PE20021061A1 - Arilsulfonamidas como agentes antivirales - Google Patents
Arilsulfonamidas como agentes antiviralesInfo
- Publication number
- PE20021061A1 PE20021061A1 PE2002000323A PE2002000323A PE20021061A1 PE 20021061 A1 PE20021061 A1 PE 20021061A1 PE 2002000323 A PE2002000323 A PE 2002000323A PE 2002000323 A PE2002000323 A PE 2002000323A PE 20021061 A1 PE20021061 A1 PE 20021061A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- halogen
- amino
- optionally substituted
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- -1 AMINO, HYDROXY Chemical group 0.000 abstract 3
- 241000701024 Human betaherpesvirus 5 Species 0.000 abstract 3
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- MAUMSNABMVEOGP-UHFFFAOYSA-N (methyl-$l^{2}-azanyl)methane Chemical class C[N]C MAUMSNABMVEOGP-UHFFFAOYSA-N 0.000 abstract 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 241000701022 Cytomegalovirus Species 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010017964 Gastrointestinal infection Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 206010035742 Pneumonitis Diseases 0.000 abstract 1
- 206010038910 Retinitis Diseases 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 238000010322 bone marrow transplantation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 229940080818 propionamide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A ARILSULFONAMIDAS DE FORMULA I; DONDE R2 Y R3 SON H, OH, HALOGENO, NITRO, CIANO, ALQUILO C1-C6, ALCOXI C1-C6, COOR5, CONR6R7; R5, R6, R7 SON H, ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON OH, HALOGENO, CIANO, ENTRE OTROS; A ES HETEROARILO; R1 ES ARILO, HETEROARILO, HETEROCICLILO; R8, R9, R10 SON H, ALQUILO C1-C6 O R9 Y R10 JUNTO A N FORMAN UN HETEROCICLO OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C4, R11 Y R12 SON TRIFLUOROMETILO, ALCOXI C1-C6, OH, ALQUILO C1-C6; R13 ES ALQUILO C1-C6, ARILO C6-C10 OPCIONALMENTE SUSTITUIDO CON HALOGENO, AMINO, HIDROXI, ALCOXI C1-C4, ALQUILO C1-C4; R4 ES ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON AMINO, HIDROXI, HALOGENO, ALCOXI C1-C6; X ES O, S; SON COMPUESTOS PREFERIDOS 3-FLUORO-2,2-DIMETIL-N-{3-[({4-[5-(2-PIRIDINIL)-1,2,4-OXADIAZOL-3-IL]FENIL}SULFONIL)AMINO]FENIL}PROPIONAMIDA; N-(3-{[(4-{5-[3-(DIMETILAMINO)FENIL]-1,2,4-OXADIAZOL-3-IL}FENIL)SULFONIL]AMINO}FENIL)-1-METILCICLOPROPANO-CARBOXAMIDA; 1-METIL-N-{3-[({4-[5-(2-PIRIDINIL)-1,2,4-OXADIAZOL-3-IL]FENIL}SULFONIL)AMINO[FENIL}CICLOPROPANOCARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS TIENEN ACTIVIDAD ANTIVIRAL Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE INFECCIONES POR HCMV EN PACIENTES CON SIDA (RETINITIS, PNEUMONITIS, INFECCIONES GASTROINTESTINALES); INFECCIONES POR CITOMEGALOVIRUS (HCMV) EN PACIENTES CON TRASPLANTE DE MEDULA OSEA, INFECCIONES POR HCMV
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10119137 | 2001-04-19 | ||
| DE10148598A DE10148598A1 (de) | 2001-04-19 | 2001-10-02 | Neue Arylsulfonamide als antivirale Mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20021061A1 true PE20021061A1 (es) | 2002-12-12 |
Family
ID=7681939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000323A PE20021061A1 (es) | 2001-04-19 | 2002-04-18 | Arilsulfonamidas como agentes antivirales |
Country Status (9)
| Country | Link |
|---|---|
| KR (1) | KR20030088509A (es) |
| AR (1) | AR034309A1 (es) |
| CO (1) | CO5540388A2 (es) |
| DE (1) | DE10148598A1 (es) |
| EC (1) | ECSP034813A (es) |
| GT (1) | GT200200075A (es) |
| PE (1) | PE20021061A1 (es) |
| SV (1) | SV2003000995A (es) |
| ZA (1) | ZA200307892B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7482366B2 (en) * | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| AU2003262831A1 (en) | 2002-08-23 | 2004-03-11 | Rigel Pharmaceuticals, Inc. | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
| EP1581213A4 (en) * | 2002-12-18 | 2008-11-19 | Cytovia Inc | 3,5-DISUBSTITUTED 1,2,4-OXADIAZOLE AND ANALOGUE TO ACTIVATE CASPASE AND INTRODUCTION OF APOPTOSIS AND THEIR USE |
| DE10300109A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Methode zur Inhibition der Replikation von Herpesviren |
| EP1620412A2 (en) | 2003-05-02 | 2006-02-01 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds and hydro isomers thereof |
| US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| WO2005049065A2 (en) | 2003-11-19 | 2005-06-02 | Rigel Pharmaceuticals, Inc. | Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections |
| US7514434B2 (en) | 2004-02-23 | 2009-04-07 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof |
| EP1883633A2 (en) | 2005-05-02 | 2008-02-06 | Rigel Pharmaceuticals, Inc. | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses |
| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| US20080255203A1 (en) * | 2007-04-12 | 2008-10-16 | Abbott Laboratories | Heterocyclic compounds and their methods of use |
| WO2010009775A1 (de) | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
| ES2397125T3 (es) | 2007-12-07 | 2013-03-04 | Abbott Gmbh & Co. Kg | Derivados de oxindol sustituidos con halógeno en la posición 5 y su uso para la producción de un medicamento para el tratamiento de enfermedades dependientes de la vasopresina |
| MX2010006204A (es) | 2007-12-07 | 2011-03-16 | Abbott Gmbh & Co Kg | Derivados de oxindol 5,6-disubstituidos y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina. |
| CN101981027B (zh) | 2007-12-07 | 2014-08-06 | Abbvie德国有限责任两合公司 | 氨基甲基取代的羟吲哚衍生物及其用于治疗加压素依赖性疾病的用途 |
| WO2010138600A2 (en) | 2009-05-29 | 2010-12-02 | Abbott Laboratories | Pharmaceutical compositions for the treatment of pain |
-
2001
- 2001-10-02 DE DE10148598A patent/DE10148598A1/de not_active Withdrawn
-
2002
- 2002-04-08 KR KR10-2003-7013617A patent/KR20030088509A/ko not_active Withdrawn
- 2002-04-17 AR ARP020101392A patent/AR034309A1/es unknown
- 2002-04-18 PE PE2002000323A patent/PE20021061A1/es not_active Application Discontinuation
- 2002-04-18 SV SV2002000995A patent/SV2003000995A/es not_active Application Discontinuation
- 2002-04-18 GT GT200200075A patent/GT200200075A/es unknown
-
2003
- 2003-10-09 ZA ZA200307892A patent/ZA200307892B/en unknown
- 2003-10-17 EC EC2003004813A patent/ECSP034813A/es unknown
- 2003-11-19 CO CO03102172A patent/CO5540388A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO5540388A2 (es) | 2005-07-29 |
| KR20030088509A (ko) | 2003-11-19 |
| GT200200075A (es) | 2002-12-24 |
| AR034309A1 (es) | 2004-02-18 |
| DE10148598A1 (de) | 2002-10-24 |
| ECSP034813A (es) | 2003-12-01 |
| SV2003000995A (es) | 2003-03-18 |
| ZA200307892B (en) | 2004-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20021061A1 (es) | Arilsulfonamidas como agentes antivirales | |
| PE20050132A1 (es) | Piperazinas heterociclicas sustituidas | |
| PE20020753A1 (es) | Heteroaromaticos fusionados como activadores de la glucoquinasa | |
| PE20010964A1 (es) | Derivados de tiazolilamida | |
| PE58399A1 (es) | Atropisomeros de 3-aril-4(3h)-quinazolinonas | |
| PE20010741A1 (es) | Derivados de piperazina como antagonistas de taquicininas | |
| PE20070187A1 (es) | Moduladores de lxr basados en pirazol | |
| PE20001088A1 (es) | Compuestos derivados de tetrahidrobenzazepina | |
| PE20080136A1 (es) | Arilsulfonamidas sustituidas como agentes antivirales | |
| PE20081059A1 (es) | Derivados de pirimidinas como inhibidores de la actividad de la tirosina quinasa de bruton (btk) | |
| PE20060361A1 (es) | Compuestos heterociclicos como inhibidores de la cinesina mitotica | |
| PE20050147A1 (es) | Derivados de pirimidina, piridina y tiazol como inhibidores de fosfatidilinositol 3-quinasa | |
| PE20001483A1 (es) | Acidos oxamicos y derivados como ligandos de receptores tiroideos | |
| PE20021002A1 (es) | Compuestos heterociclicos condensados | |
| PE20141375A1 (es) | Activadores de glucoquinasa | |
| PE20050131A1 (es) | Derivados de benzoimidazol como agentes antiproliferativos | |
| PE20051141A1 (es) | Inhibidores de la polimerasa viral | |
| PE20030968A1 (es) | Derivados de 5-feniltiazol como inhibidores de cinasas | |
| PE20121058A1 (es) | Compuestos que modulan el receptor de androgenos | |
| PE20090601A1 (es) | Derivados de piridin-il-oxi-piridinas como inhibidores de alk5 | |
| PE20090709A1 (es) | Compuestos heterociclico de 5 miembros | |
| PE20070108A1 (es) | Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n-[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida | |
| PE20071156A1 (es) | COMPUESTOS DERIVADOS DE 4,5,6,7-TETRAHIDRO-1H-INDAZOL COMO POTENCIADORES DEL RECEPTOR DEL ACIDO a-AMINO-3-HIDROXI-5-METILISOXAZOL-4-PROPIONICO (AMPA) | |
| PE20090641A1 (es) | Amidas heterociclicas | |
| PE20080404A1 (es) | Derivados bencil-amino-piperidina como inhibidores de cetp |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |