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TNSN99172A1 - 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
TNSN99172A1
TNSN99172A1 TNTNSN99172A TNSN99172A TNSN99172A1 TN SN99172 A1 TNSN99172 A1 TN SN99172A1 TN TNSN99172 A TNTNSN99172 A TN TNSN99172A TN SN99172 A TNSN99172 A TN SN99172A TN SN99172 A1 TNSN99172 A1 TN SN99172A1
Authority
TN
Tunisia
Prior art keywords
preparation
tetrahydroquinoleines
carboxyamino
methyl
pharmaceutical compositions
Prior art date
Application number
TNTNSN99172A
Other languages
English (en)
Inventor
Paul Deninno Michael
James Mularski Christian
Benjamin Ruggeri Roger
Thure Wester Ronald
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN99172A1 publication Critical patent/TNSN99172A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

-L'INVENTION CONCERNE UN COMPOSE DE FORMULE I : DANS LAQUELLE R1, R3, R4, R5, R6, R7 ET R8 REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR SA PREPARATION, ET UNE COMPOSITION PHARMACEUTIQUE LE CONTENANT. APPLICATION : UTILISATION DE CE COMPOSE OU DE CETTE COMPOSITION POUR LE TRAITEMENT DE DIVERSES MALADIES TELLES QUE L'ATHEROSCLEROSE, ET DES MALADIES CARDIO-VASCULAIRES. DANS LAQUELLE R1, R3, R4, R5, R6, R7 ET R8 REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR SA PREPARATION, ET UNE COMPOSITION PHARMACEUTIQUE LE CONTENANT. APPLICATION : UTILISATION DE CE COMPOSE OU DE CETTE COMPOSITION POUR LE TRAITEMENT DE DIVERSES MALADIES TELLES QUE L'ATHEROSCLEROSE, ET DES MALADIES CARDIO-VASCULAIRES. DANS LAQUELLE R1, R3, R4, R5, R6, R7 ET R8 REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR SA PREPARATION, ET UNE COMPOSITION PHARMACEUTIQUE LE CONTENANT. APPLICATION : UTILISATION DE CE COMPOSE OU DE CETTE COMPOSITION POUR LE TRAITEMENT DE DIVERSES MALADIES TELLES QUE L'ATHEROSCLEROSE, ET DES MALADIES CARDIO-VASCULAIRES.
TNTNSN99172A 1998-09-17 1999-09-13 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant TNSN99172A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10092998P 1998-09-17 1998-09-17

Publications (1)

Publication Number Publication Date
TNSN99172A1 true TNSN99172A1 (fr) 2005-11-10

Family

ID=22282259

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN99172A TNSN99172A1 (fr) 1998-09-17 1999-09-13 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (25)

Country Link
US (2) US6147090A (fr)
EP (1) EP1114033B1 (fr)
JP (1) JP3655193B2 (fr)
AR (1) AR021482A1 (fr)
AT (1) ATE277906T1 (fr)
AU (1) AU5439899A (fr)
BR (1) BR9913842A (fr)
CA (1) CA2344556A1 (fr)
CO (1) CO5150220A1 (fr)
DE (1) DE69920727T2 (fr)
DK (1) DK1114033T3 (fr)
DZ (1) DZ2889A1 (fr)
ES (1) ES2228086T3 (fr)
GT (1) GT199900149A (fr)
HN (1) HN1999000155A (fr)
MA (1) MA26687A1 (fr)
MY (1) MY121838A (fr)
PA (1) PA8481501A1 (fr)
PE (1) PE20001048A1 (fr)
PT (1) PT1114033E (fr)
SI (1) SI1114033T1 (fr)
SV (1) SV1999000149A (fr)
TN (1) TNSN99172A1 (fr)
TW (1) TWI232859B (fr)
WO (1) WO2000017166A1 (fr)

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WO2000017166A1 (fr) 2000-03-30
EP1114033A1 (fr) 2001-07-11
HN1999000155A (es) 2000-01-12
JP3655193B2 (ja) 2005-06-02
ATE277906T1 (de) 2004-10-15
BR9913842A (pt) 2001-06-12
DE69920727T2 (de) 2006-03-09
PA8481501A1 (es) 2001-12-14
AR021482A1 (es) 2002-07-24
EP1114033B1 (fr) 2004-09-29
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MY121838A (en) 2006-02-28
SI1114033T1 (en) 2005-02-28
US6147090A (en) 2000-11-14
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