PE20090148A1 - DERIVADOS DE DIHIDRO-BENZO [b] [1,4] DIAZEPIN-2-ONA-SULFONIDA - Google Patents
DERIVADOS DE DIHIDRO-BENZO [b] [1,4] DIAZEPIN-2-ONA-SULFONIDAInfo
- Publication number
- PE20090148A1 PE20090148A1 PE2008000663A PE2008000663A PE20090148A1 PE 20090148 A1 PE20090148 A1 PE 20090148A1 PE 2008000663 A PE2008000663 A PE 2008000663A PE 2008000663 A PE2008000663 A PE 2008000663A PE 20090148 A1 PE20090148 A1 PE 20090148A1
- Authority
- PE
- Peru
- Prior art keywords
- diazepin
- benzo
- dihydro
- nrarb
- sulfonide
- Prior art date
Links
- 229910003827 NRaRb Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 ALKYL (C1-C6) Inorganic materials 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I, EN EL QUE R1 ES H Y R2 ES -S(O)2-NRaRb O R2 ES H Y R1 ES -S(O)2-NRaRb; R3 ES H, FLUOR, ALQUILO(C1-C6), NRaRb, ENTRE OTROS; R4 ES CLORO, HALOALQUILO(C1-C6) O ARILO; Ra Y Rb SON INDEPENDIENTEMENTEH, ALQUILO(C1.C6) E HIDROXIALQUILO(C2-C6). SON SELECCIONADOS AMIDA DEL ACIDO 3'-(8-METIL-4-OXO-7-TRIFLUORMETIL-4,5-DIHIDRO-3H-BENZO[b][1,4]DIAZEPIN-2-IL)-BIFENIL-4-SULFONICO, TERT-BUTILAMIDA DEL ACIDO 3'-(4-OXO-7-TRIFLUORMETIL-4,5-DIHIDRO-3H-BENZO[b][1,4]DIAZEPIN-2-IL)-BIFENIL-3-SULFONICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR METABOTROPICO DE GLUTAMATO Y SON DE UTILIDAD EN EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS, TALES COMO ESQUIZOFRENIA, PSICOSIS, TRASTORNOS COGNITIVOS, DEFICID DE MEMORIA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07106522 | 2007-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090148A1 true PE20090148A1 (es) | 2009-02-26 |
Family
ID=39532268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000663A PE20090148A1 (es) | 2007-04-19 | 2008-04-16 | DERIVADOS DE DIHIDRO-BENZO [b] [1,4] DIAZEPIN-2-ONA-SULFONIDA |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7511033B2 (es) |
| EP (1) | EP2137167B1 (es) |
| JP (1) | JP2010524879A (es) |
| KR (1) | KR101151993B1 (es) |
| CN (1) | CN101657432B (es) |
| AR (1) | AR066086A1 (es) |
| AT (1) | ATE519751T1 (es) |
| AU (1) | AU2008240802B2 (es) |
| BR (1) | BRPI0810655A2 (es) |
| CA (1) | CA2684760A1 (es) |
| CL (1) | CL2008001083A1 (es) |
| ES (1) | ES2369866T3 (es) |
| IL (1) | IL201198A0 (es) |
| MX (1) | MX2009010729A (es) |
| PE (1) | PE20090148A1 (es) |
| TW (1) | TW200904448A (es) |
| WO (1) | WO2008128889A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012020820A1 (ja) | 2010-08-11 | 2012-02-16 | 大正製薬株式会社 | ヘテロアリール－ピラゾール誘導体 |
| US9193710B2 (en) | 2011-08-29 | 2015-11-24 | Sanford-Burnham Medical Research Institute | Benzodiazepinones as modulators of metabotropic glutamate receptor functions and neurological uses thereof |
| KR20160080799A (ko) | 2014-12-30 | 2016-07-08 | 한국해양과학기술원 | 금 촉매를 이용한 α-피론 유도체 전합성 방법 및 이에 의해 합성되어 인간 암세포주에 세포독성을 가지는 α-피론 유도체 |
| CN106243050B (zh) * | 2016-08-10 | 2019-09-06 | 安徽恒星制药有限公司 | 一种适合工业化生产氯巴占的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6032775A (ja) | 1983-07-30 | 1985-02-19 | Daikin Ind Ltd | 含フッ素ベンゾジアゼピン類 |
| GB8601004D0 (en) | 1986-01-16 | 1986-02-19 | Fujisawa Pharmaceutical Co | 1,5-benzodiazepine derivatives |
| GB9018601D0 (en) | 1990-08-24 | 1990-10-10 | Fujisawa Pharmaceutical Co | Tricyclic compounds |
| CA2054455A1 (en) | 1990-11-23 | 1992-05-24 | John James Delany | Substituted-2,3-dihydro-2-oxo-1,5-benzodiazepines and their use as fungicides |
| CA2140009A1 (en) | 1992-07-29 | 1994-02-17 | Jose Luis Castro Pineiro | Benzodiazepine derivatives |
| GB9314981D0 (en) * | 1993-07-20 | 1993-09-01 | Glaxo Spa | Chemical compounds |
| AU3414295A (en) | 1994-08-19 | 1996-03-14 | Nps Pharmaceuticals, Inc. | Methods and compounds active at metabotropic glutamate receptors useful for treatment of neurological disorders and diseases |
| EP0843660A1 (en) | 1995-07-31 | 1998-05-27 | Novo Nordisk A/S | Heterocyclic compounds, their preparation and use |
| KR100384979B1 (ko) * | 1995-09-07 | 2003-10-17 | 에프. 호프만-라 로슈 아게 | 심부전증및신부전증치료용의신규한4-(옥시알콕시페닐)-3-옥시-피페리딘 |
| EP1037878A2 (en) | 1997-11-21 | 2000-09-27 | Nps Pharmaceuticals, Inc. | Metabotropic glutamate receptor antagonists for treating central nervous system diseases |
| AU6420700A (en) | 1999-08-05 | 2001-03-05 | Prescient Neuropharma Inc. | Novel 1,4-benzodiazepine compounds and derivatives thereof |
| HRP20020259A2 (en) * | 1999-10-15 | 2004-04-30 | Hoffmann La Roche | Benzodiazepine derivatives |
| PL357433A1 (en) | 1999-10-15 | 2004-07-26 | F.Hoffmann-La Roche Ag | Benzodiazepine derivatives as metabotropic glutamate receptor antagonists |
| IL157873A0 (en) * | 2001-04-12 | 2004-03-28 | Hoffmann La Roche | DIHYDRO-BENZO [b] [1,4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II |
| YU79103A (sh) * | 2001-04-12 | 2006-05-25 | F. Hoffmann-La Roche Ag. | Derivati dihidro-benzo/b/ /1,4/diazepin-2-ona kao antagonisti mglur2 i receptora |
| US6949542B2 (en) * | 2002-02-06 | 2005-09-27 | Hoffman-La Roche Inc. | Dihydro-benzo[b][1,4]diazepin-2-one derivatives |
-
2008
- 2008-04-09 JP JP2010503459A patent/JP2010524879A/ja not_active Ceased
- 2008-04-09 KR KR1020097023810A patent/KR101151993B1/ko not_active Expired - Fee Related
- 2008-04-09 EP EP08735983A patent/EP2137167B1/en not_active Not-in-force
- 2008-04-09 AT AT08735983T patent/ATE519751T1/de active
- 2008-04-09 AU AU2008240802A patent/AU2008240802B2/en not_active Ceased
- 2008-04-09 BR BRPI0810655-0A2A patent/BRPI0810655A2/pt not_active IP Right Cessation
- 2008-04-09 WO PCT/EP2008/054257 patent/WO2008128889A1/en not_active Ceased
- 2008-04-09 CA CA002684760A patent/CA2684760A1/en not_active Abandoned
- 2008-04-09 MX MX2009010729A patent/MX2009010729A/es active IP Right Grant
- 2008-04-09 CN CN2008800121352A patent/CN101657432B/zh not_active Expired - Fee Related
- 2008-04-09 ES ES08735983T patent/ES2369866T3/es active Active
- 2008-04-14 US US12/102,140 patent/US7511033B2/en not_active Expired - Fee Related
- 2008-04-16 PE PE2008000663A patent/PE20090148A1/es not_active Application Discontinuation
- 2008-04-17 AR ARP080101574A patent/AR066086A1/es unknown
- 2008-04-17 TW TW097114007A patent/TW200904448A/zh unknown
- 2008-04-17 CL CL200801083A patent/CL2008001083A1/es unknown
-
2009
- 2009-09-24 IL IL201198A patent/IL201198A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010524879A (ja) | 2010-07-22 |
| ATE519751T1 (de) | 2011-08-15 |
| ES2369866T3 (es) | 2011-12-07 |
| CN101657432A (zh) | 2010-02-24 |
| WO2008128889A1 (en) | 2008-10-30 |
| CN101657432B (zh) | 2013-04-10 |
| CA2684760A1 (en) | 2008-10-30 |
| AU2008240802A1 (en) | 2008-10-30 |
| US7511033B2 (en) | 2009-03-31 |
| BRPI0810655A2 (pt) | 2014-11-04 |
| US20080261957A1 (en) | 2008-10-23 |
| CL2008001083A1 (es) | 2008-10-24 |
| MX2009010729A (es) | 2009-10-26 |
| IL201198A0 (en) | 2010-05-17 |
| AR066086A1 (es) | 2009-07-22 |
| EP2137167B1 (en) | 2011-08-10 |
| KR101151993B1 (ko) | 2012-06-01 |
| KR20100005715A (ko) | 2010-01-15 |
| TW200904448A (en) | 2009-02-01 |
| AU2008240802B2 (en) | 2012-07-05 |
| EP2137167A1 (en) | 2009-12-30 |
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Legal Events
| Date | Code | Title | Description |
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| FC | Refusal |