PE20021061A1 - ARYLSULFONAMIDES AS ANTIVIRAL AGENTS - Google Patents
ARYLSULFONAMIDES AS ANTIVIRAL AGENTSInfo
- Publication number
- PE20021061A1 PE20021061A1 PE2002000323A PE2002000323A PE20021061A1 PE 20021061 A1 PE20021061 A1 PE 20021061A1 PE 2002000323 A PE2002000323 A PE 2002000323A PE 2002000323 A PE2002000323 A PE 2002000323A PE 20021061 A1 PE20021061 A1 PE 20021061A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- halogen
- amino
- optionally substituted
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- -1 AMINO, HYDROXY Chemical group 0.000 abstract 3
- 241000701024 Human betaherpesvirus 5 Species 0.000 abstract 3
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- MAUMSNABMVEOGP-UHFFFAOYSA-N (methyl-$l^{2}-azanyl)methane Chemical class C[N]C MAUMSNABMVEOGP-UHFFFAOYSA-N 0.000 abstract 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 241000701022 Cytomegalovirus Species 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010017964 Gastrointestinal infection Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 206010035742 Pneumonitis Diseases 0.000 abstract 1
- 206010038910 Retinitis Diseases 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 238000010322 bone marrow transplantation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 229940080818 propionamide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A ARILSULFONAMIDAS DE FORMULA I; DONDE R2 Y R3 SON H, OH, HALOGENO, NITRO, CIANO, ALQUILO C1-C6, ALCOXI C1-C6, COOR5, CONR6R7; R5, R6, R7 SON H, ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON OH, HALOGENO, CIANO, ENTRE OTROS; A ES HETEROARILO; R1 ES ARILO, HETEROARILO, HETEROCICLILO; R8, R9, R10 SON H, ALQUILO C1-C6 O R9 Y R10 JUNTO A N FORMAN UN HETEROCICLO OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C4, R11 Y R12 SON TRIFLUOROMETILO, ALCOXI C1-C6, OH, ALQUILO C1-C6; R13 ES ALQUILO C1-C6, ARILO C6-C10 OPCIONALMENTE SUSTITUIDO CON HALOGENO, AMINO, HIDROXI, ALCOXI C1-C4, ALQUILO C1-C4; R4 ES ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON AMINO, HIDROXI, HALOGENO, ALCOXI C1-C6; X ES O, S; SON COMPUESTOS PREFERIDOS 3-FLUORO-2,2-DIMETIL-N-{3-[({4-[5-(2-PIRIDINIL)-1,2,4-OXADIAZOL-3-IL]FENIL}SULFONIL)AMINO]FENIL}PROPIONAMIDA; N-(3-{[(4-{5-[3-(DIMETILAMINO)FENIL]-1,2,4-OXADIAZOL-3-IL}FENIL)SULFONIL]AMINO}FENIL)-1-METILCICLOPROPANO-CARBOXAMIDA; 1-METIL-N-{3-[({4-[5-(2-PIRIDINIL)-1,2,4-OXADIAZOL-3-IL]FENIL}SULFONIL)AMINO[FENIL}CICLOPROPANOCARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS TIENEN ACTIVIDAD ANTIVIRAL Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE INFECCIONES POR HCMV EN PACIENTES CON SIDA (RETINITIS, PNEUMONITIS, INFECCIONES GASTROINTESTINALES); INFECCIONES POR CITOMEGALOVIRUS (HCMV) EN PACIENTES CON TRASPLANTE DE MEDULA OSEA, INFECCIONES POR HCMVREFERS TO ARYLSULPHONAMIDES OF FORMULA I; WHERE R2 AND R3 ARE H, OH, HALOGEN, NITRO, CYANE, C1-C6 ALKYL, C1-C6 ALCOXY, COOR5, CONR6R7; R5, R6, R7 ARE H, C1-C6 ALKYL OPTIONALLY SUBSTITUTED WITH OH, HALOGEN, CYANE, AMONG OTHERS; A IS HETEROARYL; R1 IS ARYL, HETEROARYL, HETEROCYCLYL; R8, R9, R10 ARE H, C1-C6 ALKYL OR R9 AND R10 TOGETHER WITH N FORM A HETERO CYCLE OPTIONALLY SUBSTITUTED WITH C1-C4 ALKYL, R11 AND R12 ARE TRIFLUOROMETHYL, C1-C6 ALKYL, OH, C1-C6 ALKYL; R13 IS C1-C6 ALKYL, C6-C10 ARYL OPTIONALLY SUBSTITUTED WITH HALOGEN, AMINO, HYDROXY, C1-C4 ALCOXY, C1-C4 ALKYL; R4 IS C1-C6 ALKYL OPTIONALLY SUBSTITUTED WITH AMINE, HYDROXY, HALOGEN, C1-C6 ALCOXY; X IS O, S; PREFERRED COMPOUNDS ARE 3-FLUORO-2,2-DIMETHYL-N- {3 - [({4- [5- (2-PYRIDINYL) -1,2,4-OXADIAZOL-3-IL] PHENYL} SULFONIL) AMINO] PHENYL} PROPIONAMIDE; N- (3 - {[(4- {5- [3- (DIMETHYLAMINO) PHENYL] -1,2,4-OXADIAZOL-3-IL} PHENYL) SULFONYL] AMINO} PHENYL) -1-METHYL CYCLOPROPANE-CARBOXAMIDE; 1-METHYL-N- {3 - [({4- [5- (2-PYRIDINYL) -1,2,4-OXADIAZOL-3-IL] PHENYL} SULFONIL) AMINO [PHENYL} CYCLOPROPANOCARBOXAMIDE, AMONG OTHERS. THE COMPOUNDS HAVE ANTIVIRAL ACTIVITY AND MAY BE USEFUL FOR THE TREATMENT OF HCMV INFECTIONS IN PATIENTS WITH AIDS (RETINITIS, PNEUMONITIS, GASTROINTESTINAL INFECTIONS); CYTOMEGALOVIRUS (HCMV) INFECTIONS IN PATIENTS WITH BONE MARROW TRANSPLANTATION, HCMV INFECTIONS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10119137 | 2001-04-19 | ||
| DE10148598A DE10148598A1 (en) | 2001-04-19 | 2001-10-02 | New N-(acylaminophenyl)-heteroaryl-benzenesulfonamide derivatives, useful as antiviral agents, especially effective against human cytomegalovirus infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20021061A1 true PE20021061A1 (en) | 2002-12-12 |
Family
ID=7681939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000323A PE20021061A1 (en) | 2001-04-19 | 2002-04-18 | ARYLSULFONAMIDES AS ANTIVIRAL AGENTS |
Country Status (9)
| Country | Link |
|---|---|
| KR (1) | KR20030088509A (en) |
| AR (1) | AR034309A1 (en) |
| CO (1) | CO5540388A2 (en) |
| DE (1) | DE10148598A1 (en) |
| EC (1) | ECSP034813A (en) |
| GT (1) | GT200200075A (en) |
| PE (1) | PE20021061A1 (en) |
| SV (1) | SV2003000995A (en) |
| ZA (1) | ZA200307892B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7482366B2 (en) * | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| AU2003262831A1 (en) | 2002-08-23 | 2004-03-11 | Rigel Pharmaceuticals, Inc. | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
| EP1581213A4 (en) * | 2002-12-18 | 2008-11-19 | Cytovia Inc | 3,5-DISUBSTITUES-1,2,4-OXADIAZOLES AND ANALOGS AS ACTIVATORS OF CASPASES AND APOPTOSIS PROMOTERS, AND USE THEREOF |
| DE10300109A1 (en) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Method for inhibiting replication of herpes viruses |
| EP1620412A2 (en) | 2003-05-02 | 2006-02-01 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds and hydro isomers thereof |
| US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| WO2005049065A2 (en) | 2003-11-19 | 2005-06-02 | Rigel Pharmaceuticals, Inc. | Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections |
| US7514434B2 (en) | 2004-02-23 | 2009-04-07 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof |
| EP1883633A2 (en) | 2005-05-02 | 2008-02-06 | Rigel Pharmaceuticals, Inc. | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses |
| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| UY30846A1 (en) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | OXINDOL DERIVATIVES REPLACED, MEDICINES THAT UNDERSTAND AND USE THEMSELVES |
| US20080255203A1 (en) * | 2007-04-12 | 2008-10-16 | Abbott Laboratories | Heterocyclic compounds and their methods of use |
| WO2010009775A1 (en) | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases |
| ES2397125T3 (en) | 2007-12-07 | 2013-03-04 | Abbott Gmbh & Co. Kg | Oxindole derivatives substituted with halogen in position 5 and its use for the production of a medicine for the treatment of vasopressin-dependent diseases |
| MX2010006204A (en) | 2007-12-07 | 2011-03-16 | Abbott Gmbh & Co Kg | 5,6-disubstituted oxindole-derivatives and use thereof for treating vasopressine-dependent diseases. |
| CN101981027B (en) | 2007-12-07 | 2014-08-06 | Abbvie德国有限责任两合公司 | Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses |
| WO2010138600A2 (en) | 2009-05-29 | 2010-12-02 | Abbott Laboratories | Pharmaceutical compositions for the treatment of pain |
-
2001
- 2001-10-02 DE DE10148598A patent/DE10148598A1/en not_active Withdrawn
-
2002
- 2002-04-08 KR KR10-2003-7013617A patent/KR20030088509A/en not_active Withdrawn
- 2002-04-17 AR ARP020101392A patent/AR034309A1/en unknown
- 2002-04-18 PE PE2002000323A patent/PE20021061A1/en not_active Application Discontinuation
- 2002-04-18 SV SV2002000995A patent/SV2003000995A/en not_active Application Discontinuation
- 2002-04-18 GT GT200200075A patent/GT200200075A/en unknown
-
2003
- 2003-10-09 ZA ZA200307892A patent/ZA200307892B/en unknown
- 2003-10-17 EC EC2003004813A patent/ECSP034813A/en unknown
- 2003-11-19 CO CO03102172A patent/CO5540388A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO5540388A2 (en) | 2005-07-29 |
| KR20030088509A (en) | 2003-11-19 |
| GT200200075A (en) | 2002-12-24 |
| AR034309A1 (en) | 2004-02-18 |
| DE10148598A1 (en) | 2002-10-24 |
| ECSP034813A (en) | 2003-12-01 |
| SV2003000995A (en) | 2003-03-18 |
| ZA200307892B (en) | 2004-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |