PE20080359A1 - Compuestos de benzoxazol y benzotiazol 6-0-sustituidos y metodos de inhibicion de la senalizacion de csf-1r - Google Patents
Compuestos de benzoxazol y benzotiazol 6-0-sustituidos y metodos de inhibicion de la senalizacion de csf-1rInfo
- Publication number
- PE20080359A1 PE20080359A1 PE2007000472A PE2007000472A PE20080359A1 PE 20080359 A1 PE20080359 A1 PE 20080359A1 PE 2007000472 A PE2007000472 A PE 2007000472A PE 2007000472 A PE2007000472 A PE 2007000472A PE 20080359 A1 PE20080359 A1 PE 20080359A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alkenyl
- benzoxazole
- benzothiazole
- csf
- Prior art date
Links
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 title 1
- 101710150918 Macrophage colony-stimulating factor 1 receptor Proteins 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000011664 signaling Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- WDFQBORIUYODSI-UHFFFAOYSA-N 4-bromoaniline Chemical compound NC1=CC=C(Br)C=C1 WDFQBORIUYODSI-UHFFFAOYSA-N 0.000 abstract 1
- -1 AMINOCARBONYL Chemical class 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A COMPUESTOS DE BENZOXAZOL Y BENZOTIAZOL 6-O-SUSTITUIDOS DE FORMULA (I), EN DONDE X ES O, S o S(O); R1 Y R2 SON INDEPENDIENTEMENTE H, ALQUILO, ACILO, CICLOALQUILO, ARILO, HETEROCICLILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; R3 ES H, HALO, ALQUENILO, ACILAMINO, AMINOCARBONILO, ENTRE OTROS; R6 ES ALQUILO, ALCOXI, ENTRE OTROS; n ES 0,1 O 2; CUANDO X ES O, R4 ES H, ALQUENILO, ALQUILO SUSTITUIDO, ENTRE OTROS Y R5 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; O R4 Y R5 JUNTOS FORMAN UN HETEROCICLILO, CICLOALQUILO, ARILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS. SON SELECCIONADOS: METILAMIDA DEL ACIDO 4-[2-(4-BROMO-FENILAMINO)-BENZOOXAZOL-6-ILOXI]-PIRIDIN-2-CARBOXILICO, (2,3-DIHIDRO-BENZO[1,4]DIOXIN-6-IL)-[6-(6,7-DIMETOXI-QUINOLIN-4-ILOXI]-BENZOOXAZOL-2-IL]-AMINA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE CSF-1R, Y SON UTILES PARA TRATAMIENTO Y PREVENCION DEL CANCER, TUMORES, ENFERMEDADES DEGENERATIVAS OSEAS COMO LA ARTRITIS REUMATOIDEA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79351706P | 2006-04-19 | 2006-04-19 | |
| US89385707P | 2007-03-08 | 2007-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080359A1 true PE20080359A1 (es) | 2008-06-06 |
Family
ID=38610468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000472A PE20080359A1 (es) | 2006-04-19 | 2007-04-18 | Compuestos de benzoxazol y benzotiazol 6-0-sustituidos y metodos de inhibicion de la senalizacion de csf-1r |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US7553854B2 (es) |
| EP (1) | EP2010528B1 (es) |
| JP (1) | JP5328640B2 (es) |
| KR (1) | KR101464385B1 (es) |
| AR (1) | AR060545A1 (es) |
| AU (1) | AU2007237904B2 (es) |
| BR (1) | BRPI0710540B1 (es) |
| CA (1) | CA2649288C (es) |
| CR (1) | CR10365A (es) |
| CY (1) | CY1119679T1 (es) |
| DK (1) | DK2010528T3 (es) |
| EA (1) | EA018917B1 (es) |
| EC (1) | ECSP088830A (es) |
| ES (1) | ES2654847T3 (es) |
| HR (1) | HRP20171924T1 (es) |
| HU (1) | HUE035654T2 (es) |
| IL (1) | IL194662A0 (es) |
| LT (1) | LT2010528T (es) |
| MA (1) | MA30407B1 (es) |
| MX (1) | MX2008013427A (es) |
| NO (1) | NO20084800L (es) |
| PE (1) | PE20080359A1 (es) |
| PL (1) | PL2010528T3 (es) |
| PT (1) | PT2010528T (es) |
| RS (1) | RS56600B1 (es) |
| SI (1) | SI2010528T1 (es) |
| SM (1) | SMP200800063B (es) |
| TN (1) | TNSN08406A1 (es) |
| TW (1) | TW200813039A (es) |
| WO (1) | WO2007121484A2 (es) |
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| EA200901548A1 (ru) * | 2007-05-21 | 2010-06-30 | Новартис Аг | Ингибиторы csf-1r, композиции и способы применения |
| AR066845A1 (es) | 2007-06-05 | 2009-09-16 | Takeda Pharmaceutical | Derivados de triazolopiridina e imidazopiridina una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento del cancer |
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| EP2295426A1 (en) | 2004-04-30 | 2011-03-16 | Bayer HealthCare, LLC | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
| US20060074102A1 (en) | 2004-05-14 | 2006-04-06 | Kevin Cusack | Kinase inhibitors as therapeutic agents |
| MXPA06014125A (es) | 2004-06-04 | 2007-01-31 | Astrazeneca Ab | Derivados de quinazolina en la forma de cinasas de tirosina de receptor erbb. |
| TW200612958A (en) | 2004-06-18 | 2006-05-01 | Chiron Corp | Substituted imidazole derivatives |
| KR101464385B1 (ko) * | 2006-04-19 | 2014-11-21 | 노파르티스 아게 | ６-ｏ-치환된 벤즈옥사졸 및 벤조티아졸 화합물, 및 ｃｓｆ-１ｒ 신호전달의 억제 방법 |
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