PE20010068A1 - Compuestos derivados de piperidina como inhibidores de renina - Google Patents
Compuestos derivados de piperidina como inhibidores de reninaInfo
- Publication number
- PE20010068A1 PE20010068A1 PE2000000377A PE0003772000A PE20010068A1 PE 20010068 A1 PE20010068 A1 PE 20010068A1 PE 2000000377 A PE2000000377 A PE 2000000377A PE 0003772000 A PE0003772000 A PE 0003772000A PE 20010068 A1 PE20010068 A1 PE 20010068A1
- Authority
- PE
- Peru
- Prior art keywords
- piperidine
- phenyl
- compounds
- iloximethyl
- propoxi
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000002461 renin inhibitor Substances 0.000 title 1
- 229940086526 renin-inhibitors Drugs 0.000 title 1
- -1 1,1,1-TRIFLUOROETHYL Chemical group 0.000 abstract 5
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical group [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010061216 Infarction Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000007574 infarction Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIPERIDINA DE FORMULA I, DONDE:M R1 ES -(CH2)k-N(R3,R4), -(CH2)k-O-R3, -(CH2)m-R5, -(CH2)l-R6; k ES 2-4; m ES 1-2; l ES 1-3; R2 ES CICLOALQUILALQUILO, 1,1,1-TRIFLUOROETILO, FENILO, BENCILO OPCIONALMENTE SUSTITUIDO CON 1-3 HALOGENO, CIANO, ALCOXILO C1-C3, NITRO; R3 ES H, ALQUILO C1-C3; R4 ES H, ALQUILO C1-C3, ALQUILSULFONILO C1-C3, AMINOSULFONILO, ALQUILAMINOSULFONILO C1-C3, ALQUILAMINOCARBONILO C1-C3, ENTRE OTROS; R5 ES ALCOXICARBONILO C1-C3, AMINOCARBONILO, ALQUILAMINOCARBONILO C1-C3, DIALQUILAMINOCARBONILO C1-C3, CIANO; R6 ES IMIDAZOLILO, TRIAZOLILO; CON LA CONDICION QUE SI EL IMIDAZOLILO O TRIAZOLILO ESTA UNIDO VIA UN ENLACE C-N, l ES 2-3. SON COMPUESTOS PREFERIDOS (3R,4R)-N-[2-[7-[4-[4-[3-(2-METOXI-BENCILOXI)-PROPOXI]-FENIL]-PIPERIDIN-3-ILOXIMETIL]-3,4-DIHIDRO-2H-QUINOLIN-1-IL]-ETIL]-ACETAMIDA; (3R,4R)-3-[7-[4-[4-[3-(2-METOXI-BENCILOXI)-PROPOXI]-FENIL]-PIPERIDIN-3-ILOXIMETIL]-3,4-DIHIDRO-2H-QUINOLIN-1-IL]-PROPAN-1-OL, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS DERIVADOS DE PIPERIDINA SON INHIBIDORES DE LA ENZIMA RENINA POR LO QUE PUEDEN SER UTILES EN EL TRAMIENTO DE ENFERMEDADES COMO RESTENOSIS, GLAUCOMA, INFARTO CARDIACO, HIPERTENSION, INSUFICIENCIA RENAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99108200 | 1999-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010068A1 true PE20010068A1 (es) | 2001-01-29 |
Family
ID=8238051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000377A PE20010068A1 (es) | 1999-04-27 | 2000-04-24 | Compuestos derivados de piperidina como inhibidores de renina |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6197959B1 (es) |
| EP (1) | EP1180103B1 (es) |
| JP (1) | JP3602449B2 (es) |
| KR (1) | KR100476916B1 (es) |
| CN (1) | CN1323079C (es) |
| AR (1) | AR018717A1 (es) |
| AT (1) | ATE363478T1 (es) |
| AU (1) | AU761392B2 (es) |
| BR (1) | BR0010076A (es) |
| CA (1) | CA2370244C (es) |
| CO (1) | CO5170512A1 (es) |
| CZ (1) | CZ20013737A3 (es) |
| DE (1) | DE60035039T2 (es) |
| ES (1) | ES2286021T3 (es) |
| HU (1) | HUP0200881A3 (es) |
| MX (1) | MXPA01010855A (es) |
| PE (1) | PE20010068A1 (es) |
| PL (1) | PL362903A1 (es) |
| SK (1) | SK15172001A3 (es) |
| TR (1) | TR200103067T2 (es) |
| WO (1) | WO2000064887A1 (es) |
| ZA (1) | ZA200108739B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040214832A1 (en) * | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
| TW200900399A (en) * | 2003-10-01 | 2009-01-01 | Speedel Experimenta Ag | Organic compounds |
| AR045950A1 (es) * | 2003-10-09 | 2005-11-16 | Speedel Experimenta Ag | Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos. |
| WO2005051911A1 (en) | 2003-11-26 | 2005-06-09 | Novartis Ag | 4-phenylpiperidine derivatives as renin inhibitors |
| TW200613274A (en) * | 2004-07-09 | 2006-05-01 | Speedel Experimenta Ag | Organic compounds |
| ATE551052T1 (de) | 2004-10-08 | 2012-04-15 | Novartis Ag | Verwendung von reninhemmern zur prävention oder behandlung von diastolischer dysfunktion oder diastolischer herzinsuffizienz |
| GB0428526D0 (en) * | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
| GB0500784D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| CN101151262B (zh) * | 2005-03-31 | 2011-07-06 | 斯皮德尔实验股份公司 | 取代的哌啶 |
| TW200833687A (en) * | 2005-03-31 | 2008-08-16 | Speedel Experimenta Ag | Substituted piperidines |
| EP1863763A1 (en) * | 2005-03-31 | 2007-12-12 | Speedel Experimenta AG | 3,4,5-substituted piperidines as renin inhibitors |
| EP1707202A1 (de) * | 2005-03-31 | 2006-10-04 | Speedel Experimenta AG | Organische Verbindungen |
| EP1897879A3 (en) * | 2005-03-31 | 2008-06-11 | Speedel Experimenta AG | 2,4,5-substituted piperidines as renin inhibitors |
| GB0508992D0 (en) * | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
| EP1885718B1 (en) * | 2005-05-11 | 2017-03-15 | Life Technologies Corporation | Fluorescent chemical compounds having high selectivity for double stranded dna, and methods for their use |
| GEP20115206B (en) | 2005-05-27 | 2011-04-26 | Actelion Pharmaceuticals Ltd | Novel piperidine carboxylic acid amide derivatives |
| GB0514203D0 (en) * | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| AU2006332124B2 (en) * | 2005-12-30 | 2011-03-03 | Novartis Ag | 3 , 5-substitgammaued piperidine compounds as renin inhibitors |
| TW200804359A (en) * | 2006-01-19 | 2008-01-16 | Speedel Experimenta Ag | Substituted 4-phenylpiperidines |
| EP1908761A1 (en) * | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Organic compounds |
| NZ582098A (en) | 2007-06-25 | 2012-03-30 | Novartis Ag | N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
| CA2699889A1 (en) * | 2007-11-02 | 2009-05-07 | Novartis Ag | 4,4-disubstituted piperdines |
| SG175877A1 (en) * | 2009-05-04 | 2011-12-29 | Plexxikon Inc | Compounds and methods for inhibition of renin, and indications therefor |
| WO2013045505A1 (en) | 2011-09-28 | 2013-04-04 | Novartis Ag | Biomarkers for raas combination therapy |
| EP2810644A1 (en) | 2013-06-06 | 2014-12-10 | Ferrer Internacional, S.A. | Oral formulation for the treatment of cardiovascular diseases |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100384979B1 (ko) * | 1995-09-07 | 2003-10-17 | 에프. 호프만-라 로슈 아게 | 심부전증및신부전증치료용의신규한4-(옥시알콕시페닐)-3-옥시-피페리딘 |
-
2000
- 2000-04-04 US US09/542,598 patent/US6197959B1/en not_active Expired - Fee Related
- 2000-04-20 CA CA002370244A patent/CA2370244C/en not_active Expired - Fee Related
- 2000-04-20 TR TR2001/03067T patent/TR200103067T2/xx unknown
- 2000-04-20 DE DE60035039T patent/DE60035039T2/de not_active Expired - Fee Related
- 2000-04-20 CZ CZ20013737A patent/CZ20013737A3/cs unknown
- 2000-04-20 AU AU47501/00A patent/AU761392B2/en not_active Ceased
- 2000-04-20 AT AT00929401T patent/ATE363478T1/de not_active IP Right Cessation
- 2000-04-20 KR KR10-2001-7013726A patent/KR100476916B1/ko not_active Expired - Fee Related
- 2000-04-20 PL PL00362903A patent/PL362903A1/xx unknown
- 2000-04-20 CN CNB008067988A patent/CN1323079C/zh not_active Expired - Fee Related
- 2000-04-20 WO PCT/EP2000/003597 patent/WO2000064887A1/en not_active Ceased
- 2000-04-20 SK SK1517-2001A patent/SK15172001A3/sk unknown
- 2000-04-20 BR BR0010076-5A patent/BR0010076A/pt not_active IP Right Cessation
- 2000-04-20 JP JP2000614239A patent/JP3602449B2/ja not_active Expired - Fee Related
- 2000-04-20 HU HU0200881A patent/HUP0200881A3/hu unknown
- 2000-04-20 MX MXPA01010855A patent/MXPA01010855A/es active IP Right Grant
- 2000-04-20 EP EP00929401A patent/EP1180103B1/en not_active Expired - Lifetime
- 2000-04-20 ES ES00929401T patent/ES2286021T3/es not_active Expired - Lifetime
- 2000-04-24 PE PE2000000377A patent/PE20010068A1/es not_active Application Discontinuation
- 2000-04-25 CO CO00029684A patent/CO5170512A1/es not_active Application Discontinuation
- 2000-04-25 AR ARP000101933A patent/AR018717A1/es active IP Right Grant
-
2001
- 2001-10-23 ZA ZA200108739A patent/ZA200108739B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2370244A1 (en) | 2000-11-02 |
| PL362903A1 (en) | 2004-11-02 |
| MXPA01010855A (es) | 2002-05-06 |
| DE60035039T2 (de) | 2008-02-07 |
| BR0010076A (pt) | 2002-01-15 |
| AU761392B2 (en) | 2003-06-05 |
| ATE363478T1 (de) | 2007-06-15 |
| JP3602449B2 (ja) | 2004-12-15 |
| DE60035039D1 (de) | 2007-07-12 |
| EP1180103A1 (en) | 2002-02-20 |
| AR018717A1 (es) | 2001-11-28 |
| HUP0200881A2 (en) | 2002-08-28 |
| CN1349524A (zh) | 2002-05-15 |
| TR200103067T2 (tr) | 2002-05-21 |
| ES2286021T3 (es) | 2007-12-01 |
| AU4750100A (en) | 2000-11-10 |
| EP1180103B1 (en) | 2007-05-30 |
| ZA200108739B (en) | 2003-01-23 |
| KR20020005017A (ko) | 2002-01-16 |
| HUP0200881A3 (en) | 2003-05-28 |
| CN1323079C (zh) | 2007-06-27 |
| US6197959B1 (en) | 2001-03-06 |
| WO2000064887A1 (en) | 2000-11-02 |
| CA2370244C (en) | 2007-03-27 |
| JP2002543072A (ja) | 2002-12-17 |
| CO5170512A1 (es) | 2002-06-27 |
| KR100476916B1 (ko) | 2005-03-17 |
| SK15172001A3 (sk) | 2002-06-04 |
| CZ20013737A3 (cs) | 2002-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |