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PE20011178A1 - Compuestos heterociclicos y su produccion - Google Patents

Compuestos heterociclicos y su produccion

Info

Publication number
PE20011178A1
PE20011178A1 PE2001000307A PE2001000307A PE20011178A1 PE 20011178 A1 PE20011178 A1 PE 20011178A1 PE 2001000307 A PE2001000307 A PE 2001000307A PE 2001000307 A PE2001000307 A PE 2001000307A PE 20011178 A1 PE20011178 A1 PE 20011178A1
Authority
PE
Peru
Prior art keywords
phenyl
metoxy
ethenyl
oxazol
trifluoromethyl
Prior art date
Application number
PE2001000307A
Other languages
English (en)
Inventor
Takenori Hitaka
Akihiro Tasaka
Etsuya Matsutani
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of PE20011178A1 publication Critical patent/PE20011178A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE REFIERE A COMPUESTOS DE ETENIL-1,3-OXAZOL-4-METOXI DE FORMULA I, DONDE n ES 1-2; R1 ES HALOGENADO, ALQUILO C1-C2 OPCIONALMENTE HALOGENO; UNO DE R2 Y R3 ES H, EL OTRO ES UN GRUPO a, b; n ES 3-4; R4 ES ALQUILO C1-C4 SUSTITUIDO CON OH. SON COMPUESTOS PREFERIDOS 1-4-{4-[(2-{(E)-2-[4-(TRIFLUOROMETIL)FENIL]ETENIL}-1,3-OXAZOL-4-IL)METOXI]FENIL}BUTIL)-1H-1,2,3-TRIAZOL; 1-(3-{3-[(2-{(E)-2-[4-(TRIFLUOROMETIL)FENIL]ETENIL}-1,3-OXAZOL-4-IL)METOXI]FENIL)PROPIL)-1H-1,2,3-TRIAZOL; 3-1-{4-[4-({2-[(E)-2-(2,4-DIFLUOROFENIL)ETENIL]-1,3-OXAZOL-4-IL}METOXI)FENIL]BUTIL)-1H-IMIDAZOL-2-IL)-1,2-PROPANDIOL. TAMBIEN SE REFIERE A UN METODO PARA LA PREPARACION; A UN COMPUESTO ESPECIFICO DE FORMULA II; A UNA COMPOSICION QUE COMPRENDE ADEMAS OTROS AGENTES ANTICANCER O AGENTES TERAPEUTICOS HORMONALES (MODULADOR-DEMODULADOR DE LH-RH TAL COMO LEUPRORELINA). EL COMPUESTO ES UN INHIBIDOR DE TIROSINQUINASA Y PUEDE SER UTIL PARA PREVENIR O TRATAR CANCER DE PECHO, PROSTATA
PE2001000307A 2000-04-07 2001-04-03 Compuestos heterociclicos y su produccion PE20011178A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000106836 2000-04-07

Publications (1)

Publication Number Publication Date
PE20011178A1 true PE20011178A1 (es) 2001-11-19

Family

ID=18619943

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000307A PE20011178A1 (es) 2000-04-07 2001-04-03 Compuestos heterociclicos y su produccion

Country Status (19)

Country Link
US (2) US6716863B2 (es)
EP (1) EP1268473A1 (es)
KR (1) KR20020028865A (es)
CN (1) CN1444582A (es)
AU (1) AU2001244726A1 (es)
BR (1) BR0109851A (es)
CA (1) CA2404760A1 (es)
CO (1) CO5261589A1 (es)
CZ (1) CZ20023264A3 (es)
EE (1) EE200200576A (es)
HU (1) HUP0300434A3 (es)
IL (1) IL152115A0 (es)
MX (1) MXPA02009621A (es)
NO (1) NO20024742L (es)
OA (1) OA12244A (es)
PE (1) PE20011178A1 (es)
PL (1) PL365787A1 (es)
SK (1) SK14132002A3 (es)
WO (1) WO2001077107A1 (es)

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CN1322139A (zh) * 1998-10-08 2001-11-14 武田药品工业株式会社 阻滞激素依赖性癌症向激素非依赖性癌症转化的药物
AU2001271058A1 (en) * 2000-07-19 2002-01-30 Takeda Chemical Industries Ltd. Method for producing 1-substituted-1,2,3-triazole derivative
CA2444727A1 (en) * 2001-04-25 2002-11-07 Takeda Chemical Industries, Ltd. Agents for preventing postoperative recurrence of premenopausal breast cancer
US20040138160A1 (en) * 2001-04-27 2004-07-15 Kenichiro Naito Preventive/therapeutic method for cancer
US20040116330A1 (en) * 2001-04-27 2004-06-17 Kenichiro Naito Preventive/therapeutic method for cancer
ATE498408T1 (de) * 2001-08-10 2011-03-15 Takeda Pharmaceutical Gnrh-agonistische kombinationsmittel
WO2003031442A1 (en) * 2001-10-05 2003-04-17 Takeda Chemical Industries, Ltd. Heterocyclic compounds, oxazole derivatives, process for preparation of the same and use thereof
CA2466659A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticancer agents
EP1460067A4 (en) * 2001-11-26 2005-12-07 Takeda Pharmaceutical BICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE
AU2003203170A1 (en) * 2002-01-17 2003-07-30 Takeda Chemical Industries, Ltd. Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof
AU2003231098A1 (en) 2002-04-25 2003-11-10 University Of Connecticut Health Center Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
CN100339078C (zh) * 2002-12-16 2007-09-26 橘生药品工业株式会社 固体口服剂型药物
TW200505913A (en) * 2003-03-28 2005-02-16 Hoffmann La Roche Novel oxazole derivatives, their manufacture and use as pharmaceutical agents
TW200423931A (en) * 2003-04-30 2004-11-16 Hoffmann La Roche Novel aniline derivatives, their manufacture and use as pharmaceutical agents
US7247649B2 (en) * 2003-08-13 2007-07-24 Hoffmann-La Roche Inc. Oxazoles, their manufacture and use as pharmaceutical agents
US7259262B2 (en) * 2003-10-24 2007-08-21 Hoffmann-La Roche Inc. Arylazole derivatives, their manufacture and use as pharmaceutical agents
US20050186275A1 (en) * 2004-02-23 2005-08-25 Standard Chem. & Pharm. Co. Ltd. Sustained release tamsulosin formulations
TW200612914A (en) * 2004-03-05 2006-05-01 Hoffmann La Roche Novel oxidized thioether derivatives, their manufacture and use as pharmaceutical agents
TW200531688A (en) 2004-03-05 2005-10-01 Hoffmann La Roche Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents
TW200533346A (en) * 2004-03-18 2005-10-16 Hoffmann La Roche Novel ether derivatives, their manufacture and use as pharmaceutical agents
EP1758897A1 (en) 2004-04-02 2007-03-07 F.Hoffmann-La Roche Ag Novel diazine derivatives, their manufacture and use as pharmaceutical agents
US7005526B2 (en) * 2004-05-25 2006-02-28 Hoffmann-La Roche Inc. Thioether derivatives
US7163953B2 (en) * 2004-05-25 2007-01-16 Hoffmann-La Roche Inc. Benzylether derivatives
US7618769B2 (en) * 2004-06-07 2009-11-17 Applied Materials, Inc. Textured chamber surface
US7288557B2 (en) 2004-09-21 2007-10-30 Hoffmann-La Roche Inc. Triazole derivatives
TW200616951A (en) 2004-09-22 2006-06-01 Hoffmann La Roche Indole derivatives, their manufacture and use as pharmaceutial agents
AR050652A1 (es) * 2004-09-24 2006-11-08 Hoffmann La Roche Derivados de oxazol, preparacion y uso como inhibidores de la tirosina quinasa
US20060116407A1 (en) * 2004-11-22 2006-06-01 Birgit Bossenmaier Amide derivatives
TW200727900A (en) * 2005-07-27 2007-08-01 Yakult Honsha Kk Aqueous solution preparation containing camptothecins
US7429605B2 (en) * 2005-08-04 2008-09-30 Hoffmann-La Roche Inc. Phenylpyridine derivatives
WO2007017222A1 (en) * 2005-08-08 2007-02-15 F. Hoffmann-La Roche Ag Pyrazole derivatives, their manufacture and their use as pharmaceutical agents
JP2009509998A (ja) * 2005-09-30 2009-03-12 エフ．ホフマン−ラ ロシュ アーゲー ジアジンアゾール誘導体、それらの製造及び薬剤としての使用
WO2008034579A1 (en) * 2006-09-20 2008-03-27 F. Hoffmann-La Roche Ag 2-heterocyclyl-5-phenoxymethylpyridine derivatives as anticancer agents
CN101611041A (zh) 2006-12-12 2009-12-23 武田药品工业株式会社 稠合杂环化合物
EP2140883B1 (en) 2007-04-20 2012-10-31 Daido Chemical Corporation Novel base for dry solid dispersion, solid dispersion containing the base, and composition containing the dispersion
WO2009113560A1 (ja) 2008-03-12 2009-09-17 武田薬品工業株式会社 縮合複素環化合物
TW201016703A (en) * 2008-09-26 2010-05-01 Takeda Pharmaceutical Prevention and treatment of cancer with LKB1 non-expression (deletion or mutation)
TW201016704A (en) * 2008-09-26 2010-05-01 Takeda Pharmaceutical Prevention and treatment of cancer with RAS gene mutation
WO2011039952A1 (ja) 2009-09-30 2011-04-07 株式会社サンギ 難溶性物質の水溶解性改善方法
JP5705206B2 (ja) 2010-02-26 2015-04-22 日新化成株式会社 硬カプセルおよびその製造方法
US9265739B2 (en) 2010-06-02 2016-02-23 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to HER2/neu receptor complex
WO2011153049A1 (en) 2010-06-02 2011-12-08 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to her2/neu receptor complex
JP5909796B2 (ja) 2012-03-02 2016-04-27 株式会社サンギ 難溶性物質の水溶解性改善方法
EP2902014B1 (en) 2012-09-26 2019-03-06 Takeda Pharmaceutical Company Limited Process for producing solid particles
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
EP3795609B1 (en) 2015-07-01 2024-04-03 California Institute of Technology Cationic mucic acid polymer-based delivery systems
EP3238711B1 (en) 2016-04-26 2023-07-12 Mitsubishi Chemical Corporation Base for solid dispersion, production method for solid dispersion using same, and solid dispersion
CA2995617A1 (en) * 2017-11-03 2019-05-03 Universite De Montreal Heterocyclic mitochondrial activity inhibitors and uses thereof
US20190381188A1 (en) 2018-06-13 2019-12-19 California Institute Of Technology Nanoparticles For Crossing The Blood Brain Barrier And Methods Of Treatment Using The Same
JPWO2020130125A1 (ja) 2018-12-21 2021-11-04 第一三共株式会社 抗体−薬物コンジュゲートとキナーゼ阻害剤の組み合わせ
JP7769388B2 (ja) 2019-12-12 2025-11-13 ティン セラピューティクス，インコーポレイテッド 聴覚損失の予防及び治療のための組成物及び方法
CN114217025B (zh) * 2021-12-17 2024-01-23 哈尔滨工业大学 评估空气质量浓度预测中气象数据对其影响的分析方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2080581A1 (en) 1990-04-16 1991-10-17 Alfred P. Spada Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit egf receptor tyrosine kinase
US6211215B1 (en) * 1996-07-19 2001-04-03 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use

Also Published As

Publication number Publication date
SK14132002A3 (sk) 2003-04-01
WO2001077107A1 (en) 2001-10-18
OA12244A (en) 2006-05-10
NO20024742L (no) 2002-11-25
PL365787A1 (en) 2005-01-10
US6716863B2 (en) 2004-04-06
HUP0300434A2 (hu) 2003-06-28
CN1444582A (zh) 2003-09-24
CA2404760A1 (en) 2001-10-18
AU2001244726A1 (en) 2001-10-23
WO2001077107A8 (en) 2003-02-13
NO20024742D0 (no) 2002-10-02
EE200200576A (et) 2004-06-15
MXPA02009621A (es) 2003-05-14
KR20020028865A (ko) 2002-04-17
WO2001077107B1 (en) 2001-12-20
EP1268473A1 (en) 2003-01-02
HUP0300434A3 (en) 2004-11-29
CZ20023264A3 (cs) 2003-02-12
BR0109851A (pt) 2003-06-03
CO5261589A1 (es) 2003-03-31
IL152115A0 (en) 2003-05-29
US20020173526A1 (en) 2002-11-21
US20040024035A1 (en) 2004-02-05

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