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PE20021002A1 - Compuestos heterociclicos condensados - Google Patents

Compuestos heterociclicos condensados

Info

Publication number
PE20021002A1
PE20021002A1 PE2002000076A PE2002000076A PE20021002A1 PE 20021002 A1 PE20021002 A1 PE 20021002A1 PE 2002000076 A PE2002000076 A PE 2002000076A PE 2002000076 A PE2002000076 A PE 2002000076A PE 20021002 A1 PE20021002 A1 PE 20021002A1
Authority
PE
Peru
Prior art keywords
aminomethyl
isoquinoline
phenyl
condensed heterocyclic
heterocyclic compounds
Prior art date
Application number
PE2002000076A
Other languages
English (en)
Inventor
Yoshihiro Banno
Koji Ikedou
Masaki Ogino
Taihei Yamane
Koji Takeuchi
Hiroyuki Tawada
Satoru Oi
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of PE20021002A1 publication Critical patent/PE20021002A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS CONDENSADOS DE FORMULA I DONDE A ES UN ANILLO AROMATICO DE 5 A 10 MIEMBROS OPCIONALMENTE SUBSTITUIDOS; R1 Y R2 SON IGUALES O DIFERENTES Y CADA UNO ES UN GRUPO HIDROCARBURO, GRUPO HETEROCICLICO; X ES UN ENLACE -O-, -S-, -SO2-, -NR3-, DONDE R3 ES H, GRUPO HIDROCARBURO; L ES UN HIDROCARBURO DIVALENTE O UNA SAL DE ESTOS EXCEPTO 3-(AMINOMETIL)-2,6,7-TRIMETIL-4-FENIL-1(2H)-ISOQUINOLINA, 3-(AMINOMETIL)-2-METIL-4-FENIL-1(2H)-ISOQUINOLINA, 3-(AMINOMETIL)-6-CLORO-2-METIL-4-FENIL-1(2H)-ISOQUINOLINA. SON COMPUESTOS PREFERIDOS 2-[3-(AMINOMETIL)-4-BUTOXI-2-ISOBUTIL-1-OXO-1,2-DIHIDRO-6-ISOQUINOLIL]-1,3-TIAZOL-4-CARBONITRILO, ACIDO 2-[3-(AMINOMETIL)-4-BUTOXI-2-ISOBUTIL-1-OXO-1,2-DIHIDRO-6-ISOQUINOLIL]-1,3-TIAZOL-4-CARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS PRESENTAN ACTIVIDAD INHIBIDORA DE LA PEPTIDASA Y SON UTILES COMO AGENTES PARA LA PROFILAXIS O TRATAMIENTO DE DIABETES
PE2002000076A 2001-02-02 2002-02-01 Compuestos heterociclicos condensados PE20021002A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001027349 2001-02-02
JP2001292388 2001-09-25
JP2001382232 2001-12-14

Publications (1)

Publication Number Publication Date
PE20021002A1 true PE20021002A1 (es) 2002-12-06

Family

ID=27345897

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000076A PE20021002A1 (es) 2001-02-02 2002-02-01 Compuestos heterociclicos condensados

Country Status (17)

Country Link
US (1) US7034039B2 (es)
EP (1) EP1355886B1 (es)
KR (1) KR20030074774A (es)
CN (1) CN1500080A (es)
AT (1) ATE366724T1 (es)
BR (1) BR0206831A (es)
CA (1) CA2437492A1 (es)
CZ (1) CZ20032321A3 (es)
DE (1) DE60221098T2 (es)
HU (1) HUP0400058A2 (es)
IL (1) IL157179A0 (es)
MX (1) MXPA03006918A (es)
NO (1) NO20033385L (es)
PE (1) PE20021002A1 (es)
PL (1) PL364221A1 (es)
SK (1) SK10802003A3 (es)
WO (1) WO2002062764A1 (es)

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