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AR050266A1 - Derivados de bencil-triazolona como inhibidores no nucleosidos de transcriptasa inversa - Google Patents

Derivados de bencil-triazolona como inhibidores no nucleosidos de transcriptasa inversa

Info

Publication number
AR050266A1
AR050266A1 ARP050103064A ARP050103064A AR050266A1 AR 050266 A1 AR050266 A1 AR 050266A1 AR P050103064 A ARP050103064 A AR P050103064A AR P050103064 A ARP050103064 A AR P050103064A AR 050266 A1 AR050266 A1 AR 050266A1
Authority
AR
Argentina
Prior art keywords
alkyl
triazolona
nucleosid
bencil
inhibitors
Prior art date
Application number
ARP050103064A
Other languages
English (en)
Inventor
James Patrick Dunn
Todd Richard Elworthy
Dimitrios Stefanidis
Zachary Kevin Sweeney
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR050266A1 publication Critical patent/AR050266A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Reivindicacion 1: Un compuesto que se ajusta a la formula (1), en la que: R1 es halogeno, alquilo C1-6 o alcoxi C1-6; R2 es hidrogeno, halogeno o alquilo C1-6; R3 es un fenilo sustituido de una a tres veces por sustituyentes elegidos con independencia entre sí entre el grupo formado por alquilo C1-6, cicloalquilo C3-8, haloalquilo C1-6, haloalcoxi C1-6, halogeno y ciano; R4 es CH2OH, CH2OC(=O)(CH2)2C(=O)OH o CH2OC(=O)-alquiloC1-6; R5 es hidrogeno o alquilo C1-6; y los hidratos, solvatos y sales del mismo.
ARP050103064A 2004-07-27 2005-07-25 Derivados de bencil-triazolona como inhibidores no nucleosidos de transcriptasa inversa AR050266A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59131104P 2004-07-27 2004-07-27

Publications (1)

Publication Number Publication Date
AR050266A1 true AR050266A1 (es) 2006-10-11

Family

ID=35056908

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103064A AR050266A1 (es) 2004-07-27 2005-07-25 Derivados de bencil-triazolona como inhibidores no nucleosidos de transcriptasa inversa

Country Status (16)

Country Link
US (1) US7666891B2 (es)
EP (1) EP1773790B1 (es)
JP (1) JP4675959B2 (es)
CN (1) CN1993332B (es)
AR (1) AR050266A1 (es)
AU (1) AU2005266530B2 (es)
BR (1) BRPI0513858B8 (es)
CA (1) CA2574308C (es)
ES (1) ES2391461T3 (es)
IL (1) IL180495A (es)
MX (1) MX2007000788A (es)
NO (1) NO338376B1 (es)
RU (1) RU2394028C2 (es)
SG (1) SG148179A1 (es)
TW (1) TWI299334B (es)
WO (1) WO2006010545A1 (es)

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AU2006303368B2 (en) 2005-10-19 2011-05-26 F. Hoffmann-La Roche Ag Non-Nucleoside Reverse Transcriptase Inhibitors
CL2007002105A1 (es) * 2006-07-21 2008-02-22 Hoffmann La Roche Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u
CN101501002B (zh) * 2006-08-16 2012-06-27 弗·哈夫曼-拉罗切有限公司 非核苷逆转录酶抑制剂
TW200831085A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
KR20090127178A (ko) 2007-03-29 2009-12-09 에프. 호프만-라 로슈 아게 비뉴클레오시드 역전사 효소 억제제
AU2008235549A1 (en) * 2007-04-09 2008-10-16 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
WO2008145563A2 (en) * 2007-05-30 2008-12-04 F. Hoffmann-La Roche Ag Process for preparing triazolones
CA2687747C (en) 2007-05-30 2015-11-17 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
WO2009000663A1 (en) * 2007-06-22 2008-12-31 F. Hoffmann-La Roche Ag Urea and carbamate derivatives as non-nucleoside reverse transcriptase inhibitors
BRPI0821349A2 (pt) 2007-12-21 2019-09-24 Hoffmann La Roche compostos antivirais heterocíclicos
US20090181068A1 (en) 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
CN101723909B (zh) * 2008-10-29 2011-12-28 天津药物研究院 三唑酮类化合物、其制备方法和用途
CN101735023B (zh) * 2008-11-24 2014-07-09 联化科技股份有限公司 一种3-溴-5-氯苯酚的制备方法
PT2501698T (pt) 2009-11-18 2018-07-23 Nat Res Council Canada Monómeros fluorados, oligómeros e polímeros para utilização em dispositivos eletrónicos orgânicos
CN102146022B (zh) * 2010-02-05 2013-07-03 中国中化股份有限公司 3-氯-5-溴苯酚的制备方法
US8692026B2 (en) 2010-07-15 2014-04-08 Albemarle Corporation Processes for producing 4-bromo-2-methoxybenzaldehyde
CN104684557A (zh) * 2012-09-26 2015-06-03 默沙东公司 逆转录酶抑制剂的晶形
EP2935228B9 (en) 2012-12-20 2017-12-06 Inception 2, Inc. Triazolone compounds and uses thereof
PE20160880A1 (es) 2013-09-06 2016-09-22 Inception 2 Inc Compuestos de triazolona y usos de los mismos
GB2598624A (en) * 2020-09-07 2022-03-09 Lorico Aurelio Use of triazole analogues for inhibition of a tripartite VOR protein complex in multicellular organisms

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JP2593084B2 (ja) 1986-12-19 1997-03-19 メレルダウファーマスーティカルズ インコーポレーテッド ５−アリールー３ｈ−１，２，４−トリアゾールー３−オン類の神経変性障害の処置への用途
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PH24094A (en) 1986-12-19 1990-03-05 Merrell Dow Pharma 5-aryl-3h-1,2,4-triazol-3-ones and their use as anticonvulsants
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Also Published As

Publication number Publication date
RU2007106928A (ru) 2008-09-10
US7666891B2 (en) 2010-02-23
NO20070258L (no) 2007-01-15
EP1773790A1 (en) 2007-04-18
IL180495A (en) 2013-12-31
MX2007000788A (es) 2007-03-23
JP4675959B2 (ja) 2011-04-27
BRPI0513858B1 (pt) 2020-11-10
IL180495A0 (en) 2007-06-03
TWI299334B (en) 2008-08-01
WO2006010545A1 (en) 2006-02-02
BRPI0513858B8 (pt) 2021-05-25
CA2574308C (en) 2014-03-25
CN1993332A (zh) 2007-07-04
US20060025462A1 (en) 2006-02-02
SG148179A1 (en) 2008-12-31
JP2008508211A (ja) 2008-03-21
NO338376B1 (no) 2016-08-15
BRPI0513858A (pt) 2008-05-20
ES2391461T3 (es) 2012-11-27
CN1993332B (zh) 2011-04-06
CA2574308A1 (en) 2006-02-02
AU2005266530B2 (en) 2012-04-12
EP1773790B1 (en) 2012-08-15
TW200616979A (en) 2006-06-01
RU2394028C2 (ru) 2010-07-10
AU2005266530A1 (en) 2006-02-02

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