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FR2844267B1 - Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant - Google Patents

Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant

Info

Publication number
FR2844267B1
FR2844267B1 FR0210962A FR0210962A FR2844267B1 FR 2844267 B1 FR2844267 B1 FR 2844267B1 FR 0210962 A FR0210962 A FR 0210962A FR 0210962 A FR0210962 A FR 0210962A FR 2844267 B1 FR2844267 B1 FR 2844267B1
Authority
FR
France
Prior art keywords
aminoindazoles
medicaments
pharmaceutical compositions
novel derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0210962A
Other languages
English (en)
Other versions
FR2844267A1 (fr
Inventor
Dominique Lesuisse
Rosset Gilles Dutruc
Franck Halley
Didier Babin
Thomas Rooney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to FR0210962A priority Critical patent/FR2844267B1/fr
Priority to PE2003000885A priority patent/PE20040995A1/es
Priority to PL03374946A priority patent/PL374946A1/xx
Priority to PCT/FR2003/002633 priority patent/WO2004022544A1/fr
Priority to YU20050165A priority patent/RS52767B/sr
Priority to RU2005109561/04A priority patent/RU2378259C2/ru
Priority to EP03769559A priority patent/EP1537087B1/fr
Priority to MEP-257/08A priority patent/MEP25708A/xx
Priority to CA2497351A priority patent/CA2497351C/fr
Priority to MXPA05001807A priority patent/MXPA05001807A/es
Priority to NZ539193A priority patent/NZ539193A/en
Priority to JP2004533563A priority patent/JP4648703B2/ja
Priority to CNA2007100042108A priority patent/CN1982316A/zh
Priority to HR20050217A priority patent/HRP20050217A2/hr
Priority to ARP030103186A priority patent/AR041131A1/es
Priority to BR0314098-9A priority patent/BR0314098A/pt
Priority to KR1020057003816A priority patent/KR101166745B1/ko
Priority to CNA03820729XA priority patent/CN1678589A/zh
Priority to AU2003278249A priority patent/AU2003278249B8/en
Priority to TW092124408A priority patent/TWI353978B/zh
Priority to US10/654,703 priority patent/US7166629B2/en
Priority to TW096144479A priority patent/TWI353245B/zh
Priority to MYPI20033345A priority patent/MY146796A/en
Publication of FR2844267A1 publication Critical patent/FR2844267A1/fr
Priority to ZA200501427A priority patent/ZA200501427B/en
Priority to MA28128A priority patent/MA27392A1/fr
Priority to NO20051645A priority patent/NO330739B1/no
Priority to US11/567,442 priority patent/US7582669B2/en
Application granted granted Critical
Publication of FR2844267B1 publication Critical patent/FR2844267B1/fr
Priority to JP2010226407A priority patent/JP5171918B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0210962A 2002-09-05 2002-09-05 Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant Expired - Fee Related FR2844267B1 (fr)

Priority Applications (28)

Application Number Priority Date Filing Date Title
FR0210962A FR2844267B1 (fr) 2002-09-05 2002-09-05 Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant
PE2003000885A PE20040995A1 (es) 2002-09-05 2003-09-01 Nuevos medicamentos derivados de aminoindazol y composiciones farmaceuticas que los contienen
KR1020057003816A KR101166745B1 (ko) 2002-09-05 2003-09-03 의약으로서의 신규한 아미노인다졸 유도체 및 이를 함유하는 약제학적 조성물
YU20050165A RS52767B (sr) 2002-09-05 2003-09-03 Novi derivati aminoindazola kao lekovi i farmaceutski oblici koji ih sadrže
RU2005109561/04A RU2378259C2 (ru) 2002-09-05 2003-09-03 Новые производные аминоиндазолов в качестве лекарственных средств и содержащие их фармацевтические композиции
EP03769559A EP1537087B1 (fr) 2002-09-05 2003-09-03 Derives de 3-aminoindazole comme inhibiteurs de kinase et compositions pharmaceutiques les renfermant
MEP-257/08A MEP25708A (en) 2002-09-05 2003-09-03 Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same
CA2497351A CA2497351C (fr) 2002-09-05 2003-09-03 Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant
MXPA05001807A MXPA05001807A (es) 2002-09-05 2003-09-03 Nuevos derivados de aminoindazol utilizados como medicamentos y composiciones farmaceuticas que los contienen.
NZ539193A NZ539193A (en) 2002-09-05 2003-09-03 Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same
JP2004533563A JP4648703B2 (ja) 2002-09-05 2003-09-03 医薬としての新規なアミノインダゾール誘導体及びこれらを含む医薬組成物
CNA2007100042108A CN1982316A (zh) 2002-09-05 2003-09-03 作为药物的新氨基吲唑衍生物与含有它们的药物组合物
HR20050217A HRP20050217A2 (en) 2002-09-05 2003-09-03 Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same
ARP030103186A AR041131A1 (es) 2002-09-05 2003-09-03 Derivados de aminoindazol utilizados como medicamentos y composiciones farmaceuticas que los contienen
PL03374946A PL374946A1 (en) 2002-09-05 2003-09-03 Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same
CNA03820729XA CN1678589A (zh) 2002-09-05 2003-09-03 作为药物的新氨基吲唑衍生物与含有它们的药物组合物
BR0314098-9A BR0314098A (pt) 2002-09-05 2003-09-03 Derivados da aminoindazóis a tìtulo de medicamentos e composições farmacêuticas que os contêm
PCT/FR2003/002633 WO2004022544A1 (fr) 2002-09-05 2003-09-03 Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant
AU2003278249A AU2003278249B8 (en) 2002-09-05 2003-09-03 Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same
MYPI20033345A MY146796A (en) 2002-09-05 2003-09-04 Aminoindazole derivatives as medicaments and pharmaceutical compositions including them
TW092124408A TWI353978B (en) 2002-09-05 2003-09-04 Novel aminoindazole derivatives as medicaments and
US10/654,703 US7166629B2 (en) 2002-09-05 2003-09-04 Aminoindazole derivatives as medicaments and pharmaceutical compositions including them
TW096144479A TWI353245B (en) 2002-09-05 2003-09-04 Novel aminoidazole derivatives as medicaments and
ZA200501427A ZA200501427B (en) 2002-09-05 2005-02-17 Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same
MA28128A MA27392A1 (fr) 2002-09-05 2005-03-03 Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant
NO20051645A NO330739B1 (no) 2002-09-05 2005-04-04 Nye aminoindozolderivater som medisin og farmakologiske preparater inneholdende disse
US11/567,442 US7582669B2 (en) 2002-09-05 2006-12-06 Aminoindazole derivatives as medicaments and pharmaceutical compositions including them
JP2010226407A JP5171918B2 (ja) 2002-09-05 2010-10-06 キナーゼ阻害剤として有用なアミノインダゾール誘導体を合成するための中間体化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0210962A FR2844267B1 (fr) 2002-09-05 2002-09-05 Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
FR2844267A1 FR2844267A1 (fr) 2004-03-12
FR2844267B1 true FR2844267B1 (fr) 2008-02-15

Family

ID=31725841

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0210962A Expired - Fee Related FR2844267B1 (fr) 2002-09-05 2002-09-05 Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant

Country Status (9)

Country Link
CN (1) CN1982316A (fr)
AR (1) AR041131A1 (fr)
FR (1) FR2844267B1 (fr)
ME (1) MEP25708A (fr)
MY (1) MY146796A (fr)
PE (1) PE20040995A1 (fr)
RS (1) RS52767B (fr)
TW (2) TWI353245B (fr)
ZA (1) ZA200501427B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007002717A1 (de) 2007-01-18 2008-07-24 Merck Patent Gmbh Heterocyclische Indazolderivate
DE102007022565A1 (de) 2007-05-14 2008-11-20 Merck Patent Gmbh Heterocyclische Indazolderivate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030032035A (ko) * 2000-09-15 2003-04-23 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서 유용한 피라졸 화합물
MXPA03005610A (es) * 2000-12-21 2003-10-06 Vertex Pharma Compuestos de pirazol utiles como inhibidores de la proteina cinasa.

Also Published As

Publication number Publication date
AR041131A1 (es) 2005-05-04
RS52767B (sr) 2013-10-31
MEP25708A (en) 2010-06-10
RS20050165A (sr) 2007-08-03
ZA200501427B (en) 2006-04-26
TW200820967A (en) 2008-05-16
CN1982316A (zh) 2007-06-20
TWI353978B (en) 2011-12-11
FR2844267A1 (fr) 2004-03-12
TW200413325A (en) 2004-08-01
PE20040995A1 (es) 2005-01-28
MY146796A (en) 2012-09-28
TWI353245B (en) 2011-12-01

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Effective date: 20150529