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PE20090904A1 - ARILOXAZOLES SUSTITUIDOS COMO LIGANDOS DE LOS RECEPTORES DE ADENOSINA A1 Y/O A2b - Google Patents

ARILOXAZOLES SUSTITUIDOS COMO LIGANDOS DE LOS RECEPTORES DE ADENOSINA A1 Y/O A2b

Info

Publication number
PE20090904A1
PE20090904A1 PE2008001198A PE2008001198A PE20090904A1 PE 20090904 A1 PE20090904 A1 PE 20090904A1 PE 2008001198 A PE2008001198 A PE 2008001198A PE 2008001198 A PE2008001198 A PE 2008001198A PE 20090904 A1 PE20090904 A1 PE 20090904A1
Authority
PE
Peru
Prior art keywords
alkyl
amino
hydroxyetoxy
dicarbonitrile
oxazol
Prior art date
Application number
PE2008001198A
Other languages
English (en)
Inventor
Peter Nell
Walter Hubsch
Barbara Albrecht-Kupper
Joerg Keldenich
Alexandros Vakalopoulos
Frank Susmeier
Katja Zimmermann
Dieter Lang
Daniel Meibom
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of PE20090904A1 publication Critical patent/PE20090904A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA A UN DERIVADO DE ARILOXAZOL DE FORMULA (I), DONDE A ES O O S; R1 ES H O ALQUILO C1-C4; R2 ES H O ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON OH, ALCOXI C1-C4 O F; R3 ES H, HALOGENO O ALQUILO C1-C4; R4 Y R5 SON H O ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON OH, ALCOXI C1-C4, AMINO, ENTRE OTROS; R6 ES ARILO C6-C10 O HETEROARILO DE 5 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON HALOGENO, CIANO, NITRO, ENTRE OTROS; R7 ES H, F, ALQUILO C1-C4, TRIFLUOROMETILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-AMINO-6-({[2-(3-CLORO-4-FLUOROFENIL)-1,3-OXAZOL-4-IL]METIL}SULFANIL)-4-[4-(2-HIDROXIETOXI)FENIL]PIRIDIN-3,5-DICARBONITRILO, 2-AMINO-6-({[2-(3,4-DIFLUOROFENIL)-1,3-OXAZOL-4-IL]METIL}SULFANIL)-4-[4-(2-HIDROXIETOXI)FENIL]PIRIDIN-3,5-DICARBONITRILO, 2-AMINO-6-({[2-(4-FLUORO-3-METILFENIL)-1,3-OXAZOL-4-IL]METIL}SULFANIL)-4-[4-(2-HIDROXIETOXI)FENIL]PIRIDIN-3,5-DICARBONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD SOBRE LOS RECEPTORES DE ADENOSINA A1 Y/O A2b Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, UROGENITALES, INFLAMATORIAS, ENTRE OTRAS
PE2008001198A 2007-07-27 2008-07-16 ARILOXAZOLES SUSTITUIDOS COMO LIGANDOS DE LOS RECEPTORES DE ADENOSINA A1 Y/O A2b PE20090904A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007035367A DE102007035367A1 (de) 2007-07-27 2007-07-27 Substituierte Aryloxazole und ihre Verwendung

Publications (1)

Publication Number Publication Date
PE20090904A1 true PE20090904A1 (es) 2009-08-08

Family

ID=39855432

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001198A PE20090904A1 (es) 2007-07-27 2008-07-16 ARILOXAZOLES SUSTITUIDOS COMO LIGANDOS DE LOS RECEPTORES DE ADENOSINA A1 Y/O A2b

Country Status (15)

Country Link
US (2) US8440700B2 (es)
EP (1) EP2185550B1 (es)
JP (1) JP5307136B2 (es)
KR (1) KR20100039358A (es)
CN (1) CN101939317A (es)
AR (1) AR067646A1 (es)
AT (1) ATE531712T1 (es)
CA (1) CA2694270A1 (es)
CL (1) CL2008002076A1 (es)
DE (1) DE102007035367A1 (es)
ES (1) ES2375506T3 (es)
PE (1) PE20090904A1 (es)
TW (1) TW200922575A (es)
UY (1) UY31228A1 (es)
WO (1) WO2009015776A1 (es)

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EP2185550B1 (de) 2011-11-02
UY31228A1 (es) 2009-03-02
DE102007035367A1 (de) 2009-01-29
US9095582B2 (en) 2015-08-04
KR20100039358A (ko) 2010-04-15
ATE531712T1 (de) 2011-11-15
TW200922575A (en) 2009-06-01
CN101939317A (zh) 2011-01-05
JP2010534693A (ja) 2010-11-11
CL2008002076A1 (es) 2009-01-30
US20140162981A1 (en) 2014-06-12
CA2694270A1 (en) 2009-02-05
US20110130377A1 (en) 2011-06-02
EP2185550A1 (de) 2010-05-19
AR067646A1 (es) 2009-10-21
ES2375506T3 (es) 2012-03-01
WO2009015776A1 (de) 2009-02-05
US8440700B2 (en) 2013-05-14

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