PE20080143A1 - Compuestos 2-oxo-3-fenil-(1,4-diazaespiro[4.5]dec-3-en-1-il)acetamida sustituidos como inhibidores del transportador de glicina - Google Patents
Compuestos 2-oxo-3-fenil-(1,4-diazaespiro[4.5]dec-3-en-1-il)acetamida sustituidos como inhibidores del transportador de glicinaInfo
- Publication number
- PE20080143A1 PE20080143A1 PE2007000281A PE2007000281A PE20080143A1 PE 20080143 A1 PE20080143 A1 PE 20080143A1 PE 2007000281 A PE2007000281 A PE 2007000281A PE 2007000281 A PE2007000281 A PE 2007000281A PE 20080143 A1 PE20080143 A1 PE 20080143A1
- Authority
- PE
- Peru
- Prior art keywords
- diazaespiro
- oxo
- dec
- phenyl
- acetamide
- Prior art date
Links
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical group CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title abstract 6
- 102000010726 Glycine Plasma Membrane Transport Proteins Human genes 0.000 title 1
- 108010063380 Glycine Plasma Membrane Transport Proteins Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 4-BROMOPHENYL Chemical class 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS 2-OXO-3-FENIL-(1,4-DIAZAESPIRO[4.5]DEC-3-EN-1-IL)ACETAMIDA SUSTITUIDOS DE FORMULA (I), EN DONDE R1, R2 Y R4 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C4), ALCOXI(C1-C4), HALO, HALOALQUILO(C1-C4), CN, ENTRE OTROS; R3 ES H, METILO, ETILO, ALCOXI(C1-C4), HALO, HALOALQUILO(C1-C4), ENTRE OTROS; O R2 Y R3 JUNTOS FORMAN -O-CH2-O- Y -O-CH2-O-; R5 Y R7 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C4), ALCOXI(C1-C4), HALO, ENTRE OTROS; CON LA CONDICION DE QUE CUANDO R5 SE SELECCIONA ENTRE H, METILO, METOXI, Cl Y F, ENTONCES R7 NO SEA H; R6 ES H Y METILO; R8 ES H Y FLUOR; n ES 0,1 y 2. SON SELECCIONADOS: N-[2-(METILOXI)FENIL]-2-{2-OXO-3-[4-(TRIFLUOROMETIL)FENIL]-1,4-DIAZAESPIRO[4.5]DEC-3-EN-1-IL}ACETAMIDA, 2-[3-(4-BROMOFENIL)-2-OXO-1,4-DIAZAESPIRO[4.5]DEC-3-EN-1-IL]-N-(3,4-DIFLUOROFENIL)ACETAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON MEDIADORES DE LOS TRANSPORTADORES DE GLICINA (GlyT1) Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS Y NEUROPSIQUIATRICOS
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0605412A GB0605412D0 (en) | 2006-03-16 | 2006-03-16 | Compounds |
| GB0605827A GB0605827D0 (en) | 2006-03-22 | 2006-03-22 | Compounds |
| GB0622995A GB0622995D0 (en) | 2006-11-17 | 2006-11-17 | Compounds |
| GB0701947A GB0701947D0 (en) | 2007-02-01 | 2007-02-01 | Compounds which inhibit the glycine transpoter and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080143A1 true PE20080143A1 (es) | 2008-04-02 |
Family
ID=38017148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000281A PE20080143A1 (es) | 2006-03-16 | 2007-03-14 | Compuestos 2-oxo-3-fenil-(1,4-diazaespiro[4.5]dec-3-en-1-il)acetamida sustituidos como inhibidores del transportador de glicina |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090062360A1 (es) |
| EP (1) | EP1994010A1 (es) |
| JP (1) | JP2009530246A (es) |
| AR (1) | AR059839A1 (es) |
| PE (1) | PE20080143A1 (es) |
| TW (1) | TW200812976A (es) |
| WO (1) | WO2007104775A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120004273A1 (en) * | 2007-01-20 | 2012-01-05 | Nadia Mamoona Ahmad | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
| US20100105713A1 (en) * | 2007-02-01 | 2010-04-29 | Glaxo Group Limited | GLYT1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders |
| WO2008092874A1 (en) * | 2007-02-01 | 2008-08-07 | Glaxo Group Limited | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
| GB0701985D0 (en) * | 2007-02-01 | 2007-03-14 | Glaxo Group Ltd | Compounds |
| GB0701955D0 (en) * | 2007-02-01 | 2007-03-14 | Glaxo Group Ltd | Compounds |
| WO2008092877A2 (en) * | 2007-02-01 | 2008-08-07 | Glaxo Group Limited | 8-oxa-1, 4-diazaspiro [4,5] dec-3-en-1-yl and 1,4, 8-triazaspiro [4,5] dec- 3-en-1-yl acetamides as glyti transporter inhibitors in treatment of neurological and neuropsychiatric disorders |
| AR065095A1 (es) * | 2007-02-01 | 2009-05-13 | Glaxo Group Ltd | COMPUESTO DE ARIL-OXO-DIAZAESPIRO, INTERMEDIARIO PARA SU SíNTESIS, USO DEL MISMO PARA PREPARAR UN MEDICAMENTO PARA EL TRATAMIENTO DE UN TRASTORNO MEDIADO POR GLYT1, COMPOSICION FARMACEUTICA Y ASOCIACION QUE LO COMPRENDEN. |
| JP2010539128A (ja) * | 2007-09-11 | 2010-12-16 | グラクソ グループ リミテッド | グリシントランスポーターを阻害する化合物および医薬におけるその使用 |
| JP2015157764A (ja) * | 2012-06-14 | 2015-09-03 | 大正製薬株式会社 | グリシントランスポーター阻害物質 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130696D0 (en) | 2001-12-21 | 2002-02-06 | Smithkline Beecham Plc | Chemical Compounds |
| JP4756031B2 (ja) * | 2004-03-24 | 2011-08-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ヘテロアリールピペリジングリシン輸送体インヒビター |
| GB0408772D0 (en) * | 2004-04-20 | 2004-05-26 | Glaxo Group Ltd | Compounds |
| US20080221185A1 (en) * | 2005-08-02 | 2008-09-11 | Anthony William Dean | Glyt1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders |
-
2007
- 2007-03-14 TW TW096108664A patent/TW200812976A/zh unknown
- 2007-03-14 EP EP07726905A patent/EP1994010A1/en not_active Withdrawn
- 2007-03-14 WO PCT/EP2007/052414 patent/WO2007104775A1/en not_active Ceased
- 2007-03-14 AR ARP070101036A patent/AR059839A1/es unknown
- 2007-03-14 US US12/282,677 patent/US20090062360A1/en not_active Abandoned
- 2007-03-14 PE PE2007000281A patent/PE20080143A1/es not_active Application Discontinuation
- 2007-03-14 JP JP2008558817A patent/JP2009530246A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1994010A1 (en) | 2008-11-26 |
| AR059839A1 (es) | 2008-04-30 |
| JP2009530246A (ja) | 2009-08-27 |
| WO2007104775A1 (en) | 2007-09-20 |
| TW200812976A (en) | 2008-03-16 |
| US20090062360A1 (en) | 2009-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |