BRPI0810655A2 - Derivados de di-hidro-benzo[b][1,4] diazepin-2-ona sulfonamida - Google Patents

Derivados de di-hidro-benzo[b][1,4] diazepin-2-ona sulfonamida

Info

Publication number: BRPI0810655A2
Authority: BR; Brazil
Prior art keywords: diazepin; ona; sulfonamide; hydro; benzo derivatives
Prior art date: 2007-04-19

Application number

BRPI0810655-0A2A

Other languages

English (en)

Inventor

Silvia Gatti Mcarthur

Juergen Wichmann

Thomas Johannes Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-04-19

Filing date

2008-04-09

Publication date

2014-11-04

2008-04-09 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2014-11-04 Publication of BRPI0810655A2 publication Critical patent/BRPI0810655A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI0810655-0A2A 2007-04-19 2008-04-09 Derivados de di-hidro-benzo[b][1,4] diazepin-2-ona sulfonamida BRPI0810655A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07106522		2007-04-19
PCT/EP2008/054257 WO2008128889A1 (en)	2007-04-19	2008-04-09	Dihydro-benzo[b][1,4]diazepin-2-one sulfonamide derivatives

Publications (1)

Publication Number	Publication Date
BRPI0810655A2 true BRPI0810655A2 (pt)	2014-11-04

Family

ID=39532268

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0810655-0A2A BRPI0810655A2 (pt)	2007-04-19	2008-04-09	Derivados de di-hidro-benzo[b][1,4] diazepin-2-ona sulfonamida

Country Status (17)

Country	Link
US (1)	US7511033B2 (pt)
EP (1)	EP2137167B1 (pt)
JP (1)	JP2010524879A (pt)
KR (1)	KR101151993B1 (pt)
CN (1)	CN101657432B (pt)
AR (1)	AR066086A1 (pt)
AT (1)	ATE519751T1 (pt)
AU (1)	AU2008240802B2 (pt)
BR (1)	BRPI0810655A2 (pt)
CA (1)	CA2684760A1 (pt)
CL (1)	CL2008001083A1 (pt)
ES (1)	ES2369866T3 (pt)
IL (1)	IL201198A0 (pt)
MX (1)	MX2009010729A (pt)
PE (1)	PE20090148A1 (pt)
TW (1)	TW200904448A (pt)
WO (1)	WO2008128889A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPWO2012020820A1 (ja)	2010-08-11	2013-10-28	大正製薬株式会社	ヘテロアリール−ピラゾール誘導体
EP2751095B1 (en) *	2011-08-29	2021-10-27	Sanford-Burnham Medical Research Institute	Novel benzodiazepinones as modulators of metabotropic glutamate receptor functions and neurological uses thereof
KR20160080799A (ko)	2014-12-30	2016-07-08	한국해양과학기술원	금 촉매를 이용한 α-피론 유도체 전합성 방법 및 이에 의해 합성되어 인간 암세포주에 세포독성을 가지는 α-피론 유도체
CN106243050B (zh) *	2016-08-10	2019-09-06	安徽恒星制药有限公司	一种适合工业化生产氯巴占的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6032775A (ja)	1983-07-30	1985-02-19	Daikin Ind Ltd	含フッ素ベンゾジアゼピン類
GB8601004D0 (en)	1986-01-16	1986-02-19	Fujisawa Pharmaceutical Co	1,5-benzodiazepine derivatives
GB9018601D0 (en)	1990-08-24	1990-10-10	Fujisawa Pharmaceutical Co	Tricyclic compounds
CA2054455A1 (en)	1990-11-23	1992-05-24	John James Delany	Substituted-2,3-dihydro-2-oxo-1,5-benzodiazepines and their use as fungicides
DE69330959T2 (de)	1992-07-29	2002-04-11	Merck Sharp & Dohme Ltd., Hoddesdon	Benzodiazepinderivate
GB9314981D0 (en) *	1993-07-20	1993-09-01	Glaxo Spa	Chemical compounds
AU3414295A (en)	1994-08-19	1996-03-14	Nps Pharmaceuticals, Inc.	Methods and compounds active at metabotropic glutamate receptors useful for treatment of neurological disorders and diseases
WO1997005109A1 (en)	1995-07-31	1997-02-13	Novo Nordisk A/S	Heterocyclic compounds, their preparation and use
IL123293A (en) *	1995-09-07	2003-06-24	Hoffmann La Roche	Piperidine derivatives, their preparation and pharmaceutical compositions containing them
CN1158264C (zh)	1997-11-21	2004-07-21	Nps药物有限公司	用于治疗中枢神经系统疾病的代谢性谷氨酸受体拮抗剂
JP2003506440A (ja)	1999-08-05	2003-02-18	プレサイエントニューロファーマインコーポレイテッド	中枢神経系に関連する疾患の処置のための１，４−ジアゼピン誘導体
PT1224174E (pt) *	1999-10-15	2004-01-30	Hoffmann La Roche	Derivados de benzodiazepina como antagonistas do receptor metabotropico do glutamato
YU27902A (sh)	1999-10-15	2004-11-25	F. Hoffmann-La Roche Ag.	Derivati benzodiazepina
JP4071115B2 (ja) *	2001-04-12	2008-04-02	エフ．ホフマン−ラロシュアーゲー	ｍＧｌｕＲ２アンタゴニストＩＩとしてのジヒドロ−ベンゾ〔ｂ〕〔１，４〕ジアゼピン−２−オン誘導体
ES2235044T3 (es) *	2001-04-12	2005-07-01	F. Hoffmann-La Roche Ag	Derivados de dihidro-benzo (b) (1,4)-diazepin-2-ona como antagonistas i de mglur2.
US6949542B2 (en)	2002-02-06	2005-09-27	Hoffman-La Roche Inc.	Dihydro-benzo[b][1,4]diazepin-2-one derivatives

2008
- 2008-04-09 WO PCT/EP2008/054257 patent/WO2008128889A1/en not_active Ceased
- 2008-04-09 AU AU2008240802A patent/AU2008240802B2/en not_active Ceased
- 2008-04-09 EP EP08735983A patent/EP2137167B1/en not_active Not-in-force
- 2008-04-09 MX MX2009010729A patent/MX2009010729A/es active IP Right Grant
- 2008-04-09 AT AT08735983T patent/ATE519751T1/de active
- 2008-04-09 JP JP2010503459A patent/JP2010524879A/ja not_active Ceased
- 2008-04-09 ES ES08735983T patent/ES2369866T3/es active Active
- 2008-04-09 CN CN2008800121352A patent/CN101657432B/zh not_active Expired - Fee Related
- 2008-04-09 BR BRPI0810655-0A2A patent/BRPI0810655A2/pt not_active IP Right Cessation
- 2008-04-09 KR KR1020097023810A patent/KR101151993B1/ko not_active Expired - Fee Related
- 2008-04-09 CA CA002684760A patent/CA2684760A1/en not_active Abandoned
- 2008-04-14 US US12/102,140 patent/US7511033B2/en not_active Expired - Fee Related
- 2008-04-16 PE PE2008000663A patent/PE20090148A1/es not_active Application Discontinuation
- 2008-04-17 AR ARP080101574A patent/AR066086A1/es unknown
- 2008-04-17 TW TW097114007A patent/TW200904448A/zh unknown
- 2008-04-17 CL CL200801083A patent/CL2008001083A1/es unknown
2009
- 2009-09-24 IL IL201198A patent/IL201198A0/en unknown

Also Published As

Publication number	Publication date
IL201198A0 (en)	2010-05-17
US7511033B2 (en)	2009-03-31
ES2369866T3 (es)	2011-12-07
CA2684760A1 (en)	2008-10-30
KR101151993B1 (ko)	2012-06-01
JP2010524879A (ja)	2010-07-22
KR20100005715A (ko)	2010-01-15
AR066086A1 (es)	2009-07-22
PE20090148A1 (es)	2009-02-26
US20080261957A1 (en)	2008-10-23
WO2008128889A1 (en)	2008-10-30
CN101657432B (zh)	2013-04-10
MX2009010729A (es)	2009-10-26
CN101657432A (zh)	2010-02-24
TW200904448A (en)	2009-02-01
AU2008240802A1 (en)	2008-10-30
ATE519751T1 (de)	2011-08-15
EP2137167A1 (en)	2009-12-30
CL2008001083A1 (es)	2008-10-24
AU2008240802B2 (en)	2012-07-05
EP2137167B1 (en)	2011-08-10

Publication	Publication Date	Title
BRPI0811718A2 (pt)	2014-11-18	Derivados de 3,3-espiroindolinona
DE602008005634D1 (de)	2011-04-28	1,1,1-trifluor-2-hydroxy-3-phenylpropan-derivate
ATE555107T1 (de)	2012-05-15	2-aza-bicyclo-ä2,2,1-üheptan-derivate
ATE469145T1 (de)	2010-06-15	4-ä5-methoxy-6-(2-methyl-6-ä1,2,4ütriazol-1-yl-
BRPI0907563A2 (pt)	2015-08-04	Derivados de 4,5-di-hidro-xazol-2-il amina
BRPI0816970A2 (pt)	2015-03-24	1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
ATE481383T1 (de)	2010-10-15	3-aza-bicycloä3.1.0ühexanderivate
BRPI0714764A2 (pt)	2014-12-30	Derivados substituídos de sulfonamida
BRPI0813707A2 (pt)	2014-12-30	Derivados de pirimidinil-piridazinona
BRPI0820112A2 (pt)	2015-05-05	Derivados de isoxazol-piridina
BRPI0809992A2 (pt)	2014-10-14	Derivados de pirrolopirimidina
BRPI0820113A2 (pt)	2015-05-05	Derivados de isoxazolo-piridazina
ATE513831T1 (de)	2011-07-15	Pyridinä3,4-büpyrazinone
EP1903866A4 (en)	2010-12-22	IMPROVED RELEASE OF TETRAHYDROCANNABINOL
BRPI0812155A2 (pt)	2019-09-24	derivados de espiroindolinona
BRPI0817935A2 (pt)	2015-04-07	Derivados de biarila
BRPI0812518A2 (pt)	2015-03-31	Derivados de indazolamida
BRPI0814236A2 (pt)	2015-01-06	Derivados de quinazolinamida
BRPI0820649A2 (pt)	2015-06-16	Derivados de isoxazalo-pirazina
DE602007001681D1 (de)	2009-09-03	1,3-dioxan-carboxylsäuren
BRPI0815059A2 (pt)	2015-02-10	Derivado de 1,3-di-hidroisoindol
BRPI0916363A2 (pt)	2018-05-29	derivados de 4,5-di-hidro-oxazol-2-ila
BRPI0814718A2 (pt)	2015-02-24	Derivados de isoxazol-imidazol
ATE492529T1 (de)	2011-01-15	Sulfonamidderivate
DE602006010581D1 (de)	2009-12-31	4-phenyl-6-substituierte pyrimidin-2-carbonitrilderivate

Legal Events

Date	Code	Title	Description
2015-08-25	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 6A E 7A ANUIDADES.
2016-05-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.
2022-07-12	B350	Update of information on the portal [chapter 15.35 patent gazette]