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TNSN99198A1 - PYRAZOLOPYRIMIDINONES NOUVELLES INHIBITRICES DE PDE-5 GMPc, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT - Google Patents

PYRAZOLOPYRIMIDINONES NOUVELLES INHIBITRICES DE PDE-5 GMPc, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

Info

Publication number
TNSN99198A1
TNSN99198A1 TNTNSN99198A TNSN99198A TNSN99198A1 TN SN99198 A1 TNSN99198 A1 TN SN99198A1 TN TNSN99198 A TNTNSN99198 A TN TNSN99198A TN SN99198 A TNSN99198 A TN SN99198A TN SN99198 A1 TNSN99198 A1 TN SN99198A1
Authority
TN
Tunisia
Prior art keywords
preparation
pyrazolopyrimidinones
pharmaceutical compositions
compositions containing
novel pde
Prior art date
Application number
TNTNSN99198A
Other languages
English (en)
Inventor
Edward Bunnage Mark
Nigel Maw Graham
James Rawson David
Wood Anthony
Paul Mathias John
Derek Albert Street Stephen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN99198A1 publication Critical patent/TNSN99198A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES DE LA FORMULE IA OU IB : DANS LAQUELLE R1, R2, R3, R4 ET A REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION ET DES FORMULATIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET FORMULATIONS PHARMACEUTIQUES, INHIBANT LA PDE-5 GMPc, POUR LE TRAITEMENT OU LA PREVENTION DE DIVERSES MALADIES
TNTNSN99198A 1998-10-23 1999-10-20 PYRAZOLOPYRIMIDINONES NOUVELLES INHIBITRICES DE PDE-5 GMPc, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT TNSN99198A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9823102.0A GB9823102D0 (en) 1998-10-23 1998-10-23 Pharmaceutically active compounds

Publications (1)

Publication Number Publication Date
TNSN99198A1 true TNSN99198A1 (fr) 2005-11-10

Family

ID=10841068

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN99198A TNSN99198A1 (fr) 1998-10-23 1999-10-20 PYRAZOLOPYRIMIDINONES NOUVELLES INHIBITRICES DE PDE-5 GMPc, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

Country Status (7)

Country Link
US (1) US6333330B1 (fr)
GB (1) GB9823102D0 (fr)
GT (1) GT199900183A (fr)
MA (1) MA26701A1 (fr)
PE (1) PE20001114A1 (fr)
TN (1) TNSN99198A1 (fr)
UY (1) UY25795A1 (fr)

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US20090257956A1 (en) * 2002-01-25 2009-10-15 Ramsey Sallis Treatment Method for Treatment of Erectile Dysfunction and Premature Ejaculation
WO2003063776A2 (fr) 2002-01-25 2003-08-07 Modular Properties Ltd Methodes et compositions de traitement de dysfonctionnement erectile
US20090035221A1 (en) * 2002-01-25 2009-02-05 Ramsey Sallis Methods and Compositions for Treatment of Erectile Dysfunction
US20050048573A1 (en) * 2003-02-03 2005-03-03 Plexxikon, Inc. PDE5A crystal structure and uses
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
GB0327319D0 (en) * 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
US7449462B2 (en) 2004-01-22 2008-11-11 Pfizer, Inc. Triazole derivatives which inhibit vasopressin antagonistic activity
EP1847531A4 (fr) * 2005-02-09 2009-04-22 Takeda Pharmaceutical Derive de pyrazole
NZ571673A (en) * 2006-04-04 2011-08-26 Dong A Pharm Co Ltd A pyrazolopyrimidinone derivative for the prevention and treatment of prostatic hyperplasia
TWI867311B (zh) 2016-09-09 2024-12-21 美商英塞特公司 吡唑并吡啶化合物及其用途
US20180072718A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine compounds and uses thereof
WO2018049152A1 (fr) 2016-09-09 2018-03-15 Incyte Corporation Dérivés de pyrazolopyrimidine en tant que modulateurs de hpk1 et leurs utilisations pour le traitement du cancer
US20180228786A1 (en) 2017-02-15 2018-08-16 Incyte Corporation Pyrazolopyridine compounds and uses thereof
WO2019051199A1 (fr) 2017-09-08 2019-03-14 Incyte Corporation Composés de 6-cyano-indazole utilisés en tant que modulateurs de kinase 1 progénitrices hématopoïétiques (hpk1)
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
US10752635B2 (en) 2018-02-20 2020-08-25 Incyte Corporation Indazole compounds and uses thereof
PE20210397A1 (es) 2018-02-20 2021-03-02 Incyte Corp Derivados de n-(fenil)-2-(fenil)pirimidina-4-carboxamida y compuestos relacionados como inhibidores hpki para tratar el cancer
US11299473B2 (en) 2018-04-13 2022-04-12 Incyte Corporation Benzimidazole and indole compounds and uses thereof
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
ES2973117T3 (es) 2018-09-25 2024-06-18 Incyte Corp Compuestos de pirazolo[4,3-d]pirimidina como moduladores de ALK2 y/o FGFR
TWI865579B (zh) 2019-08-06 2024-12-11 美商英塞特公司 Ｈｐｋ１抑制劑之固體形式

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US4663326A (en) 1985-04-04 1987-05-05 Warner-Lambert Company Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one analogs
US4666908A (en) 1985-04-05 1987-05-19 Warner-Lambert Company 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
US5075310A (en) 1988-07-01 1991-12-24 Smith Kline & French Laboratories, Ltd. Pyrimidone derivatives as bronchodilators
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EP0813534A4 (fr) * 1995-03-10 1998-06-10 Sanofi Winthrop Inc 6-aryl pyrazolo 3,4-d]pyrimidin-4-ones, compositions et procedes d'utilisation de ces composes
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EA002057B1 (ru) 1997-04-25 2001-12-24 Пфайзер Инк. ПИРАЗОЛОПИРИМИДИНОНЫ, КОТОРЫЕ ИНГИБИРУЮТ ЦИКЛИЧЕСКИЙ ГУАНОЗИН-3',5'-МОНОФОСФАТ-ФОСФОДИЭСТЕРАЗУ ТИПА 5 (cGMP PDE5), ДЛЯ ЛЕЧЕНИЯ СЕКСУАЛЬНОГО РАССТРОЙСТВА
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US6087368A (en) 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase
GB9823101D0 (en) 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds

Also Published As

Publication number Publication date
GT199900183A (es) 2001-04-14
PE20001114A1 (es) 2000-10-28
GB9823102D0 (en) 1998-12-16
UY25795A1 (es) 2000-08-21
US6333330B1 (en) 2001-12-25
MA26701A1 (fr) 2004-12-20

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