PE20110405A1 - Derivados de piridino-piridinonas como inhibidores de la actividad de la tirosina quinasa de pdgf-r y/o flt-3 y su preparacion - Google Patents
Derivados de piridino-piridinonas como inhibidores de la actividad de la tirosina quinasa de pdgf-r y/o flt-3 y su preparacionInfo
- Publication number
- PE20110405A1 PE20110405A1 PE2011000014A PE2011000014A PE20110405A1 PE 20110405 A1 PE20110405 A1 PE 20110405A1 PE 2011000014 A PE2011000014 A PE 2011000014A PE 2011000014 A PE2011000014 A PE 2011000014A PE 20110405 A1 PE20110405 A1 PE 20110405A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- oxo
- ethyl
- methyl
- amino
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 title 1
- 108091008606 PDGF receptors Proteins 0.000 title 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 title 1
- 101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 title 1
- HILFHSXPUWSKCY-UHFFFAOYSA-N pyridine;1h-pyridin-2-one Chemical class C1=CC=NC=C1.O=C1C=CC=CN1 HILFHSXPUWSKCY-UHFFFAOYSA-N 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical group [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- -1 METHYL Chemical class 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 108700014844 flt3 ligand Proteins 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A UN COMPUESTO DERIVADO DE PIRIDO-PIRIDINONAS DE FORMULA (I) DONDE R1 ES ALQUILO C1-C4; R2 ES (CH2)n'-B; U ES CARBONILO O CH2; Y, Z, V Y W SON CADA UNO CH, N, S, ENTENDIENDOSE QUE EL CICLO ES AROMATICO Y DE 5-6 ESLABONES; ENTRE OTROS; R3 Y R4 SON CADA UNO H, ALQUILO C1-C4 O R3 Y R4 FORMAN JUNTO AL CARBONO QUE ESTAN UNIDOS UN CICLOALQUILO C3-C5; B ES CICLOALQUILO C3-C5 O ALQUILO C1-C4; n' ES 0-4; m ES 1-4; R5 ES H O ALQUILO C1-C4; R6 ES (CH2)n-L; n ES DE 0-3; L ES ALQUILO C1-C5, CICLOALQUILO C3-C5; ARILO DE 6 CARBONOS; R7 ES H, ALQUILO C1-C4 O HALOGENO. SON COMPUESTOS PREFERIDOS: 2-AMINO-1-ETIL-N-METIL-4-OXO-7-{4-[2-OXO-2-(FENILAMINO)ETIL]FENIL}-1,4-DIHIDRO-1,8-NAFTIRIDINA-3-CARBOXAMIDA; 2-AMINO-1-ETIL-7-[4-(2-{[(1-ETILPIRROLIDIN-2-IL)METIL](METIL)AMINO}-2-OXOETIL)FENIL]-N-METIL-4-OXO-1,4-DIHIDRO-1,8-NAFTIRIDINA-3-CARBOXAMIDA; 2-AMINO-1-ETIL-N-METIL-4-OXO-7-{4-[2-OXO-2-(PIRIDIN-3-ILAMINO)ETIL]FENIL}-1,4-DIHIDRO-1,8-NAFTIRIDINA-3-CARBOXAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA DICHO COMPUESTO ES UN INHIBIDOR DE LA ACTIVIDAD QUINASA DE LOS RECEPTORES LIGANDOS PDGF Y OPCIONALMENTE DE LOS RECEPTORES DEL LIGANDO FLT3 UTIL EN EL TRATAMIENTO DE CANCER, LEUCEMIAS, FIBROSIS, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0803862A FR2933700B1 (fr) | 2008-07-08 | 2008-07-08 | Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110405A1 true PE20110405A1 (es) | 2011-07-04 |
Family
ID=40219672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000014A PE20110405A1 (es) | 2008-07-08 | 2009-07-06 | Derivados de piridino-piridinonas como inhibidores de la actividad de la tirosina quinasa de pdgf-r y/o flt-3 y su preparacion |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8436011B2 (es) |
| EP (1) | EP2315767B1 (es) |
| JP (1) | JP5606434B2 (es) |
| KR (1) | KR20110031372A (es) |
| CN (1) | CN102149713B (es) |
| AR (1) | AR072798A1 (es) |
| AU (1) | AU2009267827B2 (es) |
| BR (1) | BRPI0915438A2 (es) |
| CA (1) | CA2729833A1 (es) |
| CL (1) | CL2011000048A1 (es) |
| CO (1) | CO6341476A2 (es) |
| CR (1) | CR11866A (es) |
| DO (1) | DOP2011000008A (es) |
| EA (1) | EA019362B1 (es) |
| EC (1) | ECSP11010742A (es) |
| ES (1) | ES2438540T3 (es) |
| FR (1) | FR2933700B1 (es) |
| HN (1) | HN2011000076A (es) |
| IL (1) | IL210514A (es) |
| MA (1) | MA32544B1 (es) |
| MX (1) | MX2011000330A (es) |
| MY (1) | MY149705A (es) |
| NI (1) | NI201100011A (es) |
| NZ (1) | NZ590862A (es) |
| PE (1) | PE20110405A1 (es) |
| SV (1) | SV2011003800A (es) |
| TW (1) | TW201004955A (es) |
| UA (1) | UA102858C2 (es) |
| UY (1) | UY31971A (es) |
| WO (1) | WO2010004197A2 (es) |
| ZA (1) | ZA201100210B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| FR2933700B1 (fr) | 2008-07-08 | 2010-07-30 | Sanofi Aventis | Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique |
| FR2952934B1 (fr) | 2009-11-23 | 2012-06-22 | Sanofi Aventis | Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique |
| FR2954943B1 (fr) * | 2010-01-07 | 2013-03-01 | Sanofi Aventis | Derives de pyridino-pyridinones arylsulfonamides, leur preparation et leur application en therapeutique |
| FR2955109B1 (fr) * | 2010-01-08 | 2012-09-07 | Sanofi Aventis | Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| EP2524915A1 (en) * | 2011-05-20 | 2012-11-21 | Sanofi | 2-Amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors |
| SI2874625T1 (sl) * | 2012-07-17 | 2017-10-30 | Sanofi | Uporaba inhibitorjev VEGFR-3 za zdravljenje hepatoceličnega karcinoma |
| UA110688C2 (uk) * | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| JP2018052878A (ja) * | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
| WO2019099294A1 (en) | 2017-11-14 | 2019-05-23 | Merck Sharp & Dohme Corp. | Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
| BR112020008258B8 (pt) | 2017-11-14 | 2023-01-31 | Merck Sharp & Dohme | Compostos de biarila substituída ou seus sais farmaceuticamente aceitáveis, sua composição e seu uso como inibidores de indoleamina 2,3-dioxigenase (ido) |
| AU2018380132B2 (en) | 2017-12-06 | 2023-11-09 | Lin Bioscience, Inc. | Tubulin inhibitors |
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| US3845008A (en) * | 1973-03-02 | 1974-10-29 | Du Pont | Brake lining composition comprising particulate tar residue |
| US4959363A (en) * | 1989-06-23 | 1990-09-25 | Sterling Drug Inc. | Quinolonecarboxamide compounds, their preparation and use as antivirals. |
| CA2104605C (en) * | 1992-09-09 | 2000-05-02 | Peter Jones | Powder metal alloy process |
| US5332422A (en) * | 1993-07-06 | 1994-07-26 | Ford Motor Company | Solid lubricant and hardenable steel coating system |
| AU7811194A (en) * | 1993-10-02 | 1995-05-01 | Cerasiv Gmbh | Molded article |
| US5518639A (en) * | 1994-08-12 | 1996-05-21 | Hoeganaes Corp. | Powder metallurgy lubricant composition and methods for using same |
| US5641580A (en) * | 1995-10-03 | 1997-06-24 | Osram Sylvania Inc. | Advanced Mo-based composite powders for thermal spray applications |
| JP3537286B2 (ja) * | 1997-03-13 | 2004-06-14 | 株式会社三協精機製作所 | 焼結含油軸受およびそれを用いたモータ |
| CA2207579A1 (fr) * | 1997-05-28 | 1998-11-28 | Paul Caron | Piece frittee a surface anti-abrasive et procede pour sa realisation |
| US6689424B1 (en) * | 1999-05-28 | 2004-02-10 | Inframat Corporation | Solid lubricant coatings produced by thermal spray methods |
| JP4011478B2 (ja) * | 2000-11-16 | 2007-11-21 | 本田技研工業株式会社 | 金属摺動部材および内燃機関用ピストンならびにそれらの表面処理方法およびその装置 |
| JP2004124130A (ja) * | 2002-09-30 | 2004-04-22 | Fujimi Inc | 溶射用粉末及びその製造方法並びに該溶射用粉末を用いた溶射方法 |
| US7300488B2 (en) * | 2003-03-27 | 2007-11-27 | Höganäs Ab | Powder metal composition and method for producing components thereof |
| TW200502236A (en) * | 2003-03-28 | 2005-01-16 | Hoffmann La Roche | Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents |
| DE10326769B3 (de) * | 2003-06-13 | 2004-11-11 | Esk Ceramics Gmbh & Co. Kg | Dauerhafte BN-Formtrennschichten für das Druckgießen von Nichteisenmetallen |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| WO2005026156A1 (en) * | 2003-09-16 | 2005-03-24 | Astrazeneca Ab | Quinazoline derivatives |
| US7553564B2 (en) * | 2004-05-26 | 2009-06-30 | Honeywell International Inc. | Ternary carbide and nitride materials having tribological applications and methods of making same |
| US7968503B2 (en) * | 2004-06-07 | 2011-06-28 | Ppg Industries Ohio, Inc. | Molybdenum comprising nanomaterials and related nanotechnology |
| US7687112B2 (en) * | 2004-07-14 | 2010-03-30 | Kinetitec Corporation | Surface for reduced friction and wear and method of making the same |
| GB0423554D0 (en) * | 2004-10-22 | 2004-11-24 | Cancer Rec Tech Ltd | Therapeutic compounds |
| DE102005001198A1 (de) * | 2005-01-10 | 2006-07-20 | H.C. Starck Gmbh | Metallische Pulvermischungen |
| US7470307B2 (en) * | 2005-03-29 | 2008-12-30 | Climax Engineered Materials, Llc | Metal powders and methods for producing the same |
| US7575619B2 (en) * | 2005-03-29 | 2009-08-18 | Hitachi Powdered Metals Co., Ltd. | Wear resistant sintered member |
| TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
| AU2007334321B2 (en) * | 2006-12-18 | 2012-03-08 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| FR2917413B1 (fr) * | 2007-06-13 | 2009-08-21 | Sanofi Aventis Sa | Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique |
| FR2917412B1 (fr) * | 2007-06-13 | 2009-08-21 | Sanofi Aventis Sa | Derives de 7-alkynyl, 1,8-naphthyridones, leur preparation et leur application en therapeutique |
| WO2010000020A1 (en) | 2008-06-30 | 2010-01-07 | Cathrx Ltd | A catheter |
| FR2933701A1 (fr) * | 2008-07-08 | 2010-01-15 | Sanofi Aventis | Derives anticancereux, leur preparation et leur application en therapeutique |
| FR2933700B1 (fr) | 2008-07-08 | 2010-07-30 | Sanofi Aventis | Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique |
| US8038760B1 (en) * | 2010-07-09 | 2011-10-18 | Climax Engineered Materials, Llc | Molybdenum/molybdenum disulfide metal articles and methods for producing same |
-
2008
- 2008-07-08 FR FR0803862A patent/FR2933700B1/fr not_active Expired - Fee Related
-
2009
- 2009-07-03 TW TW098122666A patent/TW201004955A/zh unknown
- 2009-07-06 BR BRPI0915438A patent/BRPI0915438A2/pt not_active IP Right Cessation
- 2009-07-06 JP JP2011517200A patent/JP5606434B2/ja not_active Expired - Fee Related
- 2009-07-06 CN CN2009801348457A patent/CN102149713B/zh not_active Expired - Fee Related
- 2009-07-06 ES ES09784467.4T patent/ES2438540T3/es active Active
- 2009-07-06 CA CA2729833A patent/CA2729833A1/fr not_active Abandoned
- 2009-07-06 AU AU2009267827A patent/AU2009267827B2/en not_active Ceased
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