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BRPI0510095A - tiazol substituìdo e derivados de pirimidina como moduladores de receptores de melanocortina - Google Patents

tiazol substituìdo e derivados de pirimidina como moduladores de receptores de melanocortina

Info

Publication number
BRPI0510095A
BRPI0510095A BRPI0510095-0A BRPI0510095A BRPI0510095A BR PI0510095 A BRPI0510095 A BR PI0510095A BR PI0510095 A BRPI0510095 A BR PI0510095A BR PI0510095 A BRPI0510095 A BR PI0510095A
Authority
BR
Brazil
Prior art keywords
melanocortin receptor
pyrimidine derivatives
receptor modulators
substituted thiazole
treatment
Prior art date
Application number
BRPI0510095-0A
Other languages
English (en)
Inventor
Adnan M M Mjalli
Bapu R Gaddam
Ghassan Qabaja
Govindan Subramanian
Jeff Zhu
John Dankwardt
Murty N Arimilli
Robert C Andrews
Samuel Victory
Ye E Tian
Original Assignee
Transtech Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transtech Pharma Inc filed Critical Transtech Pharma Inc
Publication of BRPI0510095A publication Critical patent/BRPI0510095A/pt

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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
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  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Abstract

TIAZOL SUBSTITUìDO E DERIVADOS DE PIRIMIDINA COMO MODULADORES DE RECEPTORES DE MELANOCORTINA.A presente invenção refere-se a derivados de heteroarila substituída da Fórmula (1), métodos de preparação, composições farmacêuticas que contêm os compostos da Fórmula (1) e métodos de uso no tratamento de distúrbios em humanos ou animais. Os compostos da invenção podem ser úteis como inibidores da ação da AgRP em um receptor de melanocortina e, por conseguinte, podem ser úteis para a gestão, tratamento, controle ou tratamento adjunto de doenças que possam ser responsivas à modulação dos receptores da melanocortina, incluindo distúrbios relacionados à obesidade.
BRPI0510095-0A 2004-04-20 2005-04-20 tiazol substituìdo e derivados de pirimidina como moduladores de receptores de melanocortina BRPI0510095A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56388204P 2004-04-20 2004-04-20
PCT/US2005/013386 WO2005103022A1 (en) 2004-04-20 2005-04-20 Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators

Publications (1)

Publication Number Publication Date
BRPI0510095A true BRPI0510095A (pt) 2007-10-16

Family

ID=34971867

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510095-0A BRPI0510095A (pt) 2004-04-20 2005-04-20 tiazol substituìdo e derivados de pirimidina como moduladores de receptores de melanocortina

Country Status (12)

Country Link
US (1) US7820704B2 (pt)
EP (1) EP1753735A1 (pt)
JP (1) JP4879165B2 (pt)
CN (1) CN1946703A (pt)
AU (1) AU2005236055B2 (pt)
BR (1) BRPI0510095A (pt)
CA (1) CA2562075C (pt)
IL (1) IL178597A0 (pt)
MX (1) MXPA06012130A (pt)
NZ (1) NZ550114A (pt)
WO (1) WO2005103022A1 (pt)
ZA (1) ZA200608225B (pt)

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