[go: up one dir, main page]

HK1201565A1 - Quantification of adaptive immune cell genomes in a complex mixture of cells - Google Patents

Quantification of adaptive immune cell genomes in a complex mixture of cells Download PDF

Info

Publication number
HK1201565A1
HK1201565A1 HK15101905.5A HK15101905A HK1201565A1 HK 1201565 A1 HK1201565 A1 HK 1201565A1 HK 15101905 A HK15101905 A HK 15101905A HK 1201565 A1 HK1201565 A1 HK 1201565A1
Authority
HK
Hong Kong
Prior art keywords
cells
adaptive immune
quantification
lymphocytes
immune cell
Prior art date
Application number
HK15101905.5A
Other languages
English (en)
Chinese (zh)
Inventor
Harlan S. Robins
Robert J. LIVINGSTON
Jason H. BIELAS
Original Assignee
Adaptive Biotechnologies Corporation
Fred Hutchinson Cancer Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adaptive Biotechnologies Corporation, Fred Hutchinson Cancer Research Center filed Critical Adaptive Biotechnologies Corporation
Publication of HK1201565A1 publication Critical patent/HK1201565A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK15101905.5A 2011-10-21 2012-10-19 Quantification of adaptive immune cell genomes in a complex mixture of cells HK1201565A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161550311P 2011-10-21 2011-10-21
US61/550,311 2011-10-21
PCT/US2012/061193 WO2013059725A1 (fr) 2011-10-21 2012-10-19 Quantification de génomes de cellules immunitaires adaptatives dans un mélange complexe de cellules

Publications (1)

Publication Number Publication Date
HK1201565A1 true HK1201565A1 (en) 2015-09-04

Family

ID=48141432

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15101905.5A HK1201565A1 (en) 2011-10-21 2012-10-19 Quantification of adaptive immune cell genomes in a complex mixture of cells

Country Status (6)

Country Link
US (3) US9279159B2 (fr)
EP (1) EP2768982A4 (fr)
AU (1) AU2012325791B2 (fr)
CA (1) CA2853088C (fr)
HK (1) HK1201565A1 (fr)
WO (1) WO2013059725A1 (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
GB2483810B (en) 2008-11-07 2012-09-05 Sequenta Inc Methods for correlating clonotypes with diseases in a population
US8691510B2 (en) 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
PT2387627E (pt) 2009-01-15 2016-06-03 Adaptive Biotechnologies Corp Determinação do perfil de imunidade adaptativa e métodos de geração de anticorpos monoclonais
JP2012531202A (ja) 2009-06-25 2012-12-10 フレッド ハチンソン キャンサー リサーチ センター 適応免疫を測定する方法
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
KR20190002733A (ko) 2010-12-30 2019-01-08 파운데이션 메디신 인코포레이티드 종양 샘플의 다유전자 분석의 최적화
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
EP2768982A4 (fr) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp Quantification de génomes de cellules immunitaires adaptatives dans un mélange complexe de cellules
AU2012347460B2 (en) 2011-12-09 2017-05-25 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
JP6302847B2 (ja) 2012-03-05 2018-03-28 アダプティヴ バイオテクノロジーズ コーポレーション 頻度が一致したサブユニットからの、対をなす免疫受容体鎖の決定
ES2711156T3 (es) 2012-05-08 2019-04-30 Adaptive Biotechnologies Corp Método para medir y calibrar el sesgo de amplificación en reacciones de PCR multiplexadas
EP2904111B1 (fr) * 2012-10-01 2017-12-06 Adaptive Biotechnologies Corporation Évaluation de l'immunocompétence par la diversité des récepteurs de l'immunité adaptative et la caractérisation de la clonalité
US9328384B2 (en) 2013-05-13 2016-05-03 Elitechgroup B.V. Droplet digital PCR with short minor groove probes
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
CN106103711A (zh) 2013-11-21 2016-11-09 组库创世纪株式会社 T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用
US20170292149A1 (en) 2014-03-05 2017-10-12 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
WO2015188839A2 (fr) 2014-06-13 2015-12-17 Immudex Aps Détection générale et isolement de cellules spécifiques par liaison de molécules marquées
CA2964410C (fr) * 2014-10-17 2023-03-14 Accugen Pty Ltd Procede amleiore de quantification d'acides nucleiques
WO2016069886A1 (fr) * 2014-10-29 2016-05-06 Adaptive Biotechnologies Corporation Détection simultanée hautement multiplexée d'acides nucléiques codant pour des hétérodimères de récepteurs de l'immunité adaptative appariés à partir de nombreux échantillons
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
CA2968543C (fr) 2014-11-25 2024-04-02 Adaptive Biotechnologies Corporation Caracterisation de la reponse immunitaire adaptative a la vaccination ou a l'infection a l'aide du sequencage du repertoire immunitaire
ES2989276T3 (es) * 2014-12-05 2024-11-25 Found Medicine Inc Análisis multigénico de muestras tumorales
WO2016138122A1 (fr) 2015-02-24 2016-09-01 Adaptive Biotechnologies Corp. Méthodes pour le diagnostic d'une maladie infectieuse et la détermination du statut hla à l'aide du séquençage du répertoire immunitaire
WO2016161273A1 (fr) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Procédé d'identification des récepteurs de lymphocytes t spécifiques à compatibilité humaine pour une cible antigénique
CA2983937A1 (fr) 2015-04-27 2016-11-03 Abvitro Llc Procedes de sequencage, de determination, d'appariement, et de validation d'agents therapeutiques et d'antigenes specifiques de maladies
EP3303635B1 (fr) * 2015-06-01 2021-09-01 California Institute of Technology Compositions et procédés pour l'analyse de lymphocytes t avec des antigènes pour des populations spécifiques
US10539564B2 (en) 2015-07-22 2020-01-21 Roche Sequencing Solutions, Inc. Identification of antigen epitopes and immune sequences recognizing the antigens
WO2017013170A1 (fr) 2015-07-22 2017-01-26 F. Hoffmann-La Roche Ag Identification d'épitopes antigéniques et séquences immunitaires reconnaissant les antigènes
GB2557123B (en) 2015-07-31 2021-11-03 Univ Minnesota Modified cells and methods of therapy
RU2587540C1 (ru) * 2015-08-06 2016-06-20 Общество с ограниченной ответственностью "АБВ-ТЕСТ" Способ диагностики состояния иммунной системы пациента и набор праймеров, зондов и стандартных образцов для количественной оценки днк молекул trec, krec и количества геном эквивалентов днк
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
EP3299471B1 (fr) * 2016-09-23 2019-10-23 Roche Diagniostics GmbH Procédés pour déterminer la quantité d'acide nucléique utile dans un échantillon non traité
CN110520530A (zh) 2016-10-18 2019-11-29 明尼苏达大学董事会 肿瘤浸润性淋巴细胞和治疗方法
US12258613B2 (en) 2017-03-08 2025-03-25 California Institute Of Technology Pairing antigen specificity of a T cell with T cell receptor sequences
WO2019006418A2 (fr) 2017-06-30 2019-01-03 Intima Bioscience, Inc. Vecteurs viraux adéno-associés destinés à la thérapie génique
US10636512B2 (en) 2017-07-14 2020-04-28 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
EP3802923A4 (fr) 2018-06-11 2022-03-16 Foundation Medicine, Inc. Compositions et procédés d'évaluation d'altérations génomiques
US20220112557A1 (en) * 2019-01-10 2022-04-14 Iovance Biotherapeutics, Inc. System and methods for monitoring adoptive cell therapy clonality and persistence
WO2020247263A1 (fr) * 2019-06-06 2020-12-10 Natera, Inc. Procédés de détection d'adn de cellules immunitaires et de surveillance du système immunitaire
US12263179B1 (en) 2019-08-01 2025-04-01 Adaptive Biotechnologies Corporation Lyme disease-associated T cell receptor-related methods
NL2023987B1 (en) * 2019-10-09 2021-06-07 Academisch Ziekenhuis Leiden Immune cell quantification
KR20220130756A (ko) * 2020-01-22 2022-09-27 라이프 테크놀로지스 코포레이션 자가면역 질환과 면역결핍 장애의 면역 레퍼토리 바이오마커
EP4150118A1 (fr) * 2020-05-14 2023-03-22 Becton Dickinson and Company Amorces pour profilage de répertoire immunitaire
CN113684258B (zh) * 2020-05-18 2024-08-20 上海赛比曼生物科技有限公司 用于检测鼠源tcr转基因拷贝数的试剂盒及方法
US12266425B1 (en) 2020-06-10 2025-04-01 Adaptive Biotechnologies Corporation T cell receptor sequences diagnostic for COVID-19 and related compositions
KR20230160885A (ko) 2021-03-24 2023-11-24 제넨테크, 인크. T 림프구에서 효율적인 tcr 유전자 편집
WO2023054501A1 (fr) * 2021-09-29 2023-04-06 武田薬品工業株式会社 Procédé de mesure de la concentration cellulaire
WO2024227034A1 (fr) * 2023-04-27 2024-10-31 Serum Detect, Inc. Signatures de récepteur de lymphocytes t indiquant des stades précoces du cancer

Family Cites Families (310)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3270960A (en) 1964-09-11 1966-09-06 Sperry Rand Corp Fluid sensor
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE3211263A1 (de) 1981-03-31 1983-01-27 Otsuka Pharmaceutical Co. Ltd., Tokyo Human-interferon verwandte peptide, antigene und antikoerper, sowie verfahren zu deren herstellung
DE3238353A1 (de) 1982-10-15 1984-04-19 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Verfahren zur simultanen quantitativen bestimmung der blutzellen und reagenz hierfuer
US5189147A (en) 1984-06-13 1993-02-23 Massachusetts Institute Of Technology Meterodimeric T lymphocyte receptor antibody
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE3541033A1 (de) 1985-11-19 1987-05-21 Boehringer Mannheim Gmbh Verfahren zur quantifizierung von zellpopulationen bzw. subpopulationen sowie hierfuer geeignetes reagenz
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US4942124A (en) 1987-08-11 1990-07-17 President And Fellows Of Harvard College Multiplex sequencing
US5667967A (en) 1990-05-01 1997-09-16 The Board Of Trustees Of The Leland Stanford Junior University T-cell receptor varible transcripts as disease related markers
US5506126A (en) 1988-02-25 1996-04-09 The General Hospital Corporation Rapid immunoselection cloning method
US5168038A (en) 1988-06-17 1992-12-01 The Board Of Trustees Of The Leland Stanford Junior University In situ transcription in cells and tissues
WO1990004648A1 (fr) 1988-10-20 1990-05-03 Alexander Alan Morley Methode pour le diagnostic de la monoclonalite dans la leucemie et le lymphome
US5075217A (en) 1989-04-21 1991-12-24 Marshfield Clinic Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences
US5231012A (en) 1989-06-28 1993-07-27 Schering Corporation Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10)
CA2020958C (fr) 1989-07-11 2005-01-11 Daniel L. Kacian Methodes d'amplification de sequences d'acide nucleique
US5336598A (en) 1989-11-15 1994-08-09 National Jewish Center For Immunology And Respiratory Medicine Method for diagnosing a superantigen caused pathologial condition via assay of T-cells
US5298396A (en) 1989-11-15 1994-03-29 National Jewish Center For Immunology And Respiratory Medicine Method for identifying T cells disease involved in autoimmune disease
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US6054034A (en) 1990-02-28 2000-04-25 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6916605B1 (en) 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
WO1992002551A1 (fr) 1990-08-02 1992-02-20 B.R. Centre Limited Procedes de production de proteines presentant une fonction souhaitee
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
IE76732B1 (en) 1990-08-07 1997-11-05 Becton Dickinson Co One step test for absolute counts
US5699798A (en) 1990-08-10 1997-12-23 University Of Washington Method for optically imaging solid tumor tissue
US5635354A (en) 1991-01-09 1997-06-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for describing the repertoires of antibodies (Ab) and of T-cell receptors (TcR) of an individual's immune system
US5364759B2 (en) 1991-01-31 1999-07-20 Baylor College Medicine Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats
CA2079881C (fr) 1991-02-12 2007-11-06 Thierry Hercend Sequences nucleotidiques codant pour des regions variables de chaines .beta. des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques
JP3266311B2 (ja) 1991-05-02 2002-03-18 生化学工業株式会社 新規ポリペプチドおよびこれを用いる抗ｈｉｖ剤
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5213960A (en) 1992-03-09 1993-05-25 Tanox Biosystems, Inc. Methods for selecting low frequency antigen-specific single B lymphocytes
US5256542A (en) 1992-03-09 1993-10-26 Tanox Biosystems, Inc. Selecting low frequency antigen-specific single B lymphocytes with correction for background noise
US5837447A (en) 1992-04-15 1998-11-17 Blood Center Research Foundation, Inc., The Monitoring an immune response by analysis of amplified immunoglobulin or T-cell-receptor nucleic acid
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5981176A (en) 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
EP0753060A4 (fr) 1994-04-18 1999-11-24 New York Society Sequences receptrices de lymphocytes t conservees
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US6090592A (en) 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5776737A (en) 1994-12-22 1998-07-07 Visible Genetics Inc. Method and composition for internal identification of samples
US6919434B1 (en) 1995-02-20 2005-07-19 Sankyo Co., Ltd. Monoclonal antibodies that bind OCIF
US5698396A (en) 1995-06-07 1997-12-16 Ludwig Institute For Cancer Research Method for identifying auto-immunoreactive substances from a subject
WO1997013877A1 (fr) 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Mesure de profils d'expression genique pour evaluer la toxicite
US6087096A (en) 1995-11-13 2000-07-11 Dau; Peter C. Method of intrafamily fragment analysis of the T cell receptor α and β chain CDR3 regions
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
KR19990087749A (ko) 1996-03-13 1999-12-27 시오노 요시히코 류마티스성 관절염에 특이적인 인간 티 세포 클론
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
CA2257152C (fr) 1996-06-03 2009-01-27 Linda M. Pilarski Procedes de detection d'adn rearrange
AU726501B2 (en) 1996-06-04 2000-11-09 University Of Utah Research Foundation Monitoring hybridization during PCR
WO1998001738A2 (fr) 1996-06-20 1998-01-15 Cornell Research Foundation, Inc. Identification d'anomalies dans l'expression de recepteurs de reconnaissance de l'antigene des lymphocytes t et b en tant qu'indicateurs de diagnostic et de pronostic de maladies et predicteurs therapeutiques
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
ATE347103T1 (de) 1996-09-06 2006-12-15 Ortho Mcneil Pharm Inc Reinigung von antigenspezifischen t-zellen
WO1998015644A2 (fr) 1996-09-27 1998-04-16 The Chinese University Of Hong Kong Procede de sequencage en parallele de polynucleotides
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
ATE364718T1 (de) 1997-04-01 2007-07-15 Solexa Ltd Verfahren zur vervielfältigung von nukleinsäure
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
DK1801214T3 (da) 1997-07-07 2011-01-24 Medical Res Council In vitro sorteringsfremgangsmåde
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
CA2306126A1 (fr) 1997-10-15 1999-04-22 Aclara Biosciences, Inc. Dispositif a microstructure stratifiee et procede de fabrication de ce dispositif
US7351578B2 (en) 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
DE19833738A1 (de) 1998-07-27 2000-02-03 Michael Giesing Verfahren zur Isolierung von Krebszellen aus zellhaltigen Körperflüssigkeiten sowie Sets zur Durchführung dieses Verfahrens
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
DE19844931C1 (de) 1998-09-30 2000-06-15 Stefan Seeger Verfahren zur DNS- oder RNS-Sequenzierung
US6541608B1 (en) 1999-02-23 2003-04-01 Baylor College Of Medicine T cell receptor Vβ-Dβ-Jβ sequence and methods for its detection
US6307024B1 (en) 1999-03-09 2001-10-23 Zymogenetics, Inc. Cytokine zalpha11 Ligand
US6300070B1 (en) 1999-06-04 2001-10-09 Mosaic Technologies, Inc. Solid phase methods for amplifying multiple nucleic acids
US6440706B1 (en) * 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US20040209314A1 (en) 1999-09-06 2004-10-21 Institut National De La Sante Et De La Recherche Medicale France Means for detection and purification of CD8+ T lymphocyte populations specific to peptides presented in the context of HLA
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
US20040033490A1 (en) 2000-03-31 2004-02-19 Laird Peter W. Epigenetic sequences for esophageal adenocarcinoma
AUPQ687600A0 (en) 2000-04-13 2000-05-11 Flinders Technologies Pty Ltd A method of detection
US20030207300A1 (en) 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US6596492B2 (en) 2000-07-11 2003-07-22 Colorado State University Research Foundation PCR materials and methods useful to detect canine and feline lymphoid malignancies
US7567870B1 (en) 2000-07-31 2009-07-28 Institute For Systems Biology Multiparameter analysis for predictive medicine
US6939451B2 (en) 2000-09-19 2005-09-06 Aclara Biosciences, Inc. Microfluidic chip having integrated electrodes
US6858412B2 (en) 2000-10-24 2005-02-22 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
US7148040B2 (en) 2001-02-20 2006-12-12 University Of Georgia Research Foundation, Inc. Method of rapid production of hybridomas expressing monoclonal antibodies on the cell surface
US7265208B2 (en) 2001-05-01 2007-09-04 The Regents Of The University Of California Fusion molecules and treatment of IgE-mediated allergic diseases
EP1395114A2 (fr) 2001-05-24 2004-03-10 Guard Inc., Procedes de selection et de production d'animaux presentant un niveau calcule de reponse immunitaire
US20050260570A1 (en) 2001-05-29 2005-11-24 Mao Jen-I Sequencing by proxy
US6720144B1 (en) 2001-06-21 2004-04-13 Quest Diagnostics Detection of clonal T-cell receptor-γ gene rearrangement by PCR/temporal temperature gradient gel electrophoresis (TTGE)
US7112423B2 (en) 2001-07-15 2006-09-26 Keck Graduate Institute Nucleic acid amplification using nicking agents
WO2003020983A1 (fr) 2001-08-30 2003-03-13 Virginia Commonwealth University Pcr allele specifique pour genotypage
JP4317940B2 (ja) 2001-08-31 2009-08-19 イミュノコア・リミテッド 物質
AU2002322518A1 (en) 2001-08-31 2003-03-18 Rosetta Inpharmactis Llc Methods for preparing nucleic acid samples
AU2002341752B2 (en) 2001-09-19 2008-04-03 Alexion Pharmaceuticals, Inc. Engineered templates and their use in single primer amplification
US6964850B2 (en) 2001-11-09 2005-11-15 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
GB2382137A (en) 2001-11-20 2003-05-21 Mats Gullberg Nucleic acid enrichment
GB0128153D0 (en) 2001-11-23 2002-01-16 Bayer Ag Profiling of the immune gene repertoire
WO2003052101A1 (fr) 2001-12-14 2003-06-26 Rosetta Inpharmatics, Inc. Suivi des echantillons au moyen du code barres moleculaire
GB0130267D0 (en) 2001-12-19 2002-02-06 Neutec Pharma Plc Focussed antibody technology
WO2003059155A2 (fr) 2002-01-09 2003-07-24 Maxx Genetech Co. Ltd Procede de detection de la proliferation de lymphocytes t pour le diagnostique de maladies a l'aide d'un ensemble de genes
US7157274B2 (en) 2002-06-24 2007-01-02 Cytonome, Inc. Method and apparatus for sorting particles
AU2003299503A1 (en) 2002-05-16 2004-06-15 Vanderbilt University Method for predicting autoimmune diseases
AU2003247129A1 (en) 2002-07-01 2004-01-19 Centre National De La Recherche Scientifique (Cnrs) System, method, device, and computer program product for extraction, gathering, manipulation, and analysis of peak data from an automated sequencer
AU2003281336A1 (en) 2002-07-03 2004-01-23 Institute For Scientific Research, Inc. Compositions and methods for the detection of human t cell receptor variable family gene expression
US20040115216A1 (en) 2002-07-12 2004-06-17 The Johns Hopkins University Reagents and methods for engaging unique clonotypic lymphocyte receptors
EP1552010B1 (fr) 2002-07-19 2010-06-09 Althea Technologies, Inc. Strategies pour l'analyse de l'expression genique
US7157228B2 (en) 2002-09-09 2007-01-02 Bioarray Solutions Ltd. Genetic analysis and authentication
US7459273B2 (en) 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
EP2460889B1 (fr) 2002-10-11 2013-11-20 Erasmus Universiteit Rotterdam Amorces d'acides nucléiques pour les'études de la clonalité des translocations BCL2-IGH basées sur PCR
EP1597557A4 (fr) 2002-10-11 2008-06-11 Univ California Methode permettant de diagnostiquer et de pronostiquer la sclerose en plaques
US20060147925A1 (en) 2002-11-13 2006-07-06 Morley Alexander A Method of detection
US20060134704A1 (en) 2002-11-14 2006-06-22 Atsushi Muraguchi Microwell array chip for detecting antigen-specific lymphocytes, method of detecting and method of manufacturing antigen-specific lymphocytes, and method of cloning antigen-specific lymphocyte antigen receptor genes
WO2004053104A2 (fr) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. Acides nucleiques 5'cpg et leurs methodes d'utilisation
WO2004063706A2 (fr) 2003-01-08 2004-07-29 Maxx Genetech Co., Ltd. Procede permettant de detecter la surexpression des genes du recepteur des lymphocytes t par pcr en temps reel
CA2513535C (fr) 2003-01-29 2012-06-12 454 Corporation Amplification d'acides nucleiques par emulsion de billes
GB0304068D0 (en) 2003-02-22 2003-03-26 Avidex Ltd Substances
WO2004096985A2 (fr) 2003-04-24 2004-11-11 Mayo Foundation For Medical Education And Research Procedes d'evaluation de la diversite biologique
AU2003902299A0 (en) 2003-05-13 2003-05-29 Flinders Medical Centre A method of analysing a marker nucleic acid molecule
WO2005020784A2 (fr) 2003-05-23 2005-03-10 Mount Sinai School Of Medicine Of New York University Signatures d'expression genique de cellules de substitution permettant d'evaluer l'etat physique d'un patient
US20050010030A1 (en) 2003-07-02 2005-01-13 Zang Jingwu Z. T cell receptor CDR3 sequence and methods for detecting and treating rheumatoid arthritis
WO2005010145A2 (fr) 2003-07-05 2005-02-03 The Johns Hopkins University Procede et compositions de detection et d'enumeration de variations genetiques
US20060228350A1 (en) 2003-08-18 2006-10-12 Medimmune, Inc. Framework-shuffling of antibodies
US20050048498A1 (en) 2003-08-29 2005-03-03 Applera Corporation Compositions, methods, and kits for assembling probes
WO2005026686A2 (fr) 2003-09-09 2005-03-24 Compass Genetics, Llc Plate-forme analytique multiplexee
TWI333977B (en) 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
FR2863274B1 (fr) * 2003-12-05 2012-11-16 Commissariat Energie Atomique Procede d'evaluation quantitative d'un rearrangement ou d'une recombinaison genetique ciblee d'un individu et ses applications.
WO2005053603A2 (fr) 2003-12-08 2005-06-16 Yeda Research And Development Co. Ltd. Typage d'une region variable du recepteur de l'antigene
US20080166718A1 (en) 2003-12-15 2008-07-10 Institut Pasteur Repertoire determination of a lymphocyte B population
EP1544308B1 (fr) 2003-12-15 2009-01-28 Institut Pasteur Détermination du répertoire d'une population de lymphocytes B
US20070160994A1 (en) 2003-12-15 2007-07-12 Institut Pasteur Repertoire determination of a lymphocyte b population
US20060046258A1 (en) 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
WO2005084134A2 (fr) 2004-03-04 2005-09-15 Dena Leshkowitz Quantification et etablissement de profil de genes exprimes de type anticorps et recepteurs des lymphocytes t
JP4480423B2 (ja) 2004-03-08 2010-06-16 独立行政法人科学技術振興機構 免疫細胞クローンの拡大の有無の判定方法
DE102004016437A1 (de) 2004-04-04 2005-10-20 Oligene Gmbh Verfahren zur Erkennung von Signaturen in komplexen Genexpressionsprofilen
WO2005111242A2 (fr) 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Etablissement numerique de profils pour des populations de polynucleotides
JP2007536939A (ja) 2004-05-14 2007-12-20 アモークス インコーポレーティッド 免疫細胞バイオセンサーおよびその使用方法
GB0412973D0 (en) 2004-06-10 2004-07-14 Celltech R&D Ltd Identification of antibody producing cells
WO2006014869A1 (fr) 2004-07-26 2006-02-09 Parallele Bioscience, Inc. Analyse simultanee de genomes multiples
US20060094018A1 (en) 2004-08-03 2006-05-04 Bauer A R Jr Discovery and a method for the early detection of pancreatic cancer and other disease conditions
US7820382B2 (en) 2004-08-03 2010-10-26 Bauer A Robert Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation
US7476724B2 (en) 2004-08-05 2009-01-13 Genentech, Inc. Humanized anti-cmet antibodies
CA2580412A1 (fr) 2004-09-13 2006-03-23 Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services Preparations comprenant des recepteurs cellulaires t et methodes d'utilisation de ces preparations
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
EP1812563B1 (fr) 2004-10-29 2013-04-10 Benaroya Research Institute at Virginia Mason Méthodes de génération de cellules t de régulation cd4+cd25+ spécifiques à un antigène, compositions et méthodes d'utilisation associées
US7966988B2 (en) 2005-01-11 2011-06-28 Exxonmobil Research And Engineering Company Method for controlling soot induced lubricant viscosity increase
US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
FR2881436B1 (fr) 2005-02-03 2007-04-27 Commissariat Energie Atomique Procede de determination de la diversite des lymphocytes t dans un echantillon biologique
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US20080280774A1 (en) 2005-02-16 2008-11-13 Wyeth Methods and Systems for Diagnosis, Prognosis and Selection of Treatment of Leukemia
US7537894B2 (en) 2005-03-02 2009-05-26 The University Of Chicago Methods and kits for monitoring Barrett's metaplasia
WO2006099164A2 (fr) 2005-03-10 2006-09-21 Applera Corporation Methodes d'amplification multiplex
US20060211030A1 (en) 2005-03-16 2006-09-21 Sydney Brenner Methods and compositions for assay readouts on multiple analytical platforms
JP2008538496A (ja) 2005-04-12 2008-10-30 ４５４ ライフ サイエンシーズ コーポレイション ウルトラディープ配列決定を用いて配列変異体を決定するための方法
WO2006116155A2 (fr) 2005-04-21 2006-11-02 The Regents Of The University Of California Methode de diagnostic et de pronostic de sous-types de sclerose en plaques
US20060263789A1 (en) 2005-05-19 2006-11-23 Robert Kincaid Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using
US7208795B2 (en) 2005-05-24 2007-04-24 Atmel Corporation Low-cost, low-voltage single-layer polycrystalline EEPROM memory cell integration into BiCMOS technology
US20090264299A1 (en) 2006-02-24 2009-10-22 Complete Genomics, Inc. High throughput genome sequencing on DNA arrays
EP1907571B1 (fr) 2005-06-15 2017-04-26 Complete Genomics Inc. Analyse d'acides nucléiques à l'aide de mélanges aléatoires de fragments non chevauchants
WO2007008759A2 (fr) 2005-07-07 2007-01-18 Hematologics, Inc. Procedes pour detecter et confirmer une pathologie minime
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
GB0521521D0 (en) 2005-10-21 2005-11-30 Medical Res Council Diagnostic methods and kits
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
US20070105165A1 (en) 2005-11-04 2007-05-10 Charles Goolsby Composite profiles of cell antigens and target signal transduction proteins for analysis and clinical management of hematologic cancers
US7375211B2 (en) 2005-11-18 2008-05-20 Kou Zhong C Method for detection and quantification of T-cell receptor Vβ repertoire
US8137936B2 (en) 2005-11-29 2012-03-20 Macevicz Stephen C Selected amplification of polynucleotides
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
US7544473B2 (en) 2006-01-23 2009-06-09 Population Genetics Technologies Ltd. Nucleic acid analysis using sequence tokens
KR20080113223A (ko) 2006-03-06 2008-12-29 심포젠 에이/에스 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체
ES2546848T3 (es) 2006-03-10 2015-09-29 Epigenomics Ag Un método para identificar una muestra biológica para el análisis de la metilación
WO2007114693A2 (fr) 2006-04-04 2007-10-11 Keygene N.V. Detection de marqueurs moleculaires a haut rendement base sur des fragments de restriction
US20100323401A1 (en) 2006-05-11 2010-12-23 Lewis George K General method for generating human antibody responses in vitro
WO2007136518A2 (fr) 2006-05-17 2007-11-29 Torrey Pines Institute For Molecular Studies Traitement de troubles auto-immunitaires
WO2007139584A2 (fr) 2006-05-25 2007-12-06 Institute For Advanced Study Méthodes d'identification de motifs de séquence et applications associées
US7833716B2 (en) 2006-06-06 2010-11-16 Gen-Probe Incorporated Tagged oligonucleotides and their use in nucleic acid amplification methods
CN101915957B (zh) 2006-06-12 2012-12-12 加利福尼亚太平洋生物科学公司 实施分析反应的基材
US20100027896A1 (en) 2006-06-28 2010-02-04 Amir Geva Automated application interaction using a virtual operator
CA2656525A1 (fr) 2006-06-30 2008-01-10 Applera Corporation Nucleotides de sequences de terminaison reversibles et procedes d'utilisation
WO2008108803A2 (fr) 2006-07-13 2008-09-12 Amaox, Ltd. Biocapteurs de cellules immunitaires et méthodes d'utilisation correspondantes
US8394590B2 (en) 2006-08-02 2013-03-12 California Institute Of Technology Capture agents and related methods and systems for detecting and/or sorting targets
US20080274904A1 (en) 2006-08-10 2008-11-06 Niall Anthony Gormley Method of target enrichment
WO2008026927A2 (fr) 2006-08-30 2008-03-06 Academisch Medisch Centrum Procédé d'affichage des répertoires des récepteurs des lymphocytes t et b
WO2008039694A2 (fr) 2006-09-26 2008-04-03 St. Jude Children's Research Hospital Procédés et compositions de surveillance de la diversité des récepteurs des lymphocytes t
WO2008039818A2 (fr) 2006-09-26 2008-04-03 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Récepteurs des cellules t modifiés, et matériaux et méthodes s'y rapportant
JP5026047B2 (ja) 2006-10-18 2012-09-12 株式会社膠原病研究所 自己免疫疾患の発症に関わる自己応答性ｔ細胞またはｔ細胞受容体の同定方法、およびその利用
EP2102367A2 (fr) 2006-11-09 2009-09-23 XDX, Inc. Procedes pour diagnostiquer et surveiller l'etat d'un lupus erythemateux systemique
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US7862999B2 (en) 2007-01-17 2011-01-04 Affymetrix, Inc. Multiplex targeted amplification using flap nuclease
MX2009008908A (es) 2007-03-01 2009-08-28 Symphogen As Metodo para clonacion de anticuerpos analogos.
WO2008147879A1 (fr) 2007-05-22 2008-12-04 Ryan Golhar Procede et dispositif automatises d'identification et d'isolement d'adn et de definition de sequences
CA2689356A1 (fr) 2007-06-01 2008-12-11 454 Life Sciences Corporation Systeme et procede d'identification d'echantillons individuels a partir d'un melange multiplex
WO2009015296A1 (fr) 2007-07-24 2009-01-29 The Regents Of The University Of California Générateur de gouttelettes microfabriqué
ITRM20070429A1 (it) 2007-08-06 2009-02-07 Uni Cattolica Del Sacro Cuor E Mezzi per la diagnosi la prevenzione e la cura dell'artrite reumatoide.
JP5547071B2 (ja) 2007-08-09 2014-07-09 セルラ・インコーポレイテッド 関連付け多パラメーター単一細胞測定および残留する生物学的材料の回収のための方法および装置
US8268564B2 (en) 2007-09-26 2012-09-18 President And Fellows Of Harvard College Methods and applications for stitched DNA barcodes
WO2009045898A2 (fr) 2007-09-28 2009-04-09 Mayo Foundation For Medical Education And Research Évaluation de répertoires de lymphocytes t
US7960116B2 (en) 2007-09-28 2011-06-14 Pacific Biosciences Of California, Inc. Nucleic acid sequencing methods and systems
BRPI0820707A2 (pt) 2007-11-07 2015-06-16 Genentech Inc Métodos e composição para avaliar a responsividade do linfoma de células b para o tratamento com anticorpos anti-cd40
WO2009070767A2 (fr) 2007-11-28 2009-06-04 Whitehead Institute For Biomedical Research Systèmes de promotion systémique pour étudier la croissance ou métastase d'une tumeur
EP2062982A1 (fr) * 2007-11-26 2009-05-27 ImmunID Procédé d'étude de la diversité combinatoire V(D)J
CN101225441B (zh) 2007-12-05 2010-12-01 浙江大学 一种检测克隆特异性t淋巴细胞tcr bv cdr3基因组成的方法
US8621502B2 (en) 2007-12-21 2013-12-31 Microsoft Corporation Obtaining user reactions to video
US7767400B2 (en) 2008-02-03 2010-08-03 Helicos Biosciences Corporation Paired-end reads in sequencing by synthesis
EP2088432A1 (fr) 2008-02-11 2009-08-12 MorphoSys AG Procédés pour l'identification d'un anticorps ou d'une cible
CA2717030A1 (fr) 2008-02-28 2009-09-03 The Ohio State University Research Foundation Signatures en micro-arn associees a la cytogenetique et au pronostic dans la leucemie myeloide aigue (aml) et leurs utilisations
WO2009108860A2 (fr) 2008-02-28 2009-09-03 The Ohio University Rasearch Foundation Procédés et compositions à base de micro-arn permettant de diagnostiquer, de pronostiquer et de traiter des troubles liés à la prostate
US20090226975A1 (en) 2008-03-10 2009-09-10 Illumina, Inc. Constant cluster seeding
TW200938840A (en) 2008-03-12 2009-09-16 Emo Biomedicine Corp A method for in vitro study of immune modulation using pig blood cell
EP2100970B1 (fr) 2008-03-13 2017-05-10 National Institute of Immunology Oligonucléotides spécifiques aux gènes Ig et leurs utilisations
CN102084001B (zh) 2008-03-28 2015-03-18 加利福尼亚太平洋生物科学股份有限公司 用于核酸测序的组合物和方法
EP2107040B1 (fr) 2008-03-31 2011-10-26 Sony Deutschland Gmbh Procédé de fabrication d'une membrane disposant d'un pore conique
CN102066578B (zh) 2008-04-16 2016-07-06 哈森阿尔法生物技术研究院 用于评价和比较免疫组库的方法
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2277049A4 (fr) 2008-05-09 2012-05-30 Univ Duke Auto-anticorps dans la détection et le traitement du cancer
US9068181B2 (en) 2008-05-23 2015-06-30 The General Hospital Corporation Microfluidic droplet encapsulation
DK2297333T3 (en) 2008-05-30 2015-04-07 Massachusetts Inst Technology Method for spatial separation and for screening cells
WO2009151628A2 (fr) 2008-06-12 2009-12-17 Gov't Of The Usa, As Represented By The Secretary, Department Of Health Human Services Surveillance de tcr-b en vue de déterminer une thérapie de vih et l'évolution d'une maladie
MX2010014556A (es) 2008-06-25 2011-07-28 Baylor Res Inst Firma transcripcional de sangre por infeccion de mycobacterium tuberculosis.
US8394583B2 (en) 2008-07-24 2013-03-12 The Board Of Regents Of The University Of Texas System VH4 codon signature for multiple sclerosis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
CN102405402A (zh) 2008-09-23 2012-04-04 阔达生命有限公司 基于液滴的测定系统
US8699361B2 (en) 2008-09-30 2014-04-15 Qualcomm Incorporated Out-of-synchronization handling method and apparatus
US8546128B2 (en) 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
WO2010053857A1 (fr) 2008-11-04 2010-05-14 Ethanol Boosting Systems, Llc Systèmes à base d'eau pour prévention des détonations d'injection directe dans des moteurs à allumage commandé
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
GB2483810B (en) 2008-11-07 2012-09-05 Sequenta Inc Methods for correlating clonotypes with diseases in a population
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US20140234835A1 (en) 2008-11-07 2014-08-21 Sequenta, Inc. Rare clonotypes and uses thereof
US8691510B2 (en) 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
US20110105343A1 (en) 2008-11-21 2011-05-05 Emory University Systems Biology Approach Predicts Immunogenicity of Vaccines
US8367330B2 (en) * 2008-12-22 2013-02-05 Quest Diagnostics Investments Incorporated Methods for detecting TCR-gamma gene rearrangement
CA2750155A1 (fr) 2008-12-30 2010-07-08 Centocor Ortho Biotech Inc. Marqueurs seriques predisant la reponse clinique a des anticorps anti-tnf.alpha. chez les patients souffrant de spondylarthrite ankylosante
PT2387627E (pt) 2009-01-15 2016-06-03 Adaptive Biotechnologies Corp Determinação do perfil de imunidade adaptativa e métodos de geração de anticorpos monoclonais
US9329170B2 (en) 2009-01-20 2016-05-03 The Board Of Trustees Of The Leland Stanford Junior University Single cell gene expression for diagnosis, prognosis and identification of drug targets
US20100323348A1 (en) 2009-01-31 2010-12-23 The Regents Of The University Of Colorado, A Body Corporate Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US20120058902A1 (en) * 2009-06-25 2012-03-08 Livingston Robert J Method of measuring adaptive immunity
JP2012531202A (ja) 2009-06-25 2012-12-10 フレッド ハチンソン キャンサー リサーチ センター 適応免疫を測定する方法
US8497071B2 (en) 2009-06-29 2013-07-30 California Institute Of Technology Isolation of unknown rearranged T-cell receptors from single cells
EP2480683B1 (fr) 2009-09-22 2017-11-29 Roche Diagnostics GmbH Méthode servant à déterminer des haplotypes de kir par amplification des exons
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US8545248B2 (en) 2010-01-07 2013-10-01 Life Technologies Corporation System to control fluid flow based on a leak detected by a sensor
KR101323827B1 (ko) 2010-01-08 2013-10-31 키스트 유럽 에프게엠베하 강직성척추염 진단용 프라이머 및 이를 이용한 강직성 척추염 진단 방법
GB201000375D0 (en) 2010-01-09 2010-02-24 Univ Cardiff T Cell clonotypes
WO2011106738A2 (fr) 2010-02-25 2011-09-01 Fred Hutchinson Cancer Research Center Utilisation de clonotypes tcr en tant que biomarqueurs de maladie
EP2367000A1 (fr) 2010-03-04 2011-09-21 Charité Universitätsmedizin Berlin Analyse à haut rendement des répertoires de récepteur de lymphocyte T
EP3456847B1 (fr) 2010-05-06 2024-12-25 Adaptive Biotechnologies Corporation Surveillance de rejet de transplant à l'aide de profils clonotypes
CA2796822C (fr) 2010-05-07 2021-10-05 The Board Of Trustees Of The Leland Standford Junior University Mesure et comparaison de diversite immunitaire par sequencage a haut debit
EP2580353B1 (fr) 2010-06-11 2015-07-29 Life Technologies Corporation Flux alternatifs de nucléotides dans des procédés de séquençage par synthèse
ES2690753T3 (es) 2010-09-21 2018-11-22 Agilent Technologies, Inc. Aumento de la confianza en las identificaciones de alelos con el recuento molecular
EP2622103B2 (fr) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Dosages sandwich dans des gouttelettes
DK2625320T3 (da) 2010-10-08 2019-07-01 Harvard College High-throughput enkeltcellestregkodning
EP2625295B1 (fr) 2010-10-08 2019-03-13 President and Fellows of Harvard College Séquençage immunitaire à haut débit
CA2821299C (fr) 2010-11-05 2019-02-12 Frank J. Steemers Liaison entre des lectures de sequences a l'aide de codes marqueurs apparies
US9193997B2 (en) 2010-12-15 2015-11-24 The Board Of Trustees Of The Leland Stanford Junior University Measuring and monitoring of cell clonality
DK2652155T3 (en) 2010-12-16 2017-02-13 Gigagen Inc Methods for Massive Parallel Analysis of Nucleic Acids in Single Cells
US9594870B2 (en) 2010-12-29 2017-03-14 Life Technologies Corporation Time-warped background signal for sequencing-by-synthesis operations
US10146906B2 (en) 2010-12-30 2018-12-04 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US8759036B2 (en) 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
DK3246416T3 (da) 2011-04-15 2024-09-02 Univ Johns Hopkins Sikkert sekventeringssystem
MX360823B (es) 2011-05-24 2018-11-16 Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh Vacunas individualizadas para el cancer.
WO2013033721A1 (fr) 2011-09-02 2013-03-07 Atreca, Inc. Code-barres adn pour le séquençage multiplex
WO2013036459A2 (fr) 2011-09-09 2013-03-14 Sequenta, Inc. Mesure d'une réponse immunitaire basée sur les séquences
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
WO2013055595A1 (fr) 2011-10-11 2013-04-18 Sequenta, Inc. Détermination de la sensibilité de patients atteints d'une maladie auto-immune au traitement sous armm
EP2768982A4 (fr) * 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp Quantification de génomes de cellules immunitaires adaptatives dans un mélange complexe de cellules
ES2619713T3 (es) 2011-11-04 2017-06-26 Adaptive Biotechnologies Corporation Clonotipos de receptores de células T compartidos entre pacientes con espondilitis anquilosante
US20140336059A1 (en) 2011-12-05 2014-11-13 Sequenta, Inc. Clonotypes as biometric specimen tags
AU2012347460B2 (en) 2011-12-09 2017-05-25 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
WO2013086462A1 (fr) 2011-12-09 2013-06-13 Sequenta, Inc. Procédé de mesure de l'activation immunitaire
WO2013090390A2 (fr) 2011-12-13 2013-06-20 Sequenta, Inc. Procédé de mesure de l'activité immunitaire
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
EP2794925A4 (fr) 2011-12-20 2015-09-30 Sequenta Inc Suivi de la transformation du lymphome folliculaire en lymphome diffus à grandes cellules b par analyse du répertoire immunitaire
WO2013112655A1 (fr) 2012-01-24 2013-08-01 Gigagen, Inc. Procédé de correction de biais dans l'amplification multiplexée
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
WO2013131074A1 (fr) 2012-03-02 2013-09-06 Diogenix, Inc. Procédés et réactifs pour évaluer une maladie auto-immune et déterminer un répertoire d'anticorps
WO2013134302A1 (fr) 2012-03-05 2013-09-12 Sequenta, Inc. Contrôle de la réponse immunitaire à la vaccination contre le cancer
JP6302847B2 (ja) 2012-03-05 2018-03-28 アダプティヴ バイオテクノロジーズ コーポレーション 頻度が一致したサブユニットからの、対をなす免疫受容体鎖の決定
US20150038346A1 (en) 2012-03-05 2015-02-05 Sequenta, Inc. Monitoring immune responsiveness to cancer vaccination
CA2869481A1 (fr) 2012-04-13 2013-10-17 Sequenta, Inc. Detection et quantification de la contamination d'echantillons dans une analyse de repertoire immunologique
WO2013158936A1 (fr) 2012-04-20 2013-10-24 Sequenta, Inc Surveillance de l'évolution des chaînes lourdes d'immunoglobuline dans le cas d'une leucémie lymphoblastique aiguë dans le lymphocyte b
ES2711156T3 (es) 2012-05-08 2019-04-30 Adaptive Biotechnologies Corp Método para medir y calibrar el sesgo de amplificación en reacciones de PCR multiplexadas
US20150247201A1 (en) 2012-05-31 2015-09-03 Malek Faham Predicting relapse of chronic lymphocytic leukemia patients treated by allogeneic stem cell transplantation
US20130324422A1 (en) 2012-06-04 2013-12-05 Sequenta, Inc. Detecting disease-correlated clonotypes from fixed samples
SG11201407888RA (en) 2012-06-11 2014-12-30 Sequenta Inc Method of sequence determination using sequence tags
CA2876209A1 (fr) 2012-06-15 2013-12-19 Adaptive Biotechnologies Corporation Genes de recepteur immunitaire adaptatif reorganises a marquage unique dans un ensemble genique complexe
JP2015523087A (ja) 2012-07-24 2015-08-13 シーケンタ インコーポレイテッド 配列タグを用いる単一細胞分析
JP2015524282A (ja) 2012-08-10 2015-08-24 シーケンタ インコーポレイテッド 配列タグを用いた高感度突然変異検出
CA2884246C (fr) 2012-09-24 2023-11-07 Cb Biotechnologies, Inc. Pyrosequencage multiplexe a l'aide d'etiquettes d'identification de polynucleotide anti-bruit, non interferentes
AU2013331135A1 (en) 2012-10-19 2015-05-07 Adaptive Biotechnologies Corp. Monitoring diffuse large B-cell lymphoma from peripheral blood samples
EP2909344A4 (fr) 2012-10-19 2016-06-29 Adaptive Biotechnologies Corp Surveillance de clonotypes dans des troubles prolifératifs des plasmocytes dans le sang périphérique
AU2013335021A1 (en) 2012-10-22 2015-05-07 Adaptive Biotechnologies Corp. Monitoring mantle cell lymphoma clonotypes in peripheral blood after immunotransplant
WO2014130685A1 (fr) 2013-02-22 2014-08-28 Sequenta, Inc. Clonotypes rares et utilisations de ceux-ci
US20140255944A1 (en) 2013-03-08 2014-09-11 Sequenta, Inc. Monitoring treatment-resistant clones in lymphoid and myeloid neoplasms by relative levels of evolved clonotypes
US20140255929A1 (en) 2013-03-11 2014-09-11 Sequenta, Inc. Mosaic tags for labeling templates in large-scale amplifications
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
US20160186260A1 (en) 2013-07-26 2016-06-30 Sequenta, Llc Cancer vaccination with antigen evolution
AU2014337063A1 (en) 2013-10-18 2016-05-19 Adaptive Biotechnologies Corp. Predicting patient responsiveness to immune checkpoint inhibitors
US20150218656A1 (en) 2014-02-03 2015-08-06 Adaptive Biotechnologies Corp. Methods for detection and diagnosis of a lymphoid malignancy using high throughput sequencing

Also Published As

Publication number Publication date
US20130288237A1 (en) 2013-10-31
EP2768982A1 (fr) 2014-08-27
AU2012325791B2 (en) 2018-04-05
WO2013059725A1 (fr) 2013-04-25
CA2853088C (fr) 2018-03-13
US9181591B2 (en) 2015-11-10
US20150051089A1 (en) 2015-02-19
EP2768982A4 (fr) 2015-06-03
AU2012325791A1 (en) 2014-05-22
US9181590B2 (en) 2015-11-10
US9279159B2 (en) 2016-03-08
CA2853088A1 (fr) 2013-04-25
US20140186848A1 (en) 2014-07-03

Similar Documents

Publication Publication Date Title
HK1201565A1 (en) Quantification of adaptive immune cell genomes in a complex mixture of cells
WO2015200893A3 (fr) Procédés d'analyse d'acides nucléiques provenant de cellules individuelles ou de populations de cellules
EA201201036A1 (ru) Целевые геномные изменения
EP4219725A3 (fr) Modification de l'expression genique dans des lymphocytes t modifies et utilisations de ces derniers
MX2022012384A (es) Composiciones y metodos para cribar mutaciones en el cancer de tiroides.
WO2017106537A3 (fr) Disruption ciblée du récepteur des cellules du cmh
HK1246180A1 (zh) 使用自然杀伤细胞治疗血液病症、实体瘤或感染性疾病的方法
MX368931B (es) Animales no humanos que tienen un gen de proteina reguladora de señal humanizado.
IN2014DN07531A (fr)
WO2011103016A3 (fr) Compositions et méthodes d'inhibition d'ezh2
EA201170933A1 (ru) Анализ нуклеиновых кислот, полученных из единичных клеток
WO2015132670A3 (fr) Procédés et compositions de détection de cibles pour les maladies auto-immunes
WO2011119934A3 (fr) Procédés et substances pour la détection de tumeurs colorectales
MX2019013309A (es) Animales no humanos deficientes en lncrna.
WO2012103360A3 (fr) Compositions de wnt et procédés d'utilisation de celles-ci
EP2374884A3 (fr) Molécules d'ARNmi isolées des cellules souches mésenchymateuses humaines
MX2013001799A (es) Metodos para la captura y secuenciacion de acido nucleico
CA2835730C (fr) Marqueurs moleculaires du cancer de la prostate
WO2011120690A3 (fr) Séparation de protéines cibles insolubles
WO2009030884A3 (fr) Marqueurs de tumeur à la butyrophiline mannosylatée
WO2016174130A8 (fr) Modèle de culture de cellules humaines sur la base de signatures génétiques cliniques
WO2011112845A3 (fr) Méthodes et compositions associés à un essai de méthylation multiple pour prédire l'évolution de l'état de santé d'un patient
WO2012021493A3 (fr) Compositions et méthodes pour quantifier une séquence d'acides nucléiques dans un échantillon
WO2009020596A3 (fr) Liquide céphalorachidien embryonnaire (e-lcr), protéines issues du e-lcr et procédés et compositions associés
BR112012018545A2 (pt) método de determinação e confirmação da presença de um hpv em uma amostra