AR071323A1 - Derivados heterociclicos de piridazinonas activadores de glucoquinasas, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de los mismos en el tratamiento de la diabetes mellitus tipo ii. - Google Patents
Derivados heterociclicos de piridazinonas activadores de glucoquinasas, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de los mismos en el tratamiento de la diabetes mellitus tipo ii.Info
- Publication number
- AR071323A1 AR071323A1 ARP090101307A ARP090101307A AR071323A1 AR 071323 A1 AR071323 A1 AR 071323A1 AR P090101307 A ARP090101307 A AR P090101307A AR P090101307 A ARP090101307 A AR P090101307A AR 071323 A1 AR071323 A1 AR 071323A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- aryl
- lower alkyl
- halogen
- heterocyclyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title abstract 2
- 230000003213 activating effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- -1 -CH2-cycloalkyl Chemical group 0.000 abstract 10
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical class 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000001188 haloalkyl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 208000030159 metabolic disease Diseases 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Estos compuestos, y las composiciones farmacéuticas que las contienen, son utiles para el tratamiento de enfermedades metabolicas y trastornos como, por ejemplo, diabetes mellitus de tipo II. Reivindicacion 1: Compuestos de formula (1) en los que: X se selecciona de entre el grupo que consiste en O, NR, S, S(O), S(O)2, CH2, o X está ausente; R es hidrogeno o alquilo inferior, Q es hidrogeno o -O-arilo; Y es hidrogeno o, cuando X sea oxígeno, Y se selecciona de entre el grupo que consiste en hidrogeno, halogeno, alquilo inferior y arilo, o -X-R1 y Y junto a los átomos de C a los que están unidos forman una porcion fenilo, dicho fenilo no está sustituido o está mono-, bi- o trisustituido con halogeno, alquilo inferior o alcoxi, R1 se selecciona de entre el grupo que consiste en hidrogeno, alquilo inferior, cicloalquilo, sin sustituir o mono- o bi-sustituido con alquilo inferior, -CH2-cicloalquilo, heterociclilo, arilo, sin sustituir o mono-, bi- o tri-sustituido independientemente con halogeno, alquilo inferior, alcoxi inferior, hidroxialquilo inferior, halogenoalquilo inferior, halogenoalcoxi inferior, -S(O2)-alquilo inferior, arilo, -CH2-arilo, -O-arilo, heteroarilo, ciano, alcanoilo inferior, cicloalquilo, heterociclilo o -C(O)-heterociclilo, arilalquilo inferior, en el que el arilo no está sustituido o está sustituido con halogeno, alquilo inferior o halogenoalquilo inferior, heteroarilo, sin sustituir o sustituido con halogeno, alquilo inferior o halogenoalquilo inferior, 2,3-dihidro-benzo[1,4]dioxin-5-ilo, 2,3-dihidro-benzo[1,4]dioxin-2-ilmetilo, 5,6,7,8-tetrahidro-naftalen-1-ilo, 1H-indol-4-ilo, sin sustituir o sustituido con hidroxialquilo inferior, 4-hidroxi-indol-l-ilo, 2,2-dimetil-2,3-dihidro-benzofuran-7-ilo, 7-metil-indan-4-ilo, 2-metil-4-oxo-4H-piran-3-ilo, e isoquinolinilo; R2 se selecciona de entre el grupo que consiste en alquilo inferior, cicloalquilo, heterociclilo, arilo, sin sustituir o mono- o bi-sustituido independientemente con halogeno, y heteroarilo con al menos un heteroátomo en el anillo pudiendo ser O o S; y R3 es alquil-carbamoilo inferior o es un heteroarilo sin sustituir o sustituido conectado mediante un átomo de carbono del anillo al grupo amina mostrado, con un heteroátomo que es un nitrogeno adyacente al átomo de carbono conector del anillo, dicho heteroarilo sustituido está sustituido en una posicion diferente al adyacente a la de dicho átomo de carbono conector independientemente con halogeno, alquilo interior, halogenoalquilo inferior, hidroxialquilo inferior, alcoxicarbonilo inferior, carboxilo, alcanoilalcoxi inferior, cicloalquilo, arilo, -CH2-arilo, heterociclilo o -CH2-heterocicliio, o sales farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4531808P | 2008-04-16 | 2008-04-16 | |
| US11465408P | 2008-11-14 | 2008-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071323A1 true AR071323A1 (es) | 2010-06-09 |
Family
ID=40666944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101307A AR071323A1 (es) | 2008-04-16 | 2009-04-14 | Derivados heterociclicos de piridazinonas activadores de glucoquinasas, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de los mismos en el tratamiento de la diabetes mellitus tipo ii. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8258134B2 (es) |
| EP (1) | EP2268633A1 (es) |
| JP (1) | JP5301655B2 (es) |
| KR (1) | KR101270389B1 (es) |
| CN (1) | CN102007116B (es) |
| AR (1) | AR071323A1 (es) |
| AU (1) | AU2009237792B2 (es) |
| BR (1) | BRPI0911476A2 (es) |
| CA (1) | CA2720559A1 (es) |
| IL (1) | IL207349A (es) |
| MX (1) | MX2010009922A (es) |
| PE (1) | PE20091725A1 (es) |
| TW (1) | TW200944517A (es) |
| WO (1) | WO2009127544A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| MX2009008531A (es) * | 2007-02-16 | 2009-08-26 | Amgen Inc | Cetonas de heterociclilo que contienen nitrogeno y su uso como inhibidores de c-met. |
| KR101616139B1 (ko) | 2008-02-29 | 2016-04-27 | 랜티우스 메디컬 이메징, 인크. | 관류 영상화를 포함하는 용도를 위한 조영제 |
| US8088815B2 (en) | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
| MX348958B (es) | 2010-02-08 | 2017-07-04 | Lantheus Medical Imaging Inc | Métodos y aparatos para sintetizar agentes formadores de imagen e intermedios de estos. |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| AU2011235212B2 (en) | 2010-03-31 | 2014-07-31 | The Scripps Research Institute | Reprogramming cells |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TWI566663B (zh) * | 2011-03-15 | 2017-01-11 | 鴻海精密工業股份有限公司 | 鎖扣組件、帶有鎖扣組件的載具及電路板固定系統 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| JP6506836B2 (ja) | 2014-08-14 | 2019-04-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｂ型肝炎ウイルス感染症の処置および予防のための新規ピリダゾンおよびトリアジノン |
| WO2017023992A1 (en) | 2015-08-05 | 2017-02-09 | Bristol-Myers Squibb Company | Novel substituted glycine derived fxia inhibitors |
| AR127064A1 (es) | 2021-09-15 | 2023-12-13 | Hua Medicine Shanghai Ltd | Prodroga de derivados de pirrolidona como activador de glucoquinasa |
| WO2024132901A1 (en) * | 2022-12-19 | 2024-06-27 | Syngenta Crop Protection Ag | Microbiocidal pyridazine dihydrooxadiazine derivatives |
| AR132113A1 (es) * | 2023-03-13 | 2025-05-28 | Hua Medicine Shanghai Ltd | Forma sólida de derivados de pirrolidona como activador de glucoquinasa |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01009814A (es) | 1999-03-29 | 2002-04-24 | Hoffmann La Roche | Activadores de la glucoquinasa. |
| KR100502033B1 (ko) | 2000-05-03 | 2005-07-25 | 에프. 호프만-라 로슈 아게 | 알키닐 페닐 헤테로방향족 글루코키나제 활성제 |
| MXPA02010746A (es) * | 2000-05-03 | 2003-03-10 | Hoffmann La Roche | Activadores de la glucocinasa que contienen hidantoina. |
| MXPA02010795A (es) | 2000-05-08 | 2003-03-27 | Hoffmann La Roche | Activadores de glucocinasa de fenilamida sustituida por para-amino. |
| DK1282611T3 (da) | 2000-05-08 | 2005-02-14 | Hoffmann La Roche | Substituerede phenylacetatamider og anvendelse deraf som glucokinaseaktivatorer |
| AU2002221902B2 (en) | 2000-12-06 | 2006-11-23 | F. Hoffmann-La Roche Ag | Fused heteroaromatic glucokinase activators |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| US20030171411A1 (en) * | 2001-12-21 | 2003-09-11 | Kodra Janos Tibor | Amide derivatives as therapeutic agents |
| AU2003232204B8 (en) | 2002-04-26 | 2009-07-30 | F. Hoffmann-La Roche Ag | Substituted phenylacetamides and their use as glucokinase activators |
| GB0210762D0 (en) * | 2002-05-10 | 2002-06-19 | Glaxo Group Ltd | Compounds |
| JP2006509774A (ja) | 2002-10-03 | 2006-03-23 | ノバルティス アクチエンゲゼルシャフト | ２型糖尿病の処置において有用なグルコキナーゼアクチベーターとしての置換（チアゾール−２−イル）−アミドまたはスルホンアミド |
| US7132425B2 (en) | 2002-12-12 | 2006-11-07 | Hoffmann-La Roche Inc. | 5-substituted-six-membered heteroaromatic glucokinase activators |
| CN100469770C (zh) * | 2002-12-12 | 2009-03-18 | 霍夫曼-拉罗奇有限公司 | 5-取代的-吡嗪或吡啶葡糖激酶激活剂 |
| US7262196B2 (en) | 2003-02-11 | 2007-08-28 | Prosidion Limited | Tri(cyclo) substituted amide glucokinase activator compounds |
| PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| PE20050194A1 (es) | 2003-02-13 | 2005-04-23 | Banyu Pharma Co Ltd | Derivados de piridina-2-carboxamida como activadores de glucoquinasa |
| MXPA05009059A (es) | 2003-02-26 | 2005-10-19 | Banyu Pharma Co Ltd | Derivados de heteroarilcarbamoilbenceno. |
| US20080280872A1 (en) | 2004-02-18 | 2008-11-13 | Craig Johnstone | Benzamide Derivatives and Their Use as Glucokinase Activating Agents |
| CA2554686A1 (en) | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Compounds |
| AU2005223610B2 (en) | 2004-03-23 | 2008-05-29 | Banyu Pharmaceutical Co., Ltd. | Substituted quinazoline or pyridopyrimidine derivative |
| ATE524479T1 (de) | 2004-04-02 | 2011-09-15 | Novartis Ag | Sulfonamidthiazolpyridinderivate als zur behandlung von typ-2-diabetes geeignete glucokinaseaktivatoren |
| MXPA06012008A (es) | 2004-04-21 | 2007-01-25 | Prosidion Ltd | Compuestos de amida tri(ciclo) sustituidos. |
| TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| CN101035767A (zh) | 2004-08-12 | 2007-09-12 | 普洛希典有限公司 | 被取代的苯乙酰胺及其作为葡糖激酶激活剂的用途 |
| GB0423044D0 (en) | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| JP2008521864A (ja) | 2004-12-03 | 2008-06-26 | トランステック・ファーマ、インコーポレイテッド | ヘテロ芳香族グルコキナーゼ活性化剤 |
| TW200714597A (en) | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
| US20110053910A1 (en) | 2005-07-09 | 2011-03-03 | Mckerrecher Darren | 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes |
| US20080234273A1 (en) | 2005-07-09 | 2008-09-25 | Mckerrecher Darren | Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes |
| NZ575512A (en) | 2005-07-09 | 2009-11-27 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| KR100965040B1 (ko) | 2005-07-11 | 2010-06-21 | 미쓰비시 타나베 파마 코퍼레이션 | 옥심 유도체 및 그의 제조 방법 |
| EP1915367A1 (en) | 2005-08-09 | 2008-04-30 | AstraZeneca AB | Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes |
| BRPI0615236A2 (pt) | 2005-08-31 | 2011-05-10 | Astellas Pharma Inc | derivado de tiazol |
| GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
| GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
| US20080293741A1 (en) | 2005-11-03 | 2008-11-27 | Matthew Colin Thor Fyfe | Tricyclo Substituted Amides as Glucokinase Modulators |
| WO2007051845A1 (en) | 2005-11-03 | 2007-05-10 | Prosidion Ltd | Tricyclo substituted amides |
| EP1948645A1 (en) | 2005-11-03 | 2008-07-30 | Prosidion Limited | Tricyclo substituted amides |
| JP5302012B2 (ja) | 2006-03-08 | 2013-10-02 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
| EP2463283B1 (en) | 2006-04-20 | 2014-06-11 | Pfizer Products Inc. | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases |
| KR20080042286A (ko) * | 2006-11-09 | 2008-05-15 | 주식회사 엘지생명과학 | 피리다지논 구조를 포함하는 캐스파제 저해제 |
| CL2008002703A1 (es) * | 2007-09-14 | 2009-11-20 | Sumitomo Chemical Co | Compuestos derivados de 1,4-dihidro-2h-piridazin-3-ona; composicion herbicida que comprende a dichos compuestos; metodo de control de malezas; uso de dichos compuestos para el control de malezas; y compuestos intermediarios. |
| WO2009057827A1 (en) * | 2007-10-31 | 2009-05-07 | Nissan Chemical Industries, Ltd. | Pyridazinone derivatives and use thereof as p2x7 receptor inhibitors |
| EP2328586A2 (en) * | 2008-05-20 | 2011-06-08 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
| US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
-
2009
- 2009-03-09 US US12/400,319 patent/US8258134B2/en not_active Expired - Fee Related
- 2009-04-06 WO PCT/EP2009/054058 patent/WO2009127544A1/en not_active Ceased
- 2009-04-06 EP EP09733332A patent/EP2268633A1/en not_active Withdrawn
- 2009-04-06 JP JP2011504417A patent/JP5301655B2/ja not_active Expired - Fee Related
- 2009-04-06 CN CN200980113224.0A patent/CN102007116B/zh not_active Expired - Fee Related
- 2009-04-06 BR BRPI0911476-9A patent/BRPI0911476A2/pt not_active IP Right Cessation
- 2009-04-06 KR KR1020107022948A patent/KR101270389B1/ko not_active Expired - Fee Related
- 2009-04-06 AU AU2009237792A patent/AU2009237792B2/en not_active Ceased
- 2009-04-06 MX MX2010009922A patent/MX2010009922A/es active IP Right Grant
- 2009-04-06 CA CA2720559A patent/CA2720559A1/en not_active Abandoned
- 2009-04-13 TW TW098112220A patent/TW200944517A/zh unknown
- 2009-04-14 AR ARP090101307A patent/AR071323A1/es unknown
- 2009-04-15 PE PE2009000523A patent/PE20091725A1/es not_active Application Discontinuation
-
2010
- 2010-08-02 IL IL207349A patent/IL207349A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2268633A1 (en) | 2011-01-05 |
| KR101270389B1 (ko) | 2013-06-05 |
| JP2011516592A (ja) | 2011-05-26 |
| IL207349A0 (en) | 2010-12-30 |
| IL207349A (en) | 2014-08-31 |
| WO2009127544A1 (en) | 2009-10-22 |
| JP5301655B2 (ja) | 2013-09-25 |
| AU2009237792A1 (en) | 2009-10-22 |
| CA2720559A1 (en) | 2009-10-22 |
| TW200944517A (en) | 2009-11-01 |
| CN102007116A (zh) | 2011-04-06 |
| US8258134B2 (en) | 2012-09-04 |
| PE20091725A1 (es) | 2009-11-13 |
| AU2009237792B2 (en) | 2014-07-24 |
| KR20100124328A (ko) | 2010-11-26 |
| BRPI0911476A2 (pt) | 2019-03-19 |
| CN102007116B (zh) | 2014-10-22 |
| MX2010009922A (es) | 2010-09-28 |
| US20090264434A1 (en) | 2009-10-22 |
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