PE20020595A1 - Derivados de 4-(bifenilcarbonilamino)piperidina, composiciones que los comprenden y uso de los mismos - Google Patents
Derivados de 4-(bifenilcarbonilamino)piperidina, composiciones que los comprenden y uso de los mismosInfo
- Publication number
- PE20020595A1 PE20020595A1 PE2001001175A PE2001001175A PE20020595A1 PE 20020595 A1 PE20020595 A1 PE 20020595A1 PE 2001001175 A PE2001001175 A PE 2001001175A PE 2001001175 A PE2001001175 A PE 2001001175A PE 20020595 A1 PE20020595 A1 PE 20020595A1
- Authority
- PE
- Peru
- Prior art keywords
- piperidine
- biphenyl
- pyridylmethyl
- trifluoromethyl
- derivatives
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 7
- -1 CARBOXYL Chemical class 0.000 abstract 4
- 239000004305 biphenyl Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 102000006410 Apoproteins Human genes 0.000 abstract 1
- 108010083590 Apoproteins Proteins 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE PIPERIDINA DE FORMULA I DONDE Z ES BIFENILO OPCIONALMENTE SUSTITUIDO EN LA POSICION 2', 3', 4', 5', 6' CON TRIHALOMETILO, TRIHALOMETOXI; HET ES QUINOLILO, QUINOXALILO, PIRIDILO OPCIONALMENTE SUSTITUIDO CON HALO, CIANO, NITRO, ALQUILO C1-C6, ARILO C6-C12, ALCOXI C1-C6, HIDROXILO, TIOALCOXI C1-C6, CARBOXILO, ALCOXICARBONILO C1-C6. SON COMPUESTOS PREFERIDOS 1-(3-PIRIDILMETIL)-4-[(4'-TRIFLUOROMETIL-2-BIFENIL)-CARBONILAMINO]PIPERIDINA, 1-(6-METIL-2-PIRIDILMETIL)-4-[4'-TRIFLUOROMETIL-2-BIFENIL)-CABONILAMINO]PIPERIDINA, 1-(2-PIRIDILMETIL)-4-[(4'-TRIFLUOROMETIL-2-BIFENIL)-CARBONILAMINO]PIPERIDINA,ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DEL COMPUESTO I Y COMPUESTOS INTERMEDIOS. LOS COMPUESTOS SON INHIBIDORES DE LA SECRECION DE LA APOPROTEINA B Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE HIPERCOLESTEROLEMIA, HIPERTRIGLICERIDEMIA, HIPERLIPIDEMIA, PANCREATITIS, HIPERGLUCEMIA, OBESIDAD, ATEROSCLEROSIS, DISLIPIDEMIAS ASOCIADAS CON LA DIABETES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0015143A FR2816940A1 (fr) | 2000-11-23 | 2000-11-23 | Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020595A1 true PE20020595A1 (es) | 2002-07-08 |
Family
ID=8856805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001001175A PE20020595A1 (es) | 2000-11-23 | 2001-11-23 | Derivados de 4-(bifenilcarbonilamino)piperidina, composiciones que los comprenden y uso de los mismos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20040034028A1 (es) |
| EP (1) | EP1335912A1 (es) |
| JP (1) | JP2004514676A (es) |
| KR (1) | KR20030060954A (es) |
| CN (1) | CN1476445A (es) |
| AR (1) | AR031499A1 (es) |
| AU (1) | AU2002221745A1 (es) |
| BR (1) | BR0115520A (es) |
| CA (1) | CA2429326A1 (es) |
| CZ (1) | CZ20031619A3 (es) |
| FR (1) | FR2816940A1 (es) |
| HU (1) | HUP0400819A2 (es) |
| IL (1) | IL155986A0 (es) |
| MX (1) | MXPA03004540A (es) |
| NO (1) | NO20032315L (es) |
| PE (1) | PE20020595A1 (es) |
| PL (1) | PL365939A1 (es) |
| RU (1) | RU2003117458A (es) |
| SK (1) | SK7362003A3 (es) |
| WO (1) | WO2002042291A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60228447D1 (de) | 2001-06-28 | 2008-10-02 | Pfizer Prod Inc | Triamidsubstituierte indole, benzofurane und benzothiophene als inhibitoren des mikrosomalen triglyceridtransferproteins (mtp) und/oder der sekretion von apolipoprotein b (apo b) |
| KR100717098B1 (ko) | 2002-02-28 | 2007-05-10 | 니뽄 다바코 산교 가부시키가이샤 | 에스테르 화합물 및 그 의약 용도 |
| FR2856685B1 (fr) | 2003-06-25 | 2005-09-23 | Merck Sante Sas | Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1669345A4 (en) | 2003-08-29 | 2008-02-20 | Japan Tobacco Inc | ESTER DERIVATIVE AND MEDICAL USE THEREOF |
| FR2865733B1 (fr) * | 2004-02-04 | 2007-10-12 | Merck Sante Sas | Derives de thiazolylimidazole, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en medecine |
| FR2871463B1 (fr) * | 2004-06-11 | 2006-09-22 | Merck Sante Soc Par Actions Si | Derives a structure aroyl-o-piperidine, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en therapeutique |
| US8101774B2 (en) | 2004-10-18 | 2012-01-24 | Japan Tobacco Inc. | Ester derivatives and medicinal use thereof |
| FR2884831B1 (fr) * | 2005-04-22 | 2007-08-10 | Merck Sante Soc Par Actions Si | Methode de criblage de composes inhibiteurs de la mtp |
| KR101387459B1 (ko) | 2006-10-24 | 2014-05-14 | 얀센 파마슈티카 엔.브이. | Ｍｔｐ를 저해하는 테트라하이드로-나프탈렌-1-카복실산 유도체 |
| JO2653B1 (en) | 2006-10-24 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Tetrahydroflavin 1-carboxylic acid substituted with pyridine or pyrazine inhibit MTB |
| US8338455B2 (en) * | 2006-12-20 | 2012-12-25 | Amgen Inc. | Compounds and methods of use |
| AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| DK2473504T3 (en) | 2009-09-03 | 2015-03-16 | Bioenergenix | Heterocyclic Compounds for Inhibition of Passover |
| AU2012204353B2 (en) | 2011-01-05 | 2016-12-08 | Bioenergenix | Heterocyclic compounds for the inhibition of PASK |
| US8912188B2 (en) | 2011-03-02 | 2014-12-16 | Bioenergenix, Llc | Substituted quinoxaline carboxylic acids for the inhibition of PASK |
| US8916561B2 (en) | 2011-03-02 | 2014-12-23 | Bioenergenix, Llc | Substituted quinoxaline compounds for the inhibition of PASK |
| EP3053911B1 (en) * | 2013-09-30 | 2020-01-22 | The University of Tokyo | Adiponectin receptor-activating compound |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8528234D0 (en) * | 1985-11-15 | 1985-12-18 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
| CA2123728A1 (en) * | 1993-05-21 | 1994-11-22 | Noriyoshi Sueda | Urea derivatives and their use as acat inhibitors |
| AU7145996A (en) * | 1995-10-13 | 1997-04-30 | Banyu Pharmaceutical Co., Ltd. | Substituted heteroaromatic derivatives |
| AU2793197A (en) * | 1996-05-31 | 1998-01-05 | Banyu Pharmaceutical Co., Ltd. | 1,4-disubstituted piperidine derivatives |
-
2000
- 2000-11-23 FR FR0015143A patent/FR2816940A1/fr not_active Withdrawn
-
2001
- 2001-10-25 HU HU0400819A patent/HUP0400819A2/hu unknown
- 2001-10-25 CN CNA018192866A patent/CN1476445A/zh active Pending
- 2001-10-25 CZ CZ20031619A patent/CZ20031619A3/cs unknown
- 2001-10-25 WO PCT/EP2001/012326 patent/WO2002042291A1/en not_active Ceased
- 2001-10-25 IL IL15598601A patent/IL155986A0/xx unknown
- 2001-10-25 JP JP2002544425A patent/JP2004514676A/ja active Pending
- 2001-10-25 BR BR0115520-2A patent/BR0115520A/pt not_active Application Discontinuation
- 2001-10-25 RU RU2003117458/04A patent/RU2003117458A/ru not_active Application Discontinuation
- 2001-10-25 AU AU2002221745A patent/AU2002221745A1/en not_active Abandoned
- 2001-10-25 KR KR10-2003-7006923A patent/KR20030060954A/ko not_active Withdrawn
- 2001-10-25 MX MXPA03004540A patent/MXPA03004540A/es unknown
- 2001-10-25 SK SK736-2003A patent/SK7362003A3/sk unknown
- 2001-10-25 PL PL01365939A patent/PL365939A1/xx unknown
- 2001-10-25 CA CA002429326A patent/CA2429326A1/en not_active Abandoned
- 2001-10-25 US US10/432,323 patent/US20040034028A1/en not_active Abandoned
- 2001-10-25 EP EP01997486A patent/EP1335912A1/en not_active Withdrawn
- 2001-11-23 PE PE2001001175A patent/PE20020595A1/es not_active Application Discontinuation
- 2001-11-23 AR ARP010105460A patent/AR031499A1/es unknown
-
2003
- 2003-05-22 NO NO20032315A patent/NO20032315L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20032315D0 (no) | 2003-05-22 |
| MXPA03004540A (es) | 2003-09-10 |
| NO20032315L (no) | 2003-05-22 |
| CA2429326A1 (en) | 2002-05-30 |
| AU2002221745A1 (en) | 2002-06-03 |
| CN1476445A (zh) | 2004-02-18 |
| BR0115520A (pt) | 2003-09-16 |
| KR20030060954A (ko) | 2003-07-16 |
| EP1335912A1 (en) | 2003-08-20 |
| AR031499A1 (es) | 2003-09-24 |
| RU2003117458A (ru) | 2004-12-27 |
| PL365939A1 (en) | 2005-01-24 |
| CZ20031619A3 (cs) | 2003-09-17 |
| FR2816940A1 (fr) | 2002-05-24 |
| US20040034028A1 (en) | 2004-02-19 |
| WO2002042291A1 (en) | 2002-05-30 |
| SK7362003A3 (en) | 2003-11-04 |
| HUP0400819A2 (hu) | 2004-07-28 |
| JP2004514676A (ja) | 2004-05-20 |
| IL155986A0 (en) | 2003-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |