CO6321266A2 - Inhibidores limk2 compuestos de los cuales estan hechos y metodologia de uso - Google Patents
Inhibidores limk2 compuestos de los cuales estan hechos y metodologia de usoInfo
- Publication number
- CO6321266A2 CO6321266A2 CO10141442A CO10141442A CO6321266A2 CO 6321266 A2 CO6321266 A2 CO 6321266A2 CO 10141442 A CO10141442 A CO 10141442A CO 10141442 A CO10141442 A CO 10141442A CO 6321266 A2 CO6321266 A2 CO 6321266A2
- Authority
- CO
- Colombia
- Prior art keywords
- heteroalkyl
- heterocycle
- aryl
- hydrogen
- optionally substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 101001042360 Homo sapiens LIM domain kinase 2 Proteins 0.000 title 1
- 102100021756 LIM domain kinase 2 Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- -1 alkylheterocycle Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Un compuesto de la formula:O una sal farmacéuticamente aceptable, donde:A es un arilo opcionalmente substituido o heterociclo:R1 es hidrogeno, alógeno, ciano o alquilo, heteroalquilo, arilo, o heterociclo;R2 es hidrogeno, alógeno, ciano o alquilo, heteroalquilo, arilo, o heterociclo.R3 es R3A, OR3B, N(R3B)2, NC(O)R3B, NC(O)OR3B, NC(O)N(R3B)2, SR3B, SOR3B, o SO2R3B;Cada R3A es ciano C(O)R3C, CO2R3C, CON(R3C)2, o opcionalmente substituido alquilo, alquilarilo, alquiloheterociclo, arilo, heteroalquilo, heteroalquilarilo, heteroalquilheterociclo, o heterociclo;Cada R3B es independientemente hidrogeno, C(O)R3C, CO2R3C, CON(R3C)2, o alquilo opcionalmente substituido, heteroalquilo, arilo, o heterociclo;Cada R4 es independientemente alógeno, OR4A, OC(O)R4A, OC(O)N(R4A)2, N(R4A)2, Cada R4A es independientemente hidrogeno o alquilo opcionalmente substituido o heteroalquilo; y n es 0 - 3;Con la cláusula de que cuando R1 y R2 ambos son hidrogeno y A es fenilo, R4 no es alógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4660208P | 2008-04-21 | 2008-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6321266A2 true CO6321266A2 (es) | 2011-09-20 |
Family
ID=40785538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10141442A CO6321266A2 (es) | 2008-04-21 | 2010-11-11 | Inhibidores limk2 compuestos de los cuales estan hechos y metodologia de uso |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8193202B2 (es) |
| EP (2) | EP2674433A1 (es) |
| JP (1) | JP5575110B2 (es) |
| KR (2) | KR20160129909A (es) |
| CN (1) | CN101565420B (es) |
| AR (1) | AR071833A1 (es) |
| AU (1) | AU2009239500B2 (es) |
| CA (1) | CA2721919C (es) |
| CL (1) | CL2009000957A1 (es) |
| CO (1) | CO6321266A2 (es) |
| EA (1) | EA019488B1 (es) |
| IL (1) | IL208483A (es) |
| MX (1) | MX2010011450A (es) |
| NZ (1) | NZ588353A (es) |
| TW (1) | TW200948814A (es) |
| WO (1) | WO2009131940A1 (es) |
| ZA (1) | ZA201007129B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2674433A1 (en) | 2008-04-21 | 2013-12-18 | Lexicon Pharmaceuticals, Inc. | LIMK2 inhibitors, compositions comprising them and methods of their use |
| EP2525794A1 (en) | 2010-01-22 | 2012-11-28 | Lexicon Pharmaceuticals, Inc. | 5-(1h-pyrazol-5-yl)thiazole-based compounds for the treatment of diseases and disorders of the eye |
| TW201302754A (zh) * | 2010-11-05 | 2013-01-16 | Lexicon Pharmaceuticals Inc | ３－（４－（胺甲基）－１－（５－甲基－７ｈ－吡咯［２，３－ｄ］嘧啶－４－基）哌啶－４－甲醯胺基）苯基二甲基胺基甲酸酯之固態形式 |
| WO2012068232A1 (en) * | 2010-11-16 | 2012-05-24 | Purdue Research Foundation | Aurora a kinase effectors |
| PL2651417T3 (pl) | 2010-12-16 | 2017-08-31 | Calchan Limited | Pochodne pirolopirymidyny hamujące ASK1 |
| WO2012131297A1 (en) | 2011-03-28 | 2012-10-04 | Jonathan Bayldon Baell | Pyrido [3',2' :4,5] thieno [3, 2-d] pyrimidin- 4 - ylamine derivatives and their therapeutical use |
| WO2013138463A1 (en) | 2012-03-14 | 2013-09-19 | University Of Central Florida Research Foundation, Inc. | Neurofibromatoses therapeutic agents and screening for same |
| US20150238466A1 (en) * | 2012-06-28 | 2015-08-27 | Ramot At Tel-Aviv University Ltd. | Lim kinase inhibitors |
| AU2013312477B2 (en) * | 2012-09-06 | 2018-05-31 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2015025172A1 (en) * | 2013-08-22 | 2015-02-26 | Mark David Charles | 5-aryl-thiazol-2-yl-amine compounds and their therapeutic use |
| WO2015150337A1 (en) | 2014-04-01 | 2015-10-08 | Amakem Nv | Lim kinase inhibitors |
| SI3802517T1 (sl) | 2018-06-07 | 2023-04-28 | Idorsia Pharmaceuticals Ltd | Alkoksi-substituirani piridinilni derivati kot antagonisti receptorja LPA1 in njihova uporaba pri zdravljenju fibroze |
| AR119162A1 (es) | 2019-06-18 | 2021-12-01 | Idorsia Pharmaceuticals Ltd | Derivados de piridin-3-ilo |
| US20220288082A1 (en) * | 2019-09-25 | 2022-09-15 | Macquarie University | Treatment of dementia |
| KR102337947B1 (ko) * | 2020-02-25 | 2021-12-10 | 지니너스 주식회사 | 신장암 환자의 예후 예측을 위한 limk2의 용도 |
| EP3915990A1 (en) * | 2020-05-26 | 2021-12-01 | Centre National de la Recherche Scientifique | 4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-3,6-dihydropyridine-1-(2h)-carboxamide derivatives as limk and/or rock kinases inhibitors for use in the treatment of cancer |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4136173A (en) | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Mixed xanthan gum and locust beam gum therapeutic compositions |
| US4936825A (en) * | 1988-04-11 | 1990-06-26 | Ungerleider Bruce A | Method for reducing intraocular pressure caused by glaucoma |
| US5753664A (en) | 1995-03-16 | 1998-05-19 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use |
| US6686366B1 (en) * | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| HU230302B1 (hu) * | 2000-10-20 | 2015-12-28 | Eisai R&D Management Co., Ltd. | Nitrogéntartalmú aromás származékok és ezeket tartalmazó gyógyászati készítmények |
| AU2002320264B2 (en) | 2001-06-05 | 2008-05-01 | Exelixis, Inc. | GFATs as modifiers of the p53 pathway and methods of use |
| WO2003022214A2 (en) * | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
| SE0201980D0 (sv) * | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
| AU2003302377A1 (en) | 2002-11-27 | 2004-06-18 | Santen Pharmaceutical Co., Ltd. | Remedy for glaucoma containing lim kinase inhibitory compound as active ingredient |
| US7253166B2 (en) * | 2003-04-22 | 2007-08-07 | Irm Llc | 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells |
| TWI336257B (en) | 2003-06-13 | 2011-01-21 | Alcon Inc | Ophthalmic compositions containing a synergistic combination of three polymers |
| US8362017B2 (en) | 2003-08-29 | 2013-01-29 | Exelixis, Inc. | C-kit modulators and methods of use |
| CA2542076C (en) * | 2003-10-14 | 2013-02-26 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Substituted tricyclic compounds as protein kinase inhibitors |
| PH12012501891A1 (en) | 2003-11-21 | 2013-09-02 | Array Biopharma Inc | Akt protein kinase inhibitors |
| JP5213229B2 (ja) * | 2004-04-23 | 2013-06-19 | エグゼリクシス， インコーポレイテッド | キナーゼ調節因子および使用方法 |
| MY179032A (en) * | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| EP1810396A1 (en) | 2004-11-05 | 2007-07-25 | Labofa Munch A/S | A drive mechanism for elevating and lowering a tabletop |
| DK176311B1 (da) | 2004-11-08 | 2007-07-23 | Ecco Sko As | Sko og fremgangsmåde til fremstilling af sko |
| DE102004058683A1 (de) | 2004-12-06 | 2006-06-14 | Robert Bosch Gmbh | Streulichtblende zur Reduzierung des in eine Kamera fallenden Streulichts |
| US20060178388A1 (en) | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
| US7423043B2 (en) * | 2005-02-18 | 2008-09-09 | Lexicon Pharmaceuticals, Inc. | 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds |
| JP2009536620A (ja) | 2006-04-25 | 2009-10-15 | アステックス、セラピューティックス、リミテッド | 医薬組み合わせ物 |
| US20100016340A1 (en) * | 2006-04-25 | 2010-01-21 | Astex Therapeutics Limited | Pharmaceutical compounds |
| WO2007125315A2 (en) | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Pharmaceutical compounds |
| US8796293B2 (en) * | 2006-04-25 | 2014-08-05 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| US7918831B2 (en) | 2006-10-12 | 2011-04-05 | Colorado Catheter Company, Inc. | Catheter assembly having protective sheath |
| WO2008048024A1 (en) | 2006-10-20 | 2008-04-24 | Electronics And Telecommunications Research Institute | Sensor signal processor apparatus |
| WO2008051887A1 (en) * | 2006-10-23 | 2008-05-02 | Lexicon Pharmaceuticals, Inc. | Process for preparing 5-alkyl-7h-pyrrolo[2,3-d]pyrimidine-2-ols |
| AR064415A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de pirrolo-piperidinas y purinas,composiciones farmaceuticas que los contienen y usos en trastornos y/o enfermedades mediadas por pka y pkb. |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| ES2557931T3 (es) * | 2007-08-08 | 2016-01-29 | Lexicon Pharmaceuticals, Inc. | (7H-Pirrolo[2,3-d]pirimidin-4-il)-piperazinas como inhibidores de cinasas para el tratamiento de cáncer e inflamación |
| EP2674433A1 (en) | 2008-04-21 | 2013-12-18 | Lexicon Pharmaceuticals, Inc. | LIMK2 inhibitors, compositions comprising them and methods of their use |
-
2009
- 2009-04-20 EP EP13178589.1A patent/EP2674433A1/en not_active Withdrawn
- 2009-04-20 KR KR1020167030113A patent/KR20160129909A/ko not_active Ceased
- 2009-04-20 WO PCT/US2009/041126 patent/WO2009131940A1/en not_active Ceased
- 2009-04-20 CA CA2721919A patent/CA2721919C/en active Active
- 2009-04-20 MX MX2010011450A patent/MX2010011450A/es active IP Right Grant
- 2009-04-20 AU AU2009239500A patent/AU2009239500B2/en not_active Ceased
- 2009-04-20 NZ NZ588353A patent/NZ588353A/en not_active IP Right Cessation
- 2009-04-20 US US12/426,661 patent/US8193202B2/en active Active
- 2009-04-20 KR KR1020107023420A patent/KR101706391B1/ko not_active Expired - Fee Related
- 2009-04-20 EA EA201071224A patent/EA019488B1/ru not_active IP Right Cessation
- 2009-04-20 EP EP09735629.9A patent/EP2297153B1/en not_active Not-in-force
- 2009-04-20 JP JP2011505253A patent/JP5575110B2/ja not_active Expired - Fee Related
- 2009-04-21 CN CN200910136811.3A patent/CN101565420B/zh not_active Expired - Fee Related
- 2009-04-21 CL CL2009000957A patent/CL2009000957A1/es unknown
- 2009-04-21 TW TW098113230A patent/TW200948814A/zh unknown
- 2009-04-21 AR ARP090101402A patent/AR071833A1/es unknown
-
2010
- 2010-10-05 IL IL208483A patent/IL208483A/en active IP Right Grant
- 2010-10-06 ZA ZA2010/07129A patent/ZA201007129B/en unknown
- 2010-11-11 CO CO10141442A patent/CO6321266A2/es not_active Application Discontinuation
-
2012
- 2012-06-01 US US13/486,122 patent/US8450332B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2721919C (en) | 2016-08-16 |
| IL208483A0 (en) | 2010-12-30 |
| AU2009239500A1 (en) | 2009-10-29 |
| JP5575110B2 (ja) | 2014-08-20 |
| KR20160129909A (ko) | 2016-11-09 |
| US8193202B2 (en) | 2012-06-05 |
| JP2011518189A (ja) | 2011-06-23 |
| MX2010011450A (es) | 2010-11-10 |
| WO2009131940A1 (en) | 2009-10-29 |
| CN101565420A (zh) | 2009-10-28 |
| ZA201007129B (en) | 2011-12-28 |
| EA019488B1 (ru) | 2014-04-30 |
| EP2297153A1 (en) | 2011-03-23 |
| TW200948814A (en) | 2009-12-01 |
| AR071833A1 (es) | 2010-07-21 |
| AU2009239500B2 (en) | 2014-01-30 |
| EA201071224A1 (ru) | 2011-06-30 |
| US20120329818A1 (en) | 2012-12-27 |
| CN101565420B (zh) | 2015-05-20 |
| KR20110008047A (ko) | 2011-01-25 |
| IL208483A (en) | 2014-02-27 |
| KR101706391B1 (ko) | 2017-02-13 |
| US20090264450A1 (en) | 2009-10-22 |
| EP2674433A1 (en) | 2013-12-18 |
| CA2721919A1 (en) | 2009-10-29 |
| US8450332B2 (en) | 2013-05-28 |
| EP2297153B1 (en) | 2015-05-27 |
| NZ588353A (en) | 2011-10-28 |
| CL2009000957A1 (es) | 2009-09-25 |
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