[go: up one dir, main page]

PE20020473A1 - USO COMBINADO DE INHIBIDORES DE ACETILCOLINESTERASA Y AGONISTAS INVERSOS DE GABAa PARA EL TRATAMIENTO DE TRASTORNOS COGNITIVOS - Google Patents

USO COMBINADO DE INHIBIDORES DE ACETILCOLINESTERASA Y AGONISTAS INVERSOS DE GABAa PARA EL TRATAMIENTO DE TRASTORNOS COGNITIVOS

Info

Publication number
PE20020473A1
PE20020473A1 PE2001001026A PE2001001026A PE20020473A1 PE 20020473 A1 PE20020473 A1 PE 20020473A1 PE 2001001026 A PE2001001026 A PE 2001001026A PE 2001001026 A PE2001001026 A PE 2001001026A PE 20020473 A1 PE20020473 A1 PE 20020473A1
Authority
PE
Peru
Prior art keywords
gabaa
treatment
cognitive disorders
naphthyridine
carboxamide
Prior art date
Application number
PE2001001026A
Other languages
English (en)
Inventor
James Vincent Cassella
Anabella Villalobos
Lavanya Rajachandran
Original Assignee
Pfizer Prod Inc
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Neurogen Corp filed Critical Pfizer Prod Inc
Publication of PE20020473A1 publication Critical patent/PE20020473A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: a) UN INHIBIDOR DE ACETILCOLINESTERASA SELECCIONADO DE ARICEPT (DONEPEZIL); b) UN AGONISTA INVERSO DE RECEPTORES GABAa DE SUBTIPOS O1 Y/O O5 CON UNA EFICACIA FUNCIONAL EN LOS RECEPTORES DE SUBTIPOS O1 Y/O O5 MENOR DEL -5% DE PREFERENCIA MENOR A -10% Y PARA LOS RECEPTORES DE SUBTIPOS O2 Y O3 MAYOR DE 5% DE PREFERENCIA MAYOR A 10% Y c) UN VEHICULO FARMACEUTICAMENTE ACEPTABLE. EL AGONISTA INVERSO DE GABAa ES EL COMPUESTO DE FORMULA I DONDE X ES H, HALOGENO, OR1, ALQUILO C1-C6, FENILO, NAFTILO, ENTRE OTROS; Y ES ALQUILO C1-C8, CARBOCICLO, ENTRE OTROS; R1 ES H, ALQUILO C1-C6, ENTRE OTROS SIENDO LOS COMPUESTOS PREFERIDOS N-n-BUTIL-6-CLORO-4-OXO-1,4-TETRAHIDRO-1,5-NAFTIRIDINA-3-CARBOXAMIDA, N-n-BUTIL-6-ETOXI-4-OXO-1,4-TETRAHIDRO-1,S-NAFTIRIDINA-3-CARBOXAMIDA, N-(2-ETILTIO)ETIL-6-METOXI-4-OXO-1,4-TETRAHIDRO-1,5-NAFTIRIDINA-3-CARBOXAMIDA, ENTRE OTROS. LA COMPOSICION ES UTIL PARA EL TRATAMIENTO DE TRASTORNOS COGNITIVOS, ALZHEIMER
PE2001001026A 2000-10-17 2001-10-16 USO COMBINADO DE INHIBIDORES DE ACETILCOLINESTERASA Y AGONISTAS INVERSOS DE GABAa PARA EL TRATAMIENTO DE TRASTORNOS COGNITIVOS PE20020473A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24114500P 2000-10-17 2000-10-17

Publications (1)

Publication Number Publication Date
PE20020473A1 true PE20020473A1 (es) 2002-06-14

Family

ID=22909428

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001026A PE20020473A1 (es) 2000-10-17 2001-10-16 USO COMBINADO DE INHIBIDORES DE ACETILCOLINESTERASA Y AGONISTAS INVERSOS DE GABAa PARA EL TRATAMIENTO DE TRASTORNOS COGNITIVOS

Country Status (14)

Country Link
US (2) US20020151591A1 (es)
EP (1) EP1328294A2 (es)
JP (1) JP2004511512A (es)
KR (1) KR20030046509A (es)
AR (1) AR030893A1 (es)
AU (2) AU2001294117B2 (es)
CA (1) CA2426120A1 (es)
HU (1) HUP0302476A3 (es)
IL (1) IL155225A0 (es)
NZ (1) NZ525103A (es)
PE (1) PE20020473A1 (es)
UY (1) UY26970A1 (es)
WO (1) WO2002032412A2 (es)
ZA (1) ZA200302918B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10119862A1 (de) * 2001-04-24 2002-11-07 Hf Arzneimittelforsch Gmbh Verwendung von Galanthamin zur Behandlung von Krankheitserscheinungen des zentralen Nervensystems aufgrund von Intoxikationen mit psychotropen Substanzen
US20060135403A1 (en) * 2002-12-24 2006-06-22 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
US8299062B2 (en) * 2003-09-17 2012-10-30 Franklin Volvovitz Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction
JPWO2005027968A1 (ja) * 2003-09-19 2007-11-15 エーザイ・アール・アンド・ディー・マネジメント株式会社 ダウン症候群治療剤
TW200533371A (en) * 2004-04-15 2005-10-16 Dainippon Pharmaceutical Co Medicament comprising a combination of an acetylcholinesterase inhibitor and a 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1h)-one derivative
WO2005112908A1 (en) * 2004-05-14 2005-12-01 The Johns Hopkins University Method for improving cognitive function
EP1789050A1 (en) * 2004-08-09 2007-05-30 Warner-Lambert Company LLC Novel quinoxalinone norepinephrine reuptake inhibitors for the treatment of central nervous system disorders
CN100382802C (zh) * 2005-08-08 2008-04-23 赵德禄 治疗自主神经系统功能紊乱的药物
DK2032987T3 (en) 2006-05-22 2016-04-25 Univ Leland Stanford Junior Pharmacological treatment of Cognitive impairment
CA2666219C (en) 2006-10-16 2017-02-07 Bionomics Limited Novel anxiolytic compounds
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
DK2091948T3 (da) 2006-11-30 2012-07-23 Probiodrug Ag Nye inhibitorer af glutaminylcyclase
AU2008220785B2 (en) 2007-03-01 2013-02-21 Vivoryon Therapeutics N.V. New use of glutaminyl cyclase inhibitors
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
EP2475428B1 (en) 2009-09-11 2015-07-01 Probiodrug AG Heterocylcic derivatives as inhibitors of glutaminyl cyclase
CA2789014C (en) 2010-02-09 2019-01-15 Michela Gallagher Methods and compositions for improving cognitive function
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
EA022420B1 (ru) 2010-03-10 2015-12-30 Пробиодруг Аг Гетероциклические ингибиторы глутаминилциклазы (qc, ec 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
WO2012068161A1 (en) 2010-11-15 2012-05-24 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
CN103502219A (zh) 2011-03-02 2014-01-08 生态学有限公司 作为治疗剂的新型小分子
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
EP2707367B1 (en) 2011-05-12 2019-10-09 Bionomics Limited Methods for preparing naphthyridines
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
CN105142623A (zh) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 用于改善认知功能的方法和组合物
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CA3123897C (en) 2013-12-20 2024-02-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
JP6899043B2 (ja) 2015-05-22 2021-07-07 エージンバイオ， インコーポレイテッド レベチラセタムの持続放出性医薬組成物
MA42624A (fr) 2015-06-19 2021-04-28 Agenebio Inc Dérivés de benzodiazépine, compositions et méthodes de traitement de la déficience cognitive
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
EA202190076A1 (ru) 2018-06-19 2021-09-22 Эйджинбайо, Инк. Производные бензодиазепина, композиции и способы лечения когнитивных нарушений
JP2025529834A (ja) 2022-08-19 2025-09-09 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾアゼピン誘導体、組成物および方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
US5870723A (en) * 1994-11-28 1999-02-09 Pare, Jr.; David Ferrin Tokenless biometric transaction authorization method and system
US6088683A (en) * 1996-08-21 2000-07-11 Jalili; Reza Secure purchase transaction method using telephone number
US6016476A (en) * 1997-08-11 2000-01-18 International Business Machines Corporation Portable information and transaction processing system and method utilizing biometric authorization and digital certificate security
US6143760A (en) * 1997-08-25 2000-11-07 Neurogen Corporation Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands
NZ502548A (en) * 1997-08-25 2002-06-28 Neurogen Corp Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands
GB9805561D0 (en) * 1998-03-16 1998-05-13 Merck Sharp & Dohme A combination of therapeutic agents

Also Published As

Publication number Publication date
WO2002032412A2 (en) 2002-04-25
CA2426120A1 (en) 2002-04-25
IL155225A0 (en) 2003-11-23
KR20030046509A (ko) 2003-06-12
ZA200302918B (en) 2004-04-13
AR030893A1 (es) 2003-09-03
US20020151591A1 (en) 2002-10-17
US20050009861A1 (en) 2005-01-13
WO2002032412A3 (en) 2003-03-20
AU2001294117B2 (en) 2006-07-27
HUP0302476A2 (hu) 2003-11-28
EP1328294A2 (en) 2003-07-23
HUP0302476A3 (en) 2005-05-30
AU9411701A (en) 2002-04-29
UY26970A1 (es) 2002-06-20
JP2004511512A (ja) 2004-04-15
NZ525103A (en) 2004-12-24

Similar Documents

Publication Publication Date Title
PE20020473A1 (es) USO COMBINADO DE INHIBIDORES DE ACETILCOLINESTERASA Y AGONISTAS INVERSOS DE GABAa PARA EL TRATAMIENTO DE TRASTORNOS COGNITIVOS
NO20026094L (no) Kondenserte azepinderivater og deres anvendelse som antidiuretiske midler
AR034669A1 (es) Derivados de tetrahidroquinolina y su uso para controlar la fertilidad
PE20011114A1 (es) Decahidro-isoquinolinas
DK1337518T3 (da) Piperazinylpyrazinforbindelser som antagonister for serotonin-5-HT2-receptoren
MA28432B1 (fr) Antagonistes du recepteur de la chimiokine
LV11617A (lv) Morfolins un tiomorfolins ar tahikinina receptoru antagonistu ipasibam
HRP20090195T1 (hr) Inhibitori mitotičkih kinezina
HUP0301045A2 (hu) Kinolinonszármazékok mint tirozin kináz inhibitorok, ezeket tartalmazó gyógyszerkészítmények
BR0012489A (pt) Composto, composição farmacêutica, uso de um composto, e, kit para a contracepção masculina
CO5310534A1 (es) Nuevos derivados de androstano anti-inflamatorios
AR034556A1 (es) Un derivado de fenilalanina, una composicion farmaceutica que comprende al derivado de fenilalanina, el uso del derivado y proceso para preparar dicho derivado
MA30756B1 (fr) Derives de cinnamoyl-piperazine et leur utilisation comme antagonistes par-1
BR9810544A (pt) Derivados de azetidinilpropilpiperidina, intermediários e uso como antagonistas de taquicinina
TR200000725T2 (tr) Bir monoamin oksidaz inhibitörü ve h5-HT1B antagonistinin bileşimi
AR035756A1 (es) Uso de carbamatos en la preparacion de medicamentos para la prevencion o tratamiento de trastornos neurodegenerativos
PE20020329A1 (es) DERIVADOS DE 10-ARIL-11H-BENZO[b]FLUORENO Y ANALOGOS COMO COMPUESTOS ESTROGENICOS
PE20021018A1 (es) DERIVADOS DE ß - CARBOLINA
PE20001461A1 (es) Compuestos derivados de 3,16-dihidroxi-estra-1,3,5(10)-trieno, empleo de los mismos y de partes estructurales de los mismos y composiciones farmaceuticas que los contienen
PE20001234A1 (es) Compuestos azabiciclicos sustituidos de heteroaril-aminoetil/benzisoxazol como antagonistas serotonergicos 5-ht1
ATE308540T1 (de) Antithrombosemittel
PE20061147A1 (es) Procedimiento de preparacion de compuestos antagonistas del receptor cgrp e intermediarios
MY139016A (en) PYRAZOLOPYRIDINE DERIVATIVES AS INHIBITORS OF ß-ADRENERGIC RECEPTOR KINASE 1
BR0207830A (pt) Compostos de carbamato para uso em prevenir ou tratar distúrbios de ansiedade
PE20241726A1 (es) Compuestos n-acilhidrazonicos inhibidores de nav 1.7 y/o nav 1.8, sus procesos de obtencion, composiciones, usos, metodos de tratamiento de estos y kits

Legal Events

Date Code Title Description
FC Refusal