MXPA02002695A - Derivados de propilo tienoisoxazolil- y tienilpirrazolil-fenoxi sustituidos utiles como antagonistas de d4. - Google Patents
Derivados de propilo tienoisoxazolil- y tienilpirrazolil-fenoxi sustituidos utiles como antagonistas de d4.Info
- Publication number
- MXPA02002695A MXPA02002695A MXPA02002695A MXPA02002695A MXPA02002695A MX PA02002695 A MXPA02002695 A MX PA02002695A MX PA02002695 A MXPA02002695 A MX PA02002695A MX PA02002695 A MXPA02002695 A MX PA02002695A MX PA02002695 A MXPA02002695 A MX PA02002695A
- Authority
- MX
- Mexico
- Prior art keywords
- thienylpyrrazolyl
- thienoisoxazolyl
- compounds
- disorder
- phenoxy substituted
- Prior art date
Links
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 title abstract 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000011117 substance-related disease Diseases 0.000 abstract 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000027448 Attention Deficit and Disruptive Behavior disease Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000027691 Conduct disease Diseases 0.000 abstract 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 1
- 206010034010 Parkinsonism Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000024196 oppositional defiant disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
- 201000009032 substance abuse Diseases 0.000 abstract 1
- 231100000736 substance abuse Toxicity 0.000 abstract 1
- 201000006152 substance dependence Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Los compuestos son de la clase de derivados de propilo tienoisoxazolil- y tienilpirrazolil- fenoxi sustituidos, utiles como antagonistas de D4. Tales compuestos son utiles para el tratamiento de condiciones medicas mediadas por la inhibicion de receptor D4. Estas condiciones comprenden, por ejemplo, Trastorno de Deficit de Atencion/HiperactIvidad, Trastorno Obsesivo-Compulsivo, Psicosis, Abuso -de Sustancias, Dependencia de Sustancias, Enfermedad de Parkinson, Parkinsonismo, Disquinesia Tardia, Sindrome de Gilles de la Tourette, Trastorno del Comportamiento, y Trastorno Desafiante Oposicional. Un aspecto adicional de la invencion es proporcionar una composicion farmaceutica, compuestos intermedios y un metodo para elaborar dicha clase de compuestos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39608199A | 1999-09-14 | 1999-09-14 | |
| PCT/US2000/024962 WO2001019833A1 (en) | 1999-09-14 | 2000-09-13 | Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02002695A true MXPA02002695A (es) | 2002-07-30 |
Family
ID=23565772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02002695A MXPA02002695A (es) | 1999-09-14 | 2000-09-13 | Derivados de propilo tienoisoxazolil- y tienilpirrazolil-fenoxi sustituidos utiles como antagonistas de d4. |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1216250B1 (es) |
| JP (1) | JP4847662B2 (es) |
| KR (1) | KR20020027647A (es) |
| AR (1) | AR032134A1 (es) |
| AT (1) | ATE254621T1 (es) |
| AU (1) | AU7577400A (es) |
| BR (1) | BR0014515A (es) |
| CA (1) | CA2383340C (es) |
| CY (1) | CY1101692T1 (es) |
| CZ (1) | CZ2002897A3 (es) |
| DE (1) | DE60006699T2 (es) |
| DK (1) | DK1216250T3 (es) |
| EA (1) | EA200200355A1 (es) |
| EE (1) | EE200200135A (es) |
| ES (1) | ES2209995T3 (es) |
| HR (1) | HRP20020220A2 (es) |
| HU (1) | HUP0203526A3 (es) |
| IL (1) | IL148623A0 (es) |
| MX (1) | MXPA02002695A (es) |
| NO (1) | NO20021251L (es) |
| PL (1) | PL354515A1 (es) |
| PT (1) | PT1216250E (es) |
| SK (1) | SK3512002A3 (es) |
| TW (1) | TW530060B (es) |
| WO (1) | WO2001019833A1 (es) |
| ZA (1) | ZA200201762B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
| US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| US7253165B2 (en) | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
| WO2002066469A2 (en) * | 2001-02-16 | 2002-08-29 | Aventis Pharmaceuticals Inc. | Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands |
| CA2440842A1 (en) | 2001-04-16 | 2002-10-24 | Eisai Co., Ltd. | Novel 1h-indazole compounds |
| KR20040020457A (ko) * | 2002-08-30 | 2004-03-09 | 주식회사 대웅 | 3-｛2-[4-(6-플루오로벤조[ｄ]이속사졸-3-일)피페리디노]에틸｝-2-메틸-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-4-온 또는 그 산부가염의 제조방법 |
| KR20050092424A (ko) * | 2003-01-17 | 2005-09-21 | 씨브이 쎄러퓨틱스, 인코포레이티드 | 심혈관 질환의 치료에 유용한 치환된 헤테로고리 화합물 |
| JP2007297321A (ja) * | 2006-04-28 | 2007-11-15 | Daiso Co Ltd | アリール２−メチルグリシジルエーテル類の製造法 |
| JP2007297330A (ja) * | 2006-04-28 | 2007-11-15 | Daiso Co Ltd | ２−メチルグリシジル誘導体の製造法 |
| WO2014100716A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| JP2016505002A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用 |
| JP2016505597A (ja) | 2012-12-21 | 2016-02-25 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| US9604930B2 (en) | 2012-12-21 | 2017-03-28 | Epizyme, Inc. | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof |
| JP2016505000A (ja) * | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| EP3160477A4 (en) * | 2014-06-25 | 2018-07-04 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2016022605A1 (en) | 2014-08-04 | 2016-02-11 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4728651A (en) * | 1985-10-24 | 1988-03-01 | Hoechst-Roussel Pharmaceuticals Inc. | Antihypertensive thieno-isoxazoles and -pyrazoles |
| US6187774B1 (en) * | 1996-03-04 | 2001-02-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and pharmaceutical applications thereof |
| HUP9603001A3 (en) * | 1996-10-30 | 1999-07-28 | Richter Gedeon Vegyeszet | Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same |
| WO1999040067A2 (en) * | 1998-02-09 | 1999-08-12 | Duphar International Research B.V. | Benzisoxazole derivatives having d4-antagonistic activity |
-
2000
- 2000-09-13 KR KR1020027003366A patent/KR20020027647A/ko not_active Withdrawn
- 2000-09-13 MX MXPA02002695A patent/MXPA02002695A/es active IP Right Grant
- 2000-09-13 EP EP00964969A patent/EP1216250B1/en not_active Expired - Lifetime
- 2000-09-13 WO PCT/US2000/024962 patent/WO2001019833A1/en not_active Ceased
- 2000-09-13 DE DE60006699T patent/DE60006699T2/de not_active Expired - Lifetime
- 2000-09-13 AU AU75774/00A patent/AU7577400A/en not_active Abandoned
- 2000-09-13 DK DK00964969T patent/DK1216250T3/da active
- 2000-09-13 PL PL00354515A patent/PL354515A1/xx unknown
- 2000-09-13 AT AT00964969T patent/ATE254621T1/de not_active IP Right Cessation
- 2000-09-13 JP JP2001523410A patent/JP4847662B2/ja not_active Expired - Fee Related
- 2000-09-13 SK SK351-2002A patent/SK3512002A3/sk unknown
- 2000-09-13 IL IL14862300A patent/IL148623A0/xx unknown
- 2000-09-13 CA CA2383340A patent/CA2383340C/en not_active Expired - Fee Related
- 2000-09-13 PT PT00964969T patent/PT1216250E/pt unknown
- 2000-09-13 EA EA200200355A patent/EA200200355A1/ru unknown
- 2000-09-13 HR HR20020220A patent/HRP20020220A2/hr not_active Application Discontinuation
- 2000-09-13 HU HU0203526A patent/HUP0203526A3/hu unknown
- 2000-09-13 BR BR0014515-7A patent/BR0014515A/pt not_active IP Right Cessation
- 2000-09-13 AR ARP000104793A patent/AR032134A1/es not_active Application Discontinuation
- 2000-09-13 CZ CZ2002897A patent/CZ2002897A3/cs unknown
- 2000-09-13 EE EEP200200135A patent/EE200200135A/xx unknown
- 2000-09-13 ES ES00964969T patent/ES2209995T3/es not_active Expired - Lifetime
- 2000-09-14 TW TW089118850A patent/TW530060B/zh not_active IP Right Cessation
-
2002
- 2002-03-13 NO NO20021251A patent/NO20021251L/no not_active Application Discontinuation
- 2002-03-21 ZA ZA200201762A patent/ZA200201762B/en unknown
-
2004
- 2004-02-12 CY CY20041100175T patent/CY1101692T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0203526A3 (en) | 2004-12-28 |
| HUP0203526A2 (hu) | 2003-01-28 |
| NO20021251L (no) | 2002-05-10 |
| EP1216250A1 (en) | 2002-06-26 |
| WO2001019833A1 (en) | 2001-03-22 |
| ATE254621T1 (de) | 2003-12-15 |
| BR0014515A (pt) | 2002-06-25 |
| HRP20020220A2 (en) | 2004-02-29 |
| PT1216250E (pt) | 2004-04-30 |
| SK3512002A3 (en) | 2003-03-04 |
| CY1101692T1 (el) | 2010-07-28 |
| PL354515A1 (en) | 2004-01-26 |
| EP1216250B1 (en) | 2003-11-19 |
| AR032134A1 (es) | 2003-10-29 |
| KR20020027647A (ko) | 2002-04-13 |
| JP4847662B2 (ja) | 2011-12-28 |
| CA2383340C (en) | 2010-06-15 |
| CA2383340A1 (en) | 2001-03-22 |
| CZ2002897A3 (cs) | 2002-07-17 |
| IL148623A0 (en) | 2002-09-12 |
| JP2003509432A (ja) | 2003-03-11 |
| ZA200201762B (en) | 2003-08-27 |
| AU7577400A (en) | 2001-04-17 |
| EE200200135A (et) | 2003-04-15 |
| TW530060B (en) | 2003-05-01 |
| EA200200355A1 (ru) | 2002-10-31 |
| NO20021251D0 (no) | 2002-03-13 |
| DE60006699T2 (de) | 2004-09-30 |
| DK1216250T3 (da) | 2004-02-23 |
| ES2209995T3 (es) | 2004-07-01 |
| DE60006699D1 (en) | 2003-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| GB | Transfer or rights |