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CO6251287A2 - Derivados de oxadiazol y su uso como potenciadores de los receptores metabotropicos de glutamato -842 - Google Patents

Derivados de oxadiazol y su uso como potenciadores de los receptores metabotropicos de glutamato -842

Info

Publication number
CO6251287A2
CO6251287A2 CO09139153A CO09139153A CO6251287A2 CO 6251287 A2 CO6251287 A2 CO 6251287A2 CO 09139153 A CO09139153 A CO 09139153A CO 09139153 A CO09139153 A CO 09139153A CO 6251287 A2 CO6251287 A2 CO 6251287A2
Authority
CO
Colombia
Prior art keywords
solvate
hydrate
salt
pharmaceutically acceptable
compound according
Prior art date
Application number
CO09139153A
Other languages
English (en)
Inventor
Joshua Clayton
Ian Egle
Adbelmalik Slassi
Fupeng Ma
Methvin Isaac
James Folmer
James Empfield
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40093925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6251287(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO6251287A2 publication Critical patent/CO6251287A2/es

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)

Abstract

1.- Un compuesto de acuerdo con la Fórmula I:donde R1 es halo o C1-3 haloalcoxilo; Q es y R2 es hidrógeno o C1-3 alquilo, o una sal, un hidrato, un solvato, un isómero óptico o una combinación farmacéuticamente aceptable de este. 2.- Un compuesto de acuerdo con la Reivindicación 1, donde R1 es cloro o trifluorometoxilo o una sal, un hidrato, un solvato, un isómero óptico farmacéuticamente aceptable de este. 3.- Un compuesto de acuerdo con la Reivindicación 2, donde R1 es trifluorometoxilo o una sal, un hidrato, un solvato, un isómero óptico farmacéuticamente aceptable de este. 4.- Un compuesto de acuerdo con la Reivindicación 1, donde Q es o una sal, un hidrato, un solvato, un isómero óptico farmacéuticamente aceptable de este. 5.- Un compuesto de acuerdo con la Reivindicación 4, donde Q es y R2 es H o una sal, un hidrato, un solvato, un isómero óptico farmacéuticamente aceptable de este. 6.- Un compuesto de acuerdo con l Reivindicación 1, donde R1 es cloro o trifluorometoxilo y Q eso una sal, un hidrato, un solvato, un isómero óptico farmacéuticamente aceptable de este. 7.- Un compuesto de acuerdo con la Reivindicación 6, donde R1 es trifluorometoxilo y Q eso una sal, un hidrato, un solvato, un isómero óptico farmacéuticamente aceptable de este.
CO09139153A 2007-06-07 2009-12-04 Derivados de oxadiazol y su uso como potenciadores de los receptores metabotropicos de glutamato -842 CO6251287A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94255307P 2007-06-07 2007-06-07

Publications (1)

Publication Number Publication Date
CO6251287A2 true CO6251287A2 (es) 2011-02-21

Family

ID=40093925

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09139153A CO6251287A2 (es) 2007-06-07 2009-12-04 Derivados de oxadiazol y su uso como potenciadores de los receptores metabotropicos de glutamato -842

Country Status (33)

Country Link
US (2) US8377940B2 (es)
EP (2) EP2444399B1 (es)
JP (2) JP5416696B2 (es)
KR (2) KR20100017640A (es)
CN (2) CN102977086B (es)
AR (1) AR066882A1 (es)
AU (1) AU2008260717B2 (es)
BR (1) BRPI0812889A2 (es)
CA (1) CA2690856C (es)
CL (1) CL2008001667A1 (es)
CO (1) CO6251287A2 (es)
CY (2) CY1113422T1 (es)
DK (2) DK2167502T3 (es)
EC (1) ECSP109856A (es)
ES (2) ES2531443T3 (es)
HR (2) HRP20120909T4 (es)
IL (1) IL202158A (es)
ME (1) ME01488B (es)
MX (1) MX2009013078A (es)
MY (1) MY158066A (es)
NZ (1) NZ582445A (es)
PE (1) PE20090328A1 (es)
PL (2) PL2444399T3 (es)
PT (2) PT2167502E (es)
RS (2) RS52526B2 (es)
RU (2) RU2470931C2 (es)
SA (1) SA08290344B1 (es)
SI (2) SI2167502T1 (es)
TW (1) TWI417100B (es)
UA (1) UA99129C2 (es)
UY (1) UY31124A1 (es)
WO (1) WO2008150233A1 (es)
ZA (1) ZA200908285B (es)

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