 A1 PE20091413 A1 PE 20091413A1
Authority
PE
Peru
Prior art keywords
alkyl
dihidropirrolo
thiofen
metoxi
cyane
Prior art date
Application number
PE2009000177A
Other languages
English (en)
Inventor
Rijn Rachel Deborah Van
Hubert Jan Jozef Loozen
Cornelis Marius Timmers
Der Veen Lars Anders Van
Willem Frederik Johan Karstens
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of PE20091413A1 publication Critical patent/PE20091413A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1 ES HALOGENO, ALQUILO C1-C6, CIANO, FENILO, ENTRE OTROS; R2 ES H, CIANO, HALOGENO, (ALCOXI C1-C4)-(ALQUILO C1-C4), ENTRE OTROS; R3 ES ALQUILO C1-C6, CICLOALQUILO C3-C6, (HETEROCICLOALQUIL C2-C6)-(ALQUILO C1-C4), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (9-ISOPROPOXI-8-METOXI-1-TIOFEN-2-IL-5,6-DIHIDROPIRROLO[2,1-a]ISOQUINOLIN-3-IL)-[4-(TETRAHIDRO-FURANO-2-CARBONIL)-[1,4]DIAZEPAN-1-IL]METANONA; (9-ISOPROPOXI-8-METOXI-1-TIOFEN-2-IL-5,6-DIHIDROPIRROLO[2,1-a]ISOQUINOLIN-3-IL)-[4-(TIOFENO-2-SULFONIL)-[1,4]DIAZEPAN-1-IL]-METANONA; TER-BUTIL ESTER DEL ACIDO 7-(9-ISOPROPOXI-8-METOXI-1-TIOFEN-2-IL-5,6-DIHIDROPIRROLO[2,1-a]-ISOQUINOLINA-3-CARBONIL)-3,7-DIAZABICICLO[3.3.1]NONANO-3-CARBOXILICO; ENTRE OTROS. DICHOS COMPUESTOS MIMETICOS DE HORMONAS DE BAJO PESO MOLECULAR QUE ACTIVAN SELECTIVAMENTE EL RECEPTOR DE FSH UTILES EN EL TRATAMIENTO DE TRASTORNOS DE LA FERTILIDAD
PE2009000177A 2008-02-08 2009-02-05 (DIHIDRO)PIRROLO[2,1-a] ISOQUINOLINAS PE20091413A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08151199 2008-02-08

Publications (1)

Publication Number Publication Date
PE20091413A1 true PE20091413A1 (es) 2009-09-23

Family

ID=39516937

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000177A PE20091413A1 (es) 2008-02-08 2009-02-05 (DIHIDRO)PIRROLO[2,1-a] ISOQUINOLINAS

Country Status (26)

Country Link
US (1) US8394789B2 (es)
EP (1) EP2252611B1 (es)
JP (1) JP5620823B2 (es)
KR (1) KR101586870B1 (es)
CN (1) CN102216297B (es)
AR (1) AR070345A1 (es)
AT (1) ATE527260T1 (es)
AU (1) AU2009211296B2 (es)
BR (1) BRPI0906937A2 (es)
CA (1) CA2713173C (es)
CL (1) CL2009000281A1 (es)
CO (1) CO6241120A2 (es)
DK (1) DK2252611T3 (es)
EC (1) ECSP10010303A (es)
ES (1) ES2373022T3 (es)
HR (1) HRP20110942T1 (es)
IL (1) IL206378A0 (es)
MX (1) MX2010008717A (es)
NZ (1) NZ587164A (es)
PE (1) PE20091413A1 (es)
PL (1) PL2252611T3 (es)
PT (1) PT2252611E (es)
RU (1) RU2495037C2 (es)
SI (1) SI2252611T1 (es)
TW (1) TW200944523A (es)
WO (1) WO2009098283A1 (es)

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TWI461426B (zh) * 2009-05-27 2014-11-21 Merck Sharp & Dohme （二氫）咪唑並異〔５，１－ａ〕喹啉類
US8071587B2 (en) 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
EP2504316A1 (en) 2009-11-23 2012-10-03 MSD Oss B.V. Heterocylic compounds as antagonists of the orexin receptors
US20120174381A1 (en) 2011-01-10 2012-07-12 David Messick Apparatus and method for frame crimping
WO2012112958A2 (en) * 2011-02-19 2012-08-23 The Broad Institute, Inc High-throughput assays to probe leukemia within the stromal niche
AU2012311699B2 (en) * 2011-09-22 2017-06-29 Merck Sharp & Dohme B.V. FSH receptor antagonists
JP6075736B2 (ja) * 2011-12-21 2017-02-08 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． ピロール−６員ヘテロアリール環誘導体、その合成法およびその医薬用途
CN102718695B (zh) * 2012-06-25 2014-04-02 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
RU2649004C2 (ru) 2012-11-29 2018-03-29 Кемосентрикс, Инк. Антагонисты cxcr7
RU2550366C1 (ru) * 2014-05-22 2015-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 5,6-ДИГИДРОПИРРОЛО[2,1-a]ИЗОХИНОЛИНОВ
CN113194956A (zh) * 2018-12-12 2021-07-30 凯莫森特里克斯股份有限公司 用于癌症治疗的cxcr7抑制剂
CN110540519B (zh) * 2019-09-05 2022-12-02 宁波大学 一种1,6-烯炔类化合物与酮类化合物的自由基环化反应方法
CN113999103A (zh) * 2021-11-26 2022-02-01 八叶草健康产业研究院(厦门)有限公司 一种α-羟基-环丁烷甲酸的制备方法
IL322905A (en) 2023-03-08 2025-10-01 Ferring Bv Small molecule FSH receptor modulators

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GB8718980D0 (en) * 1987-08-11 1987-09-16 May & Baker Ltd Compositions of matter
DE4343649A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Neue Pyridazino[4',5':3,4]pyrrolo-[2,1-a]isochinoline und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6235755B1 (en) * 1998-08-07 2001-05-22 Applied Research Systems Ars Holding N.A. FSH mimetics for the treatment of infertility
WO2000048144A1 (fr) 1999-02-15 2000-08-17 Medailles Souvenirs Dispositif de personnalisation et de distribution de medailles
EP1307193A1 (en) 2000-07-27 2003-05-07 Affymax Research Institute Agonists of follicle stimulating hormone activity
AU2002227985A1 (en) * 2000-12-13 2002-06-24 Bayer Aktiengesellschaft Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
IL159288A0 (en) 2001-07-02 2004-06-01 Akzo Nobel Nv Tetrahydroquinoline derivatives
US20030236276A1 (en) 2001-08-06 2003-12-25 Ulrich Niewohner Pyrrolo[2.1-a]isoquinoline derivatives
WO2003014115A1 (en) 2001-08-06 2003-02-20 Bayer Aktiengesellschaft 3-substituted pyrrolo (2.1-a) isoquinoline derivatives
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ES2399047T3 (es) * 2002-09-20 2013-03-25 Merck Serono Sa Derivados de piperazina y procedimiento de uso
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ES2326337T3 (es) 2005-01-12 2009-10-07 Nycomed Gmbh Nuevas pirrolodihidroisoquinolinas como inhibidores de pde10.
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UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
JP4869336B2 (ja) 2005-05-04 2012-02-08 ナームローゼ・フエンノートチヤツプ・オルガノン ジヒドロピリジン誘導体
UA92008C2 (en) 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY

Also Published As

Publication number Publication date
NZ587164A (en) 2011-06-30
US8394789B2 (en) 2013-03-12
KR101586870B1 (ko) 2016-01-19
PT2252611E (pt) 2011-12-20
JP2011511041A (ja) 2011-04-07
CN102216297B (zh) 2014-06-25
AR070345A1 (es) 2010-03-31
ES2373022T3 (es) 2012-01-30
EP2252611A1 (en) 2010-11-24
RU2010136057A (ru) 2012-03-20
BRPI0906937A2 (pt) 2016-04-19
MX2010008717A (es) 2010-09-24
CL2009000281A1 (es) 2009-06-26
WO2009098283A1 (en) 2009-08-13
IL206378A0 (en) 2010-12-30
AU2009211296B2 (en) 2014-01-30
CA2713173A1 (en) 2009-08-13
US20110039832A1 (en) 2011-02-17
PL2252611T3 (pl) 2012-03-30
DK2252611T3 (da) 2012-01-30
SI2252611T1 (sl) 2012-02-29
TW200944523A (en) 2009-11-01
AU2009211296A1 (en) 2009-08-13
HRP20110942T1 (hr) 2012-01-31
ECSP10010303A (es) 2010-07-30
HK1150597A1 (en) 2012-01-06
RU2495037C2 (ru) 2013-10-10
CO6241120A2 (es) 2011-01-20
JP5620823B2 (ja) 2014-11-05
ATE527260T1 (de) 2011-10-15
CA2713173C (en) 2016-04-19
KR20100124279A (ko) 2010-11-26
CN102216297A (zh) 2011-10-12
EP2252611B1 (en) 2011-10-05

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