IL158997A0 - New indole derivatives with 5-ht6 receptor affinity - Google Patents

New indole derivatives with 5-ht6 receptor affinity

Info

Publication number: IL158997A0
Authority: IL; Israel
Prior art keywords: indole derivatives; receptor affinity; new indole; new; affinity
Prior art date: 2001-06-07

Application number

IL15899702A

Other languages

English (en)

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-07

Filing date

2002-05-29

Publication date

2004-05-12

2002-05-29 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-05-12 Publication of IL158997A0 publication Critical patent/IL158997A0/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL15899702A 2001-06-07 2002-05-29 New indole derivatives with 5-ht6 receptor affinity IL158997A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US29670501P	2001-06-07	2001-06-07
US34021201P	2001-12-13	2001-12-13
PCT/EP2002/005890 WO2002098857A1 (en)	2001-06-07	2002-05-29	New indole derivatives with 5-ht6 receptor affinity

Publications (1)

Publication Number	Publication Date
IL158997A0 true IL158997A0 (en)	2004-05-12

Family

ID=26969776

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15899702A IL158997A0 (en)	2001-06-07	2002-05-29	New indole derivatives with 5-ht6 receptor affinity

Country Status (32)

Country	Link
US (3)	US6787535B2 (es)
EP (1)	EP1401813B1 (es)
JP (1)	JP4187642B2 (es)
KR (1)	KR100600240B1 (es)
CN (1)	CN1257892C (es)
AR (1)	AR036233A1 (es)
AT (1)	ATE353318T1 (es)
AU (1)	AU2002310747B2 (es)
BG (1)	BG108420A (es)
BR (1)	BR0210929A (es)
CA (1)	CA2449874C (es)
CO (1)	CO5630036A2 (es)
CZ (1)	CZ20033529A3 (es)
DE (1)	DE60218037T2 (es)
ES (1)	ES2280546T3 (es)
HR (1)	HRP20030984A2 (es)
HU (1)	HUP0401307A2 (es)
IL (1)	IL158997A0 (es)
MA (1)	MA27032A1 (es)
MX (1)	MXPA03011244A (es)
NO (1)	NO20035359D0 (es)
NZ (1)	NZ529631A (es)
PA (1)	PA8546601A1 (es)
PE (1)	PE20030039A1 (es)
PL (1)	PL367305A1 (es)
RU (1)	RU2294932C2 (es)
SK (1)	SK16052003A3 (es)
TW (1)	TW591015B (es)
UY (1)	UY27322A1 (es)
WO (1)	WO2002098857A1 (es)
YU (1)	YU96103A (es)
ZA (1)	ZA200309005B (es)

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CN1492863A (zh) *	2000-12-22	2004-04-28		作为5-羟色胺-6配基的杂环基烷基-吲哚或氮杂吲哚化合物
CN1281605C (zh) *	2000-12-22	2006-10-25	惠氏公司	作为5－羟色胺－6配基的杂环基－吲唑或氮杂吲唑化合物
TW593278B (en) *	2001-01-23	2004-06-21	Wyeth Corp	1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
US6815456B2 (en) *	2001-04-20	2004-11-09	Wyeth	Heterocyclyloxy-, -thioxy- and -aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
WO2003013510A1 (en) *	2001-08-07	2003-02-20	Smithkline Beecham P.L.C.	3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders
EP1556037B1 (en) *	2002-10-18	2006-11-02	F. Hoffmann-La Roche Ag	4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity

2002
- 2002-05-29 YU YU96103A patent/YU96103A/sh unknown
- 2002-05-29 WO PCT/EP2002/005890 patent/WO2002098857A1/en not_active Ceased
- 2002-05-29 RU RU2003136731/04A patent/RU2294932C2/ru not_active IP Right Cessation
- 2002-05-29 ES ES02735394T patent/ES2280546T3/es not_active Expired - Lifetime
- 2002-05-29 HU HU0401307A patent/HUP0401307A2/hu unknown
- 2002-05-29 MX MXPA03011244A patent/MXPA03011244A/es active IP Right Grant
- 2002-05-29 IL IL15899702A patent/IL158997A0/xx unknown
- 2002-05-29 CZ CZ20033529A patent/CZ20033529A3/cs unknown
- 2002-05-29 DE DE60218037T patent/DE60218037T2/de not_active Expired - Lifetime
- 2002-05-29 BR BR0210929-8A patent/BR0210929A/pt not_active Application Discontinuation
- 2002-05-29 EP EP02735394A patent/EP1401813B1/en not_active Expired - Lifetime
- 2002-05-29 AT AT02735394T patent/ATE353318T1/de not_active IP Right Cessation
- 2002-05-29 AU AU2002310747A patent/AU2002310747B2/en not_active Ceased
- 2002-05-29 JP JP2003501846A patent/JP4187642B2/ja not_active Expired - Fee Related
- 2002-05-29 KR KR1020037016022A patent/KR100600240B1/ko not_active Expired - Fee Related
- 2002-05-29 CN CNB028115244A patent/CN1257892C/zh not_active Expired - Fee Related
- 2002-05-29 PL PL02367305A patent/PL367305A1/xx not_active Application Discontinuation
- 2002-05-29 CA CA002449874A patent/CA2449874C/en not_active Expired - Fee Related
- 2002-05-29 NZ NZ529631A patent/NZ529631A/en unknown
- 2002-05-29 SK SK16052003A patent/SK16052003A3/sk unknown
- 2002-05-29 HR HR20030984A patent/HRP20030984A2/hr not_active Application Discontinuation
- 2002-06-03 TW TW091111843A patent/TW591015B/zh not_active IP Right Cessation
- 2002-06-04 AR ARP020102066A patent/AR036233A1/es not_active Application Discontinuation
- 2002-06-04 PA PA20028546601A patent/PA8546601A1/es unknown
- 2002-06-06 UY UY27322A patent/UY27322A1/es not_active Application Discontinuation
- 2002-06-06 US US10/164,660 patent/US6787535B2/en not_active Expired - Fee Related
- 2002-06-07 PE PE2002000481A patent/PE20030039A1/es not_active Application Discontinuation
2003
- 2003-11-19 ZA ZA200309005A patent/ZA200309005B/en unknown
- 2003-12-02 NO NO20035359A patent/NO20035359D0/no not_active Application Discontinuation
- 2003-12-02 CO CO03106073A patent/CO5630036A2/es not_active Application Discontinuation
- 2003-12-03 MA MA27422A patent/MA27032A1/fr unknown
- 2003-12-05 BG BG108420A patent/BG108420A/xx unknown
2004
- 2004-06-25 US US10/876,863 patent/US20040248902A1/en not_active Abandoned
2005
- 2005-03-03 US US11/071,726 patent/US20050171118A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE60218037T2 (de)	2007-08-23
PE20030039A1 (es)	2003-02-13
HRP20030984A2 (en)	2005-10-31
AR036233A1 (es)	2004-08-25
DE60218037D1 (de)	2007-03-22
KR100600240B1 (ko)	2006-07-13
PL367305A1 (en)	2005-02-21
CA2449874C (en)	2009-06-23
NO20035359D0 (no)	2003-12-02
JP2004533460A (ja)	2004-11-04
US20030073700A1 (en)	2003-04-17
RU2294932C2 (ru)	2007-03-10
PA8546601A1 (es)	2003-01-24
BG108420A (en)	2005-02-28
US20050171118A1 (en)	2005-08-04
MXPA03011244A (es)	2004-02-27
WO2002098857A1 (en)	2002-12-12
CZ20033529A3 (cs)	2004-04-14
UY27322A1 (es)	2003-02-28
HK1068610A1 (en)	2005-04-29
MA27032A1 (fr)	2004-12-20
CN1527816A (zh)	2004-09-08
EP1401813B1 (en)	2007-02-07
CO5630036A2 (es)	2006-04-28
CA2449874A1 (en)	2002-12-12
TW591015B (en)	2004-06-11
KR20040004702A (ko)	2004-01-13
ZA200309005B (en)	2005-02-21
RU2003136731A (ru)	2005-05-20
CN1257892C (zh)	2006-05-31
US20040248902A1 (en)	2004-12-09
JP4187642B2 (ja)	2008-11-26
US6787535B2 (en)	2004-09-07
AU2002310747B2 (en)	2007-10-11
YU96103A (sh)	2006-08-17
ATE353318T1 (de)	2007-02-15
ES2280546T3 (es)	2007-09-16
WO2002098857A8 (en)	2004-04-22
HUP0401307A2 (hu)	2004-12-28
BR0210929A (pt)	2004-06-08
EP1401813A1 (en)	2004-03-31
SK16052003A3 (en)	2004-10-05
NZ529631A (en)	2006-08-31

Publication	Publication Date	Title
IL158997A0 (en)	2004-05-12	New indole derivatives with 5-ht6 receptor affinity
PL376479A1 (en)	2005-12-27	4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity
IL162105A0 (en)	2005-11-20	New indole derivatives as factor xainhibitors
AU2167002A (en)	2002-06-11	Indoline derivatives and their use as 5-ht2 receptor ligands
MXPA03003039A (es)	2003-10-15	Derivados de indola y bencimidazola como moduladores del receptor crf.
AU2003244480A1 (en)	2003-09-02	Sulphonyl compounds with 5 -ht6 receptor affinity
AU3166401A (en)	2001-08-20	Indol-3-yl derivatives
AU8664701A (en)	2002-03-22	Oxindole derivatives
ZA200501175B (en)	2007-03-28	2,4-substituted indoles and their use as 5-HT6 modulators
ZA200501306B (en)	2006-05-31	2,7-Substituted indoles and their use as 5-HT6 modulators
MXPA01012041A (es)	2003-09-04	Derivados de indol.
GB9825988D0 (en)	1999-01-20	Indole derivatives
IS6434A (is)	2002-06-19	Nýjar indól afleiður
PT1228041E (pt)	2004-02-27	Derivados de indol
IL150272A0 (en)	2002-12-01	Indole derivatives as mcp-1 receptor antagonists
IL158830A0 (en)	2004-05-12	Novel indole derivatives
AU2943899A (en)	1999-10-11	Indole derivatives as 5-ht2a receptor antagonists
AU2002323003A1 (en)	2003-02-17	5-arylsulfonyl indoles having 5-ht6 receptor affinity
AU2003281525A1 (en)	2004-02-09	Serotonin receptor
AU2003270669A8 (en)	2004-04-08	Cyclopentyl indole derivatives
GB0119696D0 (en)	2001-10-03	Indole derivatives
GB0119820D0 (en)	2001-10-10	Indole derivatives
SI1399434T1 (sl)	2006-02-28	Novi indolni derivati
GB0214544D0 (en)	2002-08-07	6-Crbamoylpyrimido[4,5-b]Indole derivatives
AU2002341102A1 (en)	2002-11-18	Benzo(d)azepine derivatives as 5-ht6 receptor antagonists.