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PE20141190A1 - Isoxazolinas como agentes terapeuticos - Google Patents

Isoxazolinas como agentes terapeuticos

Info

Publication number
PE20141190A1
PE20141190A1 PE2013002428A PE2013002428A PE20141190A1 PE 20141190 A1 PE20141190 A1 PE 20141190A1 PE 2013002428 A PE2013002428 A PE 2013002428A PE 2013002428 A PE2013002428 A PE 2013002428A PE 20141190 A1 PE20141190 A1 PE 20141190A1
Authority
PE
Peru
Prior art keywords
alkyl
isoxazolines
compounds
metoxybenzyl
dihydroisoxazole
Prior art date
Application number
PE2013002428A
Other languages
English (en)
Inventor
David J Calderwood
Eric C Breinlinger
Steven L Swann
Subhendu Mukherjee
Venkata Srikanth Chitty
Siva Sanjeeva Rao Thunuguntla
Subramanyah Seetharama Shastry Hosahalli
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47108012&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141190(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20141190A1 publication Critical patent/PE20141190A1/es

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ISOXAZOLINAS DE FORMULA (I) DONDE A ES UN COMPUESTO DE FORMULA (a), (b), ENTRE OTROS, DONDE R1 ES H, Br, F, ENTRE OTROS; Z ES -C(O)OCH3, ALQUILO(C1-C6), ARILO, ENTRE OTROS; n Y p SON CADA UNO DE 0 A 3; X ES NAFTILO, FENILO, BENZOFURANILO, ENTRE OTROS; Y ES HETEROARILO OPCIONALMENTE SUSTITUIDO; Ra ES H, ALQUILO(C1-C3) O CICLOALQUILO(C3-C6) OPCIONALMENTE SUSTITUIDOS; Rb ES H, CF3, ALQUILO(C1-C3) O CICLOALQUILO(C3-C6); m ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: 6-(5-(1-ACETILPIPERIDIN-4-IL)-4,5-DIHIDROISOXAZOL-3-IL)-N-(4-FLUORO-3-METOXIBENCIL)-2-METILPIRIMIDIN-4-CARBOXAMIDA; N-(4-FLUORO-3-METOXIBENCIL)-2-METIL-6-(5-(1-(METILSULFONIL)PIPERIDIN-4-IL)-4,5-DIHIDROISOXAZOL-3-IL)PIRIMIDIN-4-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA METALOPROTEINASA DE MATRIZ MMP-13 SIENDO UTILES EN EL TRATAMIENTO DE OSTEOARTRITIS, LESION ARTICULAR TRAUMATICA, ARTRITIS REUMATOIDE
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