ES2369837T3 - Compuestos triheterocíclicos como antagonistas de receptor cfr. - Google Patents
Compuestos triheterocíclicos como antagonistas de receptor cfr. Download PDFInfo
- Publication number
- ES2369837T3 ES2369837T3 ES07111569T ES07111569T ES2369837T3 ES 2369837 T3 ES2369837 T3 ES 2369837T3 ES 07111569 T ES07111569 T ES 07111569T ES 07111569 T ES07111569 T ES 07111569T ES 2369837 T3 ES2369837 T3 ES 2369837T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- mono
- alkyl
- ring
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 150000001875 compounds Chemical class 0.000 title abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 60
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 50
- 229910052760 oxygen Inorganic materials 0.000 abstract 27
- 239000001301 oxygen Substances 0.000 abstract 26
- 229910052717 sulfur Inorganic materials 0.000 abstract 26
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 25
- 229910052757 nitrogen Inorganic materials 0.000 abstract 25
- 239000011593 sulfur Substances 0.000 abstract 25
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 21
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 17
- 125000005843 halogen group Chemical group 0.000 abstract 15
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 14
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 13
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 125000002837 carbocyclic group Chemical group 0.000 abstract 7
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 6
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 6
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 5
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 5
- 101100134925 Gallus gallus COR6 gene Proteins 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 208000035193 Ring chromosome 10 syndrome Diseases 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- -1 cyano, nitro, amino Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004002517 | 2000-12-28 | ||
| JP2000402517 | 2000-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2369837T3 true ES2369837T3 (es) | 2011-12-07 |
Family
ID=18866787
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01995808T Expired - Lifetime ES2294047T3 (es) | 2000-12-28 | 2001-12-27 | Un compuesto de ciclopenta (d) pirazolo(1,5-a) pirimidina como antagonista del receptor de crf. |
| ES07111569T Expired - Lifetime ES2369837T3 (es) | 2000-12-28 | 2001-12-27 | Compuestos triheterocíclicos como antagonistas de receptor cfr. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01995808T Expired - Lifetime ES2294047T3 (es) | 2000-12-28 | 2001-12-27 | Un compuesto de ciclopenta (d) pirazolo(1,5-a) pirimidina como antagonista del receptor de crf. |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US7034153B2 (fr) |
| EP (2) | EP1354884B1 (fr) |
| JP (2) | JP3528968B2 (fr) |
| KR (1) | KR100843281B1 (fr) |
| CN (2) | CN1896076A (fr) |
| AT (2) | ATE375345T1 (fr) |
| AU (1) | AU2002226674B2 (fr) |
| BR (1) | BR0116609A (fr) |
| CA (1) | CA2432148C (fr) |
| CZ (1) | CZ20031777A3 (fr) |
| DE (1) | DE60130924T2 (fr) |
| DK (1) | DK1354884T3 (fr) |
| ES (2) | ES2294047T3 (fr) |
| HU (1) | HUP0303653A3 (fr) |
| IL (2) | IL156609A0 (fr) |
| MX (1) | MXPA03005913A (fr) |
| NO (1) | NO326522B1 (fr) |
| NZ (1) | NZ526712A (fr) |
| PL (1) | PL363381A1 (fr) |
| PT (1) | PT1354884E (fr) |
| RU (1) | RU2291869C2 (fr) |
| TW (1) | TWI293630B (fr) |
| WO (1) | WO2002053565A1 (fr) |
| ZA (1) | ZA200305003B (fr) |
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| US6562965B1 (en) * | 2000-07-06 | 2003-05-13 | Bristol-Myers Squibb Pharma Company | Convergent synthesis of α-aryl-β-ketonitriles |
| PT1354884E (pt) * | 2000-12-28 | 2007-12-24 | Ono Pharmaceutical Co | Composto de ciclopenta (d) pirazolo [1,5-a] piramida como antagonista de receptor de crf |
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| US7247628B2 (en) | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
| US7329658B2 (en) | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7176210B2 (en) * | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
| US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7268133B2 (en) | 2003-04-23 | 2007-09-11 | Pfizer, Inc. Patent Department | Cannabinoid receptor ligands and uses thereof |
| US7232823B2 (en) | 2003-06-09 | 2007-06-19 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
| JP4671123B2 (ja) | 2003-06-23 | 2011-04-13 | 小野薬品工業株式会社 | 新規三環性複素環化合物 |
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| WO2005061508A1 (fr) * | 2003-12-22 | 2005-07-07 | Ono Pharmaceutical Co., Ltd. | Compose tricyclique heterocyclique, et medicament dont il est le principe actif |
| WO2005087775A1 (fr) * | 2004-03-15 | 2005-09-22 | Ono Pharmaceutical Co., Ltd. | Composé hétérocyclique tricyclique et composition médicinale contenant le composé comme ingrédient actif |
| DK1773345T3 (en) * | 2004-06-30 | 2014-03-24 | Athersys Inc | NON-imidazol-tertiary amines AS HISTAMINE-3 receptor inhibitors in treating cognitive disorders, sleep disorders, obesity and other CNS DISORDERS |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| EA200700243A1 (ru) | 2004-07-14 | 2007-08-31 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения гепатита с |
| EP1781289A1 (fr) | 2004-07-22 | 2007-05-09 | PTC Therapeutics, Inc. | Thienopyridines utilisees pour traiter l'hepatite c |
| AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| DK1829874T3 (da) * | 2004-12-22 | 2014-05-12 | Ono Pharmaceutical Co | Tricyklisk forbindelse og anvendelse deraf |
| TW200639163A (en) * | 2005-02-04 | 2006-11-16 | Genentech Inc | RAF inhibitor compounds and methods |
| KR20100130596A (ko) * | 2008-01-22 | 2010-12-13 | 다케다 야쿠힌 고교 가부시키가이샤 | 부신 피질 자극 호르몬 방출 인자 길항 작용을 갖는 3 환식 화합물 및 이를 함유하는 약학 조성물 |
| WO2009093208A2 (fr) * | 2008-01-24 | 2009-07-30 | Alla Chem, Llc | 2-amino 3-sulfonyl-pyrazolo[1,5-a] pyrimidines substituées fonctionnant comme des antagonistes des récepteurs 5-ht6 de sérotonine, procédés de fabrication et d'utilisation |
| RU2376291C1 (ru) * | 2008-05-07 | 2009-12-20 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 3,5-ДИАМИНО-4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 2-АМИНО-3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| RU2369600C1 (ru) * | 2008-01-24 | 2009-10-10 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ |
| KR20130043207A (ko) * | 2010-07-22 | 2013-04-29 | 자프겐 인크. | 트리시클릭 화합물 및 이의 제조 및 사용 방법 |
| EP2621925B1 (fr) * | 2010-09-28 | 2017-06-21 | Merck Sharp & Dohme Corp. | Composés tricycliques accolés inhibiteurs de la cible mammifère de la rapamycine |
| WO2012047569A1 (fr) * | 2010-09-28 | 2012-04-12 | Schering Corporation | Composés tricycliques accolés inhibiteurs de la cible mammifère de la rapamycine |
| CA2822071C (fr) * | 2010-12-17 | 2019-07-16 | Reata Pharmaceuticals, Inc. | Pyrazolyl- et pyrimidinyl-enones tricycliques en tant que modulateurs d'inflammation antioxydants |
| ES2583477T3 (es) | 2011-09-30 | 2016-09-21 | Ipsen Pharma S.A.S. | Inhibidores macrocíclicos de cinasa de LRRK2 |
| SG11201701936WA (en) | 2014-09-17 | 2017-04-27 | Oncodesign Sa | Macrocyclic lrrk2 kinase inhibitors |
| US11220510B2 (en) | 2018-04-09 | 2022-01-11 | Incyte Corporation | Pyrrole tricyclic compounds as A2A / A2B inhibitors |
| MX2022006853A (es) * | 2019-12-03 | 2022-09-19 | Turning Point Therapeutics Inc | Macrociclos para uso en el tratamiento de enfermedades. |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0503099A4 (en) | 1990-10-09 | 1993-12-01 | Otsuka Pharmaceutical Co., Ltd. | Pyrimidine derivative, production thereof, and androgen inhibitor |
| EP0795555A4 (fr) * | 1995-09-28 | 1998-01-07 | Otsuka Pharma Co Ltd | Analgesiques |
| DE69736711T2 (de) | 1996-08-28 | 2007-09-20 | Pfizer Inc. | Substituierte 6,5-heterobicyclische-derivate |
| JP2002517501A (ja) * | 1998-06-09 | 2002-06-18 | ニューロゲン コーポレイション | ピリド［２，３−ｂ］インドリジン誘導体およびそのアザ類似化合物；ＣＲＦ１特異的リガンド |
| PT1129091E (pt) * | 1998-11-12 | 2003-02-28 | Neurocrine Biosciences Inc | Antagonistas de receptor de crf e metodos relacionados |
| JP2002529469A (ja) * | 1998-11-12 | 2002-09-10 | ニューロクライン バイオサイエンシーズ， インコーポレイテッド | Ｃｒｆレセプターアンタゴニストおよびそれに関する方法 |
| PT1354884E (pt) * | 2000-12-28 | 2007-12-24 | Ono Pharmaceutical Co | Composto de ciclopenta (d) pirazolo [1,5-a] piramida como antagonista de receptor de crf |
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2001
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- 2001-12-27 EP EP01995808A patent/EP1354884B1/fr not_active Expired - Lifetime
- 2001-12-27 PL PL01363381A patent/PL363381A1/xx unknown
- 2001-12-27 RU RU2003119138/04A patent/RU2291869C2/ru not_active IP Right Cessation
- 2001-12-27 BR BR0116609-3A patent/BR0116609A/pt not_active Application Discontinuation
- 2001-12-27 KR KR1020037008815A patent/KR100843281B1/ko not_active Expired - Fee Related
- 2001-12-27 EP EP07111569A patent/EP1832590B8/fr not_active Expired - Lifetime
- 2001-12-27 CN CNA2006101061544A patent/CN1896076A/zh active Pending
- 2001-12-27 CA CA2432148A patent/CA2432148C/fr not_active Expired - Fee Related
- 2001-12-27 AT AT01995808T patent/ATE375345T1/de active
- 2001-12-27 US US10/250,328 patent/US7034153B2/en not_active Expired - Fee Related
- 2001-12-27 AU AU2002226674A patent/AU2002226674B2/en not_active Ceased
- 2001-12-27 CN CNB018227201A patent/CN1274690C/zh not_active Expired - Fee Related
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- 2001-12-27 MX MXPA03005913A patent/MXPA03005913A/es active IP Right Grant
- 2001-12-27 NZ NZ526712A patent/NZ526712A/en unknown
- 2001-12-27 DK DK01995808T patent/DK1354884T3/da active
- 2001-12-27 DE DE60130924T patent/DE60130924T2/de not_active Expired - Lifetime
- 2001-12-27 HU HU0303653A patent/HUP0303653A3/hu unknown
- 2001-12-27 AT AT07111569T patent/ATE526330T1/de not_active IP Right Cessation
- 2001-12-27 IL IL15660901A patent/IL156609A0/xx unknown
- 2001-12-27 CZ CZ20031777A patent/CZ20031777A3/cs unknown
- 2001-12-27 ES ES07111569T patent/ES2369837T3/es not_active Expired - Lifetime
- 2001-12-27 WO PCT/JP2001/011581 patent/WO2002053565A1/fr not_active Ceased
- 2001-12-28 TW TW090132698A patent/TWI293630B/zh not_active IP Right Cessation
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2003
- 2003-06-24 IL IL156609A patent/IL156609A/en not_active IP Right Cessation
- 2003-06-26 NO NO20032956A patent/NO326522B1/no not_active IP Right Cessation
- 2003-06-26 ZA ZA2003/05003A patent/ZA200305003B/en unknown
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2005
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