LT3297653T - Postbariatrinės hipoglikemijos gydymas glp-1 antagonistais - Google Patents

Postbariatrinės hipoglikemijos gydymas glp-1 antagonistais

Info

Publication number: LT3297653T
Authority: LT; Lithuania
Prior art keywords: postbariatric; hypoglycaemia; glp; antagonists; treatment
Prior art date: 2015-05-22

Application number

LTEPPCT/US2016/033836T

Other languages

English (en)

Inventor

Tracey L. MCLAUGHLIN

Colleen M. CRAIG

Original Assignee

The Board Of Trustees Of The Leland Stanford Junior University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-05-22

Filing date

2016-05-23

Publication date

2022-01-10

2016-05-23 Application filed by The Board Of Trustees Of The Leland Stanford Junior University filed Critical The Board Of Trustees Of The Leland Stanford Junior University

2022-01-10 Publication of LT3297653T publication Critical patent/LT3297653T/lt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Dispersion Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

LTEPPCT/US2016/033836T 2015-05-22 2016-05-23 Postbariatrinės hipoglikemijos gydymas glp-1 antagonistais LT3297653T (lt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201562165743P	2015-05-22	2015-05-22
US201562254175P	2015-11-11	2015-11-11
US201662329850P	2016-04-29	2016-04-29
PCT/US2016/033836 WO2016191394A1 (en)	2015-05-22	2016-05-23	Treatment of post-bariatric hypoglycemia with glp-1 antagonists

Publications (1)

Publication Number	Publication Date
LT3297653T true LT3297653T (lt)	2022-01-10

Family

ID=57393681

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LTEPPCT/US2016/033837T LT3297654T (lt)	2015-05-22	2016-05-23	Hipoglikemijos, atsiradusios po bariatrinės chirurgijos, gydymas eksendinu(9-39)
LTEPPCT/US2016/033836T LT3297653T (lt)	2015-05-22	2016-05-23	Postbariatrinės hipoglikemijos gydymas glp-1 antagonistais

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
LTEPPCT/US2016/033837T LT3297654T (lt)	2015-05-22	2016-05-23	Hipoglikemijos, atsiradusios po bariatrinės chirurgijos, gydymas eksendinu(9-39)

Country Status (18)

Country	Link
US (10)	US10639354B2 (lt)
EP (4)	EP3297653B1 (lt)
AU (6)	AU2016267052B2 (lt)
BR (2)	BR112017024997A2 (lt)
CA (2)	CA3024353A1 (lt)
CL (2)	CL2017002911A1 (lt)
CY (2)	CY1124616T1 (lt)
DK (2)	DK3297654T3 (lt)
ES (2)	ES2887723T3 (lt)
HR (2)	HRP20211768T1 (lt)
HU (2)	HUE057301T2 (lt)
LT (2)	LT3297654T (lt)
PL (2)	PL3297654T3 (lt)
PT (2)	PT3297653T (lt)
RS (2)	RS62368B1 (lt)
SI (2)	SI3297654T1 (lt)
SM (2)	SMT202100668T1 (lt)
WO (2)	WO2016191395A1 (lt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2499390T3 (es)	2007-01-08	2014-09-29	The Trustees Of The University Of Pennsylvania	Métodos y composiciones para tratar trastornos hipoglucémicos
US11311519B2 (en)	2014-05-01	2022-04-26	Eiger Biopharmaceuticals, Inc.	Treatment of hepatitis delta virus infection
AU2016267052B2 (en)	2015-05-22	2022-01-20	The Bot Of The Leland Stanford Junior University	Treatment of post-bariatric hypoglycemia with GLP-1 antagonists
WO2017152014A1 (en)	2016-03-04	2017-09-08	Eiger Biopharmaceuticals, Inc.	Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives
EP3541366B1 (en)	2016-11-21	2024-12-25	Amylyx Pharmaceuticals, Inc.	Buffered formulations of exendin (9-39)
JP7444786B2 (ja) *	2018-01-23	2024-03-06	ゼリスファーマシューティカルズインコーポレイテッド	低用量の安定なグルカゴンを使用する肥満治療手術後の低血糖症の処置
GB201816639D0 (en) *	2018-10-12	2018-11-28	Heptares Therapeutics Ltd	GLP-1 Receptor Antagonist
AU2019359807B2 (en) *	2018-10-15	2025-04-24	Amylyx Pharmaceuticals, Inc.	Avexitide for the treatment of hyperinsulinemic hypoglycemia
EP3908274A1 (en) *	2019-01-11	2021-11-17	Universitätsspital Basel	Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia after bariatric surgery
WO2024042518A1 (en) *	2022-08-21	2024-02-29	M. Arkin (1999) Ltd	Glp-1 receptor antagonist and methods of use thereof

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL176007B1 (pl)	1992-06-15	1999-03-31	Scios Inc	Nowe pochodne polipeptydu GLP-1
US5424286A (en)	1993-05-24	1995-06-13	Eng; John	Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US20040092443A1 (en)	1996-08-06	2004-05-13	Yeda Research And Development Co., Ltd	Long-acting exendins and exendin agonists
DK0966297T4 (da)	1996-08-08	2013-03-18	Amylin Pharmaceuticals Llc	Regulering af gastrointestinal motilitet
US6458924B2 (en)	1996-08-30	2002-10-01	Novo Nordisk A/S	Derivatives of GLP-1 analogs
US7235627B2 (en)	1996-08-30	2007-06-26	Novo Nordisk A/S	Derivatives of GLP-1 analogs
US6268343B1 (en)	1996-08-30	2001-07-31	Novo Nordisk A/S	Derivatives of GLP-1 analogs
AU739020B2 (en)	1997-01-07	2001-10-04	Amylin Pharmaceuticals, Inc.	Use of exendins and agonists thereof for the reduction of food intake
PT1003581E (pt)	1998-01-30	2001-04-30	Novo Nordisk As	Seringa de injeccao
DE69923587T2 (de)	1998-12-10	2005-06-23	Agouron Pharmaceuticals, Inc., La Jolla	Nichtpeptidische antagonisten des glp-1 rezeptors und verwendungsmethoden
DE60032331T2 (de)	1999-01-14	2007-06-21	Amylin Pharmaceuticals, Inc., San Diego	Exendine zur glucagon suppression
WO2000041546A2 (en)	1999-01-14	2000-07-20	Amylin Pharmaceuticals, Inc.	Novel exendin agonist formulations and methods of administration thereof
US6924264B1 (en)	1999-04-30	2005-08-02	Amylin Pharmaceuticals, Inc.	Modified exendins and exendin agonists
US6903074B1 (en)	1999-06-04	2005-06-07	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.	Neuromedin b and somatostatin receptor agonists
US6495164B1 (en)	2000-05-25	2002-12-17	Alkermes Controlled Therapeutics, Inc. I	Preparation of injectable suspensions having improved injectability
US6479065B2 (en)	2000-08-10	2002-11-12	Alkermes Controlled Therapeutics, Inc.	Process for the preparation of polymer-based sustained release compositions
US6824822B2 (en)	2001-08-31	2004-11-30	Alkermes Controlled Therapeutics Inc. Ii	Residual solvent extraction method and microparticles produced thereby
SE0004462D0 (sv)	2000-12-04	2000-12-04	Pharmacia Ab	Novel method and use
WO2002066062A2 (en)	2001-02-01	2002-08-29	Drucker Daniel J	Enhancement of glp-2 activity
US7638598B2 (en)	2001-04-06	2009-12-29	The Trustees Of The University Of Pennsylvania	ErbB interface peptidomimetics and methods of use thereof
CN1162446C (zh)	2001-05-10	2004-08-18	上海华谊生物技术有限公司	促胰岛素分泌肽衍生物
GB0113179D0 (en)	2001-05-31	2001-07-25	Novartis Ag	Organic compounds
JP2005508895A (ja)	2001-08-28	2005-04-07	イーライ・リリー・アンド・カンパニー	Ｇｌｐ−１および基礎インスリンの予備混合物
US7378385B2 (en)	2002-08-08	2008-05-27	University Of Cincinnati	Role for GLP-1 to mediate responses to disparate stressors
JP4532408B2 (ja)	2003-03-13	2010-08-25	田辺三菱製薬株式会社	腫瘍形成抑制剤
CN102784386A (zh)	2003-11-20	2012-11-21	诺沃挪第克公司	对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂
US8076288B2 (en)	2004-02-11	2011-12-13	Amylin Pharmaceuticals, Inc.	Hybrid polypeptides having glucose lowering activity
US7456254B2 (en)	2004-04-15	2008-11-25	Alkermes, Inc.	Polymer-based sustained release device
WO2005110425A1 (en)	2004-04-15	2005-11-24	Alkermes, Inc.	Polymer-based sustained release device
DE102004043153B4 (de)	2004-09-03	2013-11-21	Philipps-Universität Marburg	Erfindung betreffend GLP-1 und Exendin
US8546326B2 (en)	2005-06-06	2013-10-01	Camurus Ab	Glp-1 analogue formulations
FI3524261T3 (fi)	2005-08-19	2024-01-11	Amylin Pharmaceuticals Llc	Exendin käytettäväksi diabeteksen hoidossa ja ruumiin painon vähentämiseksi
GEP20125628B (en)	2006-04-21	2012-09-10	Novartis Ag	Pharmaceutical compositions containing antagonist anti-cd40 antibody
JP2009538356A (ja)	2006-05-26	2009-11-05	アミリン・ファーマシューティカルズ，インコーポレイテッド	鬱血性心不全の治療のための組成物および方法
ES2499390T3 (es)	2007-01-08	2014-09-29	The Trustees Of The University Of Pennsylvania	Métodos y composiciones para tratar trastornos hipoglucémicos
DE102007016811A1 (de)	2007-04-05	2008-10-09	Tecpharma Licensing Ag	Vorrichtung zur Verabreichung eines fluiden Wirkstoffes aus einer Mehrkammerampulle
WO2008122132A1 (de)	2007-04-05	2008-10-16	Tecpharma Licensing Ag	Verabreichungsvorrichtung mit funktionalem antriebsglied
CN105688191A (zh)	2007-04-23	2016-06-22	精达制药公司	促胰岛素释放肽的混悬制剂及其应用
EP2300031B1 (en)	2008-05-05	2017-09-20	Oramed Ltd.	Methods and compositions for oral administration of exenatide
EP2303313B1 (en)	2008-05-21	2015-10-28	Amylin Pharmaceuticals, LLC	Exendins to lower cholestrol and triglycerides
US8071537B2 (en)	2008-06-25	2011-12-06	Endo Pharmaceuticals Solutions Inc.	Implantable device for the sustained release of a polypeptide
US9314508B2 (en)	2008-07-08	2016-04-19	Novartis Ag	Use of somatostatin analogs in control of hypoglycemia
SG10201703039SA (en)	2008-09-04	2017-05-30	Amylin Pharmaceuticals Llc	Sustained release formulations using non-aqueous carriers
PL2413952T3 (pl)	2009-04-03	2017-08-31	Nestec S.A.	Polepszenie promowania zdrowego doganiania wzrostu
JP5839597B2 (ja)	2009-06-08	2016-01-06	アムニクスオペレーティングインコーポレイテッド	グルコース調節ポリペプチド並びにその作成及び使用方法
WO2011109787A1 (en)	2010-03-05	2011-09-09	Conjuchem, Llc	Methods of administering insulinotropic peptides
US20130137645A1 (en)	2010-07-19	2013-05-30	Mary S. Rosendahl	Modified peptides and proteins
US8969293B2 (en)	2010-12-23	2015-03-03	Rani Therapeutics, Llc	Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US20120208755A1 (en)	2011-02-16	2012-08-16	Intarcia Therapeutics, Inc.	Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
EP2768856A4 (en)	2011-10-18	2015-05-27	Prolynx Llc	PEG CONJUGATES OF EXENATIDE
US20150005233A1 (en)	2012-02-08	2015-01-01	Seneb Biosciences, Inc.	Treatment of hypoglycemia
BR122019026701B1 (pt)	2012-03-26	2023-01-24	Sanofi	Formulações de agentes de ligação à base de igg4 estáveis, kit, e dispositivo ou recipiente pré-cheios
HK1226084A1 (zh)	2013-08-16	2017-09-22	Medimmune Limited	用於治疗糖尿病的gip和glp-1受体双重激动剂
US9932381B2 (en)	2014-06-18	2018-04-03	Sanofi	Exendin-4 derivatives as selective glucagon receptor agonists
AU2016267052B2 (en)	2015-05-22	2022-01-20	The Bot Of The Leland Stanford Junior University	Treatment of post-bariatric hypoglycemia with GLP-1 antagonists
WO2017152014A1 (en)	2016-03-04	2017-09-08	Eiger Biopharmaceuticals, Inc.	Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives
EP3541366B1 (en)	2016-11-21	2024-12-25	Amylyx Pharmaceuticals, Inc.	Buffered formulations of exendin (9-39)
IL318291A (en)	2022-08-05	2025-03-01	Univ Indiana Res & Tech Corp	Glucagon-like peptide 1 receptor antibodies

2016
- 2016-05-23 AU AU2016267052A patent/AU2016267052B2/en active Active
- 2016-05-23 PT PT16800620T patent/PT3297653T/pt unknown
- 2016-05-23 WO PCT/US2016/033837 patent/WO2016191395A1/en not_active Ceased
- 2016-05-23 BR BR112017024997-9A patent/BR112017024997A2/pt not_active Application Discontinuation
- 2016-05-23 WO PCT/US2016/033836 patent/WO2016191394A1/en not_active Ceased
- 2016-05-23 US US15/576,647 patent/US10639354B2/en active Active
- 2016-05-23 EP EP16800620.3A patent/EP3297653B1/en active Active
- 2016-05-23 ES ES16800621T patent/ES2887723T3/es active Active
- 2016-05-23 PL PL16800621T patent/PL3297654T3/pl unknown
- 2016-05-23 EP EP21176474.1A patent/EP3936143A1/en active Pending
- 2016-05-23 CA CA3024353A patent/CA3024353A1/en active Pending
- 2016-05-23 AU AU2016267057A patent/AU2016267057B2/en active Active
- 2016-05-23 LT LTEPPCT/US2016/033837T patent/LT3297654T/lt unknown
- 2016-05-23 EP EP16800621.1A patent/EP3297654B1/en active Active
- 2016-05-23 DK DK16800621.1T patent/DK3297654T3/da active
- 2016-05-23 LT LTEPPCT/US2016/033836T patent/LT3297653T/lt unknown
- 2016-05-23 SM SM20210668T patent/SMT202100668T1/it unknown
- 2016-05-23 HU HUE16800620A patent/HUE057301T2/hu unknown
- 2016-05-23 PL PL16800620T patent/PL3297653T3/pl unknown
- 2016-05-23 ES ES16800620T patent/ES2897955T3/es active Active
- 2016-05-23 SI SI201631300T patent/SI3297654T1/sl unknown
- 2016-05-23 SI SI201631362T patent/SI3297653T1/sl unknown
- 2016-05-23 BR BR112017025000-4A patent/BR112017025000A2/pt not_active Application Discontinuation
- 2016-05-23 EP EP21194982.1A patent/EP3978011A1/en active Pending
- 2016-05-23 PT PT168006211T patent/PT3297654T/pt unknown
- 2016-05-23 CA CA3024358A patent/CA3024358A1/en active Pending
- 2016-05-23 RS RS20211073A patent/RS62368B1/sr unknown
- 2016-05-23 HR HRP20211768TT patent/HRP20211768T1/hr unknown
- 2016-05-23 SM SM20210488T patent/SMT202100488T1/it unknown
- 2016-05-23 HU HUE16800621A patent/HUE055728T2/hu unknown
- 2016-05-23 US US15/576,646 patent/US10660937B2/en active Active
- 2016-05-23 HR HRP20211285TT patent/HRP20211285T1/hr unknown
- 2016-05-23 DK DK16800620.3T patent/DK3297653T3/da active
- 2016-05-23 RS RS20211458A patent/RS62627B1/sr unknown
2017
- 2017-11-16 CL CL2017002911A patent/CL2017002911A1/es unknown
- 2017-11-16 CL CL2017002913A patent/CL2017002913A1/es unknown
2020
- 2020-03-09 US US16/813,536 patent/US10993992B2/en active Active
- 2020-03-09 US US16/813,535 patent/US10993991B2/en active Active
2021
- 2021-04-09 US US17/226,164 patent/US11617782B2/en active Active
- 2021-04-09 US US17/226,161 patent/US11622995B2/en active Active
- 2021-09-01 CY CY20211100779T patent/CY1124616T1/el unknown
- 2021-11-29 CY CY20211101046T patent/CY1125147T1/el unknown
2022
- 2022-03-22 AU AU2022201973A patent/AU2022201973B2/en active Active
- 2022-04-14 AU AU2022202506A patent/AU2022202506B2/en active Active
2023
- 2023-02-22 US US18/172,543 patent/US12220444B2/en active Active
- 2023-02-22 US US18/172,546 patent/US12102663B2/en active Active
2024
- 2024-06-17 US US18/745,091 patent/US20250082730A1/en active Pending
2025
- 2025-01-02 US US19/008,248 patent/US20250255935A1/en active Pending
- 2025-08-13 AU AU2025217292A patent/AU2025217292A1/en active Pending
- 2025-08-22 AU AU2025220813A patent/AU2025220813A1/en active Pending

Also Published As

Publication number	Publication date
US20180117122A1 (en)	2018-05-03
SI3297654T1 (sl)	2021-11-30
US11622995B2 (en)	2023-04-11
US10660937B2 (en)	2020-05-26
HUE055728T2 (hu)	2021-12-28
CY1125147T1 (el)	2023-03-24
BR112017024997A2 (pt)	2018-07-31
LT3297654T (lt)	2021-10-25
PL3297653T3 (pl)	2022-01-31
US12102663B2 (en)	2024-10-01
AU2016267057A1 (en)	2017-12-14
EP3297654A4 (en)	2018-04-11
EP3297653A4 (en)	2018-12-26
AU2022201973A1 (en)	2022-04-14
PT3297653T (pt)	2021-10-25
RS62368B1 (sr)	2021-10-29
AU2022202506B2 (en)	2025-06-05
US12220444B2 (en)	2025-02-11
HRP20211285T1 (hr)	2022-01-07
US11617782B2 (en)	2023-04-04
RS62627B1 (sr)	2021-12-31
BR112017025000A2 (pt)	2018-08-07
US20180147261A1 (en)	2018-05-31
SMT202100668T1 (it)	2022-01-10
ES2887723T3 (es)	2021-12-27
US20230346890A1 (en)	2023-11-02
HRP20211768T1 (hr)	2022-02-18
SMT202100488T1 (it)	2021-11-12
EP3297653B1 (en)	2021-09-15
HUE057301T2 (hu)	2022-05-28
AU2025220813A1 (en)	2025-09-11
CL2017002911A1 (es)	2018-05-25
US20210315974A1 (en)	2021-10-14
AU2022201973B2 (en)	2025-05-15
US20210290731A1 (en)	2021-09-23
EP3297653A1 (en)	2018-03-28
CL2017002913A1 (es)	2018-06-01
CY1124616T1 (el)	2022-07-22
US10639354B2 (en)	2020-05-05
DK3297653T3 (da)	2021-10-18
SI3297653T1 (sl)	2022-01-31
DK3297654T3 (da)	2021-09-06
AU2016267057B2 (en)	2021-12-23
EP3936143A1 (en)	2022-01-12
US20250255935A1 (en)	2025-08-14
EP3978011A1 (en)	2022-04-06
CA3024358A1 (en)	2016-12-01
AU2025217292A1 (en)	2025-09-04
PT3297654T (pt)	2021-09-06
CA3024353A1 (en)	2016-12-01
EP3297654B1 (en)	2021-07-07
ES2897955T3 (es)	2022-03-03
PL3297654T3 (pl)	2021-12-20
US20250082730A1 (en)	2025-03-13
AU2016267052A1 (en)	2017-12-14
US10993992B2 (en)	2021-05-04
US10993991B2 (en)	2021-05-04
AU2022202506A1 (en)	2022-05-12
US20200276272A1 (en)	2020-09-03
WO2016191395A1 (en)	2016-12-01
WO2016191394A1 (en)	2016-12-01
US20200276271A1 (en)	2020-09-03
AU2016267052B2 (en)	2022-01-20
EP3297654A1 (en)	2018-03-28
US20240000894A1 (en)	2024-01-04

Publication	Publication Date	Title
IL272232A (en)	2020-03-31	Glp-1 compositions and uses thereof
PL3265053T3 (pl)	2020-03-31	Sposoby leczenia skóry
PT3242887T (pt)	2019-10-29	Compostos coagonistas de gip e glp-1
HRP20181692T1 (hr)	2018-12-14	Liječenje fibroze
LT3297653T (lt)	2022-01-10	Postbariatrinės hipoglikemijos gydymas glp-1 antagonistais
DK3134530T3 (da)	2019-09-09	Behandling af hyperbilirubinæmi
PL3157512T3 (pl)	2019-02-28	Zastosowanie kannabidioli w leczeniu padaczki
KR102494289B9 (ko)	2024-08-22	활성 혼합물
HUE050944T2 (hu)	2021-01-28	Kezelési eljárás tradipitant alkalmazásával
HUE049413T2 (hu)	2020-09-28	Nazális porkészítmény hipoglikémia kezelésére
EP3375108A4 (en)	2019-10-23	SELECTIVE WIFI
DK3391902T5 (da)	2024-09-23	Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati
DK3408265T3 (da)	2020-06-02	Terapeutiske forbindelser
DK3307267T3 (da)	2019-07-01	Behandling af multipel sklerose
EP3394091A4 (en)	2019-12-18	CO-AGONISTS OF GLUCAGON AND GLP-1 RECEPTORS
HRP20181570T1 (hr)	2018-11-30	Režim doziranja spoja fgf-18
DK3393478T3 (da)	2020-03-23	Kombinationsterapi
DK3236960T3 (da)	2025-03-31	Fluralaner til anvendelse i behandling af demodicose
EP3362091A4 (en)	2019-04-24	COMBINATION THERAPY
HUE055778T2 (hu)	2021-12-28	Oligo-ovulációval összefüggõ májzsírosodás kezelése
EP3367914A4 (en)	2019-06-12	ECHOGENIC NEEDLE
EP3493821A4 (en)	2020-04-08	METHOD OF TREATING THE RESPIRATORY TRACT
PL3377500T3 (pl)	2023-01-23	Związki oksadiazaspiro do leczenia nadużywania i uzależnienia od narkotyków/leków
EP3372264A4 (en)	2019-07-03	SYRINGE
EP3271434C0 (de)	2025-08-20	Niedertemperatur-plasmabehandlung