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PE20020451A1 - Compuestos de pirazol utiles como inhibidores de cinasa proteina - Google Patents

Compuestos de pirazol utiles como inhibidores de cinasa proteina

Info

Publication number
PE20020451A1
PE20020451A1 PE2001000931A PE2001000931A PE20020451A1 PE 20020451 A1 PE20020451 A1 PE 20020451A1 PE 2001000931 A PE2001000931 A PE 2001000931A PE 2001000931 A PE2001000931 A PE 2001000931A PE 20020451 A1 PE20020451 A1 PE 20020451A1
Authority
PE
Peru
Prior art keywords
halo
compounds
aliphatic group
heteroaryl
replaced
Prior art date
Application number
PE2001000931A
Other languages
English (en)
Inventor
Robert Davies
David Bebbington
Ronald Knegtel
Marion Wannamaker
Pan Li
Cornelia J Forster
David Lauffer
Albert Pierce
David Kay
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27398347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20020451(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PE20020451A1 publication Critical patent/PE20020451A1/es

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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

SE REFIERE A COMPUESTOS DE PIRAZOL DE FORMULA I DONDE EL ANILO C ES FENILO, PIRIDINILO, PIRIMIDINILO, PIRIDAZINILO, PIRAZINILO, 1,2,4-TRIAZINILO SUSTITUIDO EN LA POSICION ORTO POR HALO, CN, NO2, T-V-R6, FENILO, HETEROARILO, HETEROCICLO, UN GRUPO ALIFATICO C1-C6; EN LA POSICION DIFERENTE DE ORTO ES SUSTITUIDO POR R5; R1 Y R2 SON R, R-W-R6, ANILLO DE 5-8 MIEMBROS SUSTITUIDO CON HALO, OXO, CN, NO2R7, VR6; Rx Y Ry SON T-R3, ANILLO FUSIONADO SUSTITUIDO CON T-R3, OXO, R4; T ES ENLACE, ALQUILIDENO, C1-C4; R3 ES R, HALO, OR, COR, N(R4)2, CON(R7)2, ENTRE OTROS; R ES H, ARILO C6-C10, HETEROARILO C5-C10, HETEROCICLO 5-10 MIEMBROS; R4 ES R7, CON(R7)2, SO2R7; R7 ES H, GRUPO ALIFATICO, DOS R7 FORMAN HETEROARILO, HETEROCICLO; R5 ES R, HALO, OR, NR4COR, COCOR, ENTRE OTROS; V ES O, S, SO, SO2, NR6SO2, SO2NR6, CONR6, ENTRE OTROS; R6 ES H, GRUPO ALIFATICO C1-C4, DOS R6 FORMAN HETEROARILO, HETEROCICLO; W ES C(R6)2O, C(R6)2S, CO2, CONR6. TAMBIEN SE REFIERE A COMPUESTOS DE FORMULA A, B, ENTRE OTROS; R10 ES F, Br, HALOALQUILO C1-C6, NITRO, 1-PIRROLO; R1 ES Cl, F, CF3, CN, NO2; LOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE CINASAS GLICOGENO SINTASA GSK-3; SERINA TREONINA AURORA-2, AUMENTAN LA SINTESIS DE GLICOGENO, DISMINUYEN NIVEL SANGUINEO DE GLUCOSA, INHIBEN LA PRODUCCION DE PROTEINA TAU HIPERFOSFORILADA, INHIBEN LA FOSFORILACION DE ß-CATEINA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE DIABETES, ALZHEIMER, ESQUIZOFRENIA, CANCER
PE2001000931A 2000-09-15 2001-09-14 Compuestos de pirazol utiles como inhibidores de cinasa proteina PE20020451A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23279500P 2000-09-15 2000-09-15
US25788700P 2000-12-21 2000-12-21
US28694901P 2001-04-27 2001-04-27

Publications (1)

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PE20020451A1 true PE20020451A1 (es) 2002-06-06

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PE2001000931A PE20020451A1 (es) 2000-09-15 2001-09-14 Compuestos de pirazol utiles como inhibidores de cinasa proteina

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US (7) US7098330B2 (es)
EP (8) EP1318814B1 (es)
JP (9) JP4105949B2 (es)
KR (4) KR20030032035A (es)
CN (3) CN1469875A (es)
AP (1) AP2003002762A0 (es)
AT (8) ATE326459T1 (es)
AU (9) AU2001294558A1 (es)
BR (1) BR0114088A (es)
CA (8) CA2422299C (es)
DE (8) DE60120194T2 (es)
DK (1) DK1318997T3 (es)
ES (3) ES2266258T3 (es)
HU (4) HUP0302173A2 (es)
IL (6) IL154786A0 (es)
MX (8) MXPA03002299A (es)
NO (4) NO20031188L (es)
NZ (4) NZ525014A (es)
PE (1) PE20020451A1 (es)
PL (1) PL361676A1 (es)
PT (2) PT1317448E (es)
TW (1) TWI303636B (es)
WO (8) WO2002022603A1 (es)

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