PE20061108A1 - Derivados de aril 1,4-pirazina sustituidos - Google Patents
Derivados de aril 1,4-pirazina sustituidosInfo
- Publication number
- PE20061108A1 PE20061108A1 PE2006000289A PE2006000289A PE20061108A1 PE 20061108 A1 PE20061108 A1 PE 20061108A1 PE 2006000289 A PE2006000289 A PE 2006000289A PE 2006000289 A PE2006000289 A PE 2006000289A PE 20061108 A1 PE20061108 A1 PE 20061108A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- pirazin
- ilamino
- indan
- pyridin
- Prior art date
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 102400000739 Corticotropin Human genes 0.000 abstract 1
- 101800000414 Corticotropin Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
- 229960000258 corticotropin Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Anesthesiology (AREA)
- Communicable Diseases (AREA)
Abstract
SE SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 ES ALQUILO C1-C6, ALQUENILO C1-C6, C(O)-ALQUILO C1-C6, ENTRE OTROS; R2 Y R22 SON CADA UNO ALQUILO C1-C6, ALQUENILO C1-C6, ALQUINILO C1-C6; R3 ES ALQUILO C1-C6, ALQUENILO C1-C6, O-ALQUINILO C1-C6, HALOGENO, ENTRE OTROS; R4 ES ALQUILO C1-C6, HALOGENO, O-ALQUIL0 C1-C6, ALQUENILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (1R, 2S) 1-[5-(6-DIMETILAMINO-2-METIL-PIRIDIN-3-IL)-3,6-DIETIL-PIRAZIN-2-ILAMINO]-INDAN-2-IL-ESTER DEL ACIDO ACETICO; (1R, 2S) 1-[5-(6-DIMETILAMINO-2-METIL-PIRIDIN-3-IL)-3,6-DIETIL-PIRAZIN-2-ILAMINO]-INDAN-2-IL ESTER DEL ACIDO ACETICO. SE REFIERE TABIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR CRF (FACTOR DE LIBERACION DE CORTICOTROPINA) UTILES EN EL TRATAMIENTO DE TRASTORNOS RELACIONADOS CON LA DEPRESION Y EL ESTRES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66291705P | 2005-03-17 | 2005-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061108A1 true PE20061108A1 (es) | 2006-10-13 |
Family
ID=36617394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000289A PE20061108A1 (es) | 2005-03-17 | 2006-03-15 | Derivados de aril 1,4-pirazina sustituidos |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20060211710A1 (es) |
| EP (1) | EP1871763A1 (es) |
| JP (1) | JP2008533124A (es) |
| KR (1) | KR20070113294A (es) |
| CN (1) | CN101160304A (es) |
| AP (1) | AP2007004174A0 (es) |
| AR (1) | AR056279A1 (es) |
| AU (1) | AU2006238976A1 (es) |
| BR (1) | BRPI0606284A2 (es) |
| CA (1) | CA2601600C (es) |
| CR (1) | CR9436A (es) |
| DO (1) | DOP2006000056A (es) |
| EA (1) | EA012874B1 (es) |
| GT (1) | GT200600116A (es) |
| IL (1) | IL185997A0 (es) |
| MA (1) | MA29336B1 (es) |
| MX (1) | MX2007011423A (es) |
| NL (1) | NL1031384C2 (es) |
| NO (1) | NO20075209L (es) |
| PE (1) | PE20061108A1 (es) |
| TN (1) | TNSN07355A1 (es) |
| TW (1) | TWI315670B (es) |
| UA (1) | UA86873C2 (es) |
| UY (1) | UY29418A1 (es) |
| WO (1) | WO2006114666A1 (es) |
| ZA (1) | ZA200707933B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| EP2493878B1 (en) * | 2009-10-30 | 2016-10-12 | Janssen Pharmaceutica NV | Pyrazines as delta opioid receptor modulators |
| JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体 |
| WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
| CN102753527B (zh) | 2010-02-02 | 2014-12-24 | 诺华股份有限公司 | 用作crf受体拮抗剂的环己基酰胺衍生物 |
| JP2022062287A (ja) * | 2019-02-27 | 2022-04-20 | 住友化学株式会社 | ピリジルピラジン化合物の製造方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5883105A (en) * | 1996-04-03 | 1999-03-16 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5880140A (en) * | 1996-04-03 | 1999-03-09 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
| US5872136A (en) * | 1996-04-03 | 1999-02-16 | Merck & Co., Inc. | Arylheteroaryl inhibitors of farnesyl-protein transferase |
| PA8467401A1 (es) * | 1998-02-17 | 2000-09-29 | Pfizer Prod Inc | Procedimiento para tratar la insuficiencia cardiaca |
| MXPA02003436A (es) * | 1999-10-07 | 2002-08-20 | Amgen Inc | Inhibidores de triazina cinasa. |
| IL139197A0 (en) * | 1999-10-29 | 2001-11-25 | Pfizer Prod Inc | Use of corticotropin releasing factor antagonists and related compositions |
| CA2651825A1 (en) * | 2000-02-16 | 2001-08-23 | Neurogen Corporation | Substituted arylpyrazines |
| US6992087B2 (en) * | 2001-11-21 | 2006-01-31 | Pfizer Inc | Substituted aryl 1,4-pyrazine derivatives |
| AU2002343557A1 (en) * | 2001-11-21 | 2003-06-10 | Pharmacia And Upjohn Company | Substituted aryl 1,4-pyrazine derivatives |
| BR0309551A (pt) * | 2002-04-26 | 2005-02-09 | Upjohn Co | Derivados substituìdos de pirazina |
| CA2494975A1 (en) * | 2002-09-12 | 2004-03-25 | Pharmacia & Upjohn Company Llc | Substituted 1,4-pyrazine derivatives |
-
2006
- 2006-02-27 US US11/363,009 patent/US20060211710A1/en not_active Abandoned
- 2006-03-02 DO DO2006000056A patent/DOP2006000056A/es unknown
- 2006-03-06 JP JP2008501437A patent/JP2008533124A/ja not_active Ceased
- 2006-03-06 MX MX2007011423A patent/MX2007011423A/es not_active Application Discontinuation
- 2006-03-06 CA CA2601600A patent/CA2601600C/en not_active Expired - Fee Related
- 2006-03-06 EP EP06765409A patent/EP1871763A1/en not_active Withdrawn
- 2006-03-06 EA EA200701758A patent/EA012874B1/ru not_active IP Right Cessation
- 2006-03-06 KR KR1020077023701A patent/KR20070113294A/ko not_active Ceased
- 2006-03-06 BR BRPI0606284-9A patent/BRPI0606284A2/pt not_active IP Right Cessation
- 2006-03-06 UA UAA200710557A patent/UA86873C2/ru unknown
- 2006-03-06 AP AP2007004174A patent/AP2007004174A0/xx unknown
- 2006-03-06 WO PCT/IB2006/000564 patent/WO2006114666A1/en not_active Ceased
- 2006-03-06 CN CNA2006800128070A patent/CN101160304A/zh active Pending
- 2006-03-06 AU AU2006238976A patent/AU2006238976A1/en not_active Abandoned
- 2006-03-13 UY UY29418A patent/UY29418A1/es not_active Application Discontinuation
- 2006-03-15 AR ARP060100986A patent/AR056279A1/es unknown
- 2006-03-15 PE PE2006000289A patent/PE20061108A1/es not_active Application Discontinuation
- 2006-03-16 TW TW095108969A patent/TWI315670B/zh not_active IP Right Cessation
- 2006-03-16 NL NL1031384A patent/NL1031384C2/nl not_active IP Right Cessation
- 2006-03-16 GT GT200600116A patent/GT200600116A/es unknown
-
2007
- 2007-09-17 MA MA30226A patent/MA29336B1/fr unknown
- 2007-09-17 TN TNP2007000355A patent/TNSN07355A1/fr unknown
- 2007-09-17 ZA ZA200707933A patent/ZA200707933B/xx unknown
- 2007-09-17 IL IL185997A patent/IL185997A0/en unknown
- 2007-10-11 NO NO20075209A patent/NO20075209L/no not_active Application Discontinuation
- 2007-10-12 CR CR9436A patent/CR9436A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1871763A1 (en) | 2008-01-02 |
| ZA200707933B (en) | 2009-08-26 |
| UY29418A1 (es) | 2006-10-31 |
| TWI315670B (en) | 2009-10-11 |
| CR9436A (es) | 2007-11-23 |
| NL1031384A1 (nl) | 2006-09-20 |
| JP2008533124A (ja) | 2008-08-21 |
| US20060211710A1 (en) | 2006-09-21 |
| WO2006114666A1 (en) | 2006-11-02 |
| BRPI0606284A2 (pt) | 2009-06-09 |
| CA2601600A1 (en) | 2006-11-02 |
| CN101160304A (zh) | 2008-04-09 |
| AP2007004174A0 (en) | 2007-10-31 |
| AU2006238976A1 (en) | 2006-11-02 |
| NL1031384C2 (nl) | 2007-01-23 |
| KR20070113294A (ko) | 2007-11-28 |
| TW200700067A (en) | 2007-01-01 |
| CA2601600C (en) | 2010-09-14 |
| MX2007011423A (es) | 2007-10-12 |
| AR056279A1 (es) | 2007-10-03 |
| TNSN07355A1 (fr) | 2008-12-31 |
| EA200701758A1 (ru) | 2008-02-28 |
| DOP2006000056A (es) | 2006-08-30 |
| EA012874B1 (ru) | 2009-12-30 |
| WO2006114666A8 (en) | 2008-04-03 |
| UA86873C2 (en) | 2009-05-25 |
| IL185997A0 (en) | 2008-01-20 |
| NO20075209L (no) | 2007-10-11 |
| MA29336B1 (fr) | 2008-03-03 |
| GT200600116A (es) | 2006-11-09 |
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