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EE200200135A - D4 antagonistidena toimivad tienoisoksasolüül- jatienüülpürrasolüülfenoksü-asendatud propüülderivaadid - Google Patents

D4 antagonistidena toimivad tienoisoksasolüül- jatienüülpürrasolüülfenoksü-asendatud propüülderivaadid

Info

Publication number
EE200200135A
EE200200135A EEP200200135A EEP200200135A EE200200135A EE 200200135 A EE200200135 A EE 200200135A EE P200200135 A EEP200200135 A EE P200200135A EE P200200135 A EEP200200135 A EE P200200135A EE 200200135 A EE200200135 A EE 200200135A
Authority
EE
Estonia
Prior art keywords
thienylpyrazolylphenoxy
thienoisoxazolyl
antagonists
substituted propyl
propyl derivatives
Prior art date
Application number
EEP200200135A
Other languages
English (en)
Inventor
M. Fink David
S. Freed Brian
J. Hrib Nicholas
W. Kosley Raymond Jr.
E. Lee George
H. Merriman Gregory
S. Rauckman Barbara
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of EE200200135A publication Critical patent/EE200200135A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
EEP200200135A 1999-09-14 2000-09-13 D4 antagonistidena toimivad tienoisoksasolüül- jatienüülpürrasolüülfenoksü-asendatud propüülderivaadid EE200200135A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39608199A 1999-09-14 1999-09-14
PCT/US2000/024962 WO2001019833A1 (en) 1999-09-14 2000-09-13 Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists

Publications (1)

Publication Number Publication Date
EE200200135A true EE200200135A (et) 2003-04-15

Family

ID=23565772

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200135A EE200200135A (et) 1999-09-14 2000-09-13 D4 antagonistidena toimivad tienoisoksasolüül- jatienüülpürrasolüülfenoksü-asendatud propüülderivaadid

Country Status (26)

Country Link
EP (1) EP1216250B1 (et)
JP (1) JP4847662B2 (et)
KR (1) KR20020027647A (et)
AR (1) AR032134A1 (et)
AT (1) ATE254621T1 (et)
AU (1) AU7577400A (et)
BR (1) BR0014515A (et)
CA (1) CA2383340C (et)
CY (1) CY1101692T1 (et)
CZ (1) CZ2002897A3 (et)
DE (1) DE60006699T2 (et)
DK (1) DK1216250T3 (et)
EA (1) EA200200355A1 (et)
EE (1) EE200200135A (et)
ES (1) ES2209995T3 (et)
HR (1) HRP20020220A2 (et)
HU (1) HUP0203526A3 (et)
IL (1) IL148623A0 (et)
MX (1) MXPA02002695A (et)
NO (1) NO20021251L (et)
PL (1) PL354515A1 (et)
PT (1) PT1216250E (et)
SK (1) SK3512002A3 (et)
TW (1) TW530060B (et)
WO (1) WO2001019833A1 (et)
ZA (1) ZA200201762B (et)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
MXPA03006524A (es) * 2001-02-16 2003-09-25 Aventis Pharma Inc Derivados heterociclicos novedosos de amidas y su uso como ligandos para receptor d3 de dopamina.
CA2440842A1 (en) 2001-04-16 2002-10-24 Eisai Co., Ltd. Novel 1h-indazole compounds
KR20040020457A (ko) * 2002-08-30 2004-03-09 주식회사 대웅 3-｛2-[4-(6-플루오로벤조[ｄ]이속사졸-3-일)피페리디노]에틸｝-2-메틸-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-4-온 또는 그 산부가염의 제조방법
JP2006515891A (ja) * 2003-01-17 2006-06-08 シーブイ・セラピューティクス・インコーポレイテッド 循環器疾患の処置に有効な置換ヘテロ環化合物
JP2007297321A (ja) * 2006-04-28 2007-11-15 Daiso Co Ltd アリール２−メチルグリシジルエーテル類の製造法
JP2007297330A (ja) * 2006-04-28 2007-11-15 Daiso Co Ltd ２−メチルグリシジル誘導体の製造法
HRP20182037T1 (hr) 2012-12-21 2019-02-08 Epizyme, Inc. Inhibitori prmt5 i njihova uporaba
WO2014100695A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
WO2014100716A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
EP2935247B1 (en) 2012-12-21 2019-08-28 Epizyme, Inc. Prmt5 inhibitors and uses thereof
EP3406607A1 (en) 2012-12-21 2018-11-28 Epizyme, Inc. Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
EP3160477A4 (en) * 2014-06-25 2018-07-04 Epizyme, Inc. Prmt5 inhibitors and uses thereof
AU2015301196A1 (en) 2014-08-04 2017-01-12 Epizyme, Inc. PRMT5 inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728651A (en) * 1985-10-24 1988-03-01 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive thieno-isoxazoles and -pyrazoles
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
US6335326B1 (en) * 1998-02-09 2002-01-01 Duphar International Research B.V. Benzisoxazole derivatives having d4-antagonistic activity

Also Published As

Publication number Publication date
BR0014515A (pt) 2002-06-25
HUP0203526A2 (hu) 2003-01-28
CY1101692T1 (el) 2010-07-28
PL354515A1 (en) 2004-01-26
HUP0203526A3 (en) 2004-12-28
CZ2002897A3 (cs) 2002-07-17
CA2383340A1 (en) 2001-03-22
TW530060B (en) 2003-05-01
ZA200201762B (en) 2003-08-27
SK3512002A3 (en) 2003-03-04
NO20021251D0 (no) 2002-03-13
CA2383340C (en) 2010-06-15
KR20020027647A (ko) 2002-04-13
EP1216250A1 (en) 2002-06-26
AR032134A1 (es) 2003-10-29
ATE254621T1 (de) 2003-12-15
WO2001019833A1 (en) 2001-03-22
IL148623A0 (en) 2002-09-12
DE60006699D1 (en) 2003-12-24
EA200200355A1 (ru) 2002-10-31
MXPA02002695A (es) 2002-07-30
ES2209995T3 (es) 2004-07-01
JP2003509432A (ja) 2003-03-11
AU7577400A (en) 2001-04-17
NO20021251L (no) 2002-05-10
HRP20020220A2 (en) 2004-02-29
JP4847662B2 (ja) 2011-12-28
PT1216250E (pt) 2004-04-30
EP1216250B1 (en) 2003-11-19
DK1216250T3 (da) 2004-02-23
DE60006699T2 (de) 2004-09-30

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