FI905481A0 - Substituerade n-(imidazolyl) -alkylalaninderivat. - Google Patents
Substituerade n-(imidazolyl) -alkylalaninderivat.Info
- Publication number
- FI905481A0 FI905481A0 FI905481A FI905481A FI905481A0 FI 905481 A0 FI905481 A0 FI 905481A0 FI 905481 A FI905481 A FI 905481A FI 905481 A FI905481 A FI 905481A FI 905481 A0 FI905481 A0 FI 905481A0
- Authority
- FI
- Finland
- Prior art keywords
- alkylalaninderderat
- substituerade
- imidazolyl
- angiotensin
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43211189A | 1989-11-06 | 1989-11-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI905481A0 true FI905481A0 (fi) | 1990-11-05 |
| FI905481A7 FI905481A7 (fi) | 1991-05-07 |
Family
ID=23714819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI905481A FI905481A7 (fi) | 1989-11-06 | 1990-11-05 | Substituoituja N-(imidatsolyyli)-alkyylialaniinijohdannaisia |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0427463B1 (fi) |
| JP (1) | JPH03169866A (fi) |
| KR (1) | KR910009669A (fi) |
| CN (1) | CN1051555A (fi) |
| AT (1) | ATE119524T1 (fi) |
| AU (1) | AU641952B2 (fi) |
| CA (1) | CA2028925A1 (fi) |
| DE (1) | DE69017593T2 (fi) |
| FI (1) | FI905481A7 (fi) |
| HU (1) | HU207851B (fi) |
| IE (1) | IE903976A1 (fi) |
| IL (1) | IL96225A0 (fi) |
| MA (1) | MA22096A1 (fi) |
| MY (1) | MY106159A (fi) |
| NO (1) | NO904799L (fi) |
| NZ (1) | NZ235959A (fi) |
| PL (1) | PL287631A1 (fi) |
| PT (1) | PT95802A (fi) |
| ZA (1) | ZA908843B (fi) |
| ZW (1) | ZW16090A1 (fi) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE122010000024I1 (de) * | 1990-02-19 | 2010-07-08 | Novartis Ag | Acylverbindungen |
| NZ238688A (en) * | 1990-06-28 | 1992-05-26 | Smithkline Beecham Corp | Substituted histidines: pharmaceutical compositions, preparation and uses thereof |
| NZ239161A (en) * | 1990-07-31 | 1994-01-26 | Smithkline Beecham Corp | Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments, |
| GB9110636D0 (en) * | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
| US5364869A (en) * | 1992-03-09 | 1994-11-15 | Abbott Laboratories | Heterocycle-substituted benzyaminopyridine angiotensin II receptor antagonists |
| FR2689508B1 (fr) * | 1992-04-01 | 1994-06-17 | Fournier Ind & Sante | Derives de l'imidazole, leur procede de preparation et leur application en therapeutique. |
| US5728842A (en) * | 1992-06-30 | 1998-03-17 | Smithkline Beecham Corporation | Substituted imidazolyl-alkylthio-alkanoic acids |
| GB9213934D0 (en) * | 1992-06-30 | 1992-08-12 | Smithkline Beecham Corp | Chemical compounds |
| GB9218449D0 (en) | 1992-08-29 | 1992-10-14 | Boots Co Plc | Therapeutic agents |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| WO2008142576A2 (en) | 2007-05-24 | 2008-11-27 | Eldrug S.A. | 1,(3,)5-substituted imidazoles, their use in the treatment of hypertension and methods for their preparation |
| US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US20100216854A1 (en) * | 2007-08-01 | 2010-08-26 | Eldrug S.A. | 1,3 and 1,3,5 substituted imidazoles as antihypertensives |
| GR1006917B (el) * | 2007-10-24 | 2010-07-30 | Ελληνικα Φαρμακα Ερευνα Και Αναπτυξη Eldrug Α.Ε., | Ανταγωνιστες του υποδοχεα της αγγειοτενσινης ιι με βαση την ισταμινη (και παραγωγα αυτης) με ιδιοτητες καταστολης του συμπαθητικου συστηματος και συνθετικες μεθοδοι στη θεραπεια της υπερτασης και αλλων καρδιοαγγειακων ασθενειων. |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| CN105764916B (zh) | 2013-06-05 | 2021-05-18 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5671073A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | Imidazole derivative |
| JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| IL85556A (en) * | 1987-03-05 | 1994-06-24 | May & Baker Ltd | Pesticidal method using 2-phenylimidazole derivatives, some such novel compounds and process for their preparation |
| CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| US4916129A (en) * | 1989-01-19 | 1990-04-10 | E. I. Du Pont De Nemours And Company | Combination β-blocking/angiotensin II blocking antihypertensives |
-
1990
- 1990-10-30 CA CA002028925A patent/CA2028925A1/en not_active Abandoned
- 1990-10-31 AU AU65649/90A patent/AU641952B2/en not_active Ceased
- 1990-11-01 EP EP90311991A patent/EP0427463B1/en not_active Expired - Lifetime
- 1990-11-01 DE DE69017593T patent/DE69017593T2/de not_active Expired - Fee Related
- 1990-11-01 AT AT90311991T patent/ATE119524T1/de not_active IP Right Cessation
- 1990-11-01 MA MA22267A patent/MA22096A1/fr unknown
- 1990-11-02 MY MYPI90001926A patent/MY106159A/en unknown
- 1990-11-02 ZW ZW160/90A patent/ZW16090A1/xx unknown
- 1990-11-02 IL IL96225A patent/IL96225A0/xx unknown
- 1990-11-05 NO NO90904799A patent/NO904799L/no unknown
- 1990-11-05 PL PL28763190A patent/PL287631A1/xx unknown
- 1990-11-05 NZ NZ235959A patent/NZ235959A/xx unknown
- 1990-11-05 ZA ZA908843A patent/ZA908843B/xx unknown
- 1990-11-05 HU HU907025A patent/HU207851B/hu not_active IP Right Cessation
- 1990-11-05 IE IE397690A patent/IE903976A1/en unknown
- 1990-11-05 FI FI905481A patent/FI905481A7/fi not_active IP Right Cessation
- 1990-11-06 KR KR1019900017998A patent/KR910009669A/ko not_active Withdrawn
- 1990-11-06 JP JP2302307A patent/JPH03169866A/ja active Pending
- 1990-11-06 PT PT95802A patent/PT95802A/pt unknown
- 1990-11-06 CN CN90108945A patent/CN1051555A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03169866A (ja) | 1991-07-23 |
| AU641952B2 (en) | 1993-10-07 |
| DE69017593T2 (de) | 1995-07-20 |
| KR910009669A (ko) | 1991-06-28 |
| AU6564990A (en) | 1991-05-09 |
| ATE119524T1 (de) | 1995-03-15 |
| ZW16090A1 (en) | 1991-02-27 |
| NZ235959A (en) | 1991-09-25 |
| HUT56077A (en) | 1991-07-29 |
| DE69017593D1 (de) | 1995-04-13 |
| CN1051555A (zh) | 1991-05-22 |
| MY106159A (en) | 1995-03-31 |
| IL96225A0 (en) | 1991-08-16 |
| PL287631A1 (en) | 1991-12-16 |
| NO904799D0 (no) | 1990-11-05 |
| EP0427463A1 (en) | 1991-05-15 |
| PT95802A (pt) | 1991-09-13 |
| HU907025D0 (en) | 1991-05-28 |
| HU207851B (en) | 1993-06-28 |
| NO904799L (no) | 1991-05-07 |
| MA22096A1 (fr) | 1991-12-31 |
| FI905481A7 (fi) | 1991-05-07 |
| EP0427463B1 (en) | 1995-03-08 |
| IE903976A1 (en) | 1991-05-08 |
| CA2028925A1 (en) | 1991-05-07 |
| ZA908843B (en) | 1992-01-29 |
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| ES2062403T3 (es) | 5-((tetrazolil)-alquenil)-imidazoles sustituidos. | |
| FI905481A0 (fi) | Substituerade n-(imidazolyl) -alkylalaninderivat. | |
| WO1992020651A3 (en) | N-(heteroaryl)-imidazolyl-alkenoic acids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed | ||
| MM | Patent lapsed |
Owner name: SMITHKLINE BEECHAM CORPORATION |