PE20051034A1 - Pentafluorosulfanilbenzoilguanidinas como inhibidores del antiportador celular de sodio-protones (nhe) - Google Patents
Pentafluorosulfanilbenzoilguanidinas como inhibidores del antiportador celular de sodio-protones (nhe)Info
- Publication number
- PE20051034A1 PE20051034A1 PE2004001110A PE2004001110A PE20051034A1 PE 20051034 A1 PE20051034 A1 PE 20051034A1 PE 2004001110 A PE2004001110 A PE 2004001110A PE 2004001110 A PE2004001110 A PE 2004001110A PE 20051034 A1 PE20051034 A1 PE 20051034A1
- Authority
- PE
- Peru
- Prior art keywords
- nhe
- inhibitors
- carrier
- methanosulfonyl
- alcoxy
- Prior art date
Links
- 230000001413 cellular effect Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 102000050381 Na+/H+ exchanger Human genes 0.000 abstract 1
- 108091006672 Sodium–hydrogen antiporter Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 229960004198 guanidine Drugs 0.000 abstract 1
- 229960000789 guanidine hydrochloride Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE R1 ES H, ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS; R2 ES H, ALQUILO C1-C4, ALCOXI C1-C4, F, CL, ENTRE OTROS; R3 ES CL, BR, I, -SO2CH3, ENTRE OTROS; R4 ES H, F, CL, BR, ALCOXI C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(5-METANOSULFONIL-2-METIL-4-PENTAFLUOROSULFANILBENZOIL)GUANIDINA; SAL DE ACIDO N-(5-METANOSULFONIL-2-METIL-PENTAFLUOROSULFANILBENZOIL)-GUANIDINA-METANOSULFONICO; HIDROCLORURO DE N-(5-METANOSULFONIL-2-METIL-4-PENTAFLUOROSULFANILBENZOIL)-GUANIDINA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DEL ANTIPORTADOR CELULAR DE SODIO-PROTONES (INTERCAMBIADOR NA+/H+, NHE) UTILES EN EL TRATAMIENTO O PROFILAXIS DE TRASTORNOS FIBROTICOS DEL CORAZON, DE FALLO DE CORAZON O DE CORAZON CONGESTIVO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10353202A DE10353202A1 (de) | 2003-11-13 | 2003-11-13 | Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20051034A1 true PE20051034A1 (es) | 2005-12-23 |
Family
ID=34585094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004001110A PE20051034A1 (es) | 2003-11-13 | 2004-11-12 | Pentafluorosulfanilbenzoilguanidinas como inhibidores del antiportador celular de sodio-protones (nhe) |
Country Status (38)
| Country | Link |
|---|---|
| EP (1) | EP1685096B1 (es) |
| JP (1) | JP4528304B2 (es) |
| KR (1) | KR101262065B1 (es) |
| CN (1) | CN100445265C (es) |
| AR (1) | AR046620A1 (es) |
| AT (1) | ATE368029T1 (es) |
| AU (1) | AU2004288758B2 (es) |
| BR (1) | BRPI0416487A (es) |
| CA (1) | CA2551057C (es) |
| CR (1) | CR8321A (es) |
| CY (1) | CY1106868T1 (es) |
| DE (2) | DE10353202A1 (es) |
| DK (1) | DK1685096T3 (es) |
| DO (1) | DOP2004001028A (es) |
| EC (1) | ECSP066563A (es) |
| ES (1) | ES2287788T3 (es) |
| GT (1) | GT200400217A (es) |
| HN (1) | HN2004000474A (es) |
| HR (1) | HRP20070364T3 (es) |
| IL (1) | IL175237A (es) |
| JO (1) | JO2466B1 (es) |
| MA (1) | MA28161A1 (es) |
| MY (1) | MY144211A (es) |
| NI (1) | NI200600112A (es) |
| NO (1) | NO20062635L (es) |
| NZ (1) | NZ547172A (es) |
| OA (1) | OA13285A (es) |
| PE (1) | PE20051034A1 (es) |
| PL (1) | PL1685096T3 (es) |
| PT (1) | PT1685096E (es) |
| RS (1) | RS50520B (es) |
| RU (1) | RU2380358C2 (es) |
| TN (1) | TNSN06116A1 (es) |
| TW (1) | TWI334411B (es) |
| UA (1) | UA84307C2 (es) |
| UY (1) | UY28616A1 (es) |
| WO (1) | WO2005047239A1 (es) |
| ZA (1) | ZA200602579B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7317124B2 (en) | 2003-11-13 | 2008-01-08 | Sanofi-Aventis Deutschland Gmbh | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates |
| WO2009097972A1 (de) | 2008-02-05 | 2009-08-13 | Sanofi-Aventis | Sf5-derivate als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel |
| WO2012094451A1 (en) * | 2011-01-06 | 2012-07-12 | Beta Pharma Canada Inc. | Novel ureas for the treatment and prevention of cancer |
| US9682931B2 (en) | 2013-11-01 | 2017-06-20 | Ube Industries, Ltd. | Aryloyl(oxy or amino)pentafluorosulfanylbenzene compound, pharmaceutically acceptable salt thereof, and prodrugs thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2097409T3 (es) * | 1992-09-22 | 1997-04-01 | Hoechst Ag | Benzoilguanidinas, procedimiento para su preparacion, asi como su empleo como antiarritmicos. |
| DE4417004A1 (de) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19517848A1 (de) * | 1995-05-16 | 1996-11-21 | Merck Patent Gmbh | Fluorhaltige Benzoylguanidine |
| DE19526381A1 (de) * | 1995-07-19 | 1997-01-23 | Hoechst Ag | 4-Fluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19713427A1 (de) * | 1997-04-01 | 1998-10-08 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19950898A1 (de) * | 1999-10-22 | 2001-04-26 | Aventis Pharma Gmbh | Heterocyclisch substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10222192A1 (de) * | 2002-05-18 | 2003-11-27 | Aventis Pharma Gmbh | Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10338554A1 (de) * | 2003-08-22 | 2005-03-31 | Aventis Pharma Deutschland Gmbh | Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
2003
- 2003-11-03 OA OA1200600153A patent/OA13285A/en unknown
- 2003-11-13 DE DE10353202A patent/DE10353202A1/de not_active Withdrawn
-
2004
- 2004-10-06 JO JO2004140A patent/JO2466B1/en active
- 2004-10-27 GT GT200400217A patent/GT200400217A/es unknown
- 2004-11-03 JP JP2006538730A patent/JP4528304B2/ja not_active Expired - Fee Related
- 2004-11-03 WO PCT/EP2004/012393 patent/WO2005047239A1/de not_active Ceased
- 2004-11-03 UA UAA200606449A patent/UA84307C2/ru unknown
- 2004-11-03 BR BRPI0416487-3A patent/BRPI0416487A/pt not_active IP Right Cessation
- 2004-11-03 NZ NZ547172A patent/NZ547172A/en not_active IP Right Cessation
- 2004-11-03 HR HR20070364T patent/HRP20070364T3/xx unknown
- 2004-11-03 AT AT04797535T patent/ATE368029T1/de active
- 2004-11-03 PT PT04797535T patent/PT1685096E/pt unknown
- 2004-11-03 RU RU2006120448/04A patent/RU2380358C2/ru not_active IP Right Cessation
- 2004-11-03 ES ES04797535T patent/ES2287788T3/es not_active Expired - Lifetime
- 2004-11-03 AU AU2004288758A patent/AU2004288758B2/en not_active Ceased
- 2004-11-03 PL PL04797535T patent/PL1685096T3/pl unknown
- 2004-11-03 DE DE502004004460T patent/DE502004004460D1/de not_active Expired - Lifetime
- 2004-11-03 CA CA2551057A patent/CA2551057C/en not_active Expired - Fee Related
- 2004-11-03 CN CNB200480033483XA patent/CN100445265C/zh not_active Expired - Fee Related
- 2004-11-03 DK DK04797535T patent/DK1685096T3/da active
- 2004-11-03 EP EP04797535A patent/EP1685096B1/de not_active Expired - Lifetime
- 2004-11-03 RS RSP-2007/0368A patent/RS50520B/sr unknown
- 2004-11-10 DO DO2004001028A patent/DOP2004001028A/es unknown
- 2004-11-11 TW TW093134390A patent/TWI334411B/zh not_active IP Right Cessation
- 2004-11-11 AR ARP040104156A patent/AR046620A1/es not_active Application Discontinuation
- 2004-11-11 HN HN2004000474A patent/HN2004000474A/es unknown
- 2004-11-12 UY UY28616A patent/UY28616A1/es not_active Application Discontinuation
- 2004-11-12 PE PE2004001110A patent/PE20051034A1/es not_active Application Discontinuation
- 2004-11-12 MY MYPI20044737A patent/MY144211A/en unknown
-
2006
- 2006-03-29 ZA ZA200602579A patent/ZA200602579B/xx unknown
- 2006-03-31 CR CR8321A patent/CR8321A/es unknown
- 2006-04-21 TN TNP2006000116A patent/TNSN06116A1/en unknown
- 2006-04-26 IL IL175237A patent/IL175237A/en not_active IP Right Cessation
- 2006-05-11 EC EC2006006563A patent/ECSP066563A/es unknown
- 2006-05-11 KR KR1020067009186A patent/KR101262065B1/ko not_active Expired - Fee Related
- 2006-05-12 NI NI200600112A patent/NI200600112A/es unknown
- 2006-05-12 MA MA29028A patent/MA28161A1/fr unknown
- 2006-06-08 NO NO20062635A patent/NO20062635L/no unknown
-
2007
- 2007-09-14 CY CY20071101190T patent/CY1106868T1/el unknown
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