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PE20090328A1 - Derivados de oxadiazol como moduladores de los receptores metabotropicos de glutamato - Google Patents

Derivados de oxadiazol como moduladores de los receptores metabotropicos de glutamato

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Publication number
PE20090328A1
PE20090328A1 PE2008000965A PE2008000965A PE20090328A1 PE 20090328 A1 PE20090328 A1 PE 20090328A1 PE 2008000965 A PE2008000965 A PE 2008000965A PE 2008000965 A PE2008000965 A PE 2008000965A PE 20090328 A1 PE20090328 A1 PE 20090328A1
Authority
PE
Peru
Prior art keywords
modulators
metabotropic glutamate
glutamate receptors
oxadiazol
oxadiazole derivatives
Prior art date
Application number
PE2008000965A
Other languages
English (en)
Inventor
Joshua Clayton
Ian Egle
James Empfield
Methvin Isaac
Fupeng Ma
Abdelmalik Slassi
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40093925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090328(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20090328A1 publication Critical patent/PE20090328A1/es

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE OXADIAZOL DE FORMULA (I) DONDE R1 ES HALO O HALOALCOXILO(C1-C3); Q ES UN COMPUESTO DE FORMULA (i) O (ii), EN DONDE R2 ES H O ALQUILO(C1-C3). SON COMPUESTOS PREFERIDOS: 7-METIL-5-(3-PIPERAZIN-1-ILMETIL-[1,2,4]OXADIAZOL-5-IL)-2-(4-TRIFLUOROMETOXIBENCIL)-2,3-DIHIDROISOINDOL-1-ONA, 2-(4-CLORO-BENCIL)-5-[3-(2,5-DIAZA-BICICLO[2,2,1]HEPT-2-ILMETIL)-[1,2,4]OXADIAZOL-5-IL]-7-METIL-2,3-DIHIDRO-ISOINDOL-1-ONA, 2-(4-CLORO-BENCIL)-7-METIL-5-[3-(3-METIL-PIPERAZIN-1-ILMETIL)-[1,2,4]OXADIAZOL-5-IL]-2,3-DIHIDRO-ISOINDOL-1-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES METABOTROPICOS DE GLUTAMATO (mGluR) SIENDO UTILES EN EL TRATAMIENTO DE ACCIDENTE CEREBROVASCULAR, DEMENCIA, RETINOPATIA, EPILEPSIA, MIGRANA
PE2008000965A 2007-06-07 2008-06-06 Derivados de oxadiazol como moduladores de los receptores metabotropicos de glutamato PE20090328A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94255307P 2007-06-07 2007-06-07

Publications (1)

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PE20090328A1 true PE20090328A1 (es) 2009-04-24

Family

ID=40093925

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000965A PE20090328A1 (es) 2007-06-07 2008-06-06 Derivados de oxadiazol como moduladores de los receptores metabotropicos de glutamato

Country Status (33)

Country Link
US (2) US8377940B2 (es)
EP (2) EP2167502B3 (es)
JP (2) JP5416696B2 (es)
KR (2) KR20150116907A (es)
CN (2) CN102977086B (es)
AR (1) AR066882A1 (es)
AU (1) AU2008260717B2 (es)
BR (1) BRPI0812889A2 (es)
CA (1) CA2690856C (es)
CL (1) CL2008001667A1 (es)
CO (1) CO6251287A2 (es)
CY (2) CY1113422T1 (es)
DK (2) DK2167502T3 (es)
EC (1) ECSP109856A (es)
ES (2) ES2531443T3 (es)
HR (2) HRP20120909T4 (es)
IL (1) IL202158A (es)
ME (1) ME01488B (es)
MX (1) MX2009013078A (es)
MY (1) MY158066A (es)
NZ (1) NZ582445A (es)
PE (1) PE20090328A1 (es)
PL (2) PL2444399T3 (es)
PT (2) PT2444399E (es)
RS (2) RS53845B1 (es)
RU (2) RU2470931C2 (es)
SA (1) SA08290344B1 (es)
SI (2) SI2167502T1 (es)
TW (1) TWI417100B (es)
UA (1) UA99129C2 (es)
UY (1) UY31124A1 (es)
WO (1) WO2008150233A1 (es)
ZA (1) ZA200908285B (es)

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