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ES2191611T3 - Compuesto bajo forma de isomero geometrico u optico puro o de mezcla de tales isomeros. - Google Patents

Compuesto bajo forma de isomero geometrico u optico puro o de mezcla de tales isomeros.

Info

Publication number
ES2191611T3
ES2191611T3 ES00907746T ES00907746T ES2191611T3 ES 2191611 T3 ES2191611 T3 ES 2191611T3 ES 00907746 T ES00907746 T ES 00907746T ES 00907746 T ES00907746 T ES 00907746T ES 2191611 T3 ES2191611 T3 ES 2191611T3
Authority
ES
Spain
Prior art keywords
alkyl group
phenyl
group
alkyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00907746T
Other languages
English (en)
Inventor
Frederic Galli
Samir Jegham
Alistair Lochead
Axelle Samson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of ES2191611T3 publication Critical patent/ES2191611T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compuesto bajo forma de isomero geométrico u óptico puro o de mezcla de tales isomeros, de fórmula general (I), **(Fórmula)** en la que R1 representa un átomo de hidrógeno, un grupo (C1-C4)alquilo, un grupo fenil(C1-C4)alquilo, un grupo fenil hidroxi(C1-C4)alquilo, un grupo furanil(C1-C4)alquilo o un grupo furanil hidroxi(C1-C4)alquilo, R2 representa o bien un átomo de hidrógeno o de halógeno o un grupo trifluorometilo, ciano, hidroxi, nitro, acetilo, (C1-C6)alquilo, (C1-C6)alcoxi o un grupo de fórmula general NR4R5 en la que R4 representa un átomo de hidrógeno o un grupo (C1-C4)alquilo o (C1-C4)alcanoilo y R5 representa un átomo de hidrógeno o un grupo (C1-C4)alquilo, o bien R4 y R5 forman, con el átomo de nitrógeno que los lleva, un ciclo de C4-C7, ya sea un grupo fenilo o naftilo eventualmente sustituido por un átomo de halógeno o un grupo trifluorometilo, trifluorometoxi, ciano, hidroxi, nitro, acetilo, (C1-C6)alquilo, (C1-C6, )alcoxi, metilenedioxi unido a las posiciones 2 y 3 o 3 y 4del ciclo fenilo, o fenilo, y R3 representa un átomo de hidrógeno o de halógeno o un grupo (C1-C4) alquilo en estado de base o de sal de adición con un ácido.
ES00907746T 1999-03-05 2000-03-01 Compuesto bajo forma de isomero geometrico u optico puro o de mezcla de tales isomeros. Expired - Lifetime ES2191611T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9902784A FR2790474B1 (fr) 1999-03-05 1999-03-05 Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ES2191611T3 true ES2191611T3 (es) 2003-09-16

Family

ID=9542888

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00907746T Expired - Lifetime ES2191611T3 (es) 1999-03-05 2000-03-01 Compuesto bajo forma de isomero geometrico u optico puro o de mezcla de tales isomeros.

Country Status (37)

Country Link
US (2) US6538003B1 (es)
EP (1) EP1161434B1 (es)
JP (1) JP4806123B2 (es)
KR (2) KR100768355B1 (es)
CN (1) CN1137894C (es)
AR (1) AR022820A1 (es)
AT (1) ATE231869T1 (es)
AU (1) AU764625B2 (es)
BG (1) BG65211B1 (es)
BR (1) BR0008763A (es)
CA (1) CA2372063C (es)
CO (1) CO5160250A1 (es)
CZ (1) CZ302259B6 (es)
DE (1) DE60001307T2 (es)
DK (1) DK1161434T3 (es)
EE (1) EE04497B1 (es)
ES (1) ES2191611T3 (es)
FR (1) FR2790474B1 (es)
HK (1) HK1040398B (es)
HR (1) HRP20010655B1 (es)
HU (1) HU228671B1 (es)
ID (1) ID30116A (es)
IL (2) IL145150A0 (es)
MX (1) MXPA01008972A (es)
NO (1) NO327119B1 (es)
NZ (1) NZ513561A (es)
PE (1) PE20001543A1 (es)
PL (1) PL201683B1 (es)
RS (1) RS49997B (es)
RU (1) RU2238273C2 (es)
SK (1) SK284339B6 (es)
TR (1) TR200102403T2 (es)
TW (1) TWI222975B (es)
UA (1) UA61164C2 (es)
UY (1) UY26048A1 (es)
WO (1) WO2000053608A1 (es)
ZA (1) ZA200106811B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
WO2004009116A2 (en) 2002-07-18 2004-01-29 Cytos Biotechnology Ag Hapten-carrier conjugates comprising virus like particles and uses thereof
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
DE60317564T2 (de) * 2002-12-06 2008-10-23 The Feinstein Institute For Medical Research Hemmung von entzündungen unter verwendung von alpha-7-rezeptor verbindenden cholinergen agonisten
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8486979B2 (en) * 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (es) * 2006-12-30 2008-07-31 Abbott Gmbh & Amp Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
US20080255203A1 (en) * 2007-04-12 2008-10-16 Abbott Laboratories Heterocyclic compounds and their methods of use
US20090076059A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched dianicline
WO2010009775A1 (de) 2007-12-07 2010-01-28 Abbott Gmbh & Co. Kg Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen
ES2397125T3 (es) * 2007-12-07 2013-03-04 Abbott Gmbh & Co. Kg Derivados de oxindol sustituidos con halógeno en la posición 5 y su uso para la producción de un medicamento para el tratamiento de enfermedades dependientes de la vasopresina
MX2010006204A (es) 2007-12-07 2011-03-16 Abbott Gmbh & Co Kg Derivados de oxindol 5,6-disubstituidos y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina.
CN101981027B (zh) 2007-12-07 2014-08-06 Abbvie德国有限责任两合公司 氨基甲基取代的羟吲哚衍生物及其用于治疗加压素依赖性疾病的用途
US20090221648A1 (en) * 2007-12-21 2009-09-03 Abbott Laboratories Compositions for treatment of cognitive disorders
US8383657B2 (en) * 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
WO2009146031A1 (en) 2008-03-31 2009-12-03 University Of South Florida Methods of treating disease-induced ataxia and non-ataxic imbalance
PL2540297T3 (pl) 2008-11-19 2015-12-31 Forum Pharmaceuticals Inc Leczenie zaburzeń funkcji poznawczych(R)-7-chloro-N-(chinuklidyn-3-ylo)benzo[b]tiofeno-2-karboksyamidem i jego farmaceutyczne dopuszczalnymi solami
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
CN102802620A (zh) * 2009-05-11 2012-11-28 英维沃医药有限公司 使用某种α-7烟酸受体与乙酰胆碱酯酶抑制剂结合治疗认知障碍
WO2010138600A2 (en) * 2009-05-29 2010-12-02 Abbott Laboratories Pharmaceutical compositions for the treatment of pain
KR101698250B1 (ko) 2010-05-17 2017-01-19 포럼 파마슈티칼즈 인크. (R)-7-클로로-N-(퀴누클리딘-3-일)벤조[b]티오펜-2-카르복사미드 히드로클로리드 모노히드레이트의 결정질 형태
RU2635522C2 (ru) 2012-05-08 2017-11-13 Форум Фармасьютикалз, Инк. Способы поддержания, лечения или улучшения когнитивной функции
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
JPH11512443A (ja) * 1995-09-22 1999-10-26 ノボ ノルディスク アクティーゼルスカブ 新規な置換アザ環式またはアザ二環式化合物
FR2761072B1 (fr) * 1997-03-20 1999-04-23 Synthelabo Derives de 2,3-dihydrofuro[3,2-b]pyridine, leur preparation et leur application en therapeutique
ATE254618T1 (de) * 1997-05-30 2003-12-15 Neurosearch As Spiro chinuclidin-derivate, ihre herstellung und verwendung
AR013184A1 (es) * 1997-07-18 2000-12-13 Astrazeneca Ab Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
SE9900100D0 (sv) * 1999-01-15 1999-01-15 Astra Ab New compounds

Also Published As

Publication number Publication date
CO5160250A1 (es) 2002-05-30
PE20001543A1 (es) 2001-03-18
PL352330A1 (en) 2003-08-11
WO2000053608A1 (fr) 2000-09-14
ZA200106811B (en) 2002-08-19
UY26048A1 (es) 2000-09-29
NO20014270L (no) 2001-11-05
KR20010102492A (ko) 2001-11-15
NZ513561A (en) 2003-06-30
UA61164C2 (uk) 2003-11-17
FR2790474B1 (fr) 2001-04-06
PL201683B1 (pl) 2009-04-30
BG105828A (bg) 2002-03-29
NO20014270D0 (no) 2001-09-03
ID30116A (id) 2001-11-08
DE60001307T2 (de) 2003-12-11
CZ302259B6 (cs) 2011-01-19
HUP0201753A3 (en) 2004-12-28
ATE231869T1 (de) 2003-02-15
DE60001307D1 (de) 2003-03-06
AR022820A1 (es) 2002-09-04
HK1040398A1 (en) 2002-06-07
TR200102403T2 (tr) 2001-12-21
SK284339B6 (sk) 2005-02-04
AU2922600A (en) 2000-09-28
BG65211B1 (bg) 2007-07-31
HU228671B1 (en) 2013-05-28
EP1161434A1 (fr) 2001-12-12
YU59601A (sh) 2004-03-12
HK1040398B (zh) 2003-07-18
HRP20010655B1 (en) 2003-06-30
KR100768355B1 (ko) 2007-10-17
CN1343208A (zh) 2002-04-03
RU2238273C2 (ru) 2004-10-20
MXPA01008972A (es) 2002-03-27
HRP20010655A2 (en) 2002-08-31
CN1137894C (zh) 2004-02-11
US6538003B1 (en) 2003-03-25
JP2002539129A (ja) 2002-11-19
HUP0201753A2 (en) 2002-09-28
EE200100470A (et) 2002-12-16
BR0008763A (pt) 2002-01-02
TWI222975B (en) 2004-11-01
DK1161434T3 (da) 2003-05-26
IL145150A (en) 2007-06-03
RS49997B (sr) 2008-09-29
JP4806123B2 (ja) 2011-11-02
US20030187012A1 (en) 2003-10-02
EP1161434B1 (fr) 2003-01-29
KR20070086359A (ko) 2007-08-27
CA2372063C (en) 2011-01-11
CZ20013102A3 (cs) 2002-01-16
NO327119B1 (no) 2009-04-27
FR2790474A1 (fr) 2000-09-08
EE04497B1 (et) 2005-06-15
AU764625B2 (en) 2003-08-28
IL145150A0 (en) 2002-06-30
US6908927B2 (en) 2005-06-21
SK12422001A3 (sk) 2002-04-04
CA2372063A1 (en) 2000-09-14

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