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AU2002221745A1 - 4-(biphenylcarbonylamino)piperidine derivatives as MTP inhibitors - Google Patents

4-(biphenylcarbonylamino)piperidine derivatives as MTP inhibitors

Info

Publication number
AU2002221745A1
AU2002221745A1 AU2002221745A AU2174502A AU2002221745A1 AU 2002221745 A1 AU2002221745 A1 AU 2002221745A1 AU 2002221745 A AU2002221745 A AU 2002221745A AU 2174502 A AU2174502 A AU 2174502A AU 2002221745 A1 AU2002221745 A1 AU 2002221745A1
Authority
AU
Australia
Prior art keywords
biphenyl
methyl
formula
trifluoromethyl
piperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002221745A
Other languages
English (en)
Inventor
Olivier Chevreuil
Francois Collonges
Didier Festal
Daniel Guerrier
Alyx-Caroline Guevel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2002221745A1 publication Critical patent/AU2002221745A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
AU2002221745A 2000-11-23 2001-10-25 4-(biphenylcarbonylamino)piperidine derivatives as MTP inhibitors Abandoned AU2002221745A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0015143 2000-11-23
FR0015143A FR2816940A1 (fr) 2000-11-23 2000-11-23 Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation
PCT/EP2001/012326 WO2002042291A1 (en) 2000-11-23 2001-10-25 4-(biphenylcarbonylamino)piperidine derivatives as mtp inhibitors

Publications (1)

Publication Number Publication Date
AU2002221745A1 true AU2002221745A1 (en) 2002-06-03

Family

ID=8856805

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002221745A Abandoned AU2002221745A1 (en) 2000-11-23 2001-10-25 4-(biphenylcarbonylamino)piperidine derivatives as MTP inhibitors

Country Status (20)

Country Link
US (1) US20040034028A1 (es)
EP (1) EP1335912A1 (es)
JP (1) JP2004514676A (es)
KR (1) KR20030060954A (es)
CN (1) CN1476445A (es)
AR (1) AR031499A1 (es)
AU (1) AU2002221745A1 (es)
BR (1) BR0115520A (es)
CA (1) CA2429326A1 (es)
CZ (1) CZ20031619A3 (es)
FR (1) FR2816940A1 (es)
HU (1) HUP0400819A2 (es)
IL (1) IL155986A0 (es)
MX (1) MXPA03004540A (es)
NO (1) NO20032315L (es)
PE (1) PE20020595A1 (es)
PL (1) PL365939A1 (es)
RU (1) RU2003117458A (es)
SK (1) SK7362003A3 (es)
WO (1) WO2002042291A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS50712B (sr) 2001-06-28 2010-06-30 Pfizer Products Inc. Triamid-supstituisani indoli, benzofurani i benzotiofeni kao inhibitori mikrozomalnog triglicerid transfer proteina (mtp) i/ili sekrecije apolipoproteina b (apo b)
RU2293721C2 (ru) 2002-02-28 2007-02-20 Джапан Тобакко Инк. Сложноэфирные соединения и их применение в медицине
FR2856685B1 (fr) 2003-06-25 2005-09-23 Merck Sante Sas Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
WO2005021486A1 (ja) 2003-08-29 2005-03-10 Japan Tobacco Inc. エステル誘導体及びその医薬用途
FR2865733B1 (fr) * 2004-02-04 2007-10-12 Merck Sante Sas Derives de thiazolylimidazole, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en medecine
FR2871463B1 (fr) * 2004-06-11 2006-09-22 Merck Sante Soc Par Actions Si Derives a structure aroyl-o-piperidine, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en therapeutique
US8101774B2 (en) 2004-10-18 2012-01-24 Japan Tobacco Inc. Ester derivatives and medicinal use thereof
FR2884831B1 (fr) * 2005-04-22 2007-08-10 Merck Sante Soc Par Actions Si Methode de criblage de composes inhibiteurs de la mtp
JO2653B1 (en) * 2006-10-24 2012-06-17 شركة جانسين فارماسوتيكا ان. في Tetrahydroflavin 1-carboxylic acid substituted with pyridine or pyrazine inhibit MTB
WO2008049808A1 (en) 2006-10-24 2008-05-02 Janssen Pharmaceutica Nv Mtp inhibiting tetrahydro-naphthalene-1-carboxylic acid derivatives
JP5528812B2 (ja) * 2006-12-20 2014-06-25 アムジエン・インコーポレーテツド 複素環式化合物ならびに炎症、血管形成および癌の治療におけるこれらの使用
AR074466A1 (es) 2008-12-05 2011-01-19 Sanofi Aventis Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3.
BR112012004533B1 (pt) 2009-09-03 2021-11-09 Bioenergenix Composto, composição farmacêutica, e uso do composto
EP2661431B1 (en) 2011-01-05 2018-07-11 Bioenergenix Heterocyclic compounds for the inhibition of pask
WO2012119046A2 (en) 2011-03-02 2012-09-07 Bioenergenix Heterocyclic compounds for the inhibition of pask
US8916561B2 (en) 2011-03-02 2014-12-23 Bioenergenix, Llc Substituted quinoxaline compounds for the inhibition of PASK
JP6664632B2 (ja) * 2013-09-30 2020-03-13 国立大学法人 東京大学 アディポネクチン受容体活性化化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8528234D0 (en) * 1985-11-15 1985-12-18 Wyeth John & Brother Ltd Heterocyclic compounds
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
CA2123728A1 (en) * 1993-05-21 1994-11-22 Noriyoshi Sueda Urea derivatives and their use as acat inhibitors
US6130232A (en) * 1995-10-13 2000-10-10 Banyu Pharmaceutical Coaltd Substituted piperidine derivatives as muscarinic M3 receptor antagonists
WO1997045414A1 (en) * 1996-05-31 1997-12-04 Banyu Pharmaceutical Co., Ltd. 1,4-disubstituted piperidine derivatives

Also Published As

Publication number Publication date
RU2003117458A (ru) 2004-12-27
AR031499A1 (es) 2003-09-24
US20040034028A1 (en) 2004-02-19
PE20020595A1 (es) 2002-07-08
WO2002042291A1 (en) 2002-05-30
CZ20031619A3 (cs) 2003-09-17
IL155986A0 (en) 2003-12-23
PL365939A1 (en) 2005-01-24
FR2816940A1 (fr) 2002-05-24
MXPA03004540A (es) 2003-09-10
EP1335912A1 (en) 2003-08-20
NO20032315D0 (no) 2003-05-22
JP2004514676A (ja) 2004-05-20
KR20030060954A (ko) 2003-07-16
HUP0400819A2 (hu) 2004-07-28
SK7362003A3 (en) 2003-11-04
NO20032315L (no) 2003-05-22
CA2429326A1 (en) 2002-05-30
CN1476445A (zh) 2004-02-18
BR0115520A (pt) 2003-09-16

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