PE20001114A1 - PIRAZOLOPIRIMIDINONAS INHIBIDORAS DE GMPc PDE5 PARA EL TRATAMIENTO DE LA DISFUNCION SEXUAL - Google Patents
PIRAZOLOPIRIMIDINONAS INHIBIDORAS DE GMPc PDE5 PARA EL TRATAMIENTO DE LA DISFUNCION SEXUALInfo
- Publication number
- PE20001114A1 PE20001114A1 PE1999001063A PE00106399A PE20001114A1 PE 20001114 A1 PE20001114 A1 PE 20001114A1 PE 1999001063 A PE1999001063 A PE 1999001063A PE 00106399 A PE00106399 A PE 00106399A PE 20001114 A1 PE20001114 A1 PE 20001114A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- het
- gmpc
- coor12
- dysfunction
- Prior art date
Links
- 101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 title abstract 2
- 101150098694 PDE5A gene Proteins 0.000 title abstract 2
- 102100029175 cGMP-specific 3',5'-cyclic phosphodiesterase Human genes 0.000 title abstract 2
- 201000001880 Sexual dysfunction Diseases 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 231100000872 sexual dysfunction Toxicity 0.000 title 1
- -1 AZETIDINYL Chemical class 0.000 abstract 3
- 101100134925 Gallus gallus COR6 gene Proteins 0.000 abstract 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000004064 dysfunction Effects 0.000 abstract 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 abstract 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 229940029575 guanosine Drugs 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- DOTPSQVYOBAWPQ-UHFFFAOYSA-N pyrazolo[4,3-d]pyrimidin-3-one Chemical class N1=CN=C2C(=O)N=NC2=C1 DOTPSQVYOBAWPQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A DERIVADOS DE PIRAZOLOPIRIMIDINONAS DE FORMULA IA o IB DONDE, A ES CH o N; R1 ES H, ALQUILO, HET, ALQUILHET, ARILO, ALQUILARILO, OPCIONALMENTE SUTITUIDOS POR HALO, CIANO, NITRO, ALQUILO, OR5, COR6, COOR7, CONR8R9, NR10aR10b, SO2NR11aR11b; R2 ES CONR12R13, COOR12, NR12R13, NHSO2R12, NHSO2NR12R13, NHCOR12, OR12a, ALQUILO OPCIONALMENTE INTERRUMPIDO POR O, S, NR12 U OPCIONALMENTE SUSTITUIDO POR CONR12R13, COOR12, COOR12, ARILO, HET1; R3, R12 Y R13 SON H, ALQUILO OPCIONALMENTE SUSTITUIDO CON ARILO, HET, HALO, CN, NITRO, OR5, COR6, ENTRE OTROS; R4 ES SO2NR14R15; R14 Y R15 JUNTO CON N FORMAN HET;HET ES UN HETEROCICLO DE 4-12 MIEMBROS CON AL MENOS UN N Y UNO O MAS N, O Y S; HET 1 ES UN HETEROCILO DE 4-12 MIEMBROS CON AL MENOS UN N o O Y UNO O MAS N, O, S; R5, R6, R7, R8, R9, R11a, R11b, R12a SON H O ALQUILO; R1Oa Y R10b SON H, ALQUILO O JUNTO A N REPRESENTAN AZETIDINILO, PIRROLIDINILO O PIPERIDINILO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y A COMPUESTOS INTERMEDIOS. LOS COMPUESTOS IA Y IB INHIBEN LA GUANOSINA 3`,5'-MONOFOSFATO CICLICO FOSFODIESTERASAS (GMPc PDE), DE PREFERENCIA GMPc PDE5 POR LO QUE PUEDEN SER UTILES EN EL TRATAMIENTO DE LA DISFUNCION ERECTIL MASCULINA, DISFUNCION SEXUAL FEMENINA, PARTO PREMATURO, DISMENORREA, HIPERPLASIA PROSTATICA BENIGNA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9823102.0A GB9823102D0 (en) | 1998-10-23 | 1998-10-23 | Pharmaceutically active compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001114A1 true PE20001114A1 (es) | 2000-10-28 |
Family
ID=10841068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999001063A PE20001114A1 (es) | 1998-10-23 | 1999-10-21 | PIRAZOLOPIRIMIDINONAS INHIBIDORAS DE GMPc PDE5 PARA EL TRATAMIENTO DE LA DISFUNCION SEXUAL |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6333330B1 (es) |
| GB (1) | GB9823102D0 (es) |
| GT (1) | GT199900183A (es) |
| MA (1) | MA26701A1 (es) |
| PE (1) | PE20001114A1 (es) |
| TN (1) | TNSN99198A1 (es) |
| UY (1) | UY25795A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6627632B2 (en) * | 1998-12-14 | 2003-09-30 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
| US20090257956A1 (en) * | 2002-01-25 | 2009-10-15 | Ramsey Sallis | Treatment Method for Treatment of Erectile Dysfunction and Premature Ejaculation |
| WO2003063776A2 (en) | 2002-01-25 | 2003-08-07 | Modular Properties Ltd | Methods and compositions for treating male erectile dysfunction |
| US20090035221A1 (en) * | 2002-01-25 | 2009-02-05 | Ramsey Sallis | Methods and Compositions for Treatment of Erectile Dysfunction |
| US20050048573A1 (en) * | 2003-02-03 | 2005-03-03 | Plexxikon, Inc. | PDE5A crystal structure and uses |
| US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
| GB0327319D0 (en) * | 2003-11-24 | 2003-12-24 | Pfizer Ltd | Novel pharmaceuticals |
| US7449462B2 (en) | 2004-01-22 | 2008-11-11 | Pfizer, Inc. | Triazole derivatives which inhibit vasopressin antagonistic activity |
| EP1847531A4 (en) * | 2005-02-09 | 2009-04-22 | Takeda Pharmaceutical | PYRAZOLE DERIVATIVE |
| NZ571673A (en) * | 2006-04-04 | 2011-08-26 | Dong A Pharm Co Ltd | A pyrazolopyrimidinone derivative for the prevention and treatment of prostatic hyperplasia |
| TWI867311B (zh) | 2016-09-09 | 2024-12-21 | 美商英塞特公司 | 吡唑并吡啶化合物及其用途 |
| US20180072718A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| WO2018049152A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| US20180228786A1 (en) | 2017-02-15 | 2018-08-16 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| WO2019051199A1 (en) | 2017-09-08 | 2019-03-14 | Incyte Corporation | 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS |
| US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
| US10752635B2 (en) | 2018-02-20 | 2020-08-25 | Incyte Corporation | Indazole compounds and uses thereof |
| PE20210397A1 (es) | 2018-02-20 | 2021-03-02 | Incyte Corp | Derivados de n-(fenil)-2-(fenil)pirimidina-4-carboxamida y compuestos relacionados como inhibidores hpki para tratar el cancer |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| ES2973117T3 (es) | 2018-09-25 | 2024-06-18 | Incyte Corp | Compuestos de pirazolo[4,3-d]pirimidina como moduladores de ALK2 y/o FGFR |
| TWI865579B (zh) | 2019-08-06 | 2024-12-11 | 美商英塞特公司 | Ｈｐｋ１抑制劑之固體形式 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4371843A (en) | 1980-07-07 | 1983-02-01 | Bell Telephone Laboratories, Incorporated | Semiconductor differential amplifier circuit with feedback bias control |
| US4670978A (en) | 1985-01-28 | 1987-06-09 | Amp Incorporated | Connector mounting press |
| US4663326A (en) | 1985-04-04 | 1987-05-05 | Warner-Lambert Company | Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one analogs |
| US4666908A (en) | 1985-04-05 | 1987-05-19 | Warner-Lambert Company | 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use |
| US5075310A (en) | 1988-07-01 | 1991-12-24 | Smith Kline & French Laboratories, Ltd. | Pyrimidone derivatives as bronchodilators |
| GB8817651D0 (en) | 1988-07-25 | 1988-09-01 | Smith Kline French Lab | Chemical compounds |
| GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| US5250534A (en) * | 1990-06-20 | 1993-10-05 | Pfizer Inc. | Pyrazolopyrimidinone antianginal agents |
| GB9114760D0 (en) | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
| GB9119704D0 (en) | 1991-09-14 | 1991-10-30 | Pfizer Ltd | Therapeutic agents |
| GB9121028D0 (en) | 1991-10-03 | 1991-11-13 | Pfizer Ltd | Therapeutic agents |
| GB9126260D0 (en) | 1991-12-11 | 1992-02-12 | Pfizer Ltd | Therapeutic agents |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5294612A (en) | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
| GB9213623D0 (en) | 1992-06-26 | 1992-08-12 | Pfizer Ltd | Therapeutic agents |
| US5734053A (en) | 1992-06-26 | 1998-03-31 | Pfizer Inc | Purinone antianginal agents |
| GB9218322D0 (en) | 1992-08-28 | 1992-10-14 | Pfizer Ltd | Therapeutic agents |
| GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| GB9315017D0 (en) | 1993-07-20 | 1993-09-01 | Glaxo Lab Sa | Chemical compounds |
| GB9423911D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| GB9423910D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| US5656629A (en) | 1995-03-10 | 1997-08-12 | Sanofi Winthrop, Inc. | 6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof |
| EP0813534A4 (en) * | 1995-03-10 | 1998-06-10 | Sanofi Winthrop Inc | 6-ARYL PYRAZOLO 3,4-D] PYRIMIDIN-4-ONES, COMPOSITIONS AND METHODS OF USE THEREOF |
| GB9612514D0 (en) | 1996-06-14 | 1996-08-14 | Pfizer Ltd | Novel process |
| EA002057B1 (ru) | 1997-04-25 | 2001-12-24 | Пфайзер Инк. | ПИРАЗОЛОПИРИМИДИНОНЫ, КОТОРЫЕ ИНГИБИРУЮТ ЦИКЛИЧЕСКИЙ ГУАНОЗИН-3',5'-МОНОФОСФАТ-ФОСФОДИЭСТЕРАЗУ ТИПА 5 (cGMP PDE5), ДЛЯ ЛЕЧЕНИЯ СЕКСУАЛЬНОГО РАССТРОЙСТВА |
| KR100449790B1 (ko) | 1998-04-20 | 2004-09-22 | 화이자 인코포레이티드 | 성기능장애를 치료하기 위한, 유형 5의 환상 구아노신3',5'-모노포스페이트 포스포디에스테라제에 대한피라졸로피리미디논 저해제 |
| US6087368A (en) | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
| GB9823101D0 (en) | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
-
1998
- 1998-10-23 GB GBGB9823102.0A patent/GB9823102D0/en not_active Ceased
-
1999
- 1999-10-20 MA MA25821A patent/MA26701A1/fr unknown
- 1999-10-20 TN TNTNSN99198A patent/TNSN99198A1/fr unknown
- 1999-10-21 PE PE1999001063A patent/PE20001114A1/es not_active Application Discontinuation
- 1999-10-22 GT GT199900183A patent/GT199900183A/es unknown
- 1999-10-22 US US09/426,554 patent/US6333330B1/en not_active Expired - Fee Related
- 1999-11-11 UY UY25795A patent/UY25795A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GT199900183A (es) | 2001-04-14 |
| TNSN99198A1 (fr) | 2005-11-10 |
| GB9823102D0 (en) | 1998-12-16 |
| UY25795A1 (es) | 2000-08-21 |
| US6333330B1 (en) | 2001-12-25 |
| MA26701A1 (fr) | 2004-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |