SK10802003A3 - Kondenzovaná heterocyklická zlúčenina, jej použitie a jej farmaceutický prípravok - Google Patents

Kondenzovaná heterocyklická zlúčenina, jej použitie a jej farmaceutický prípravok Download PDF

Info

Publication number: SK10802003A3
Authority: SK; Slovakia
Prior art keywords: optionally substituted; group; compound; hydrocarbon group; salt
Prior art date: 2001-02-02

Application number

SK1080-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Satoru Oi

Koji Ikedou

Koji Takeuchi

Masaki Ogino

Yoshihiro Banno

Hiroyuki Tawada

Taihei Yamane

Original Assignee

Takeda Chemical Industries, Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-02

Filing date

2002-02-01

Publication date

2004-05-04

2002-02-01 Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.

2004-05-04 Publication of SK10802003A3 publication Critical patent/SK10802003A3/sk

Links

150000002391 heterocyclic compounds Chemical class 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims abstract description 289
150000003839 salts Chemical class 0.000 claims abstract description 89
239000003795 chemical substances by application Substances 0.000 claims abstract description 67
125000003118 aryl group Chemical group 0.000 claims abstract description 54
125000000623 heterocyclic group Chemical group 0.000 claims abstract description 41
238000011282 treatment Methods 0.000 claims abstract description 30
206010012601 diabetes mellitus Diseases 0.000 claims abstract description 29
238000011321 prophylaxis Methods 0.000 claims abstract description 23
125000001183 hydrocarbyl group Chemical group 0.000 claims abstract 32
-1 cyano, amino Chemical group 0.000 claims description 335
125000004432 carbon atom Chemical group C* 0.000 claims description 121
238000000034 method Methods 0.000 claims description 106
125000001424 substituent group Chemical group 0.000 claims description 79
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 56
239000013078 crystal Substances 0.000 claims description 54
125000005843 halogen group Chemical group 0.000 claims description 52
150000002430 hydrocarbons Chemical group 0.000 claims description 48
125000000217 alkyl group Chemical group 0.000 claims description 43
125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 37
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 37
SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 35
125000003277 amino group Chemical group 0.000 claims description 32
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 32
229930195733 hydrocarbon Natural products 0.000 claims description 31
239000004215 Carbon black (E152) Substances 0.000 claims description 30
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 30
229910052739 hydrogen Inorganic materials 0.000 claims description 29
230000008569 process Effects 0.000 claims description 29
229940002612 prodrug Drugs 0.000 claims description 29
239000000651 prodrug Substances 0.000 claims description 29
239000002253 acid Substances 0.000 claims description 27
125000000753 cycloalkyl group Chemical group 0.000 claims description 26
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 25
229910052799 carbon Inorganic materials 0.000 claims description 24
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
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125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 21
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125000003710 aryl alkyl group Chemical group 0.000 claims description 19
239000008177 pharmaceutical agent Substances 0.000 claims description 19
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 16
102000004877 Insulin Human genes 0.000 claims description 15
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238000002360 preparation method Methods 0.000 claims description 14
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125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims description 12
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235000019833 protease Nutrition 0.000 claims description 12
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239000003112 inhibitor Substances 0.000 claims description 11
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239000003888 alpha glucosidase inhibitor Substances 0.000 claims description 10
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229910052736 halogen Inorganic materials 0.000 claims description 10
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208000008589 Obesity Diseases 0.000 claims description 7
235000020824 obesity Nutrition 0.000 claims description 7
125000005236 alkanoylamino group Chemical group 0.000 claims description 6
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UIKDPMGTFQHKLC-UHFFFAOYSA-N 3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenylisoquinoline-6-carboxamide Chemical compound C12=CC(C(N)=O)=CC=C2C(=O)N(CC(C)C)C(CN)=C1C1=CC=CC=C1 UIKDPMGTFQHKLC-UHFFFAOYSA-N 0.000 claims description 5
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229940122344 Peptidase inhibitor Drugs 0.000 claims description 4
231100000489 sensitizer Toxicity 0.000 claims description 4
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
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DKQBRLQWVWNHDR-VQHVLOKHSA-N (e)-3-[3-(aminomethyl)-4-butoxy-2-(2-methylpropyl)-1-oxoisoquinolin-6-yl]prop-2-enamide Chemical compound C1=C(\C=C\C(N)=O)C=C2C(OCCCC)=C(CN)N(CC(C)C)C(=O)C2=C1 DKQBRLQWVWNHDR-VQHVLOKHSA-N 0.000 claims description 2
NFVBKMXFIDHWAB-UHFFFAOYSA-N 2-[3-(aminomethyl)-4-butoxy-2-(2-methylpropyl)-1-oxoisoquinolin-6-yl]-1,3-thiazole-4-carboxylic acid Chemical compound C1=C2C(OCCCC)=C(CN)N(CC(C)C)C(=O)C2=CC=C1C1=NC(C(O)=O)=CS1 NFVBKMXFIDHWAB-UHFFFAOYSA-N 0.000 claims description 2
ZEIBESNNLHERGM-UHFFFAOYSA-N ethyl 2-[3-(aminomethyl)-4-butoxy-2-(2-methylpropyl)-1-oxoisoquinolin-6-yl]-1,3-thiazole-4-carboxylate Chemical compound C1=C2C(OCCCC)=C(CN)N(CC(C)C)C(=O)C2=CC=C1C1=NC(C(=O)OCC)=CS1 ZEIBESNNLHERGM-UHFFFAOYSA-N 0.000 claims description 2
UMRSSKBWGUGDJF-PKNBQFBNSA-N (e)-3-[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenylisoquinolin-6-yl]prop-2-enamide Chemical compound C12=CC(\C=C\C(N)=O)=CC=C2C(=O)N(CC(C)C)C(CN)=C1C1=CC=CC=C1 UMRSSKBWGUGDJF-PKNBQFBNSA-N 0.000 claims 2
HMVYYTRDXNKRBQ-UHFFFAOYSA-N 1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC=N1 HMVYYTRDXNKRBQ-UHFFFAOYSA-N 0.000 claims 1
230000000694 effects Effects 0.000 abstract description 11
FBWHFOSIHPOUBP-UHFFFAOYSA-N 3-(aminomethyl)-2,6,7-trimethyl-4-phenylisoquinolin-1-one Chemical compound NCC=1N(C)C(=O)C=2C=C(C)C(C)=CC=2C=1C1=CC=CC=C1 FBWHFOSIHPOUBP-UHFFFAOYSA-N 0.000 abstract description 2
VYQYMBJHVZPUFM-UHFFFAOYSA-N 3-(aminomethyl)-4-phenyl-2-propan-2-ylisoquinolin-1-one Chemical compound C12=CC=CC=C2C(=O)N(C(C)C)C(CN)=C1C1=CC=CC=C1 VYQYMBJHVZPUFM-UHFFFAOYSA-N 0.000 abstract description 2
NIOVGJUPPKMWOB-UHFFFAOYSA-N 3-(aminomethyl)-2-methyl-4-phenylisoquinolin-1-one Chemical compound C12=CC=CC=C2C(=O)N(C)C(CN)=C1C1=CC=CC=C1 NIOVGJUPPKMWOB-UHFFFAOYSA-N 0.000 abstract 1
IFTJNHCJDRPDTQ-UHFFFAOYSA-N 3-(aminomethyl)-6-chloro-2-methyl-4-phenylisoquinolin-1-one Chemical compound C12=CC(Cl)=CC=C2C(=O)N(C)C(CN)=C1C1=CC=CC=C1 IFTJNHCJDRPDTQ-UHFFFAOYSA-N 0.000 abstract 1
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WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 100
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RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 82
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239000000460 chlorine Substances 0.000 description 67
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 22
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WRGVLTAWMNZWGT-VQSPYGJZSA-N taspoglutide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)(C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 WRGVLTAWMNZWGT-VQSPYGJZSA-N 0.000 description 1
229950007151 taspoglutide Drugs 0.000 description 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
229960005187 telmisartan Drugs 0.000 description 1
230000002123 temporal effect Effects 0.000 description 1
WMOVHXAZOJBABW-UHFFFAOYSA-N tert-butyl acetate Chemical compound CC(=O)OC(C)(C)C WMOVHXAZOJBABW-UHFFFAOYSA-N 0.000 description 1
CXGTZJYQWSUFET-IBGZPJMESA-N tesaglitazar Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCCC1=CC=C(OS(C)(=O)=O)C=C1 CXGTZJYQWSUFET-IBGZPJMESA-N 0.000 description 1
125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 description 1
229940126585 therapeutic drug Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000003451 thiazide diuretic agent Substances 0.000 description 1
229960002663 thioctic acid Drugs 0.000 description 1
150000003573 thiols Chemical group 0.000 description 1
229960000103 thrombolytic agent Drugs 0.000 description 1
229960005344 tiapride Drugs 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
229960002277 tolazamide Drugs 0.000 description 1
OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
229960005371 tolbutamide Drugs 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
150000003623 transition metal compounds Chemical class 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
229960001288 triamterene Drugs 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
DLQYXUGCCKQSRJ-UHFFFAOYSA-N tris(furan-2-yl)phosphane Chemical compound C1=COC(P(C=2OC=CC=2)C=2OC=CC=2)=C1 DLQYXUGCCKQSRJ-UHFFFAOYSA-N 0.000 description 1
UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
201000008827 tuberculosis Diseases 0.000 description 1
208000019206 urinary tract infection Diseases 0.000 description 1
229960005356 urokinase Drugs 0.000 description 1
229960004699 valsartan Drugs 0.000 description 1
ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
WQEVDHBJGNOKKO-UHFFFAOYSA-K vanadic acid Chemical compound O[V](O)(O)=O WQEVDHBJGNOKKO-UHFFFAOYSA-K 0.000 description 1
230000002792 vascular Effects 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
229960004528 vincristine Drugs 0.000 description 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
HHJUWIANJFBDHT-KOTLKJBCSA-N vindesine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(N)=O)N4C)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 HHJUWIANJFBDHT-KOTLKJBCSA-N 0.000 description 1
229960004355 vindesine Drugs 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
229960001729 voglibose Drugs 0.000 description 1
229960005080 warfarin Drugs 0.000 description 1
PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
229960000883 warfarin potassium Drugs 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
239000011995 wilkinson's catalyst Substances 0.000 description 1
GTLDTDOJJJZVBW-UHFFFAOYSA-N zinc cyanide Chemical compound [Zn+2].N#[C-].N#[C-] GTLDTDOJJJZVBW-UHFFFAOYSA-N 0.000 description 1
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SK1080-2003A 2001-02-02 2002-02-01 Kondenzovaná heterocyklická zlúčenina, jej použitie a jej farmaceutický prípravok SK10802003A3 (sk)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2001027349		2001-02-02
JP2001292388		2001-09-25
JP2001382232		2001-12-14
PCT/JP2002/000831 WO2002062764A1 (en)	2001-02-02	2002-02-01	Fused heterocyclic compounds

Publications (1)

Publication Number	Publication Date
SK10802003A3 true SK10802003A3 (sk)	2004-05-04

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ID=27345897

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Application Number	Title	Priority Date	Filing Date
SK1080-2003A SK10802003A3 (sk)	2001-02-02	2002-02-01	Kondenzovaná heterocyklická zlúčenina, jej použitie a jej farmaceutický prípravok

Country Status (17)

Country	Link
US (1)	US7034039B2 (es)
EP (1)	EP1355886B1 (es)
KR (1)	KR20030074774A (es)
CN (1)	CN1500080A (es)
AT (1)	ATE366724T1 (es)
BR (1)	BR0206831A (es)
CA (1)	CA2437492A1 (es)
CZ (1)	CZ20032321A3 (es)
DE (1)	DE60221098T2 (es)
HU (1)	HUP0400058A2 (es)
IL (1)	IL157179A0 (es)
MX (1)	MXPA03006918A (es)
NO (1)	NO20033385L (es)
PE (1)	PE20021002A1 (es)
PL (1)	PL364221A1 (es)
SK (1)	SK10802003A3 (es)
WO (1)	WO2002062764A1 (es)

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2002
- 2002-02-01 BR BR0206831-1A patent/BR0206831A/pt not_active Application Discontinuation
- 2002-02-01 US US10/470,805 patent/US7034039B2/en not_active Expired - Fee Related
- 2002-02-01 DE DE60221098T patent/DE60221098T2/de not_active Expired - Lifetime
- 2002-02-01 CZ CZ20032321A patent/CZ20032321A3/cs unknown
- 2002-02-01 CA CA002437492A patent/CA2437492A1/en not_active Abandoned
- 2002-02-01 MX MXPA03006918A patent/MXPA03006918A/es unknown
- 2002-02-01 KR KR10-2003-7010229A patent/KR20030074774A/ko not_active Withdrawn
- 2002-02-01 HU HU0400058A patent/HUP0400058A2/hu unknown
- 2002-02-01 PL PL02364221A patent/PL364221A1/xx not_active Application Discontinuation
- 2002-02-01 EP EP02711278A patent/EP1355886B1/en not_active Expired - Lifetime
- 2002-02-01 PE PE2002000076A patent/PE20021002A1/es not_active Application Discontinuation
- 2002-02-01 CN CNA028074297A patent/CN1500080A/zh active Pending
- 2002-02-01 WO PCT/JP2002/000831 patent/WO2002062764A1/en not_active Ceased
- 2002-02-01 IL IL15717902A patent/IL157179A0/xx unknown
- 2002-02-01 SK SK1080-2003A patent/SK10802003A3/sk unknown
- 2002-02-01 AT AT02711278T patent/ATE366724T1/de not_active IP Right Cessation
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EP1355886A1 (en)	2003-10-29
CA2437492A1 (en)	2002-08-15
ATE366724T1 (de)	2007-08-15
US7034039B2 (en)	2006-04-25
MXPA03006918A (es)	2004-05-24
KR20030074774A (ko)	2003-09-19
NO20033385D0 (no)	2003-07-29
PE20021002A1 (es)	2002-12-06
WO2002062764A9 (en)	2002-10-10
HUP0400058A2 (hu)	2004-04-28
IL157179A0 (en)	2004-02-08
US20040082607A1 (en)	2004-04-29
CN1500080A (zh)	2004-05-26
DE60221098D1 (de)	2007-08-23
DE60221098T2 (de)	2008-01-24
NO20033385L (no)	2003-09-30
BR0206831A (pt)	2004-07-06
CZ20032321A3 (en)	2004-03-17
EP1355886B1 (en)	2007-07-11
PL364221A1 (en)	2004-12-13
WO2002062764A1 (en)	2002-08-15

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