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PE20060436A1 - Derivados de piridazin-3(2h)-ona como inhibidores de pde4 - Google Patents

Derivados de piridazin-3(2h)-ona como inhibidores de pde4

Info

Publication number
PE20060436A1
PE20060436A1 PE2005000683A PE2005000683A PE20060436A1 PE 20060436 A1 PE20060436 A1 PE 20060436A1 PE 2005000683 A PE2005000683 A PE 2005000683A PE 2005000683 A PE2005000683 A PE 2005000683A PE 20060436 A1 PE20060436 A1 PE 20060436A1
Authority
PE
Peru
Prior art keywords
ethyl
ilamine
dihydropyridazine
carboxylate
alkyl
Prior art date
Application number
PE2005000683A
Other languages
English (en)
Inventor
Albero Maria Antonia Buil
Vittorio Dal Piaz
Ferrer Jordi Gracia
Joan Taltavull Moll
Santacana Lluis Miquel Pages
Yolanda Garrido Rubio
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of PE20060436A1 publication Critical patent/PE20060436A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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Abstract

SE REFIERE A COMPUESTOS DE PIRIDAZIN-3(2H)-ONA DE FORMULA (I), EN DONDE R1 ES H, ALQUILO INFERIOR, ENTRE OTROS; R2 ES HETEROARILO QUE CONTIENE N, MONO O BICICLICO, OPCIONALMENTE SUSTITUIDO CON HALOGENO, O ALQUILO INFERIOR; R3 ES H O ALQUILCARBONILO; R4 ES UN GRUPO G-L1-(CRR')n-, EN DONDE n ES DE 0 A 3; R Y R' SON INDEPENDIENTEMENTE H Y ALQUILO INFERIOR; L1 ES UN FRAGMENTO ENLAZADOR SELECCIONADO DEL GRUPO QUE CONSISTE EN UN ENLACE DIRECTO, -O-, -NR"-, -O(CO)-, -(CO)O-, -O(CO)O-, ENTRE OTROS; G ES ALQUILO, CICLOALQUILO, HETEROCICLILO, ARILO, HETEROARILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS POR HALOGENO, ALQUILO O ALQUENILO QUE ESTAN SUSTITUIDOS CON HALOGENOS, HIDROXI, ALCOXI, ENTRE OTROS. SON PREFERIDOS: 4-ACETIL-1-ETIL-6-OXO-5-(QUINOLIN-5-ILAMINO)-1,6-DIHIDROPIRIDAZINA-3-CARBOXILATO DE ETILO, 4-ACETIL-1-ETIL-5-(ISOQUINOLIN-4-ILAMINO)-6-OXO-1,6-DIHIDROPIRIDAZINA-3-CARBOXILATO DE ETILO, 4-ACETIL-1-ETIL-6-OXO5-(PIRIDIN-3-ILAMINO)-1,6-DIHIDROPIRIDAZINA-3-CARBOXILATO DE ETILO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES POTENTES Y SELECTIVOS DE LA FOSFODIESTERASA 4 (PDE4), POR LO QUE SON UTILES EN EL TRATAMIENTO DEL ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, ARTRITIS REUMATOIDEA, DERMATITIS ATOPICA, PSORIASIS O ENFERMADAD DEL INTESTINO IRRITABLE
PE2005000683A 2004-06-18 2005-06-15 Derivados de piridazin-3(2h)-ona como inhibidores de pde4 PE20060436A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200401500A ES2251866B1 (es) 2004-06-18 2004-06-18 Nuevos derivados de piridazin-3(2h)-ona.

Publications (1)

Publication Number Publication Date
PE20060436A1 true PE20060436A1 (es) 2006-06-02

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PE2005000683A PE20060436A1 (es) 2004-06-18 2005-06-15 Derivados de piridazin-3(2h)-ona como inhibidores de pde4

Country Status (24)

Country Link
US (1) US7960383B2 (es)
EP (1) EP1758869B1 (es)
JP (1) JP2008502628A (es)
KR (1) KR20070029808A (es)
CN (1) CN1964952A (es)
AR (1) AR049402A1 (es)
AT (1) ATE492538T1 (es)
AU (1) AU2005254659A1 (es)
BR (1) BRPI0511383A (es)
CA (1) CA2570170A1 (es)
DE (1) DE602005025478D1 (es)
EC (1) ECSP067058A (es)
ES (2) ES2251866B1 (es)
IL (1) IL179734A0 (es)
MX (1) MXPA06013593A (es)
NO (1) NO20070321L (es)
PE (1) PE20060436A1 (es)
RU (1) RU2376293C2 (es)
SG (1) SG155909A1 (es)
TW (1) TW200612951A (es)
UA (1) UA88472C2 (es)
UY (1) UY28958A1 (es)
WO (1) WO2005123692A1 (es)
ZA (1) ZA200609403B (es)

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