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PE20090892A1 - MODULADORES DUALES DE LOS RECEPTORES 5-HT2a Y D3 - Google Patents

MODULADORES DUALES DE LOS RECEPTORES 5-HT2a Y D3

Info

Publication number
PE20090892A1
PE20090892A1 PE2008001250A PE2008001250A PE20090892A1 PE 20090892 A1 PE20090892 A1 PE 20090892A1 PE 2008001250 A PE2008001250 A PE 2008001250A PE 2008001250 A PE2008001250 A PE 2008001250A PE 20090892 A1 PE20090892 A1 PE 20090892A1
Authority
PE
Peru
Prior art keywords
piperidin
benzo
alkyl
isoxazol
fluoro
Prior art date
Application number
PE2008001250A
Other languages
English (en)
Inventor
Luca Gobbi
Georg Jaeschke
Olivier Roche
Sarmiento Rosa Maria Rodriguez
Lucinda Steward
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20090892A1 publication Critical patent/PE20090892A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDO A COMPUESTOS DERIVADOS DE BENZO[D]ISOXAZOL-3-IL-PIPERIDIN-1-L DE FORMULA (I): DONDE X ES HALOGENO, CIANO, ALQUILO(C1-C6), ENTRE OTROS; n ES 0, 1, 2 O 3; R1 ES H O ALQUILO(C1-C6); R2 ES (A) O (B); R3 ES H, ALQUILO(C1-C6), ALQUENILO(C2-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4N-TRANS(4-{2-[4-(6-FLUORO-BENZO[d]ISOXAZOL-3-IL)-PIPERIDIN-1-IL]-ETIL}-CICLOHEXIL)-ACETAMIDA, TRANS-(4-{2-[4-(6-FLUORO-BENZO[d]ISOXAZOL-3-IL)-PIPERIDIN-1-IL]-ETIL}-CICLOHEXIL)-AMIDA DEL ACIDO TETRAHIDRO-PIRAN-4-CARBOXILICO, N-TRANS-(4-{2-[4-(6-FLUORO-BENZO[d]ISOZAXOL-3-IL)-PIPERIDIN-1-IL]ETIL}-CICLOHEXIL)-3-METOXI-PROPIONAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA FORMULACION Y A UN METODO DE PREPARACION DE UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DUALES DE LOS RECEPTORES5-HT2a DE LA SEROTONINA Y DE LO RECEPTORES D3 DE LA DOPAMINA Y ES UTIL EN EL TRATAMIENTO DE TRANSTORNOS PSICOTICOS TALES COMO LA DEPRESION , LA ANSIEDAD, ENTRE OTROS
PE2008001250A 2007-07-26 2008-07-23 MODULADORES DUALES DE LOS RECEPTORES 5-HT2a Y D3 PE20090892A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07113252 2007-07-26

Publications (1)

Publication Number Publication Date
PE20090892A1 true PE20090892A1 (es) 2009-07-13

Family

ID=40281888

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001250A PE20090892A1 (es) 2007-07-26 2008-07-23 MODULADORES DUALES DE LOS RECEPTORES 5-HT2a Y D3

Country Status (16)

Country Link
US (4) US20090029977A1 (es)
EP (1) EP2183245B1 (es)
JP (1) JP5502733B2 (es)
KR (1) KR101169518B1 (es)
CN (1) CN101778844B (es)
AR (1) AR067662A1 (es)
AU (1) AU2008280187B2 (es)
BR (1) BRPI0815092A2 (es)
CA (1) CA2694009A1 (es)
CL (1) CL2008002162A1 (es)
ES (1) ES2498673T3 (es)
PE (1) PE20090892A1 (es)
RU (1) RU2480466C2 (es)
TW (1) TWI363623B (es)
WO (1) WO2009013212A2 (es)
ZA (1) ZA201000354B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1987019B1 (en) * 2006-02-17 2012-11-28 F. Hoffmann-La Roche AG Benzoyl-piperidine derivatives as 5ht2/d3 modulators
AU2009294695B2 (en) * 2008-09-22 2012-09-13 F. Hoffmann-La Roche Ag Piperazine D3 and 5-HT2a receptor modulators
JP2012502948A (ja) * 2008-09-23 2012-02-02 エフ．ホフマン−ラ ロシュ アーゲー ドーパミンｄ３受容体の調節剤として有用なイソオキサゾロ［４，５］ピリジン−３−イル−ピペラジン誘導体
US8470828B2 (en) * 2010-07-06 2013-06-25 Hoffmann-La Roche Inc. Anellated pyridine compounds
US8877778B2 (en) * 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
US8722683B2 (en) * 2011-02-17 2014-05-13 Hoffmann La-Roche Inc. Benzodioxole piperazine compounds
US8598357B2 (en) * 2011-03-03 2013-12-03 Hoffmann-La Roche Inc. Benzodioxole piperidine compounds
US8921397B2 (en) * 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds
CN105367565B (zh) * 2014-08-20 2018-10-02 上海医药工业研究院 哌嗪(啶)环己基衍生物及其治疗精神神经疾病的应用
CN106518841B (zh) * 2015-09-15 2019-03-05 浙江京新药业股份有限公司 环己烷衍生物或其立体异构体或盐及其制备与应用
WO2017045599A1 (zh) * 2015-09-15 2017-03-23 浙江京新药业股份有限公司 环己烷衍生物或其立体异构体或盐及其制备与应用
US10870660B2 (en) 2016-07-28 2020-12-22 Shionogi & Co., Ltd. Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
MX2020007849A (es) 2018-01-26 2020-09-25 Shionogi & Co Compuesto ciclico condensado que tiene efecto antagonista del receptor de dopamina d3.
US11447484B2 (en) 2018-01-26 2022-09-20 Shionogi & Co., Ltd. Cyclic compound having dopamine D3 receptor antagonistic effect
BR112022007238A2 (pt) 2019-10-29 2022-07-05 Shanghai Hansoh Biomedical Co Ltd Compostos modificadores derivados de anel de quatro membros, métodos para preparar os referidos compostos, composição e uso
EP4056568A4 (en) * 2019-11-05 2024-02-28 Shanghai Hansoh Biomedical Co., Ltd. BENZOTHIOPHENE DERIVATIVE REGULATOR, PRODUCTION METHOD THEREOF AND USE THEREOF
CN115667236B (zh) * 2020-04-26 2024-04-26 江苏恩华药业股份有限公司 1,5-二氢-2,4-苯二氮䓬-3-酮衍生物及其应用
EP4332093A4 (en) 2021-04-28 2025-04-30 Shanghai Hansoh Biomedical Co., Ltd. Salt with polycyclic piperazine derivative, crystalline form thereof, production process therefor and use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776963A (en) 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
DK60693D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
WO1998034933A1 (en) 1997-02-07 1998-08-13 Hoechst Marion Roussel, Inc. (4-piperidinyl)-1h-2-benzopyran derivatives useful as antipsychotic agents
US6335326B1 (en) * 1998-02-09 2002-01-01 Duphar International Research B.V. Benzisoxazole derivatives having d4-antagonistic activity
DE10010612A1 (de) * 2000-03-03 2001-09-27 Merck Patent Gmbh Verwendung von PDE V-Inhibitoren
GB0117577D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
GB0117950D0 (en) 2001-02-16 2001-09-19 Aventis Pharma Inc Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
MXPA03006524A (es) 2001-02-16 2003-09-25 Aventis Pharma Inc Derivados heterociclicos novedosos de amidas y su uso como ligandos para receptor d3 de dopamina.
AU2002250107B8 (en) 2001-02-16 2008-06-12 Aventis Pharmaceuticals Inc. Heterocyclic substituted carbonyl derivatives and their use as dopamine D3 receptor ligands
EP1987019B1 (en) * 2006-02-17 2012-11-28 F. Hoffmann-La Roche AG Benzoyl-piperidine derivatives as 5ht2/d3 modulators
MX2009004615A (es) * 2006-10-31 2009-05-22 Hoffmann La Roche Derivados de eter como moduladores duales de los receptores de 5-hidroxitriptamina a (5-ht2a) y dopamina (d3).
MX2010001195A (es) * 2007-08-09 2010-03-01 Hoffmann La Roche Derivados de benzoil-peperidina como moduladores dobles de los receptores 5-ht2a y d3.
AU2009294695B2 (en) * 2008-09-22 2012-09-13 F. Hoffmann-La Roche Ag Piperazine D3 and 5-HT2a receptor modulators
EP2420558B1 (en) * 2010-08-17 2017-08-02 The Procter & Gamble Company Stable sustainable hand dish-washing detergents
US8877778B2 (en) * 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds

Also Published As

Publication number Publication date
CA2694009A1 (en) 2009-01-29
TWI363623B (en) 2012-05-11
JP2010534632A (ja) 2010-11-11
AU2008280187B2 (en) 2013-05-16
WO2009013212A2 (en) 2009-01-29
WO2009013212A3 (en) 2009-06-11
AR067662A1 (es) 2009-10-21
KR101169518B1 (ko) 2012-07-27
EP2183245B1 (en) 2014-07-09
CN101778844B (zh) 2013-01-02
RU2480466C2 (ru) 2013-04-27
US20130165432A1 (en) 2013-06-27
AU2008280187A1 (en) 2009-01-29
ES2498673T3 (es) 2014-09-25
CL2008002162A1 (es) 2009-05-29
US20120040972A1 (en) 2012-02-16
TW200911236A (en) 2009-03-16
US8829029B2 (en) 2014-09-09
CN101778844A (zh) 2010-07-14
US20140350051A1 (en) 2014-11-27
KR20100036384A (ko) 2010-04-07
EP2183245A2 (en) 2010-05-12
ZA201000354B (en) 2010-10-27
RU2010104631A (ru) 2011-09-10
JP5502733B2 (ja) 2014-05-28
US20090029977A1 (en) 2009-01-29
BRPI0815092A2 (pt) 2015-02-03

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