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EE200200576A - Oksasooli derivaadid ja nende kasutamine türosiini kinaasi inhibiitoritena - Google Patents

Oksasooli derivaadid ja nende kasutamine türosiini kinaasi inhibiitoritena

Info

Publication number
EE200200576A
EE200200576A EEP200200576A EEP200200576A EE200200576A EE 200200576 A EE200200576 A EE 200200576A EE P200200576 A EEP200200576 A EE P200200576A EE P200200576 A EEP200200576 A EE P200200576A EE 200200576 A EE200200576 A EE 200200576A
Authority
EE
Estonia
Prior art keywords
tyrosine kinase
kinase inhibitors
oxazole derivatives
oxazole
derivatives
Prior art date
Application number
EEP200200576A
Other languages
English (en)
Inventor
Tasaka Akihiro
Hitaka Takenori
Matsutani Etsuya
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of EE200200576A publication Critical patent/EE200200576A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EEP200200576A 2000-04-07 2001-04-05 Oksasooli derivaadid ja nende kasutamine türosiini kinaasi inhibiitoritena EE200200576A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000106836 2000-04-07
PCT/JP2001/002937 WO2001077107A1 (en) 2000-04-07 2001-04-05 Oxazole derivatives and their uses as tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
EE200200576A true EE200200576A (et) 2004-06-15

Family

ID=18619943

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200576A EE200200576A (et) 2000-04-07 2001-04-05 Oksasooli derivaadid ja nende kasutamine türosiini kinaasi inhibiitoritena

Country Status (19)

Country Link
US (2) US6716863B2 (et)
EP (1) EP1268473A1 (et)
KR (1) KR20020028865A (et)
CN (1) CN1444582A (et)
AU (1) AU2001244726A1 (et)
BR (1) BR0109851A (et)
CA (1) CA2404760A1 (et)
CO (1) CO5261589A1 (et)
CZ (1) CZ20023264A3 (et)
EE (1) EE200200576A (et)
HU (1) HUP0300434A3 (et)
IL (1) IL152115A0 (et)
MX (1) MXPA02009621A (et)
NO (1) NO20024742L (et)
OA (1) OA12244A (et)
PE (1) PE20011178A1 (et)
PL (1) PL365787A1 (et)
SK (1) SK14132002A3 (et)
WO (1) WO2001077107A1 (et)

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CA2415961A1 (en) * 2000-07-19 2002-01-24 Hirohiko Nishiyama Production method of 1-substituted-1,2,3-triazole derivatives
CA2444727A1 (en) * 2001-04-25 2002-11-07 Takeda Chemical Industries, Ltd. Agents for preventing postoperative recurrence of premenopausal breast cancer
WO2002087619A1 (en) * 2001-04-27 2002-11-07 Takeda Chemical Industries, Ltd. Preventive/therapeutic method for cancer
WO2002087618A1 (en) * 2001-04-27 2002-11-07 Takeda Chemical Industries, Ltd. Preventive/therapeutic method for cancer
JP2003137814A (ja) * 2001-08-10 2003-05-14 Takeda Chem Ind Ltd ＧｎＲＨアゴニストの併用剤
WO2003031442A1 (en) * 2001-10-05 2003-04-17 Takeda Chemical Industries, Ltd. Heterocyclic compounds, oxazole derivatives, process for preparation of the same and use thereof
EP1444988A4 (en) 2001-11-13 2007-04-25 Takeda Pharmaceutical CANCER AGENT
EP1460067A4 (en) * 2001-11-26 2005-12-07 Takeda Pharmaceutical BICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE
AU2003203170A1 (en) * 2002-01-17 2003-07-30 Takeda Chemical Industries, Ltd. Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof
AU2003231098A1 (en) 2002-04-25 2003-11-10 University Of Connecticut Health Center Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
RS58025B1 (sr) * 2002-12-16 2019-02-28 Kissei Pharmaceutical Co Ltd Lekovi u čvrstom stanju za oralnu upotrebu
TW200505913A (en) * 2003-03-28 2005-02-16 Hoffmann La Roche Novel oxazole derivatives, their manufacture and use as pharmaceutical agents
TW200423931A (en) 2003-04-30 2004-11-16 Hoffmann La Roche Novel aniline derivatives, their manufacture and use as pharmaceutical agents
US7247649B2 (en) 2003-08-13 2007-07-24 Hoffmann-La Roche Inc. Oxazoles, their manufacture and use as pharmaceutical agents
US7259262B2 (en) * 2003-10-24 2007-08-21 Hoffmann-La Roche Inc. Arylazole derivatives, their manufacture and use as pharmaceutical agents
US20050186275A1 (en) * 2004-02-23 2005-08-25 Standard Chem. & Pharm. Co. Ltd. Sustained release tamsulosin formulations
TW200531688A (en) 2004-03-05 2005-10-01 Hoffmann La Roche Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents
TW200612914A (en) 2004-03-05 2006-05-01 Hoffmann La Roche Novel oxidized thioether derivatives, their manufacture and use as pharmaceutical agents
TW200533346A (en) 2004-03-18 2005-10-16 Hoffmann La Roche Novel ether derivatives, their manufacture and use as pharmaceutical agents
CA2561206A1 (en) * 2004-04-02 2005-10-20 F. Hoffmann-La Roche Ag Novel diazine derivatives, their manufacture and use as pharmaceutical agents
US7005526B2 (en) 2004-05-25 2006-02-28 Hoffmann-La Roche Inc. Thioether derivatives
US7163953B2 (en) 2004-05-25 2007-01-16 Hoffmann-La Roche Inc. Benzylether derivatives
US7618769B2 (en) * 2004-06-07 2009-11-17 Applied Materials, Inc. Textured chamber surface
US7288557B2 (en) 2004-09-21 2007-10-30 Hoffmann-La Roche Inc. Triazole derivatives
TW200616951A (en) * 2004-09-22 2006-06-01 Hoffmann La Roche Indole derivatives, their manufacture and use as pharmaceutial agents
AR050652A1 (es) * 2004-09-24 2006-11-08 Hoffmann La Roche Derivados de oxazol, preparacion y uso como inhibidores de la tirosina quinasa
US20060116407A1 (en) * 2004-11-22 2006-06-01 Birgit Bossenmaier Amide derivatives
TW200727900A (en) * 2005-07-27 2007-08-01 Yakult Honsha Kk Aqueous solution preparation containing camptothecins
US7429605B2 (en) * 2005-08-04 2008-09-30 Hoffmann-La Roche Inc. Phenylpyridine derivatives
CN101208335A (zh) * 2005-08-08 2008-06-25 霍夫曼-拉罗奇有限公司 吡唑衍生物，它们的制备和作为药剂的应用
EP1934210A1 (en) * 2005-09-30 2008-06-25 F.Hoffmann-La Roche Ag Diazine azole derivatives, their manufacture and use as pharmaceutical agents
WO2008034579A1 (en) * 2006-09-20 2008-03-27 F. Hoffmann-La Roche Ag 2-heterocyclyl-5-phenoxymethylpyridine derivatives as anticancer agents
RU2009126576A (ru) 2006-12-12 2011-01-20 Такеда Фармасьютикал Компани Лимитед (Jp) Конденсированное гетероциклическое соединение
JP5328643B2 (ja) 2007-04-20 2013-10-30 大同化成工業株式会社 新規乾式固体分散体用基剤、該基剤を含有する固体分散体及び該分散体を含有する組成物
WO2009113560A1 (ja) 2008-03-12 2009-09-17 武田薬品工業株式会社 縮合複素環化合物
WO2010036928A1 (en) * 2008-09-26 2010-04-01 Takeda Pharmaceutical Company Limited Prevention and treatment of cancer with lkb1 non-expression (deletion or mutation)
WO2010036917A1 (en) * 2008-09-26 2010-04-01 Takeda Pharmaceutical Company Limited Prevention and treatment of cancer with ras gene mutation
JP5663750B2 (ja) 2009-09-30 2015-02-04 株式会社サンギ 難溶性物質の水溶解性改善方法
JP5705206B2 (ja) 2010-02-26 2015-04-22 日新化成株式会社 硬カプセルおよびその製造方法
US9265739B2 (en) 2010-06-02 2016-02-23 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to HER2/neu receptor complex
WO2011153049A1 (en) 2010-06-02 2011-12-08 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to her2/neu receptor complex
JP5909796B2 (ja) 2012-03-02 2016-04-27 株式会社サンギ 難溶性物質の水溶解性改善方法
US9364438B2 (en) 2012-09-26 2016-06-14 Takeda Pharmaceutical Company Limited Process for producing solid particles
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
ES2882255T3 (es) 2015-07-01 2021-12-01 California Inst Of Techn Sistemas de administración basados en polímeros de ácido múcico catiónicos
EP3238711B1 (en) 2016-04-26 2023-07-12 Mitsubishi Chemical Corporation Base for solid dispersion, production method for solid dispersion using same, and solid dispersion
CA2995617A1 (en) * 2017-11-03 2019-05-03 Universite De Montreal Heterocyclic mitochondrial activity inhibitors and uses thereof
US20190381188A1 (en) 2018-06-13 2019-12-19 California Institute Of Technology Nanoparticles For Crossing The Blood Brain Barrier And Methods Of Treatment Using The Same
BR112021011894A2 (pt) 2018-12-21 2021-09-08 Daiichi Sankyo Company, Limited Composição farmacêutica
EP4073102A4 (en) 2019-12-12 2024-05-08 Ting Therapeutics LLC Compositions and methods for the prevention and treatment of hearing loss
CN114217025B (zh) * 2021-12-17 2024-01-23 哈尔滨工业大学 评估空气质量浓度预测中气象数据对其影响的分析方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05506857A (ja) * 1990-04-16 1993-10-07 ローヌ―プーラン　ローラー　インターナショナル　（ホウルディングス）インコーポレイテッド Ｅｇｆレセプタチロシンキナーゼを阻害するスチリル―置換単環式および二環式複素アリール化合物
ATE338754T1 (de) * 1996-07-19 2006-09-15 Takeda Pharmaceutical Heterocyclische verbindungen, ihre herstellung und verwendung

Also Published As

Publication number Publication date
WO2001077107A8 (en) 2003-02-13
KR20020028865A (ko) 2002-04-17
SK14132002A3 (sk) 2003-04-01
HUP0300434A3 (en) 2004-11-29
EP1268473A1 (en) 2003-01-02
US20040024035A1 (en) 2004-02-05
NO20024742L (no) 2002-11-25
WO2001077107B1 (en) 2001-12-20
WO2001077107A1 (en) 2001-10-18
CN1444582A (zh) 2003-09-24
AU2001244726A1 (en) 2001-10-23
HUP0300434A2 (hu) 2003-06-28
CA2404760A1 (en) 2001-10-18
MXPA02009621A (es) 2003-05-14
CO5261589A1 (es) 2003-03-31
US20020173526A1 (en) 2002-11-21
NO20024742D0 (no) 2002-10-02
IL152115A0 (en) 2003-05-29
OA12244A (en) 2006-05-10
CZ20023264A3 (cs) 2003-02-12
BR0109851A (pt) 2003-06-03
US6716863B2 (en) 2004-04-06
PE20011178A1 (es) 2001-11-19
PL365787A1 (en) 2005-01-10

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