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CY1119679T1 - Ενωσεις 6-o-υποκατεστημενης βενζοξαζολης και βενζοθειαζολης και μεθοδοι αναστολης της σηματοδoτησης toy csf-1r - Google Patents

Ενωσεις 6-o-υποκατεστημενης βενζοξαζολης και βενζοθειαζολης και μεθοδοι αναστολης της σηματοδoτησης toy csf-1r

Info

Publication number
CY1119679T1
CY1119679T1 CY20171101315T CY171101315T CY1119679T1 CY 1119679 T1 CY1119679 T1 CY 1119679T1 CY 20171101315 T CY20171101315 T CY 20171101315T CY 171101315 T CY171101315 T CY 171101315T CY 1119679 T1 CY1119679 T1 CY 1119679T1
Authority
CY
Cyprus
Prior art keywords
compounds
csf
benzoxazolis
benzothisiazol
signature
Prior art date
Application number
CY20171101315T
Other languages
English (en)
Inventor
James C. Sutton
Marion Wiesmann
Weibo Wang
Mika K. Lindvall
Jiong Lan
Savithri Ramurthy
Anu Sharma
Elizabeth J. Mieuli
Liana M. Klivansky
William P. Lenahan
Susan Kaufman
Hong Yang
Simon C. Ng
Keith Pfister
Allan Wagman
Victoria Sung
Martin Sendzik
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1119679T1 publication Critical patent/CY1119679T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Αποκαλύπτονται ενώσεις βενζοξαζόλης και βενζοθειαζόλης και τα στερεοϊσομερή, ταυτομερή, επιδιαλυτώματα, οξείδια, εστέρες και προφάρμακα αυτών και φαρμακευτικά αποδεκτά άλατα αυτών. Αποκαλύπτονται επίσης συνθέσεις των ενώσεων, είτε μόνες τους είτε σε συνδυασμό με τουλάχιστον έναν επιπρόσθετο θεραπευτικό παράγοντα, με έναν φαρμακευτικά αποδεκτό φορέα και χρήσεις των ενώσεων, είτε μόνες τους είτε σε συνδυασμό με τουλάχιστον έναν επιπρόσθετο θεραπευτικό παράγοντα. Οι ενσωματώσεις είναι χρήσιμες για την αναστολή του κυτταρικού πολλαπλασιασμού, την αναστολή της ανάπτυξης και/ή της μετάστασης των όγκων, τη θεραπεία ή την πρόληψη του καρκίνου, τη θεραπεία ή τη πρόληψη των εκφυλιστικών παθήσεων των οστών, όπως της ρευματοειδούς αρθρίτιδας, και/ή την αναστολή μορίων, όπως του CSF-IR.
CY20171101315T 2006-04-19 2017-12-15 Ενωσεις 6-o-υποκατεστημενης βενζοξαζολης και βενζοθειαζολης και μεθοδοι αναστολης της σηματοδoτησης toy csf-1r CY1119679T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79351706P 2006-04-19 2006-04-19
US89385707P 2007-03-08 2007-03-08
PCT/US2007/066898 WO2007121484A2 (en) 2006-04-19 2007-04-18 6-o-substituted benzoxazole and benzothiazole compounds and methods of inhibiting csf-1r signaling

Publications (1)

Publication Number Publication Date
CY1119679T1 true CY1119679T1 (el) 2018-04-04

Family

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CY20171101315T CY1119679T1 (el) 2006-04-19 2017-12-15 Ενωσεις 6-o-υποκατεστημενης βενζοξαζολης και βενζοθειαζολης και μεθοδοι αναστολης της σηματοδoτησης toy csf-1r

Country Status (30)

Country Link
US (3) US7553854B2 (el)
EP (1) EP2010528B1 (el)
JP (1) JP5328640B2 (el)
KR (1) KR101464385B1 (el)
AR (1) AR060545A1 (el)
AU (1) AU2007237904B2 (el)
BR (1) BRPI0710540B1 (el)
CA (1) CA2649288C (el)
CR (1) CR10365A (el)
CY (1) CY1119679T1 (el)
DK (1) DK2010528T3 (el)
EA (1) EA018917B1 (el)
EC (1) ECSP088830A (el)
ES (1) ES2654847T3 (el)
HR (1) HRP20171924T1 (el)
HU (1) HUE035654T2 (el)
IL (1) IL194662A0 (el)
LT (1) LT2010528T (el)
MA (1) MA30407B1 (el)
MX (1) MX2008013427A (el)
NO (1) NO20084800L (el)
PE (1) PE20080359A1 (el)
PL (1) PL2010528T3 (el)
PT (1) PT2010528T (el)
RS (1) RS56600B1 (el)
SI (1) SI2010528T1 (el)
SM (1) SMP200800063B (el)
TN (1) TNSN08406A1 (el)
TW (1) TW200813039A (el)
WO (1) WO2007121484A2 (el)

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