PE20091425A1 - Derivados de aminotiazol - Google Patents
Derivados de aminotiazolInfo
- Publication number
- PE20091425A1 PE20091425A1 PE2008001973A PE2008001973A PE20091425A1 PE 20091425 A1 PE20091425 A1 PE 20091425A1 PE 2008001973 A PE2008001973 A PE 2008001973A PE 2008001973 A PE2008001973 A PE 2008001973A PE 20091425 A1 PE20091425 A1 PE 20091425A1
- Authority
- PE
- Peru
- Prior art keywords
- benzothiophene
- thiazol
- sulfonamide
- bromo
- aminotiazole
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- KKFDJZZADQONDE-UHFFFAOYSA-N (hydridonitrato)hydroxidocarbon(.) Chemical compound O[C]=N KKFDJZZADQONDE-UHFFFAOYSA-N 0.000 abstract 1
- 101710099475 3'-phosphoadenosine 5'-phosphate phosphatase Proteins 0.000 abstract 1
- GSXOAOHZAIYLCY-UHFFFAOYSA-N D-F6P Natural products OCC(=O)C(O)C(O)C(O)COP(O)(O)=O GSXOAOHZAIYLCY-UHFFFAOYSA-N 0.000 abstract 1
- 101710196411 Fructose-1,6-bisphosphatase Proteins 0.000 abstract 1
- 101710186733 Fructose-1,6-bisphosphatase, chloroplastic Proteins 0.000 abstract 1
- 101710109119 Fructose-1,6-bisphosphatase, cytosolic Proteins 0.000 abstract 1
- 101710198902 Fructose-1,6-bisphosphate aldolase/phosphatase Proteins 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- BGWGXPAPYGQALX-ARQDHWQXSA-N beta-D-fructofuranose 6-phosphate Chemical compound OC[C@@]1(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O BGWGXPAPYGQALX-ARQDHWQXSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDA A COMPUESTOS DERIVADOS DE AMINOTIAZOL DE FORMULA (I), DONDE R1 ES (Ia) O (Ib); X ES S, N-R7 U O; R2 Y R3 SON CADA UNO H, ALQUILO, ALCOXI, ENTRE OTROS; R4 Y R5 SON CADA UNO H, ALCOXI, CICLOALQUILO, ENTRE OTROS; R6 ES H, HALO, HALOALQUILO, ENTRE OTROS; R7 ES H, HALOALCOXI, ALCOXIALQUILO, ENTRE OTROS; R7 ES H, ALQUILO, HIDROXIALCOXI, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[(5-BROMO-1,3-TIAZOL-2-IL)CARBAMOIL]-5-METIL-1-BENZOTIOFENO-2-SULFONAMIDA; N-[(5-BROMO-1,3-TIAZOL-2-IL)CARBAMOIL]-1-BENZOTIOFENO-2-SULFONAMIDA, N-[(5-BROMO-1,3-TIAZOL-2-IL)CARBAMOIL]-5-FLUOR-3-METIL-1-BENZOTIOFENO-2-SULFONAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A SU PROCEDIMIENTO DE PREPARACION Y A COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. DICHOS COMPUESTOS SON INHIBIDORES DE FRUCTOSA-6-FOSFATO (FBPasa) SIENDO UTILES PARA EL TRATAMIENTO DE DIABETES MELLITUS TIPO I, DIABETES MELLITUS TIPO II, TRASTORNOS DE GLUCOSA EN AYUNAS, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07122019 | 2007-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091425A1 true PE20091425A1 (es) | 2009-09-23 |
Family
ID=40430064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001973A PE20091425A1 (es) | 2007-11-30 | 2008-11-25 | Derivados de aminotiazol |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7973051B2 (es) |
| EP (1) | EP2227468A1 (es) |
| JP (1) | JP2011504897A (es) |
| KR (1) | KR20100080853A (es) |
| CN (1) | CN101878211A (es) |
| AR (1) | AR069435A1 (es) |
| AU (1) | AU2008328955B2 (es) |
| BR (1) | BRPI0820622A2 (es) |
| CA (1) | CA2706574A1 (es) |
| IL (1) | IL205751A0 (es) |
| MX (1) | MX2010005824A (es) |
| PE (1) | PE20091425A1 (es) |
| TW (1) | TW200922563A (es) |
| WO (1) | WO2009068467A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101990337B (zh) * | 2009-08-03 | 2014-03-26 | 联咏科技股份有限公司 | 可动态维持定电流驱动的光源驱动装置及其相关方法 |
| KR101772834B1 (ko) | 2009-12-04 | 2017-08-29 | 선오비온 파마슈티컬스 인코포레이티드 | 다환형 화합물 및 이의 사용 방법 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| ES2578363B1 (es) | 2015-01-22 | 2017-01-31 | Palobiofarma, S.L. | Moduladores de los receptores A3 de adenosina |
| CN116283877A (zh) | 2016-07-29 | 2023-06-23 | 赛诺维信制药公司 | 化合物、组合物及其用途 |
| EP3490607A4 (en) | 2016-07-29 | 2020-04-08 | Sunovion Pharmaceuticals Inc. | COMPOUNDS AND COMPOSITIONS, AND USES THEREOF |
| KR102605854B1 (ko) | 2017-02-16 | 2023-11-23 | 선오비온 파마슈티컬스 인코포레이티드 | 조현병의 치료방법 |
| KR20200036008A (ko) | 2017-08-02 | 2020-04-06 | 선오비온 파마슈티컬스 인코포레이티드 | 이소크로만 화합물 및 이의 용도 |
| CA3091292A1 (en) | 2018-02-16 | 2019-08-22 | Sunovion Pharmaceuticals Inc. | Salts, crystal forms, and production methods thereof |
| WO2020002090A1 (de) | 2018-06-25 | 2020-01-02 | Bayer Aktiengesellschaft | Substituierte thiazolylpyrrolone sowie deren salze und ihre verwendung als herbizide wirkstoffe |
| EP3870565A1 (en) * | 2018-10-24 | 2021-09-01 | Novartis AG | Compounds and compositions for treating conditions associated with nlrp activity |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CA3130849A1 (en) | 2019-03-14 | 2020-09-17 | Sunovion Pharmaceuticals Inc. | Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
| MX2022012833A (es) | 2020-04-14 | 2022-11-07 | Sunovion Pharmaceuticals Inc | (s)-(4,5-dihidro-7h-tieno[2,3-c]piran-7-il)-n-metilmetanamina para tratar trastornos neurologicos y psiquiatricos. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4933355A (en) | 1988-04-14 | 1990-06-12 | Sankyo Company Limited | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications |
| DE69729762T2 (de) * | 1997-01-29 | 2005-07-14 | Pfizer Inc. | 4-Substituiertes Furan-2-sulfonamid und dessen Verwendung in der Herstellung von Sulfonylharnstoff-Derivate |
| DE60114994T2 (de) | 2000-02-04 | 2006-08-03 | Portola Pharmaceuticals, Inc., South San Francisco | Blutplättchen-adp-rezeptor-inhibitoren |
| US20050004134A1 (en) | 2001-11-08 | 2005-01-06 | Hideo Tsutsumi | Thiazole derivative and pharmaceutical use thereof |
| BRPI0510095A (pt) * | 2004-04-20 | 2007-10-16 | Transtech Pharma Inc | tiazol substituìdo e derivados de pirimidina como moduladores de receptores de melanocortina |
| DK200600313A (da) | 2006-03-03 | 2006-03-13 | Novo Nordisk As | Treating type 2 diabetes or metabolic syndrome with an interleukin 1beta inhibitor or an interleukin 1beta synthesis or release inhibitor |
| CA2652162A1 (en) | 2006-06-01 | 2007-12-06 | Marcel Gubler | Thiazole derivatives |
-
2008
- 2008-11-10 US US12/267,661 patent/US7973051B2/en not_active Expired - Fee Related
- 2008-11-20 JP JP2010535336A patent/JP2011504897A/ja active Pending
- 2008-11-20 CA CA2706574A patent/CA2706574A1/en not_active Abandoned
- 2008-11-20 CN CN2008801184683A patent/CN101878211A/zh active Pending
- 2008-11-20 EP EP08853191A patent/EP2227468A1/en not_active Withdrawn
- 2008-11-20 WO PCT/EP2008/065910 patent/WO2009068467A1/en not_active Ceased
- 2008-11-20 MX MX2010005824A patent/MX2010005824A/es active IP Right Grant
- 2008-11-20 KR KR1020107011826A patent/KR20100080853A/ko not_active Abandoned
- 2008-11-20 AU AU2008328955A patent/AU2008328955B2/en not_active Expired - Fee Related
- 2008-11-20 BR BRPI0820622-8A patent/BRPI0820622A2/pt not_active IP Right Cessation
- 2008-11-25 PE PE2008001973A patent/PE20091425A1/es not_active Application Discontinuation
- 2008-11-27 AR ARP080105161A patent/AR069435A1/es unknown
- 2008-11-27 TW TW097146042A patent/TW200922563A/zh unknown
-
2010
- 2010-05-13 IL IL205751A patent/IL205751A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010005824A (es) | 2010-06-11 |
| CN101878211A (zh) | 2010-11-03 |
| JP2011504897A (ja) | 2011-02-17 |
| AR069435A1 (es) | 2010-01-20 |
| KR20100080853A (ko) | 2010-07-12 |
| TW200922563A (en) | 2009-06-01 |
| AU2008328955B2 (en) | 2012-12-13 |
| AU2008328955A1 (en) | 2009-06-04 |
| IL205751A0 (en) | 2010-11-30 |
| BRPI0820622A2 (pt) | 2015-06-16 |
| US7973051B2 (en) | 2011-07-05 |
| EP2227468A1 (en) | 2010-09-15 |
| US20090143448A1 (en) | 2009-06-04 |
| WO2009068467A1 (en) | 2009-06-04 |
| CA2706574A1 (en) | 2009-06-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |