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PE20050310A1 - Derivados del acido 3-(1-[3-(1,3--benzotiazol-6-il)propilcarbamoil]cicloalquil)propanoico como inhibidores de nep - Google Patents

Derivados del acido 3-(1-[3-(1,3--benzotiazol-6-il)propilcarbamoil]cicloalquil)propanoico como inhibidores de nep

Info

Publication number
PE20050310A1
PE20050310A1 PE2004000259A PE2004000259A PE20050310A1 PE 20050310 A1 PE20050310 A1 PE 20050310A1 PE 2004000259 A PE2004000259 A PE 2004000259A PE 2004000259 A PE2004000259 A PE 2004000259A PE 20050310 A1 PE20050310 A1 PE 20050310A1
Authority
PE
Peru
Prior art keywords
benzothiazol
nep
propanoic acid
inhibitors
cyclopentil
Prior art date
Application number
PE2004000259A
Other languages
English (en)
Inventor
David Hepworth
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0305916A external-priority patent/GB0305916D0/en
Priority claimed from GB0329143A external-priority patent/GB0329143D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PE20050310A1 publication Critical patent/PE20050310A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Medicinal Chemistry (AREA)
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  • Child & Adolescent Psychology (AREA)
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE LA FORMULA (I), EN DONDE R1 ES H o CH3; R2 ES ALQUILO(C1-C2); n ES 1 O 2. SON COMPUESTOS PREFERIDOS: ACIDO (R)-2-METIL-3-(1-{[3-(2-METIL-1,3-BENZOTIAZOL-6-IL)PROPIL]CARBAMOIL}CICLOPENTIL)PROPANOICO, ACIDO 3-(1-{[3-(2-ETIL-1,3-BENZOTIAZOL-6-IL)PROPIL]CARBAMOIL}CICLOPENTIL)PROPANOICO, ACIDO (R)-2-METIL-3-(1-{[3-(2-ETIL-1,3-BENZOTIAZOL-6-IL)PROPIL]CARBAMOIL}CICLOPENTIL)PROPANOICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE LA ENZIMA ENDOPEPTIDASA NEUTRA (NEP) SIENDO SELECTIVOS PARA LA NEP SOBRE LA ENDOPEPTIDASA SOLUBLE(SEP) Y SON UTILES PARA TRATAR LA DISFUNCION SEXUAL MASCULINA Y FEMENINA, PARTICULARMENTE DE LA DISFUNCION SEXUAL FEMENINA (FSD), ESPECIALMENTE CUANDO LA FSD ES UN TRANSTORNO DE EXCITACION SEXUAL FEMENINA (FSAD)
PE2004000259A 2003-03-14 2004-03-10 Derivados del acido 3-(1-[3-(1,3--benzotiazol-6-il)propilcarbamoil]cicloalquil)propanoico como inhibidores de nep PE20050310A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0305916A GB0305916D0 (en) 2003-03-14 2003-03-14 New N-phenpropylcyclopentyl-substituted glutaramide derivatives as NEP inhibitors
GB0329143A GB0329143D0 (en) 2003-12-16 2003-12-16 Novel pharmaceuticals

Publications (1)

Publication Number Publication Date
PE20050310A1 true PE20050310A1 (es) 2005-05-04

Family

ID=32992599

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000259A PE20050310A1 (es) 2003-03-14 2004-03-10 Derivados del acido 3-(1-[3-(1,3--benzotiazol-6-il)propilcarbamoil]cicloalquil)propanoico como inhibidores de nep

Country Status (25)

Country Link
US (1) US20040180941A1 (es)
EP (1) EP1606272A1 (es)
JP (1) JP3923512B2 (es)
KR (1) KR20050110003A (es)
AP (1) AP2005003393A0 (es)
AR (1) AR043551A1 (es)
AU (1) AU2004220269A1 (es)
BR (1) BRPI0408377A (es)
CA (1) CA2519072A1 (es)
CL (1) CL2004000512A1 (es)
EA (1) EA200501204A1 (es)
EC (1) ECSP056017A (es)
HR (1) HRP20050797A2 (es)
IS (1) IS8003A (es)
MA (1) MA27720A1 (es)
MX (1) MXPA05009788A (es)
NL (1) NL1025709C2 (es)
NO (1) NO20054169L (es)
OA (1) OA13039A (es)
PA (1) PA8597401A1 (es)
PE (1) PE20050310A1 (es)
TN (1) TNSN05227A1 (es)
TW (1) TW200504038A (es)
UY (1) UY28226A1 (es)
WO (1) WO2004080985A1 (es)

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US20130131007A1 (en) 2005-09-07 2013-05-23 Bebaas, Inc. Vitamin b12 compositions
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CA3103695A1 (en) * 2018-06-14 2019-12-19 Astrazeneca Uk Limited Methods for treating erectile dysfunction with a cgmp-specific phosphodiesterase 5 inhibitor pharmaceutical composition
AU2019287549A1 (en) * 2018-06-14 2021-01-28 Astrazeneca Uk Limited Methods for treating erectile dysfunction with a cgmp-specific phosphodiesterase 5 inhibitor pharmaceutical composition
MA53706A (fr) 2018-09-25 2021-12-29 Antabio Sas Dérivés d'indane destinés à être utilisés dans le traitement d'une infection bactérienne
CN114901071A (zh) * 2019-11-08 2022-08-12 维拉生物科技有限公司 外周作用的含有大麻二酚(cbd)的组合物及其用于增强女性性功能或治疗女性性障碍的用途
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Also Published As

Publication number Publication date
HRP20050797A2 (en) 2006-02-28
UY28226A1 (es) 2004-11-08
CL2004000512A1 (es) 2005-01-21
ECSP056017A (es) 2006-01-27
WO2004080985A1 (en) 2004-09-23
NL1025709A1 (nl) 2004-09-16
US20040180941A1 (en) 2004-09-16
JP3923512B2 (ja) 2007-06-06
NO20054169L (no) 2005-12-07
EP1606272A1 (en) 2005-12-21
AR043551A1 (es) 2005-08-03
OA13039A (en) 2006-11-10
NL1025709C2 (nl) 2005-03-14
TNSN05227A1 (fr) 2007-06-11
AP2005003393A0 (en) 2005-09-30
MA27720A1 (fr) 2006-01-02
IS8003A (is) 2005-08-29
JP2006526572A (ja) 2006-11-24
KR20050110003A (ko) 2005-11-22
CA2519072A1 (en) 2004-09-23
AU2004220269A1 (en) 2004-09-23
MXPA05009788A (es) 2005-10-26
PA8597401A1 (es) 2005-05-24
TW200504038A (en) 2005-02-01
EA200501204A1 (ru) 2006-06-30
BRPI0408377A (pt) 2006-03-21
NO20054169D0 (no) 2005-09-07

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